HIPHOP chemogenomics database

YHR017W / YSC83

Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR017W / YSC83

Click on Significant Values for Screen Details

Top fitness defect scores for YHR017W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2834	9001755	10.80	58.4 µM	2.94E-22		3	1.38E-27
2	SGTC_2009	4012297	8.12	12.1 µM	2.44E-13	cell wall signaling	13	2.29E-16
3	SGTC_3029	9088683	6.78	49.5 µM	7.83E-10		2	5.83E-12
4	SGTC_821	1114-0266	6.12	29.2 µM	2.62E-8		2	4.76E-10
5	SGTC_3207	9114163	5.57	49.5 µM	3.67E-7		9	1.30E-8
6	SGTC_2837	9008476	5.50	45.5 µM	4.94E-7		8	1.90E-8
7	SGTC_1666	st014829	5.29	29.0 µM	1.27E-6	calcium & mitochondrial duress	13	6.17E-8
8	SGTC_3016	9080866	5.28	49.5 µM	1.30E-6		6	6.36E-8
9	SGTC_538	2922-0838	5.28	53.3 µM	1.31E-6	Golgi	11	6.45E-8
10	SGTC_2738	aclarubicin	5.26	5.5 µM	1.41E-6	RNA pol III & RNase P/MRP	3	7.02E-8
11	SGTC_3212	9128307	5.14	49.5 µM	2.43E-6		25	1.39E-7
12	SGTC_2055	5235184	5.11	200.0 µM	2.72E-6	ERG2	10	1.60E-7
13	SGTC_1985	st071382	4.93	65.5 µM	5.69E-6		7	4.04E-7
14	SGTC_2529	gangaleoidin	4.83	93.6 µM	8.78E-6		9	6.95E-7
15	SGTC_2749	bexarotene	4.80	57.4 µM	9.94E-6		11	8.11E-7
16	SGTC_1024	4507-0395	4.76	26.0 µM	1.15E-5	TSC3-RPN4	15	9.76E-7
17	SGTC_1811	st050069	4.73	61.5 µM	1.29E-5		2	1.12E-6
18	SGTC_1436	4092-1007	4.66	8.3 µM	1.68E-5		5	1.56E-6
19	SGTC_1611	st001856	4.65	99.4 µM	1.74E-5		7	1.63E-6
20	SGTC_2011	4012611	4.65	177.0 µM	1.79E-5	mitochondrial processes	17	1.70E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.086	5.76E-7	YJR075W	HOC1	hom	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.086	5.88E-7	YKL133C_p	YKL133C_p	hom	Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)
0.085	7.22E-7	YFR040W	SAP155	hom	Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress
0.085	7.71E-7	YCL064C	CHA1	hom	Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
0.085	9.40E-7	YGR196C	FYV8	hom	Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.083	1.62E-6	YPL127C	HHO1	hom	Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination
0.078	6.30E-6	YJL217W	REE1	hom	Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle
0.075	1.23E-5	YPL110C	GDE1	hom	Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.073	2.61E-5	YPL061W	ALD6	hom	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.072	2.92E-5	YGL141W	HUL5	hom	Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.069	5.71E-5	YHL005C_d	YHL005C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W
0.069	6.06E-5	YLL010C	PSR1	hom	Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.069	6.64E-5	YNL104C	LEU4	hom	Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.065	1.81E-4	YHL003C	LAG1	hom	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.061	3.90E-4	YBL037W	APL3	hom	Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport