YHR032W / ERC1

Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR032W / ERC1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.29|P-value:6.87E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.26|P-value:7.73E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.96|P-value:7.99E-7 ID:SGTC_692|Compound:k241-0027|FD-Score:3.60|P-value:2.37E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:4.87|P-value:1.21E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:3.92|P-value:7.19E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-4.64|P-value:5.42E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:5.05|P-value:5.19E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.62|P-value:3.92E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.09|P-value:4.38E-7 ID:SGTC_1351|Compound:1496-0003|FD-Score:5.03|P-value:5.63E-7 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.47|P-value:3.83E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-3.74|P-value:2.02E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.97|P-value:5.90E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.16|P-value:3.04E-7 ID:SGTC_1717|Compound:st033143|FD-Score:-4.18|P-value:3.73E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.25|P-value:1.94E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.73|P-value:1.49E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.26|P-value:7.74E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-3.36|P-value:7.62E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-3.89|P-value:1.13E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.44|P-value:4.15E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.41|P-value:4.63E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.33|P-value:1.38E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.55|P-value:2.87E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.35|P-value:1.25E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.43|P-value:5.85E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.62|P-value:2.25E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.37|P-value:5.31E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.40|P-value:4.79E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-4.12|P-value:4.67E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.71|P-value:1.58E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-4.12|P-value:4.79E-5 ID:SGTC_2954|Compound:9074818|FD-Score:3.28|P-value:7.08E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.33|P-value:6.19E-4 ID:SGTC_3130|Compound:9127414|FD-Score:4.11|P-value:3.37E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.57|P-value:2.70E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.28|P-value:9.67E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.29|P-value:6.87E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.26|P-value:7.73E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.96|P-value:7.99E-7 ID:SGTC_692|Compound:k241-0027|FD-Score:3.60|P-value:2.37E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:4.87|P-value:1.21E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:3.92|P-value:7.19E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-4.64|P-value:5.42E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:5.05|P-value:5.19E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.62|P-value:3.92E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.09|P-value:4.38E-7 ID:SGTC_1351|Compound:1496-0003|FD-Score:5.03|P-value:5.63E-7 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.47|P-value:3.83E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-3.74|P-value:2.02E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.97|P-value:5.90E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.16|P-value:3.04E-7 ID:SGTC_1717|Compound:st033143|FD-Score:-4.18|P-value:3.73E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.25|P-value:1.94E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.73|P-value:1.49E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.26|P-value:7.74E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-3.36|P-value:7.62E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-3.89|P-value:1.13E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.44|P-value:4.15E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.41|P-value:4.63E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.33|P-value:1.38E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.55|P-value:2.87E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.35|P-value:1.25E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.43|P-value:5.85E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.62|P-value:2.25E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.37|P-value:5.31E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.40|P-value:4.79E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-4.12|P-value:4.67E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.71|P-value:1.58E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-4.12|P-value:4.79E-5 ID:SGTC_2954|Compound:9074818|FD-Score:3.28|P-value:7.08E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.33|P-value:6.19E-4 ID:SGTC_3130|Compound:9127414|FD-Score:4.11|P-value:3.37E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.57|P-value:2.70E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.28|P-value:9.67E-4

Top fitness defect scores for YHR032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 5.16 54.9 µM 3.04E-7 redox potentiating 41 1.23E-7
2 SGTC_1250 0485-0349 5.09 40.2 µM 4.38E-7 10 1.82E-7
3 SGTC_889 0919-1524 5.05 82.7 µM 5.19E-7 4 2.19E-7
4 SGTC_1351 1496-0003 5.03 46.5 µM 5.63E-7 8 2.39E-7
5 SGTC_607 4491-0986 4.96 66.8 µM 7.99E-7 heme requiring 10 3.49E-7
6 SGTC_759 3486-0358 4.87 89.3 µM 1.21E-6 11 5.46E-7
7 SGTC_1137 ixabepilone 4.62 100.0 µM 3.92E-6 14 1.93E-6
8 SGTC_2381 9035592 4.35 200.0 µM 1.25E-5 11 6.70E-6
9 SGTC_2313 7726885 4.33 200.0 µM 1.38E-5 RPP1 & pyrimidine depletion 25 7.50E-6
10 SGTC_1874 staurosporine 4.25 7.6 µM 1.94E-5 cell wall signaling 22 1.08E-5
11 SGTC_3130 9127414 4.11 49.5 µM 3.37E-5 18 1.95E-5
12 SGTC_1592 4',5'-dihydroxyflavone 3.97 8.8 µM 5.90E-5 60S ribosome export 9 3.56E-5
13 SGTC_763 3453-1109 3.92 128.0 µM 7.19E-5 17 4.40E-5
14 SGTC_1979 st071809 3.73 45.3 µM 1.49E-4 RPP1 & pyrimidine depletion 19 9.59E-5
15 SGTC_2910 7948405 3.71 26.0 µM 1.58E-4 plasma membrane duress 29 1.03E-4
16 SGTC_2592 piperlongumine 3.62 83.3 µM 2.25E-4 TSC3-RPN4 57 1.49E-4
17 SGTC_692 k241-0027 3.60 77.8 µM 2.37E-4 17 1.58E-4
18 SGTC_3154 9100113 3.57 49.5 µM 2.70E-4 43 1.82E-4
19 SGTC_2332 7982454 3.55 138.9 µM 2.87E-4 69 1.94E-4
20 SGTC_1363 1636-0063 3.47 10.4 µM 3.83E-4 Golgi 45 2.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.087 4.86E-7 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.084 1.25E-6 YBL104C SEA4 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites
0.079 4.96E-6 YNR051C BRE5 hom Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
0.078 6.60E-6 YGR154C GTO1 hom Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
0.074 1.63E-5 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.071 3.72E-5 YMR194W RPL36A hom Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication
0.071 4.12E-5 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.069 5.70E-5 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene
0.069 6.48E-5 YOR142W LSC1 hom Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
0.067 9.35E-5 YKL096C-B_p YKL096C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.066 1.25E-4 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.066 1.24E-4 YPR068C HOS1 hom Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex
0.065 1.63E-4 YPR168W NUT2 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress
0.065 1.80E-4 YMR077C VPS20 hom Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.064 1.93E-4 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p