YHR022C-A_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR022C-A / YHR022C-A

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:-3.46|P-value:1.83E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.93|P-value:2.68E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.68|P-value:7.77E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.66|P-value:8.40E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.01|P-value:9.58E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.04|P-value:8.69E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.13|P-value:6.27E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.83|P-value:4.00E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.34|P-value:2.93E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.00|P-value:1.31E-7 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.14|P-value:6.12E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.18|P-value:5.27E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.34|P-value:2.92E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.65|P-value:8.51E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.12|P-value:6.67E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.95|P-value:2.38E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.07|P-value:7.84E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.63|P-value:9.33E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.77|P-value:5.36E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.20|P-value:5.00E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.19|P-value:7.91E-6 ID:SGTC_1846|Compound:st056244|FD-Score:-3.60|P-value:1.08E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.52|P-value:1.65E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.06|P-value:8.07E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.34|P-value:2.98E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.32|P-value:3.21E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.84|P-value:3.79E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.59|P-value:1.17E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.26|P-value:3.02E-8 ID:SGTC_2455|Compound:5377712|FD-Score:6.38|P-value:2.66E-11 ID:SGTC_2456|Compound:5770359|FD-Score:3.06|P-value:8.23E-4 ID:SGTC_2462|Compound:5162487|FD-Score:4.42|P-value:2.63E-6 ID:SGTC_2483|Compound:5729050|FD-Score:3.27|P-value:3.80E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.44|P-value:2.02E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.10|P-value:6.96E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.13|P-value:6.26E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.46|P-value:1.83E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.93|P-value:2.68E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.68|P-value:7.77E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.66|P-value:8.40E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.01|P-value:9.58E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.04|P-value:8.69E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.13|P-value:6.27E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.83|P-value:4.00E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.34|P-value:2.93E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.00|P-value:1.31E-7 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.14|P-value:6.12E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.18|P-value:5.27E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.34|P-value:2.92E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.65|P-value:8.51E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.12|P-value:6.67E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.95|P-value:2.38E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.07|P-value:7.84E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.63|P-value:9.33E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.77|P-value:5.36E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.20|P-value:5.00E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.19|P-value:7.91E-6 ID:SGTC_1846|Compound:st056244|FD-Score:-3.60|P-value:1.08E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.52|P-value:1.65E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.06|P-value:8.07E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.34|P-value:2.98E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.32|P-value:3.21E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.84|P-value:3.79E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.59|P-value:1.17E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.26|P-value:3.02E-8 ID:SGTC_2455|Compound:5377712|FD-Score:6.38|P-value:2.66E-11 ID:SGTC_2456|Compound:5770359|FD-Score:3.06|P-value:8.23E-4 ID:SGTC_2462|Compound:5162487|FD-Score:4.42|P-value:2.63E-6 ID:SGTC_2483|Compound:5729050|FD-Score:3.27|P-value:3.80E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.44|P-value:2.02E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.10|P-value:6.96E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.13|P-value:6.26E-4

Top fitness defect scores for YHR022C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2455 5377712 6.38 9.8 µM 2.66E-11 5 9.12E-11
2 SGTC_2454 5-benzylidenerhodanine 5.26 10.4 µM 3.02E-8 TRP & mitochondrial translation 17 7.07E-8
3 SGTC_423 5-fluorouracil 5.00 457.0 µM 1.31E-7 exosome 8 2.82E-7
4 SGTC_2420 aureobasidin a 4.59 50.0 nM 1.17E-6 26 2.24E-6
5 SGTC_1854 st056233 4.52 32.9 µM 1.65E-6 amide catabolism 12 3.11E-6
6 SGTC_2462 5162487 4.42 171.8 µM 2.63E-6 12 4.84E-6
7 SGTC_1845 st056753 4.19 3.0 µM 7.91E-6 TSC3-RPN4 29 1.37E-5
8 SGTC_1331 1472-0049 3.95 76.2 µM 2.38E-5 19 3.89E-5
9 SGTC_2385 9074692 3.84 200.0 µM 3.79E-5 44 6.04E-5
10 SGTC_401 neomycin 3.83 50.0 µM 4.00E-5 13 6.36E-5
11 SGTC_236 1509-0011 3.66 5.3 µM 8.40E-5 400 1.28E-4
12 SGTC_920 mycophenolic acid 3.65 780.4 nM 8.51E-5 41 1.30E-4
13 SGTC_1654 st012436 3.63 41.8 µM 9.33E-5 21 1.42E-4
14 SGTC_883 0850-0245 3.34 24.6 µM 2.92E-4 cell wall 51 4.18E-4
15 SGTC_2315 7733312 3.34 200.0 µM 2.98E-4 43 4.26E-4
16 SGTC_2483 5729050 3.27 27.2 µM 3.80E-4 50 5.36E-4
17 SGTC_450 aminopyrene 3.14 156.0 nM 6.12E-4 71 8.43E-4
18 SGTC_3152 9099253 3.13 49.5 µM 6.26E-4 NEO1-PIK1 192 8.61E-4
19 SGTC_400 oxethazaine 3.13 37.5 µM 6.27E-4 calcium & mitochondrial duress 44 8.62E-4
20 SGTC_1099 5-nonyloxytryptamine 3.12 2.9 µM 6.67E-4 54 9.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 3.24E-17 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.129 6.85E-14 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.128 1.08E-13 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.123 8.54E-13 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.123 8.75E-13 YDR116C MRPL1 hom Mitochondrial ribosomal protein of the large subunit
0.122 1.50E-12 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.119 4.26E-12 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.119 5.57E-12 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.117 1.22E-11 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.115 2.31E-11 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.115 2.71E-11 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.114 3.23E-11 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.114 4.14E-11 YCR071C IMG2 hom Mitochondrial ribosomal protein of the large subunit
0.113 5.88E-11 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.111 1.02E-10 YIL157C COA1 hom Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly