YHR024C / MAS2

Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR024C / MAS2

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.68|P-value:3.78E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.01|P-value:1.17E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.55|P-value:5.79E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:-4.02|P-value:9.22E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.90|P-value:1.43E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.40|P-value:9.38E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.44|P-value:8.04E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.83|P-value:2.27E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.51|P-value:1.72E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.59|P-value:1.29E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.43|P-value:6.94E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-5.11|P-value:1.03E-6 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.48|P-value:5.95E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.32|P-value:9.77E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:4.79|P-value:5.48E-6 ID:SGTC_1648|Compound:st011736|FD-Score:3.99|P-value:1.29E-4 ID:SGTC_1664|Compound:st014217|FD-Score:4.01|P-value:1.20E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.44|P-value:8.16E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.43|P-value:8.31E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-3.34|P-value:9.27E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.32|P-value:9.99E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.21|P-value:5.53E-5 ID:SGTC_2279|Compound:7948423|FD-Score:4.77|P-value:6.01E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.95|P-value:1.20E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-5.80|P-value:3.75E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:3.68|P-value:3.78E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.01|P-value:1.17E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.55|P-value:5.79E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:-4.02|P-value:9.22E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.90|P-value:1.43E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.40|P-value:9.38E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.44|P-value:8.04E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.83|P-value:2.27E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.51|P-value:1.72E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.59|P-value:1.29E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.43|P-value:6.94E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-5.11|P-value:1.03E-6 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.48|P-value:5.95E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.32|P-value:9.77E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:4.79|P-value:5.48E-6 ID:SGTC_1648|Compound:st011736|FD-Score:3.99|P-value:1.29E-4 ID:SGTC_1664|Compound:st014217|FD-Score:4.01|P-value:1.20E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.44|P-value:8.16E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.43|P-value:8.31E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-3.34|P-value:9.27E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.32|P-value:9.99E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.21|P-value:5.53E-5 ID:SGTC_2279|Compound:7948423|FD-Score:4.77|P-value:6.01E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.95|P-value:1.20E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-5.80|P-value:3.75E-8

Top fitness defect scores for YHR024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1645 Cervolide 4.79 78.0 µM 5.48E-6 2 8.32E-7 0.73
2 SGTC_2279 7948423 4.77 32.9 µM 6.01E-6 3 9.29E-7 0.22
3 SGTC_1152 3909-8331 4.59 15.9 µM 1.29E-5 4 2.27E-6 0.55
4 SGTC_969 1313-0238 4.51 134.0 µM 1.72E-5 mitochondrial processes 15 3.18E-6 0.12
5 SGTC_2018 5133068 4.21 143.0 µM 5.53E-5 7 1.25E-5 0.16
6 SGTC_173 1273-0061 4.01 2.7 µM 1.17E-4 mitochondrial stress 25 2.99E-5 0.01
7 SGTC_1664 st014217 4.01 9.0 µM 1.20E-4 60S ribosome export 3 3.08E-5 0.03
8 SGTC_1648 st011736 3.99 69.8 µM 1.29E-4 PDR1 1 3.36E-5 0.25
9 SGTC_765 1319-0117 3.83 244.0 µM 2.27E-4 60S ribosome export 7 6.51E-5 0.19
10 SGTC_43 0570-0105 3.68 72.5 µM 3.78E-4 ERG2 10 1.18E-4 0.08
11 SGTC_178 4092-0806 3.55 87.5 µM 5.79E-4 ergosterol depletion effects on membrane 26 1.95E-4 0.02
12 SGTC_757 1066-0008 3.44 322.0 µM 8.04E-4 Golgi 8 2.86E-4 0.23
13 SGTC_1674 st016616 3.44 23.6 µM 8.16E-4 13 2.91E-4 0.22
14 SGTC_1785 bathophenanthroline 3.43 24.0 µM 8.31E-4 heme requiring 33 2.97E-4 0.06
15 SGTC_579 4491-1009 3.40 110.0 µM 9.38E-4 60S ribosome export 12 3.43E-4 0.02
16 SGTC_2626 ethyl orsellinate 3.35 100.0 µM 0.00107 19 4.00E-4 0.02
17 SGTC_1373 2887-0003 3.33 58.5 µM 0.00115 Golgi 20 4.34E-4 0.02
18 SGTC_1816 st051957 3.31 91.6 µM 0.00123 6 4.70E-4 0.18
19 SGTC_582 0987-0078 3.27 156.0 µM 0.00138 calcium & mitochondrial duress 18 5.39E-4 0.12
20 SGTC_1670 st016595 3.26 4.0 µM 0.00142 4 5.57E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 8.78E-11 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.110 1.72E-10 YFR003C YPI1 het Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance
0.106 8.79E-10 YDL202W MRPL11 hom Mitochondrial ribosomal protein of the large subunit
0.105 9.45E-10 YDR143C SAN1 hom Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition
0.098 1.17E-8 YGR103W NOP7 het Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation
0.096 2.17E-8 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.093 5.94E-8 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.092 8.52E-8 YNL117W MLS1 hom Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic
0.092 8.59E-8 YLL047W_d YLL047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
0.092 1.05E-7 YIL070C MAM33 hom Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
0.091 1.41E-7 YMR257C PET111 hom Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.090 1.83E-7 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.087 4.77E-7 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.085 8.55E-7 YGL068W MNP1 het Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
0.084 1.01E-6 YHR068W DYS1 het Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric