YHR016C / YSC84

Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR016C / YSC84

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:-3.73|P-value:1.24E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.62|P-value:1.98E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.20|P-value:8.38E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.59|P-value:2.15E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.16|P-value:9.54E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.69|P-value:1.48E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.28|P-value:6.59E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.22|P-value:8.06E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.30|P-value:6.08E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.74|P-value:1.21E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.89|P-value:6.92E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:4.16|P-value:2.31E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:3.95|P-value:5.44E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:4.44|P-value:6.64E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:7.08|P-value:1.89E-12 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.10|P-value:2.93E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.16|P-value:9.64E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.08|P-value:3.19E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.60|P-value:3.32E-6 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.40|P-value:4.30E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.29|P-value:6.35E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.21|P-value:8.44E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.36|P-value:4.96E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.86|P-value:7.72E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-5.06|P-value:3.36E-7 ID:SGTC_1742|Compound:st038235|FD-Score:-3.59|P-value:2.12E-4 ID:SGTC_1749|Compound:st037932|FD-Score:6.58|P-value:5.69E-11 ID:SGTC_1822|Compound:st052468|FD-Score:3.48|P-value:3.19E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.46|P-value:3.48E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.43|P-value:3.94E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.34|P-value:5.39E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.65|P-value:1.72E-4 ID:SGTC_1997|Compound:st073024|FD-Score:-3.18|P-value:9.02E-4 ID:SGTC_2037|Compound:5169046|FD-Score:4.73|P-value:1.75E-6 ID:SGTC_2062|Compound:5245942|FD-Score:4.27|P-value:1.42E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.18|P-value:9.18E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.26|P-value:6.98E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.94|P-value:5.42E-5 ID:SGTC_2484|Compound:5809818|FD-Score:3.17|P-value:9.45E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-4.90|P-value:7.50E-7 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.38|P-value:4.61E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.33|P-value:5.56E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.36|P-value:9.64E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.19|P-value:8.88E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.83|P-value:8.65E-5 ID:SGTC_2892|Compound:9047358|FD-Score:3.53|P-value:2.74E-4 ID:SGTC_2941|Compound:9056145|FD-Score:7.68|P-value:2.47E-14 ID:SGTC_2942|Compound:9052777|FD-Score:6.21|P-value:5.65E-10 ID:SGTC_2946|Compound:9065502|FD-Score:-3.57|P-value:2.27E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.44|P-value:3.74E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.71|P-value:1.33E-4 ID:SGTC_3075|Compound:9116269|FD-Score:7.00|P-value:3.34E-12 ID:SGTC_3174|Compound:9107204|FD-Score:3.57|P-value:2.34E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.73|P-value:1.24E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.62|P-value:1.98E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.20|P-value:8.38E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.59|P-value:2.15E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.16|P-value:9.54E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.69|P-value:1.48E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.28|P-value:6.59E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.22|P-value:8.06E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.30|P-value:6.08E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.74|P-value:1.21E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.89|P-value:6.92E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:4.16|P-value:2.31E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:3.95|P-value:5.44E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:4.44|P-value:6.64E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:7.08|P-value:1.89E-12 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.10|P-value:2.93E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.16|P-value:9.64E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.08|P-value:3.19E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.60|P-value:3.32E-6 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.40|P-value:4.30E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.29|P-value:6.35E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.21|P-value:8.44E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.36|P-value:4.96E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.86|P-value:7.72E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-5.06|P-value:3.36E-7 ID:SGTC_1742|Compound:st038235|FD-Score:-3.59|P-value:2.12E-4 ID:SGTC_1749|Compound:st037932|FD-Score:6.58|P-value:5.69E-11 ID:SGTC_1822|Compound:st052468|FD-Score:3.48|P-value:3.19E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.46|P-value:3.48E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.43|P-value:3.94E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.34|P-value:5.39E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.65|P-value:1.72E-4 ID:SGTC_1997|Compound:st073024|FD-Score:-3.18|P-value:9.02E-4 ID:SGTC_2037|Compound:5169046|FD-Score:4.73|P-value:1.75E-6 ID:SGTC_2062|Compound:5245942|FD-Score:4.27|P-value:1.42E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.18|P-value:9.18E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.26|P-value:6.98E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.94|P-value:5.42E-5 ID:SGTC_2484|Compound:5809818|FD-Score:3.17|P-value:9.45E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-4.90|P-value:7.50E-7 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.38|P-value:4.61E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.33|P-value:5.56E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.36|P-value:9.64E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.19|P-value:8.88E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.83|P-value:8.65E-5 ID:SGTC_2892|Compound:9047358|FD-Score:3.53|P-value:2.74E-4 ID:SGTC_2941|Compound:9056145|FD-Score:7.68|P-value:2.47E-14 ID:SGTC_2942|Compound:9052777|FD-Score:6.21|P-value:5.65E-10 ID:SGTC_2946|Compound:9065502|FD-Score:-3.57|P-value:2.27E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.44|P-value:3.74E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.71|P-value:1.33E-4 ID:SGTC_3075|Compound:9116269|FD-Score:7.00|P-value:3.34E-12 ID:SGTC_3174|Compound:9107204|FD-Score:3.57|P-value:2.34E-4

Top fitness defect scores for YHR016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2941 9056145 7.68 11.2 µM 2.47E-14 2 7.69E-15
2 SGTC_1070 indatraline 7.08 8.8 µM 1.89E-12 60S ribosome export 3 6.99E-13
3 SGTC_3075 9116269 7.00 49.5 µM 3.34E-12 3 1.26E-12
4 SGTC_1749 st037932 6.58 54.2 µM 5.69E-11 4 2.40E-11
5 SGTC_2942 9052777 6.21 62.2 µM 5.65E-10 4 2.61E-10
6 SGTC_2037 5169046 4.73 200.0 µM 1.75E-6 60S ribosome export 4 1.11E-6
7 SGTC_1244 0416-0015 4.60 52.5 µM 3.32E-6 ERG2 16 2.15E-6
8 SGTC_893 0958-0369 4.44 48.9 µM 6.64E-6 18 4.42E-6
9 SGTC_2841 9004761 4.36 39.0 µM 9.64E-6 amide catabolism 16 6.50E-6
10 SGTC_2062 5245942 4.27 200.0 µM 1.42E-5 10 9.70E-6
11 SGTC_792 4534-1957 4.16 155.0 µM 2.31E-5 27 1.61E-5
12 SGTC_1083 didemethylchlorpromazine sulfoxide 4.10 707.4 nM 2.93E-5 redox potentiating 72 2.06E-5
13 SGTC_1239 0337-0584 4.08 35.4 µM 3.19E-5 unfolded protein response 46 2.26E-5
14 SGTC_848 0368-0089 3.95 85.6 µM 5.44E-5 iron homeostasis 14 3.92E-5
15 SGTC_786 4544-0069 3.89 423.0 µM 6.92E-5 31 5.04E-5
16 SGTC_1725 st036284 3.86 20.6 µM 7.72E-5 26 5.64E-5
17 SGTC_2889 9059656 3.83 52.0 µM 8.65E-5 10 6.35E-5
18 SGTC_686 1319-0111 3.74 510.0 µM 1.21E-4 60S ribosome export 33 9.02E-5
19 SGTC_1995 st072814 3.65 61.1 µM 1.72E-4 17 1.29E-4
20 SGTC_325 2810-4341 3.62 181.0 µM 1.98E-4 amide catabolism 14 1.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 5.64E-18 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.115 2.19E-11 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.109 2.28E-10 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.106 6.34E-10 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.105 1.18E-9 YML060W OGG1 hom Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
0.099 8.50E-9 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 5.10E-8 YFR028C CDC14 het Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
0.094 5.70E-8 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.089 2.70E-7 YDL083C RPS16B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication
0.087 4.31E-7 YGR194C XKS1 hom Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
0.084 1.05E-6 YPR145W ASN1 hom Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication
0.082 1.92E-6 YPL218W SAR1 het GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
0.080 3.34E-6 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.080 3.86E-6 YNR019W ARE2 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication
0.079 4.67E-6 YDL208W NHP2 het Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing