YHR026W / VMA16

Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR026W / VMA16

Click on Significant Values for Screen Details ID:SGTC_89|Compound:0302-0250|FD-Score:4.49|P-value:1.76E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.25|P-value:3.77E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:4.21|P-value:4.21E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.61|P-value:1.19E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.69|P-value:4.71E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.75|P-value:3.96E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.58|P-value:4.82E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:4.89|P-value:4.62E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:4.64|P-value:1.07E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:-5.00|P-value:5.28E-6 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.52|P-value:7.73E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.00|P-value:7.86E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:4.35|P-value:2.75E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:5.21|P-value:1.44E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:5.52|P-value:4.58E-6 ID:SGTC_1037|Compound:k284-1091|FD-Score:5.82|P-value:1.34E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.76|P-value:1.30E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:5.40|P-value:7.27E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.43|P-value:2.15E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.12|P-value:5.54E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.34|P-value:2.83E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:7.41|P-value:8.08E-10 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.10|P-value:5.83E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:8.37|P-value:4.14E-12 ID:SGTC_1529|Compound:apigenin|FD-Score:8.97|P-value:1.07E-13 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.30|P-value:3.17E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.08|P-value:6.27E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.39|P-value:2.46E-4 ID:SGTC_1636|Compound:st007707|FD-Score:5.87|P-value:1.11E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.62|P-value:5.89E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.62|P-value:1.14E-4 ID:SGTC_1923|Compound:st058458|FD-Score:8.17|P-value:1.30E-11 ID:SGTC_1930|Compound:st074634|FD-Score:-3.73|P-value:4.13E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.65|P-value:1.05E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.29|P-value:1.10E-5 ID:SGTC_1969|Compound:st069479|FD-Score:5.19|P-value:1.59E-5 ID:SGTC_1970|Compound:st070122|FD-Score:6.45|P-value:8.96E-8 ID:SGTC_1972|Compound:st070201|FD-Score:7.91|P-value:5.53E-11 ID:SGTC_1975|Compound:st070967|FD-Score:8.53|P-value:1.58E-12 ID:SGTC_2079|Compound:5212404|FD-Score:4.69|P-value:9.17E-5 ID:SGTC_2123|Compound:5259487|FD-Score:-3.74|P-value:4.09E-4 ID:SGTC_2124|Compound:5246320|FD-Score:-3.49|P-value:8.55E-4 ID:SGTC_2142|Compound:5622915|FD-Score:5.54|P-value:4.10E-6 ID:SGTC_2149|Compound:5554786|FD-Score:5.81|P-value:1.39E-6 ID:SGTC_2156|Compound:5649887|FD-Score:-4.35|P-value:5.53E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-4.06|P-value:1.49E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.99|P-value:8.04E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.39|P-value:2.42E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.53|P-value:1.57E-4 ID:SGTC_2681|Compound:menadione|FD-Score:4.59|P-value:1.26E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.46|P-value:9.23E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.58|P-value:3.56E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:-4.80|P-value:1.11E-5 ID:SGTC_2908|Compound:7930301|FD-Score:7.41|P-value:8.31E-10 ID:SGTC_2911|Compound:7942208|FD-Score:-3.62|P-value:5.78E-4 ID:SGTC_2916|Compound:7875993|FD-Score:11.20|P-value:1.80E-20 ID:SGTC_2930|Compound:9013230|FD-Score:-4.61|P-value:2.27E-5 ID:SGTC_2932|Compound:9016711|FD-Score:4.45|P-value:2.00E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.46|P-value:1.94E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.13|P-value:5.36E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.73|P-value:4.19E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-4.16|P-value:1.07E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.15|P-value:5.08E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.58|P-value:6.50E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.84|P-value:5.42E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:4.49|P-value:1.76E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.25|P-value:3.77E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:4.21|P-value:4.21E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.61|P-value:1.19E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.69|P-value:4.71E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.75|P-value:3.96E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.58|P-value:4.82E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:4.89|P-value:4.62E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:4.64|P-value:1.07E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:-5.00|P-value:5.28E-6 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.52|P-value:7.73E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.00|P-value:7.86E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:4.35|P-value:2.75E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:5.21|P-value:1.44E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:5.52|P-value:4.58E-6 ID:SGTC_1037|Compound:k284-1091|FD-Score:5.82|P-value:1.34E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.76|P-value:1.30E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:5.40|P-value:7.27E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.43|P-value:2.15E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.12|P-value:5.54E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.34|P-value:2.83E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:7.41|P-value:8.08E-10 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.10|P-value:5.83E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:8.37|P-value:4.14E-12 ID:SGTC_1529|Compound:apigenin|FD-Score:8.97|P-value:1.07E-13 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.30|P-value:3.17E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.08|P-value:6.27E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.39|P-value:2.46E-4 ID:SGTC_1636|Compound:st007707|FD-Score:5.87|P-value:1.11E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.62|P-value:5.89E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.62|P-value:1.14E-4 ID:SGTC_1923|Compound:st058458|FD-Score:8.17|P-value:1.30E-11 ID:SGTC_1930|Compound:st074634|FD-Score:-3.73|P-value:4.13E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.65|P-value:1.05E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.29|P-value:1.10E-5 ID:SGTC_1969|Compound:st069479|FD-Score:5.19|P-value:1.59E-5 ID:SGTC_1970|Compound:st070122|FD-Score:6.45|P-value:8.96E-8 ID:SGTC_1972|Compound:st070201|FD-Score:7.91|P-value:5.53E-11 ID:SGTC_1975|Compound:st070967|FD-Score:8.53|P-value:1.58E-12 ID:SGTC_2079|Compound:5212404|FD-Score:4.69|P-value:9.17E-5 ID:SGTC_2123|Compound:5259487|FD-Score:-3.74|P-value:4.09E-4 ID:SGTC_2124|Compound:5246320|FD-Score:-3.49|P-value:8.55E-4 ID:SGTC_2142|Compound:5622915|FD-Score:5.54|P-value:4.10E-6 ID:SGTC_2149|Compound:5554786|FD-Score:5.81|P-value:1.39E-6 ID:SGTC_2156|Compound:5649887|FD-Score:-4.35|P-value:5.53E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-4.06|P-value:1.49E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.99|P-value:8.04E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.39|P-value:2.42E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.53|P-value:1.57E-4 ID:SGTC_2681|Compound:menadione|FD-Score:4.59|P-value:1.26E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.46|P-value:9.23E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.58|P-value:3.56E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:-4.80|P-value:1.11E-5 ID:SGTC_2908|Compound:7930301|FD-Score:7.41|P-value:8.31E-10 ID:SGTC_2911|Compound:7942208|FD-Score:-3.62|P-value:5.78E-4 ID:SGTC_2916|Compound:7875993|FD-Score:11.20|P-value:1.80E-20 ID:SGTC_2930|Compound:9013230|FD-Score:-4.61|P-value:2.27E-5 ID:SGTC_2932|Compound:9016711|FD-Score:4.45|P-value:2.00E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.46|P-value:1.94E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.13|P-value:5.36E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.73|P-value:4.19E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-4.16|P-value:1.07E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.15|P-value:5.08E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.58|P-value:6.50E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.84|P-value:5.42E-5

Top fitness defect scores for YHR026W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2916 7875993 11.20 68.8 µM 1.80E-20 1 2.59E-29
2 SGTC_1529 apigenin 8.97 74.0 µM 1.07E-13 1 1.52E-19
3 SGTC_1975 st070967 8.53 30.8 µM 1.58E-12 5 7.40E-18
4 SGTC_1511 0906-3109 8.37 28.5 µM 4.14E-12 excess fatty acid 6 2.97E-17
5 SGTC_1923 st058458 8.17 19.1 µM 1.30E-11 2 1.56E-16
6 SGTC_1972 st070201 7.91 17.4 µM 5.53E-11 4 1.26E-15
7 SGTC_1505 k297-0037 7.41 20.6 µM 8.08E-10 2 6.15E-14
8 SGTC_2908 7930301 7.41 100.0 µM 8.31E-10 2 6.40E-14
9 SGTC_1970 st070122 6.45 35.8 µM 8.96E-8 TSC3-RPN4 6 5.69E-11
10 SGTC_1636 st007707 5.87 68.9 µM 1.11E-6 21 2.22E-9
11 SGTC_1037 k284-1091 5.82 78.7 µM 1.34E-6 1 2.90E-9
12 SGTC_2149 5554786 5.81 194.8 µM 1.39E-6 cell wall signaling 9 3.06E-9
13 SGTC_2752 diclazuril 5.58 33.1 µM 3.56E-6 65 1.20E-8
14 SGTC_2142 5622915 5.54 118.5 µM 4.10E-6 4 1.48E-8
15 SGTC_984 1492-0255 5.52 2.9 µM 4.58E-6 SWF1 & branched chain AA biosynthesis 14 1.74E-8
16 SGTC_1104 tacrolimus 5.40 29.8 µM 7.27E-6 19 3.40E-8
17 SGTC_1934 st074720 5.29 32.6 µM 1.10E-5 21 6.25E-8
18 SGTC_981 1488-1094 5.21 54.9 µM 1.44E-5 10 9.21E-8
19 SGTC_1969 st069479 5.19 40.1 µM 1.59E-5 3 1.07E-7
20 SGTC_830 4076-0286 4.89 57.8 µM 4.62E-5 translation 34 5.04E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 9.28E-18 YDL185W VMA1 hom Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
0.130 4.06E-14 YPR036W VMA13 hom Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
0.115 2.66E-11 YEL051W VMA8 hom Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
0.114 3.08E-11 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.106 8.45E-10 YDR264C AKR1 hom Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication
0.105 1.08E-9 YKL118W_d YKL118W_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
0.105 1.15E-9 YOR331C_d YOR331C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W
0.095 3.66E-8 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.094 5.38E-8 YGR020C VMA7 hom Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.088 3.57E-7 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.086 5.73E-7 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.084 9.76E-7 YCL005W-A VMA9 hom Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis
0.082 1.94E-6 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.080 3.32E-6 YOR189W IES4 hom Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses
0.080 3.56E-6 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator