YHR025W / THR1

Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR025W / THR1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:5.18|P-value:8.56E-7 ID:SGTC_12|Compound:0849-0099|FD-Score:3.65|P-value:3.75E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.40|P-value:2.38E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-5.45|P-value:1.92E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:-11.10|P-value:4.60E-25 ID:SGTC_37|Compound:0566-0070|FD-Score:32.00|P-value:7.54E-194 ID:SGTC_40|Compound:0327-0103|FD-Score:-9.57|P-value:2.95E-19 ID:SGTC_45|Compound:0kpi-0036|FD-Score:6.70|P-value:2.88E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:40.40|P-value:1.48E-307 ID:SGTC_56|Compound:0957-0365|FD-Score:-4.72|P-value:5.41E-6 ID:SGTC_57|Compound:miconazole|FD-Score:-3.50|P-value:5.40E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.63|P-value:3.41E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:15.00|P-value:3.33E-44 ID:SGTC_81|Compound:0411-0046|FD-Score:5.77|P-value:4.85E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:9.40|P-value:1.57E-18 ID:SGTC_90|Compound:0870-0863|FD-Score:20.40|P-value:5.08E-80 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.44|P-value:1.73E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:24.40|P-value:6.90E-114 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.48|P-value:5.80E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:6.82|P-value:1.38E-10 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.31|P-value:9.97E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.79|P-value:2.01E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.54|P-value:4.79E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.46|P-value:7.06E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-6.29|P-value:2.42E-9 ID:SGTC_159|Compound:3970-0959|FD-Score:7.93|P-value:1.10E-13 ID:SGTC_163|Compound:1327-0036|FD-Score:32.50|P-value:2.33E-200 ID:SGTC_168|Compound:3970-0862|FD-Score:4.03|P-value:9.90E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:19.30|P-value:9.31E-72 ID:SGTC_195|Compound:4234-0266|FD-Score:9.66|P-value:1.89E-19 ID:SGTC_214|Compound:4373-3496|FD-Score:4.78|P-value:5.10E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:7.48|P-value:2.26E-12 ID:SGTC_310|Compound:1273-0058|FD-Score:10.10|P-value:3.53E-21 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.70|P-value:2.75E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:12.20|P-value:7.91E-30 ID:SGTC_386|Compound:1509-0011|FD-Score:11.90|P-value:9.72E-29 ID:SGTC_451|Compound:chloral hydrate|FD-Score:13.10|P-value:5.81E-34 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.46|P-value:1.88E-15 ID:SGTC_513|Compound:4245-1575|FD-Score:10.20|P-value:1.29E-21 ID:SGTC_673|Compound:1082-0474|FD-Score:11.70|P-value:9.15E-28 ID:SGTC_690|Compound:glyoxal|FD-Score:12.30|P-value:3.60E-30 ID:SGTC_717|Compound:1532-0246|FD-Score:3.94|P-value:1.36E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:16.40|P-value:1.56E-52 ID:SGTC_984|Compound:1492-0255|FD-Score:5.39|P-value:3.20E-7 ID:SGTC_985|Compound:1493-0307|FD-Score:4.98|P-value:2.09E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.47|P-value:6.95E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.45|P-value:1.69E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:11.20|P-value:1.69E-25 ID:SGTC_1195|Compound:1502-0147|FD-Score:17.10|P-value:5.28E-57 ID:SGTC_1242|Compound:0402-0103|FD-Score:7.60|P-value:9.87E-13 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.67|P-value:3.51E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:7.27|P-value:8.92E-12 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.11|P-value:1.15E-6 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.26|P-value:4.21E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.52|P-value:1.51E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.52|P-value:5.10E-4 ID:SGTC_1696|Compound:st025591|FD-Score:8.76|P-value:2.57E-16 ID:SGTC_1727|Compound:st034309|FD-Score:4.47|P-value:1.82E-5 ID:SGTC_1732|Compound:st034308|FD-Score:5.51|P-value:1.80E-7 ID:SGTC_1733|Compound:st037357|FD-Score:-3.50|P-value:5.45E-4 ID:SGTC_1786|Compound:berberine|FD-Score:8.41|P-value:3.63E-15 ID:SGTC_1803|Compound:st050068|FD-Score:4.39|P-value:2.55E-5 ID:SGTC_1833|Compound:st055984|FD-Score:-3.77|P-value:2.18E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.60|P-value:4.12E-27 ID:SGTC_1945|Compound:st075991|FD-Score:3.96|P-value:1.26E-4 ID:SGTC_2063|Compound:5246145|FD-Score:-3.58|P-value:4.24E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.53|P-value:5.62E-4 ID:SGTC_2192|Compound:5915882|FD-Score:3.87|P-value:1.77E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:21.70|P-value:1.72E-90 ID:SGTC_2238|Compound:6671620|FD-Score:5.97|P-value:1.68E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.93|P-value:1.24E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.52|P-value:5.81E-4 ID:SGTC_2389|Compound:9091542|FD-Score:6.45|P-value:1.20E-9 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.77|P-value:1.86E-10 ID:SGTC_2411|Compound:st077133|FD-Score:3.44|P-value:7.52E-4 ID:SGTC_2430|Compound:5571206|FD-Score:12.20|P-value:7.66E-30 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.05|P-value:1.56E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.87|P-value:1.78E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.19|P-value:4.10E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:3.88|P-value:1.70E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:9.17|P-value:1.08E-17 ID:SGTC_2651|Compound:1327-0036|FD-Score:12.20|P-value:6.60E-30 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.21|P-value:7.60E-18 ID:SGTC_2689|Compound:tacrolimus|FD-Score:14.40|P-value:7.58E-41 ID:SGTC_2739|Compound:tacrine|FD-Score:3.88|P-value:1.72E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.54|P-value:4.75E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-4.14|P-value:5.78E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-3.44|P-value:6.62E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.26|P-value:4.21E-5 ID:SGTC_2888|Compound:9058547|FD-Score:3.84|P-value:1.98E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.22|P-value:9.09E-12 ID:SGTC_2921|Compound:7974240|FD-Score:3.38|P-value:9.24E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.58|P-value:4.79E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.61|P-value:3.77E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.82|P-value:4.31E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-4.73|P-value:5.14E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:14.70|P-value:1.29E-42 ID:SGTC_3060|Compound:1327-0027|FD-Score:11.90|P-value:1.31E-28 ID:SGTC_3063|Compound:1327-0034|FD-Score:9.21|P-value:7.73E-18 ID:SGTC_3064|Compound:1327-0027|FD-Score:5.48|P-value:2.07E-7 ID:SGTC_3107|Compound:9121808|FD-Score:-3.96|P-value:1.13E-4 ID:SGTC_3188|Compound:9110789|FD-Score:4.16|P-value:6.05E-5 ID:SGTC_3227|Compound:9130768|FD-Score:3.89|P-value:1.63E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.45|P-value:7.36E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.05|P-value:9.41E-5 ID:SGTC_3307|Compound:9126885|FD-Score:3.44|P-value:7.49E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.80|P-value:4.58E-6 ID:SGTC_7|Compound:0192-1582|FD-Score:5.18|P-value:8.56E-7 ID:SGTC_12|Compound:0849-0099|FD-Score:3.65|P-value:3.75E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.40|P-value:2.38E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-5.45|P-value:1.92E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:-11.10|P-value:4.60E-25 ID:SGTC_37|Compound:0566-0070|FD-Score:32.00|P-value:7.54E-194 ID:SGTC_40|Compound:0327-0103|FD-Score:-9.57|P-value:2.95E-19 ID:SGTC_45|Compound:0kpi-0036|FD-Score:6.70|P-value:2.88E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:40.40|P-value:1.48E-307 ID:SGTC_56|Compound:0957-0365|FD-Score:-4.72|P-value:5.41E-6 ID:SGTC_57|Compound:miconazole|FD-Score:-3.50|P-value:5.40E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.63|P-value:3.41E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:15.00|P-value:3.33E-44 ID:SGTC_81|Compound:0411-0046|FD-Score:5.77|P-value:4.85E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:9.40|P-value:1.57E-18 ID:SGTC_90|Compound:0870-0863|FD-Score:20.40|P-value:5.08E-80 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.44|P-value:1.73E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:24.40|P-value:6.90E-114 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.48|P-value:5.80E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:6.82|P-value:1.38E-10 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.31|P-value:9.97E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.79|P-value:2.01E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.54|P-value:4.79E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.46|P-value:7.06E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-6.29|P-value:2.42E-9 ID:SGTC_159|Compound:3970-0959|FD-Score:7.93|P-value:1.10E-13 ID:SGTC_163|Compound:1327-0036|FD-Score:32.50|P-value:2.33E-200 ID:SGTC_168|Compound:3970-0862|FD-Score:4.03|P-value:9.90E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:19.30|P-value:9.31E-72 ID:SGTC_195|Compound:4234-0266|FD-Score:9.66|P-value:1.89E-19 ID:SGTC_214|Compound:4373-3496|FD-Score:4.78|P-value:5.10E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:7.48|P-value:2.26E-12 ID:SGTC_310|Compound:1273-0058|FD-Score:10.10|P-value:3.53E-21 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.70|P-value:2.75E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:12.20|P-value:7.91E-30 ID:SGTC_386|Compound:1509-0011|FD-Score:11.90|P-value:9.72E-29 ID:SGTC_451|Compound:chloral hydrate|FD-Score:13.10|P-value:5.81E-34 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.46|P-value:1.88E-15 ID:SGTC_513|Compound:4245-1575|FD-Score:10.20|P-value:1.29E-21 ID:SGTC_673|Compound:1082-0474|FD-Score:11.70|P-value:9.15E-28 ID:SGTC_690|Compound:glyoxal|FD-Score:12.30|P-value:3.60E-30 ID:SGTC_717|Compound:1532-0246|FD-Score:3.94|P-value:1.36E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:16.40|P-value:1.56E-52 ID:SGTC_984|Compound:1492-0255|FD-Score:5.39|P-value:3.20E-7 ID:SGTC_985|Compound:1493-0307|FD-Score:4.98|P-value:2.09E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.47|P-value:6.95E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.45|P-value:1.69E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:11.20|P-value:1.69E-25 ID:SGTC_1195|Compound:1502-0147|FD-Score:17.10|P-value:5.28E-57 ID:SGTC_1242|Compound:0402-0103|FD-Score:7.60|P-value:9.87E-13 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.67|P-value:3.51E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:7.27|P-value:8.92E-12 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.11|P-value:1.15E-6 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.26|P-value:4.21E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.52|P-value:1.51E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.52|P-value:5.10E-4 ID:SGTC_1696|Compound:st025591|FD-Score:8.76|P-value:2.57E-16 ID:SGTC_1727|Compound:st034309|FD-Score:4.47|P-value:1.82E-5 ID:SGTC_1732|Compound:st034308|FD-Score:5.51|P-value:1.80E-7 ID:SGTC_1733|Compound:st037357|FD-Score:-3.50|P-value:5.45E-4 ID:SGTC_1786|Compound:berberine|FD-Score:8.41|P-value:3.63E-15 ID:SGTC_1803|Compound:st050068|FD-Score:4.39|P-value:2.55E-5 ID:SGTC_1833|Compound:st055984|FD-Score:-3.77|P-value:2.18E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.60|P-value:4.12E-27 ID:SGTC_1945|Compound:st075991|FD-Score:3.96|P-value:1.26E-4 ID:SGTC_2063|Compound:5246145|FD-Score:-3.58|P-value:4.24E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.53|P-value:5.62E-4 ID:SGTC_2192|Compound:5915882|FD-Score:3.87|P-value:1.77E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:21.70|P-value:1.72E-90 ID:SGTC_2238|Compound:6671620|FD-Score:5.97|P-value:1.68E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.93|P-value:1.24E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.52|P-value:5.81E-4 ID:SGTC_2389|Compound:9091542|FD-Score:6.45|P-value:1.20E-9 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.77|P-value:1.86E-10 ID:SGTC_2411|Compound:st077133|FD-Score:3.44|P-value:7.52E-4 ID:SGTC_2430|Compound:5571206|FD-Score:12.20|P-value:7.66E-30 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.05|P-value:1.56E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.87|P-value:1.78E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.19|P-value:4.10E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:3.88|P-value:1.70E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:9.17|P-value:1.08E-17 ID:SGTC_2651|Compound:1327-0036|FD-Score:12.20|P-value:6.60E-30 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.21|P-value:7.60E-18 ID:SGTC_2689|Compound:tacrolimus|FD-Score:14.40|P-value:7.58E-41 ID:SGTC_2739|Compound:tacrine|FD-Score:3.88|P-value:1.72E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.54|P-value:4.75E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-4.14|P-value:5.78E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-3.44|P-value:6.62E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.26|P-value:4.21E-5 ID:SGTC_2888|Compound:9058547|FD-Score:3.84|P-value:1.98E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.22|P-value:9.09E-12 ID:SGTC_2921|Compound:7974240|FD-Score:3.38|P-value:9.24E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.58|P-value:4.79E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.61|P-value:3.77E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.82|P-value:4.31E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-4.73|P-value:5.14E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:14.70|P-value:1.29E-42 ID:SGTC_3060|Compound:1327-0027|FD-Score:11.90|P-value:1.31E-28 ID:SGTC_3063|Compound:1327-0034|FD-Score:9.21|P-value:7.73E-18 ID:SGTC_3064|Compound:1327-0027|FD-Score:5.48|P-value:2.07E-7 ID:SGTC_3107|Compound:9121808|FD-Score:-3.96|P-value:1.13E-4 ID:SGTC_3188|Compound:9110789|FD-Score:4.16|P-value:6.05E-5 ID:SGTC_3227|Compound:9130768|FD-Score:3.89|P-value:1.63E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.45|P-value:7.36E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.05|P-value:9.41E-5 ID:SGTC_3307|Compound:9126885|FD-Score:3.44|P-value:7.49E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.80|P-value:4.58E-6

Top fitness defect scores for YHR025W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_46 0329-0187a 40.40 2.2 µM 1.48E-307 1 0
2 SGTC_163 1327-0036 32.50 7.5 µM 2.33E-200 2 1.13E-232
3 SGTC_37 0566-0070 32.00 1.6 µM 7.54E-194 1 4.16E-225
4 SGTC_107 0358-0022 24.40 2.7 µM 6.90E-114 SWF1 & branched chain AA biosynthesis 2 3.69E-132
5 SGTC_2233 sulbentine 21.70 40.4 µM 1.72E-90 1 5.83E-105
6 SGTC_90 0870-0863 20.40 4.6 µM 5.08E-80 2 8.65E-93
7 SGTC_177 1327-0068 19.30 8.4 µM 9.31E-72 2 3.49E-83
8 SGTC_1195 1502-0147 17.10 41.1 µM 5.28E-57 1 4.95E-66
9 SGTC_852 0418-0143 16.40 439.0 µM 1.56E-52 calcium & mitochondrial duress 5 7.78E-61
10 SGTC_59 0330-0160 15.00 1.3 µM 3.33E-44 4 3.76E-51
11 SGTC_3059 1327-0034 14.70 3.0 µM 1.29E-42 4 2.64E-49
12 SGTC_2689 tacrolimus 14.40 100.0 µM 7.58E-41 2 3.00E-47
13 SGTC_451 chloral hydrate 13.10 100.0 µM 5.81E-34 2 3.03E-39
14 SGTC_690 glyoxal 12.30 20.3 µM 3.60E-30 11 7.74E-35
15 SGTC_2651 1327-0036 12.20 5.0 µM 6.60E-30 14 1.57E-34
16 SGTC_2430 5571206 12.20 200.0 µM 7.66E-30 6 1.86E-34
17 SGTC_371 0195-0006 12.20 7.4 µM 7.91E-30 1 1.94E-34
18 SGTC_386 1509-0011 11.90 3.1 µM 9.72E-29 34 3.57E-33
19 SGTC_3060 1327-0027 11.90 12.5 µM 1.31E-28 5 5.07E-33
20 SGTC_673 1082-0474 11.70 110.0 µM 9.15E-28 RSC complex & mRNA processing 4 4.84E-32

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.503 1.12E-214 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.502 7.18E-213 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.377 6.55E-114 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.334 2.41E-88 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.306 9.08E-74 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.264 1.06E-54 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.258 3.75E-52 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.253 8.28E-50 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.249 9.48E-49 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.232 3.54E-42 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.226 4.63E-40 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.216 9.60E-37 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.216 1.17E-36 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.213 1.00E-35 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.210 1.15E-34 YDL040C NAT1 hom Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing