YHR023W / MYO1

Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR023W / MYO1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:6.56|P-value:3.52E-12 ID:SGTC_63|Compound:0099-0242|FD-Score:4.69|P-value:4.80E-7 ID:SGTC_72|Compound:0744-0168|FD-Score:4.59|P-value:8.04E-7 ID:SGTC_151|Compound:3013-0144|FD-Score:3.42|P-value:1.70E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.10|P-value:5.86E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.74|P-value:5.06E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:3.62|P-value:7.62E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:2.99|P-value:8.75E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.40|P-value:1.86E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.35|P-value:2.45E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.56|P-value:9.06E-7 ID:SGTC_566|Compound:0958-0068|FD-Score:4.38|P-value:2.33E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.80|P-value:3.78E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.04|P-value:1.18E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.04|P-value:7.25E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.17|P-value:4.54E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.06|P-value:6.87E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.81|P-value:3.41E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.45|P-value:1.65E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.02|P-value:8.35E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.50|P-value:1.38E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.61|P-value:7.93E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.92|P-value:2.06E-5 ID:SGTC_1755|Compound:st041960|FD-Score:4.90|P-value:1.47E-7 ID:SGTC_1784|Compound:st039334|FD-Score:4.21|P-value:5.39E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.40|P-value:1.86E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.18|P-value:4.29E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-3.02|P-value:8.38E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.74|P-value:4.99E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.37|P-value:2.07E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.32|P-value:2.59E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.33|P-value:2.48E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.03|P-value:7.55E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.79|P-value:3.96E-5 ID:SGTC_2275|Compound:7947463|FD-Score:3.24|P-value:3.44E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.71|P-value:5.54E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.40|P-value:1.87E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.02|P-value:7.86E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.75|P-value:4.36E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.47|P-value:1.41E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.07|P-value:6.56E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.98|P-value:8.96E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.16|P-value:4.99E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-4.80|P-value:2.91E-7 ID:SGTC_2940|Compound:9060638|FD-Score:-3.00|P-value:9.14E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.33|P-value:3.03E-6 ID:SGTC_3020|Compound:9089140|FD-Score:4.66|P-value:5.62E-7 ID:SGTC_3028|Compound:9087778|FD-Score:-3.01|P-value:8.76E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.77|P-value:4.01E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.02|P-value:8.29E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:6.56|P-value:3.52E-12 ID:SGTC_63|Compound:0099-0242|FD-Score:4.69|P-value:4.80E-7 ID:SGTC_72|Compound:0744-0168|FD-Score:4.59|P-value:8.04E-7 ID:SGTC_151|Compound:3013-0144|FD-Score:3.42|P-value:1.70E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.10|P-value:5.86E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.74|P-value:5.06E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:3.62|P-value:7.62E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:2.99|P-value:8.75E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.40|P-value:1.86E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.35|P-value:2.45E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.56|P-value:9.06E-7 ID:SGTC_566|Compound:0958-0068|FD-Score:4.38|P-value:2.33E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.80|P-value:3.78E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.04|P-value:1.18E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.04|P-value:7.25E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.17|P-value:4.54E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.06|P-value:6.87E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.81|P-value:3.41E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.45|P-value:1.65E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.02|P-value:8.35E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.50|P-value:1.38E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.61|P-value:7.93E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.92|P-value:2.06E-5 ID:SGTC_1755|Compound:st041960|FD-Score:4.90|P-value:1.47E-7 ID:SGTC_1784|Compound:st039334|FD-Score:4.21|P-value:5.39E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.40|P-value:1.86E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.18|P-value:4.29E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-3.02|P-value:8.38E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.74|P-value:4.99E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.37|P-value:2.07E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.32|P-value:2.59E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.33|P-value:2.48E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.03|P-value:7.55E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.79|P-value:3.96E-5 ID:SGTC_2275|Compound:7947463|FD-Score:3.24|P-value:3.44E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.71|P-value:5.54E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.40|P-value:1.87E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.02|P-value:7.86E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.75|P-value:4.36E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.47|P-value:1.41E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.07|P-value:6.56E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.98|P-value:8.96E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.16|P-value:4.99E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-4.80|P-value:2.91E-7 ID:SGTC_2940|Compound:9060638|FD-Score:-3.00|P-value:9.14E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.33|P-value:3.03E-6 ID:SGTC_3020|Compound:9089140|FD-Score:4.66|P-value:5.62E-7 ID:SGTC_3028|Compound:9087778|FD-Score:-3.01|P-value:8.76E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.77|P-value:4.01E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.02|P-value:8.29E-4

Top fitness defect scores for YHR023W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_22 0964-0034 6.56 14.5 µM 3.52E-12 unfolded protein response 13 2.68E-11 0.09
2 SGTC_1755 st041960 4.90 45.2 µM 1.47E-7 4 4.73E-7 0.18
3 SGTC_63 0099-0242 4.69 26.7 µM 4.80E-7 mitochondrial stress 16 1.40E-6 0.25
4 SGTC_3020 9089140 4.66 49.5 µM 5.62E-7 7 1.62E-6 0.30
5 SGTC_72 0744-0168 4.59 198.4 µM 8.04E-7 RPP1 & pyrimidine depletion 5 2.25E-6 0.43
6 SGTC_535 2293-4129 4.56 48.2 µM 9.06E-7 NEO1 5 2.51E-6 0.33
7 SGTC_566 0958-0068 4.38 16.5 µM 2.33E-6 RSC & ERG11 13 5.99E-6 0.02
8 SGTC_2941 9056145 4.33 11.2 µM 3.03E-6 8 7.62E-6 0.07
9 SGTC_1784 st039334 4.21 36.3 µM 5.39E-6 7 1.29E-5 0.17
10 SGTC_1166 k206-0078 4.04 225.0 µM 1.18E-5 4 2.66E-5 0.09
11 SGTC_1590 st077108 3.92 57.8 µM 2.06E-5 7 4.45E-5 0.08
12 SGTC_1371 2421-0008 3.81 32.7 µM 3.41E-5 mitochondrial processes 26 7.06E-5 0.00
13 SGTC_3034 9090421 3.77 49.5 µM 4.01E-5 60S ribosome export 3 8.20E-5 0.03
14 SGTC_2398 5228213 3.75 48.8 µM 4.36E-5 iron homeostasis 15 8.86E-5 0.04
15 SGTC_225 nsc-122657 3.62 1.0 µM 7.62E-5 5 1.48E-4 0.14
16 SGTC_1581 himbacine 3.61 57.9 µM 7.93E-5 Golgi 7 1.54E-4 0.16
17 SGTC_2555 cholic acid 3.47 100.0 µM 1.41E-4 2 2.62E-4 0.37
18 SGTC_151 3013-0144 3.42 2.3 µM 1.70E-4 iron homeostasis 17 3.09E-4 0.10
19 SGTC_1789 tunicamycin 3.40 25.0 nM 1.86E-4 unfolded protein response 20 3.37E-4 0.02
20 SGTC_387 norethindrone acetate 3.40 66.7 µM 1.86E-4 7 3.37E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.29E-13 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.126 2.31E-13 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.099 8.93E-9 YBR101C FES1 hom Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.094 4.50E-8 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.085 8.36E-7 YBR136W MEC1 het Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres
0.085 9.15E-7 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.084 1.19E-6 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.081 2.56E-6 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.68E-6 YBR175W SWD3 hom Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
0.080 3.92E-6 YHR086W NAM8 hom RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.077 7.57E-6 YIL127C_p RRT14_p hom Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.076 1.00E-5 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.076 1.03E-5 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.074 1.60E-5 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.073 2.13E-5 YCR069W CPR4 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway