YHR022C_p

Putative protein of unknown function; YHR022C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR022C / YHR022C

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:-3.32|P-value:9.78E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:-3.85|P-value:1.57E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.61|P-value:2.16E-4 ID:SGTC_480|Compound:am 92016|FD-Score:5.26|P-value:1.75E-7 ID:SGTC_490|Compound:phenamil|FD-Score:-3.90|P-value:1.27E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.14|P-value:2.83E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:5.89|P-value:6.05E-9 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.45|P-value:6.28E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.33|P-value:5.84E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.56|P-value:2.58E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.26|P-value:7.22E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.86|P-value:8.77E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.87|P-value:8.38E-5 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.97|P-value:5.75E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.21|P-value:8.72E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.46|P-value:6.19E-8 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.71|P-value:2.60E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-4.50|P-value:1.21E-5 ID:SGTC_2027|Compound:5150920|FD-Score:4.80|P-value:1.64E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.75|P-value:1.31E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.33|P-value:5.77E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.54|P-value:2.83E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.67|P-value:2.99E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.86|P-value:1.26E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.55|P-value:2.74E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.36|P-value:5.15E-4 ID:SGTC_2955|Compound:9076254|FD-Score:6.74|P-value:3.85E-11 ID:SGTC_2959|Compound:9079155|FD-Score:3.17|P-value:9.87E-4 ID:SGTC_3014|Compound:9081533|FD-Score:-3.74|P-value:2.32E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.34|P-value:5.49E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.32|P-value:1.38E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.72|P-value:1.47E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.31|P-value:6.08E-4 ID:SGTC_3267|Compound:9137951|FD-Score:-3.67|P-value:2.96E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:-3.32|P-value:9.78E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:-3.85|P-value:1.57E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.61|P-value:2.16E-4 ID:SGTC_480|Compound:am 92016|FD-Score:5.26|P-value:1.75E-7 ID:SGTC_490|Compound:phenamil|FD-Score:-3.90|P-value:1.27E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.14|P-value:2.83E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:5.89|P-value:6.05E-9 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.45|P-value:6.28E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.33|P-value:5.84E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.56|P-value:2.58E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.26|P-value:7.22E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.86|P-value:8.77E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.87|P-value:8.38E-5 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.97|P-value:5.75E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.21|P-value:8.72E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.46|P-value:6.19E-8 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.71|P-value:2.60E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-4.50|P-value:1.21E-5 ID:SGTC_2027|Compound:5150920|FD-Score:4.80|P-value:1.64E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.75|P-value:1.31E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.33|P-value:5.77E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.54|P-value:2.83E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.67|P-value:2.99E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.86|P-value:1.26E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.55|P-value:2.74E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.36|P-value:5.15E-4 ID:SGTC_2955|Compound:9076254|FD-Score:6.74|P-value:3.85E-11 ID:SGTC_2959|Compound:9079155|FD-Score:3.17|P-value:9.87E-4 ID:SGTC_3014|Compound:9081533|FD-Score:-3.74|P-value:2.32E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.34|P-value:5.49E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.32|P-value:1.38E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.72|P-value:1.47E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.31|P-value:6.08E-4 ID:SGTC_3267|Compound:9137951|FD-Score:-3.67|P-value:2.96E-4

Top fitness defect scores for YHR022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2955 9076254 6.74 12.2 µM 3.85E-11 3 7.92E-12
2 SGTC_530 4358-1714 5.89 28.0 µM 6.05E-9 9 1.88E-9
3 SGTC_1728 st035614 5.46 33.8 µM 6.19E-8 12 2.33E-8
4 SGTC_480 am 92016 5.26 50.0 µM 1.75E-7 1 7.13E-8
5 SGTC_2605 digitonin 4.86 300.0 nM 1.26E-6 9 6.00E-7
6 SGTC_2027 5150920 4.80 200.0 µM 1.64E-6 3 8.01E-7
7 SGTC_3137 9097352 4.32 49.5 µM 1.38E-5 34 7.92E-6
8 SGTC_529 4076-0302 4.14 30.3 µM 2.83E-5 mitochondrial processes 18 1.71E-5
9 SGTC_1500 4488-1866 3.97 171.0 µM 5.75E-5 RPP1 & pyrimidine depletion 19 3.67E-5
10 SGTC_1493 4348-0038 3.87 111.0 µM 8.38E-5 RSC complex & mRNA processing 30 5.49E-5
11 SGTC_1485 3909-9022 3.86 254.0 µM 8.77E-5 RPP1 & pyrimidine depletion 9 5.77E-5
12 SGTC_2042 p-Dimethylaminoacetophenone 3.75 200.0 µM 1.31E-4 24 8.87E-5
13 SGTC_3205 9113483 3.72 49.5 µM 1.47E-4 34 1.00E-4
14 SGTC_86 0417-1630 3.61 471.9 µM 2.16E-4 ubiquinone biosynthesis & proteasome 175 1.52E-4
15 SGTC_875 0709-0210 3.56 25.7 µM 2.58E-4 fatty acid desaturase (OLE1) 47 1.83E-4
16 SGTC_2687 chenodiol 3.55 100.0 µM 2.74E-4 36 1.95E-4
17 SGTC_2378 9074213 3.54 121.4 µM 2.83E-4 RSC complex & mRNA processing 32 2.03E-4
18 SGTC_2832 7992762 3.36 52.0 µM 5.15E-4 53 3.85E-4
19 SGTC_3033 9090887 3.34 49.5 µM 5.49E-4 fatty acid desaturase (OLE1) 51 4.12E-4
20 SGTC_2183 6420625 3.33 130.5 µM 5.77E-4 mitochondrial processes 88 4.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 1.07E-26 YDR196C CAB5 het Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies
0.107 5.63E-10 YHR061C GIC1 hom Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress
0.094 5.24E-8 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.090 1.87E-7 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.089 2.08E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.086 5.63E-7 YDL093W PMT5 hom Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals
0.084 1.14E-6 YNL200C YNL200C hom NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.44E-6 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.081 2.37E-6 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.081 2.38E-6 YOR018W ROD1 hom Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
0.078 5.71E-6 YMR157C AIM36 hom Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
0.078 6.28E-6 YHR179W OYE2 hom Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress
0.075 1.37E-5 YLL002W RTT109 hom Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p
0.075 1.54E-5 YOR021C SFM1 hom SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
0.074 1.75E-5 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data