YHR017W / YSC83

Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR017W / YSC83

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:4.04|P-value:1.65E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.53|P-value:8.55E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:5.28|P-value:1.31E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:3.78|P-value:3.87E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.80|P-value:3.61E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.90|P-value:2.62E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.63|P-value:6.20E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.83|P-value:3.27E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.92|P-value:2.48E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.77|P-value:4.01E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:6.12|P-value:2.62E-8 ID:SGTC_944|Compound:3370-0224|FD-Score:4.40|P-value:4.61E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.69|P-value:5.10E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.25|P-value:7.73E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:4.25|P-value:7.71E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.60|P-value:6.94E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.33|P-value:5.87E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.76|P-value:1.15E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.73|P-value:4.51E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.51|P-value:8.98E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.48|P-value:3.43E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.84|P-value:3.06E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.56|P-value:7.66E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.59|P-value:2.26E-5 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.66|P-value:1.68E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.45|P-value:3.76E-5 ID:SGTC_1609|Compound:st001574|FD-Score:4.41|P-value:4.38E-5 ID:SGTC_1611|Compound:st001856|FD-Score:4.65|P-value:1.74E-5 ID:SGTC_1666|Compound:st014829|FD-Score:5.29|P-value:1.27E-6 ID:SGTC_1811|Compound:st050069|FD-Score:4.73|P-value:1.29E-5 ID:SGTC_1812|Compound:st052057|FD-Score:3.49|P-value:9.46E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.90|P-value:2.61E-4 ID:SGTC_1949|Compound:st076024|FD-Score:4.05|P-value:1.58E-4 ID:SGTC_1985|Compound:st071382|FD-Score:4.93|P-value:5.69E-6 ID:SGTC_2003|Compound:4023581|FD-Score:3.65|P-value:5.83E-4 ID:SGTC_2009|Compound:4012297|FD-Score:8.12|P-value:2.44E-13 ID:SGTC_2011|Compound:4012611|FD-Score:4.65|P-value:1.79E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-4.31|P-value:5.97E-5 ID:SGTC_2055|Compound:5235184|FD-Score:5.11|P-value:2.72E-6 ID:SGTC_2187|Compound:6125751|FD-Score:4.13|P-value:1.20E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.53|P-value:8.35E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.76|P-value:4.02E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.74|P-value:4.41E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.83|P-value:8.78E-6 ID:SGTC_2738|Compound:aclarubicin|FD-Score:5.26|P-value:1.41E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:3.58|P-value:7.28E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.80|P-value:9.94E-6 ID:SGTC_2823|Compound:7987624|FD-Score:3.74|P-value:4.45E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.50|P-value:9.24E-4 ID:SGTC_2834|Compound:9001755|FD-Score:10.80|P-value:2.94E-22 ID:SGTC_2836|Compound:9010338|FD-Score:4.19|P-value:9.75E-5 ID:SGTC_2837|Compound:9008476|FD-Score:5.50|P-value:4.94E-7 ID:SGTC_3016|Compound:9080866|FD-Score:5.28|P-value:1.30E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.70|P-value:4.91E-4 ID:SGTC_3029|Compound:9088683|FD-Score:6.78|P-value:7.83E-10 ID:SGTC_3073|Compound:9114972|FD-Score:4.23|P-value:8.46E-5 ID:SGTC_3207|Compound:9114163|FD-Score:5.57|P-value:3.67E-7 ID:SGTC_3209|Compound:9113616|FD-Score:3.56|P-value:7.84E-4 ID:SGTC_3212|Compound:9128307|FD-Score:5.14|P-value:2.43E-6 ID:SGTC_3282|Compound:9108498|FD-Score:3.57|P-value:7.38E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.04|P-value:1.65E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.53|P-value:8.55E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:5.28|P-value:1.31E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:3.78|P-value:3.87E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.80|P-value:3.61E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.90|P-value:2.62E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.63|P-value:6.20E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.83|P-value:3.27E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.92|P-value:2.48E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.77|P-value:4.01E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:6.12|P-value:2.62E-8 ID:SGTC_944|Compound:3370-0224|FD-Score:4.40|P-value:4.61E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.69|P-value:5.10E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.25|P-value:7.73E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:4.25|P-value:7.71E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.60|P-value:6.94E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.33|P-value:5.87E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.76|P-value:1.15E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.73|P-value:4.51E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.51|P-value:8.98E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.48|P-value:3.43E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.84|P-value:3.06E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.56|P-value:7.66E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.59|P-value:2.26E-5 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.66|P-value:1.68E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.45|P-value:3.76E-5 ID:SGTC_1609|Compound:st001574|FD-Score:4.41|P-value:4.38E-5 ID:SGTC_1611|Compound:st001856|FD-Score:4.65|P-value:1.74E-5 ID:SGTC_1666|Compound:st014829|FD-Score:5.29|P-value:1.27E-6 ID:SGTC_1811|Compound:st050069|FD-Score:4.73|P-value:1.29E-5 ID:SGTC_1812|Compound:st052057|FD-Score:3.49|P-value:9.46E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.90|P-value:2.61E-4 ID:SGTC_1949|Compound:st076024|FD-Score:4.05|P-value:1.58E-4 ID:SGTC_1985|Compound:st071382|FD-Score:4.93|P-value:5.69E-6 ID:SGTC_2003|Compound:4023581|FD-Score:3.65|P-value:5.83E-4 ID:SGTC_2009|Compound:4012297|FD-Score:8.12|P-value:2.44E-13 ID:SGTC_2011|Compound:4012611|FD-Score:4.65|P-value:1.79E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-4.31|P-value:5.97E-5 ID:SGTC_2055|Compound:5235184|FD-Score:5.11|P-value:2.72E-6 ID:SGTC_2187|Compound:6125751|FD-Score:4.13|P-value:1.20E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.53|P-value:8.35E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.76|P-value:4.02E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.74|P-value:4.41E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.83|P-value:8.78E-6 ID:SGTC_2738|Compound:aclarubicin|FD-Score:5.26|P-value:1.41E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:3.58|P-value:7.28E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.80|P-value:9.94E-6 ID:SGTC_2823|Compound:7987624|FD-Score:3.74|P-value:4.45E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.50|P-value:9.24E-4 ID:SGTC_2834|Compound:9001755|FD-Score:10.80|P-value:2.94E-22 ID:SGTC_2836|Compound:9010338|FD-Score:4.19|P-value:9.75E-5 ID:SGTC_2837|Compound:9008476|FD-Score:5.50|P-value:4.94E-7 ID:SGTC_3016|Compound:9080866|FD-Score:5.28|P-value:1.30E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.70|P-value:4.91E-4 ID:SGTC_3029|Compound:9088683|FD-Score:6.78|P-value:7.83E-10 ID:SGTC_3073|Compound:9114972|FD-Score:4.23|P-value:8.46E-5 ID:SGTC_3207|Compound:9114163|FD-Score:5.57|P-value:3.67E-7 ID:SGTC_3209|Compound:9113616|FD-Score:3.56|P-value:7.84E-4 ID:SGTC_3212|Compound:9128307|FD-Score:5.14|P-value:2.43E-6 ID:SGTC_3282|Compound:9108498|FD-Score:3.57|P-value:7.38E-4

Top fitness defect scores for YHR017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2834 9001755 10.80 58.4 µM 2.94E-22 3 1.38E-27
2 SGTC_2009 4012297 8.12 12.1 µM 2.44E-13 cell wall signaling 13 2.29E-16
3 SGTC_3029 9088683 6.78 49.5 µM 7.83E-10 2 5.83E-12
4 SGTC_821 1114-0266 6.12 29.2 µM 2.62E-8 2 4.76E-10
5 SGTC_3207 9114163 5.57 49.5 µM 3.67E-7 9 1.30E-8
6 SGTC_2837 9008476 5.50 45.5 µM 4.94E-7 8 1.90E-8
7 SGTC_1666 st014829 5.29 29.0 µM 1.27E-6 calcium & mitochondrial duress 13 6.17E-8
8 SGTC_3016 9080866 5.28 49.5 µM 1.30E-6 6 6.36E-8
9 SGTC_538 2922-0838 5.28 53.3 µM 1.31E-6 Golgi 11 6.45E-8
10 SGTC_2738 aclarubicin 5.26 5.5 µM 1.41E-6 RNA pol III & RNase P/MRP 3 7.02E-8
11 SGTC_3212 9128307 5.14 49.5 µM 2.43E-6 25 1.39E-7
12 SGTC_2055 5235184 5.11 200.0 µM 2.72E-6 ERG2 10 1.60E-7
13 SGTC_1985 st071382 4.93 65.5 µM 5.69E-6 7 4.04E-7
14 SGTC_2529 gangaleoidin 4.83 93.6 µM 8.78E-6 9 6.95E-7
15 SGTC_2749 bexarotene 4.80 57.4 µM 9.94E-6 11 8.11E-7
16 SGTC_1024 4507-0395 4.76 26.0 µM 1.15E-5 TSC3-RPN4 15 9.76E-7
17 SGTC_1811 st050069 4.73 61.5 µM 1.29E-5 2 1.12E-6
18 SGTC_1436 4092-1007 4.66 8.3 µM 1.68E-5 5 1.56E-6
19 SGTC_1611 st001856 4.65 99.4 µM 1.74E-5 7 1.63E-6
20 SGTC_2011 4012611 4.65 177.0 µM 1.79E-5 mitochondrial processes 17 1.70E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.086 5.76E-7 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.086 5.88E-7 YKL133C_p YKL133C_p hom Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)
0.085 7.22E-7 YFR040W SAP155 hom Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress
0.085 7.71E-7 YCL064C CHA1 hom Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
0.085 9.40E-7 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.083 1.62E-6 YPL127C HHO1 hom Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination
0.078 6.30E-6 YJL217W REE1 hom Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle
0.075 1.23E-5 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.073 2.61E-5 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.072 2.92E-5 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.069 5.71E-5 YHL005C_d YHL005C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W
0.069 6.06E-5 YLL010C PSR1 hom Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.069 6.64E-5 YNL104C LEU4 hom Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.065 1.81E-4 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.061 3.90E-4 YBL037W APL3 hom Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport