YHR029C / YHI9

Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR029C / YHI9

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:5.23|P-value:3.38E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:4.80|P-value:2.56E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.52|P-value:8.29E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.49|P-value:4.47E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.16|P-value:3.87E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.30|P-value:8.49E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.68|P-value:4.36E-6 ID:SGTC_349|Compound:k015-0014|FD-Score:3.61|P-value:3.04E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.71|P-value:2.09E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:8.15|P-value:4.81E-15 ID:SGTC_428|Compound:3448-4153|FD-Score:3.53|P-value:3.96E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.80|P-value:2.59E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.35|P-value:7.15E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.40|P-value:6.28E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:-3.36|P-value:6.80E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.73|P-value:1.97E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.79|P-value:1.60E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.77|P-value:2.75E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:3.95|P-value:8.66E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:4.02|P-value:6.66E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.80|P-value:1.56E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.40|P-value:6.02E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.71|P-value:2.04E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.51|P-value:9.10E-6 ID:SGTC_1912|Compound:st060209|FD-Score:-3.25|P-value:9.83E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.59|P-value:6.13E-6 ID:SGTC_1946|Compound:st076057|FD-Score:4.53|P-value:8.46E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-4.26|P-value:2.52E-5 ID:SGTC_1985|Compound:st071382|FD-Score:-3.46|P-value:5.00E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.08|P-value:5.22E-5 ID:SGTC_2341|Compound:7987486|FD-Score:3.26|P-value:9.89E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.28|P-value:2.30E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:7.12|P-value:6.48E-12 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.80|P-value:2.39E-6 ID:SGTC_2416|Compound:tofa|FD-Score:3.72|P-value:2.02E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-4.72|P-value:3.44E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.76|P-value:1.71E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.87|P-value:1.13E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.95|P-value:8.67E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:-4.38|P-value:1.51E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.14|P-value:4.27E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.28|P-value:2.42E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.63|P-value:2.05E-13 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.32|P-value:7.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.24|P-value:3.02E-7 ID:SGTC_2712|Compound:st079126|FD-Score:3.62|P-value:2.92E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-5.79|P-value:1.75E-8 ID:SGTC_2878|Compound:9043973|FD-Score:-6.85|P-value:3.47E-11 ID:SGTC_3058|Compound:9093861|FD-Score:-3.26|P-value:9.62E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-3.70|P-value:2.10E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.81|P-value:1.49E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:5.23|P-value:3.38E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:4.80|P-value:2.56E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.52|P-value:8.29E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.49|P-value:4.47E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.16|P-value:3.87E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.30|P-value:8.49E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.68|P-value:4.36E-6 ID:SGTC_349|Compound:k015-0014|FD-Score:3.61|P-value:3.04E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.71|P-value:2.09E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:8.15|P-value:4.81E-15 ID:SGTC_428|Compound:3448-4153|FD-Score:3.53|P-value:3.96E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.80|P-value:2.59E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.35|P-value:7.15E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.40|P-value:6.28E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:-3.36|P-value:6.80E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.73|P-value:1.97E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.79|P-value:1.60E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.77|P-value:2.75E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:3.95|P-value:8.66E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:4.02|P-value:6.66E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.80|P-value:1.56E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.40|P-value:6.02E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.71|P-value:2.04E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.51|P-value:9.10E-6 ID:SGTC_1912|Compound:st060209|FD-Score:-3.25|P-value:9.83E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.59|P-value:6.13E-6 ID:SGTC_1946|Compound:st076057|FD-Score:4.53|P-value:8.46E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-4.26|P-value:2.52E-5 ID:SGTC_1985|Compound:st071382|FD-Score:-3.46|P-value:5.00E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.08|P-value:5.22E-5 ID:SGTC_2341|Compound:7987486|FD-Score:3.26|P-value:9.89E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.28|P-value:2.30E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:7.12|P-value:6.48E-12 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.80|P-value:2.39E-6 ID:SGTC_2416|Compound:tofa|FD-Score:3.72|P-value:2.02E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-4.72|P-value:3.44E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.76|P-value:1.71E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.87|P-value:1.13E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.95|P-value:8.67E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:-4.38|P-value:1.51E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.14|P-value:4.27E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.28|P-value:2.42E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.63|P-value:2.05E-13 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.32|P-value:7.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.24|P-value:3.02E-7 ID:SGTC_2712|Compound:st079126|FD-Score:3.62|P-value:2.92E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-5.79|P-value:1.75E-8 ID:SGTC_2878|Compound:9043973|FD-Score:-6.85|P-value:3.47E-11 ID:SGTC_3058|Compound:9093861|FD-Score:-3.26|P-value:9.62E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-3.70|P-value:2.10E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.81|P-value:1.49E-4

Top fitness defect scores for YHR029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_422 cantharidin 8.15 155.0 µM 4.81E-15 cell wall signaling 11 1.86E-16
2 SGTC_2582 agaric acid 7.63 100.0 µM 2.05E-13 redox potentiating 111 1.17E-14
3 SGTC_2405 ticlatone 7.12 3.5 µM 6.48E-12 18 5.31E-13
4 SGTC_52 0329-0193 5.23 875.0 nM 3.38E-7 TSC3-RPN4 15 8.53E-8
5 SGTC_58 0957-0393 4.80 9.0 µM 2.56E-6 cell wall 306 7.96E-7
6 SGTC_430 0958-0115 4.80 16.4 µM 2.59E-6 13 8.05E-7
7 SGTC_346 4513-0042 4.68 7.2 µM 4.36E-6 azole & statin 21 1.43E-6
8 SGTC_1946 st076057 4.53 65.1 µM 8.46E-6 1 2.97E-6
9 SGTC_1859 st055998 4.51 20.0 µM 9.10E-6 16 3.22E-6
10 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 4.28 13.2 µM 2.42E-5 23 9.48E-6
11 SGTC_227 fluconazole 4.16 33.5 µM 3.87E-5 azole & statin 74 1.59E-5
12 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 4.14 15.3 µM 4.27E-5 31 1.77E-5
13 SGTC_976 1348-1067 4.02 47.6 µM 6.66E-5 60S ribosome export 27 2.89E-5
14 SGTC_975 1335-0046 3.95 28.5 µM 8.66E-5 RPP1 & pyrimidine depletion 34 3.86E-5
15 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.95 66.7 µM 8.67E-5 24 3.86E-5
16 SGTC_3346 9158254 3.81 43.6 µM 1.49E-4 20 7.02E-5
17 SGTC_1179 1021-1431 3.80 9.3 µM 1.56E-4 46 7.36E-5
18 SGTC_883 0850-0245 3.79 24.6 µM 1.60E-4 cell wall 34 7.57E-5
19 SGTC_780 0109-0199 3.73 192.0 µM 1.97E-4 22 9.53E-5
20 SGTC_2416 tofa 3.72 880.0 nM 2.02E-4 sphingolipid biosynthesis & PDR1 59 9.81E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.206 2.62E-33 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.184 7.96E-27 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.165 1.11E-21 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.156 1.13E-19 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.153 6.81E-19 YKL028W TFA1 het TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
0.151 1.80E-18 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.149 4.22E-18 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.149 4.06E-18 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.148 6.41E-18 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.146 1.65E-17 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.144 5.82E-17 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.142 1.50E-16 YDR403W DIT1 hom Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
0.138 9.01E-16 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.138 1.29E-15 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.134 8.74E-15 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane