YHR028C / DAP2

Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR028C / DAP2

Click on Significant Values for Screen Details ID:SGTC_176|Compound:1486-1328|FD-Score:-3.69|P-value:3.21E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.48|P-value:7.11E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.79|P-value:5.38E-6 ID:SGTC_282|Compound:k297-0036|FD-Score:3.71|P-value:3.30E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-4.14|P-value:6.38E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:-4.51|P-value:1.52E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.63|P-value:4.32E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.44|P-value:7.92E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:4.13|P-value:7.49E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.59|P-value:4.49E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.50|P-value:6.63E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.83|P-value:4.66E-6 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.76|P-value:2.79E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.55|P-value:1.46E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.53|P-value:6.03E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.70|P-value:3.48E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.45|P-value:7.75E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.58|P-value:5.06E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.70|P-value:3.39E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.19|P-value:5.97E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:7.63|P-value:1.15E-12 ID:SGTC_1738|Compound:st035555|FD-Score:3.59|P-value:5.03E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.73|P-value:6.99E-6 ID:SGTC_1741|Compound:st038134|FD-Score:-5.54|P-value:1.55E-7 ID:SGTC_1746|Compound:st038117|FD-Score:-8.88|P-value:1.24E-16 ID:SGTC_1956|Compound:st077085|FD-Score:4.10|P-value:8.29E-5 ID:SGTC_2013|Compound:4024628|FD-Score:-4.04|P-value:9.43E-5 ID:SGTC_2424|Compound:5537928|FD-Score:3.57|P-value:5.30E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.60|P-value:4.87E-4 ID:SGTC_2511|Compound:berberine|FD-Score:5.19|P-value:9.25E-7 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.74|P-value:2.70E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.42|P-value:7.67E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-4.15|P-value:6.19E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.82|P-value:2.27E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-5.89|P-value:2.60E-8 ID:SGTC_2695|Compound:st077686|FD-Score:3.45|P-value:7.88E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.77|P-value:2.75E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-5.21|P-value:7.20E-7 ID:SGTC_2866|Compound:9034245|FD-Score:-7.42|P-value:3.56E-12 ID:SGTC_2867|Compound:9039098|FD-Score:-3.72|P-value:2.91E-4 ID:SGTC_2868|Compound:9035608|FD-Score:5.03|P-value:1.93E-6 ID:SGTC_2879|Compound:9041815|FD-Score:-4.38|P-value:2.57E-5 ID:SGTC_2918|Compound:7977171|FD-Score:-3.47|P-value:6.51E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.51|P-value:5.75E-4 ID:SGTC_3204|Compound:9114183|FD-Score:11.60|P-value:1.10E-26 ID:SGTC_3206|Compound:9114350|FD-Score:8.57|P-value:1.65E-15 ID:SGTC_3208|Compound:9114115|FD-Score:-3.94|P-value:1.33E-4 ID:SGTC_3340|Compound:9146634|FD-Score:4.30|P-value:4.01E-5 ID:SGTC_3342|Compound:9147791|FD-Score:-3.94|P-value:1.32E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.65|P-value:4.12E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.69|P-value:3.21E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.48|P-value:7.11E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.79|P-value:5.38E-6 ID:SGTC_282|Compound:k297-0036|FD-Score:3.71|P-value:3.30E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-4.14|P-value:6.38E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:-4.51|P-value:1.52E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.63|P-value:4.32E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.44|P-value:7.92E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:4.13|P-value:7.49E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.59|P-value:4.49E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.50|P-value:6.63E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.83|P-value:4.66E-6 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.76|P-value:2.79E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.55|P-value:1.46E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.53|P-value:6.03E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.70|P-value:3.48E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.45|P-value:7.75E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.58|P-value:5.06E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.70|P-value:3.39E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.19|P-value:5.97E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:7.63|P-value:1.15E-12 ID:SGTC_1738|Compound:st035555|FD-Score:3.59|P-value:5.03E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.73|P-value:6.99E-6 ID:SGTC_1741|Compound:st038134|FD-Score:-5.54|P-value:1.55E-7 ID:SGTC_1746|Compound:st038117|FD-Score:-8.88|P-value:1.24E-16 ID:SGTC_1956|Compound:st077085|FD-Score:4.10|P-value:8.29E-5 ID:SGTC_2013|Compound:4024628|FD-Score:-4.04|P-value:9.43E-5 ID:SGTC_2424|Compound:5537928|FD-Score:3.57|P-value:5.30E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.60|P-value:4.87E-4 ID:SGTC_2511|Compound:berberine|FD-Score:5.19|P-value:9.25E-7 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.74|P-value:2.70E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.42|P-value:7.67E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-4.15|P-value:6.19E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.82|P-value:2.27E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-5.89|P-value:2.60E-8 ID:SGTC_2695|Compound:st077686|FD-Score:3.45|P-value:7.88E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.77|P-value:2.75E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-5.21|P-value:7.20E-7 ID:SGTC_2866|Compound:9034245|FD-Score:-7.42|P-value:3.56E-12 ID:SGTC_2867|Compound:9039098|FD-Score:-3.72|P-value:2.91E-4 ID:SGTC_2868|Compound:9035608|FD-Score:5.03|P-value:1.93E-6 ID:SGTC_2879|Compound:9041815|FD-Score:-4.38|P-value:2.57E-5 ID:SGTC_2918|Compound:7977171|FD-Score:-3.47|P-value:6.51E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.51|P-value:5.75E-4 ID:SGTC_3204|Compound:9114183|FD-Score:11.60|P-value:1.10E-26 ID:SGTC_3206|Compound:9114350|FD-Score:8.57|P-value:1.65E-15 ID:SGTC_3208|Compound:9114115|FD-Score:-3.94|P-value:1.33E-4 ID:SGTC_3340|Compound:9146634|FD-Score:4.30|P-value:4.01E-5 ID:SGTC_3342|Compound:9147791|FD-Score:-3.94|P-value:1.32E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.65|P-value:4.12E-4

Top fitness defect scores for YHR028C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3204 9114183 11.60 49.5 µM 1.10E-26 1 3.63E-31
2 SGTC_3206 9114350 8.57 49.5 µM 1.65E-15 1 5.26E-18
3 SGTC_1681 tripelennamine 7.63 100.0 µM 1.15E-12 1 1.18E-14
4 SGTC_2511 berberine 5.19 10.5 µM 9.25E-7 60S ribosome export 6 1.04E-7
5 SGTC_2868 9035608 5.03 32.5 µM 1.93E-6 5 2.47E-7
6 SGTC_1111 tnp00062 4.83 510.7 nM 4.66E-6 4 6.94E-7
7 SGTC_260 nsc-65238 4.79 4.0 µM 5.38E-6 endomembrane recycling 6 8.20E-7
8 SGTC_1740 st038286 4.73 13.2 µM 6.99E-6 14 1.12E-6
9 SGTC_1249 0481-0015 4.55 10.2 µM 1.46E-5 15 2.66E-6
10 SGTC_3340 9146634 4.30 11.1 µM 4.01E-5 8 8.66E-6
11 SGTC_1676 st018489 4.19 23.4 µM 5.97E-5 60S ribosome export 28 1.38E-5
12 SGTC_784 4579-0127 4.13 173.0 µM 7.49E-5 17 1.80E-5
13 SGTC_1956 st077085 4.10 54.0 µM 8.29E-5 17 2.03E-5
14 SGTC_2557 derrustone 3.82 83.8 µM 2.27E-4 40 6.61E-5
15 SGTC_2856 9022925 3.77 19.5 µM 2.75E-4 25 8.27E-5
16 SGTC_1184 1269-1718 3.76 139.0 µM 2.79E-4 34 8.42E-5
17 SGTC_282 k297-0036 3.71 65.7 µM 3.30E-4 5 1.02E-4
18 SGTC_1605 st000082 3.70 49.1 µM 3.39E-4 60S ribosome export 23 1.06E-4
19 SGTC_1471 k673-0312 3.70 37.0 µM 3.48E-4 RNA processing & uracil transport 16 1.09E-4
20 SGTC_3352 9151559 3.65 45.6 µM 4.12E-4 18 1.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.59E-11 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.114 3.31E-11 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.113 5.69E-11 YDL127W PCL2 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth
0.101 4.61E-9 YKR101W SIR1 hom Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
0.098 1.49E-8 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.092 9.22E-8 YHR157W REC104 hom Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination
0.090 2.02E-7 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.088 3.25E-7 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.085 9.40E-7 YKL009W MRT4 hom Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
0.084 1.12E-6 YKL156W RPS27A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.084 1.17E-6 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.084 1.17E-6 YML111W BUL2 hom Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication
0.082 2.19E-6 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.081 2.60E-6 YHL037C_d YHL037C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 7.69E-6 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair