YHR034C / PIH1

Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR034C / PIH1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.49|P-value:3.40E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.56|P-value:2.59E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:3.61|P-value:6.65E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.58|P-value:2.42E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.35|P-value:1.35E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:3.51|P-value:9.08E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.27|P-value:7.51E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.70|P-value:5.09E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:6.60|P-value:2.43E-9 ID:SGTC_182|Compound:3448-4371|FD-Score:-4.17|P-value:1.32E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.18|P-value:1.03E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.56|P-value:7.75E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.55|P-value:7.91E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:-5.05|P-value:4.72E-6 ID:SGTC_466|Compound:geldanamycin|FD-Score:-3.81|P-value:4.22E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.76|P-value:5.05E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.98|P-value:2.01E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.74|P-value:5.36E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:-4.28|P-value:8.77E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:4.96|P-value:5.31E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:6.46|P-value:5.09E-9 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.81|P-value:9.97E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:3.49|P-value:9.49E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:6.95|P-value:3.64E-10 ID:SGTC_708|Compound:3448-5400|FD-Score:4.74|P-value:1.30E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:3.83|P-value:3.34E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.90|P-value:2.60E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.56|P-value:7.83E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.94|P-value:2.85E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.91|P-value:2.53E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.99|P-value:5.44E-8 ID:SGTC_1521|Compound:st012942|FD-Score:3.52|P-value:8.75E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.59|P-value:6.96E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.23|P-value:1.04E-4 ID:SGTC_1768|Compound:st044301|FD-Score:4.26|P-value:7.84E-5 ID:SGTC_1910|Compound:st062352|FD-Score:5.25|P-value:1.63E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-3.96|P-value:2.66E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.00|P-value:1.92E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.59|P-value:7.15E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.76|P-value:1.52E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.62|P-value:6.43E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.47|P-value:9.98E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.82|P-value:9.34E-6 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.66|P-value:6.91E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.12|P-value:1.54E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.56|P-value:3.23E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.38|P-value:5.09E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.33|P-value:6.04E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.88|P-value:7.42E-6 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:4.00|P-value:1.90E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-5.47|P-value:7.97E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.21|P-value:9.08E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.79|P-value:3.74E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-4.59|P-value:2.89E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.90|P-value:2.64E-4 ID:SGTC_2875|Compound:9039966|FD-Score:4.69|P-value:1.58E-5 ID:SGTC_2917|Compound:7979103|FD-Score:4.37|P-value:5.17E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.97|P-value:2.08E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.90|P-value:2.60E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.98|P-value:4.88E-6 ID:SGTC_3260|Compound:9137109|FD-Score:-4.48|P-value:4.27E-5 ID:SGTC_3333|Compound:9141820|FD-Score:-4.41|P-value:5.66E-5 ID:SGTC_3335|Compound:9143315|FD-Score:4.12|P-value:1.27E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.49|P-value:3.40E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.56|P-value:2.59E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:3.61|P-value:6.65E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.58|P-value:2.42E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.35|P-value:1.35E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:3.51|P-value:9.08E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.27|P-value:7.51E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.70|P-value:5.09E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:6.60|P-value:2.43E-9 ID:SGTC_182|Compound:3448-4371|FD-Score:-4.17|P-value:1.32E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.18|P-value:1.03E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.56|P-value:7.75E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.55|P-value:7.91E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:-5.05|P-value:4.72E-6 ID:SGTC_466|Compound:geldanamycin|FD-Score:-3.81|P-value:4.22E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.76|P-value:5.05E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.98|P-value:2.01E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.74|P-value:5.36E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:-4.28|P-value:8.77E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:4.96|P-value:5.31E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:6.46|P-value:5.09E-9 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.81|P-value:9.97E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:3.49|P-value:9.49E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:6.95|P-value:3.64E-10 ID:SGTC_708|Compound:3448-5400|FD-Score:4.74|P-value:1.30E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:3.83|P-value:3.34E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.90|P-value:2.60E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.56|P-value:7.83E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.94|P-value:2.85E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.91|P-value:2.53E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.99|P-value:5.44E-8 ID:SGTC_1521|Compound:st012942|FD-Score:3.52|P-value:8.75E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.59|P-value:6.96E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.23|P-value:1.04E-4 ID:SGTC_1768|Compound:st044301|FD-Score:4.26|P-value:7.84E-5 ID:SGTC_1910|Compound:st062352|FD-Score:5.25|P-value:1.63E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-3.96|P-value:2.66E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.00|P-value:1.92E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.59|P-value:7.15E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.76|P-value:1.52E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.62|P-value:6.43E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.47|P-value:9.98E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.82|P-value:9.34E-6 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.66|P-value:6.91E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.12|P-value:1.54E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.56|P-value:3.23E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.38|P-value:5.09E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.33|P-value:6.04E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.88|P-value:7.42E-6 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:4.00|P-value:1.90E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-5.47|P-value:7.97E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.21|P-value:9.08E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.79|P-value:3.74E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-4.59|P-value:2.89E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.90|P-value:2.64E-4 ID:SGTC_2875|Compound:9039966|FD-Score:4.69|P-value:1.58E-5 ID:SGTC_2917|Compound:7979103|FD-Score:4.37|P-value:5.17E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.97|P-value:2.08E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.90|P-value:2.60E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.98|P-value:4.88E-6 ID:SGTC_3260|Compound:9137109|FD-Score:-4.48|P-value:4.27E-5 ID:SGTC_3333|Compound:9141820|FD-Score:-4.41|P-value:5.66E-5 ID:SGTC_3335|Compound:9143315|FD-Score:4.12|P-value:1.27E-4

Top fitness defect scores for YHR034C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_696 1560-0013 6.95 611.0 µM 3.64E-10 3 1.78E-12
2 SGTC_177 1327-0068 6.60 8.4 µM 2.43E-9 20 1.99E-11
3 SGTC_625 k213-0058 6.46 121.0 µM 5.09E-9 translation 27 5.10E-11
4 SGTC_1129 3453-1384 5.99 223.0 µM 5.44E-8 11 1.04E-9
5 SGTC_1910 st062352 5.25 60.4 µM 1.63E-6 9 7.76E-8
6 SGTC_3242 9133940 4.98 49.5 µM 4.88E-6 2 3.11E-7
7 SGTC_573 3702-0553 4.96 84.7 µM 5.31E-6 4 3.46E-7
8 SGTC_2651 1327-0036 4.88 5.0 µM 7.42E-6 115 5.28E-7
9 SGTC_2430 5571206 4.82 200.0 µM 9.34E-6 36 7.08E-7
10 SGTC_636 0kpi-0074 4.81 126.0 µM 9.97E-6 10 7.68E-7
11 SGTC_708 3448-5400 4.74 146.0 µM 1.30E-5 23 1.08E-6
12 SGTC_2875 9039966 4.69 71.4 µM 1.58E-5 5 1.37E-6
13 SGTC_59 0330-0160 4.58 1.3 µM 2.42E-5 82 2.36E-6
14 SGTC_28 pentachloropyridine N-oxide 4.56 1.6 µM 2.59E-5 TSC3-RPN4 42 2.58E-6
15 SGTC_18 0111-0177 4.49 500.0 nM 3.40E-5 45 3.63E-6
16 SGTC_2601 securinine 4.38 100.0 µM 5.09E-5 21 6.03E-6
17 SGTC_2917 7979103 4.37 53.8 µM 5.17E-5 18 6.15E-6
18 SGTC_2603 homopterocarpin 4.33 100.0 µM 6.04E-5 22 7.49E-6
19 SGTC_163 1327-0036 4.27 7.5 µM 7.51E-5 91 9.85E-6
20 SGTC_1768 st044301 4.26 37.2 µM 7.84E-5 13 1.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.75E-19 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.152 1.14E-18 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.136 2.44E-15 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.136 3.18E-15 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.134 7.85E-15 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.130 4.07E-14 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.129 6.73E-14 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.122 1.33E-12 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.118 5.97E-12 YKL143W LTV1 hom Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
0.117 1.16E-11 YER107C GLE2 hom RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1
0.117 1.18E-11 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.115 2.36E-11 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.113 5.04E-11 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.113 5.38E-11 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.113 6.36E-11 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M