YHR038W / RRF1

Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR038W / RRF1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.21|P-value:4.22E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.00|P-value:1.47E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:3.48|P-value:5.74E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.07|P-value:7.03E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.61|P-value:3.75E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.69|P-value:2.84E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.59|P-value:4.02E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.91|P-value:1.65E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.60|P-value:3.45E-10 ID:SGTC_277|Compound:nystatin|FD-Score:3.57|P-value:4.30E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:9.90|P-value:1.02E-20 ID:SGTC_341|Compound:1486-1430|FD-Score:3.74|P-value:2.39E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.33|P-value:9.21E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-4.05|P-value:7.61E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.82|P-value:1.74E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.51|P-value:4.98E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.60|P-value:3.81E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.55|P-value:4.50E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.83|P-value:3.14E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:4.81|P-value:3.42E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:3.35|P-value:8.58E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.87|P-value:2.65E-6 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.73|P-value:2.44E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.76|P-value:2.19E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.72|P-value:2.50E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.52|P-value:1.18E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:9.76|P-value:3.49E-20 ID:SGTC_1433|Compound:4060-0023|FD-Score:-4.00|P-value:8.99E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:4.82|P-value:3.34E-6 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.47|P-value:1.47E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.74|P-value:2.32E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-4.93|P-value:1.94E-6 ID:SGTC_1623|Compound:st003709|FD-Score:4.06|P-value:7.24E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.16|P-value:4.94E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-3.61|P-value:3.57E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.31|P-value:9.61E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.35|P-value:8.52E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.45|P-value:1.69E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.34|P-value:8.77E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-4.88|P-value:2.46E-6 ID:SGTC_1742|Compound:st038235|FD-Score:4.73|P-value:4.86E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.95|P-value:1.09E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.75|P-value:2.23E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.39|P-value:7.70E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.33|P-value:9.26E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.25|P-value:3.48E-5 ID:SGTC_2094|Compound:5332512|FD-Score:3.48|P-value:5.72E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.47|P-value:5.94E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.80|P-value:2.98E-8 ID:SGTC_2400|Compound:5203494|FD-Score:3.32|P-value:9.51E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.85|P-value:2.86E-6 ID:SGTC_2448|Compound:5185112|FD-Score:3.98|P-value:9.85E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.34|P-value:9.11E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.55|P-value:4.52E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.74|P-value:2.35E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.33|P-value:9.03E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.63|P-value:3.34E-4 ID:SGTC_2792|Compound:7535235|FD-Score:5.46|P-value:1.65E-7 ID:SGTC_2797|Compound:7859098|FD-Score:4.74|P-value:4.70E-6 ID:SGTC_2872|Compound:9044037|FD-Score:3.40|P-value:7.36E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.90|P-value:1.34E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.98|P-value:9.98E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.21|P-value:4.22E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.00|P-value:1.47E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:3.48|P-value:5.74E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.07|P-value:7.03E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.61|P-value:3.75E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.69|P-value:2.84E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.59|P-value:4.02E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.91|P-value:1.65E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.60|P-value:3.45E-10 ID:SGTC_277|Compound:nystatin|FD-Score:3.57|P-value:4.30E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:9.90|P-value:1.02E-20 ID:SGTC_341|Compound:1486-1430|FD-Score:3.74|P-value:2.39E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.33|P-value:9.21E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-4.05|P-value:7.61E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.82|P-value:1.74E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.51|P-value:4.98E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.60|P-value:3.81E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.55|P-value:4.50E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.83|P-value:3.14E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:4.81|P-value:3.42E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:3.35|P-value:8.58E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.87|P-value:2.65E-6 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.73|P-value:2.44E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.76|P-value:2.19E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.72|P-value:2.50E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.52|P-value:1.18E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:9.76|P-value:3.49E-20 ID:SGTC_1433|Compound:4060-0023|FD-Score:-4.00|P-value:8.99E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:4.82|P-value:3.34E-6 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.47|P-value:1.47E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.74|P-value:2.32E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-4.93|P-value:1.94E-6 ID:SGTC_1623|Compound:st003709|FD-Score:4.06|P-value:7.24E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.16|P-value:4.94E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-3.61|P-value:3.57E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.31|P-value:9.61E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.35|P-value:8.52E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.45|P-value:1.69E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.34|P-value:8.77E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-4.88|P-value:2.46E-6 ID:SGTC_1742|Compound:st038235|FD-Score:4.73|P-value:4.86E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.95|P-value:1.09E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.75|P-value:2.23E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.39|P-value:7.70E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.33|P-value:9.26E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.25|P-value:3.48E-5 ID:SGTC_2094|Compound:5332512|FD-Score:3.48|P-value:5.72E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.47|P-value:5.94E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.80|P-value:2.98E-8 ID:SGTC_2400|Compound:5203494|FD-Score:3.32|P-value:9.51E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.85|P-value:2.86E-6 ID:SGTC_2448|Compound:5185112|FD-Score:3.98|P-value:9.85E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.34|P-value:9.11E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.55|P-value:4.52E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.74|P-value:2.35E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.33|P-value:9.03E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.63|P-value:3.34E-4 ID:SGTC_2792|Compound:7535235|FD-Score:5.46|P-value:1.65E-7 ID:SGTC_2797|Compound:7859098|FD-Score:4.74|P-value:4.70E-6 ID:SGTC_2872|Compound:9044037|FD-Score:3.40|P-value:7.36E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.90|P-value:1.34E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.98|P-value:9.98E-5

Top fitness defect scores for YHR038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 9.90 1.1 µM 1.02E-20 mitochondrial stress 42 2.06E-23
2 SGTC_1427 4048-4900 9.76 550.0 nM 3.49E-20 7 8.42E-23
3 SGTC_275 trichlorophene 6.60 5.7 µM 3.45E-10 mitochondrial stress 99 2.11E-11
4 SGTC_236 1509-0011 5.91 5.3 µM 1.65E-8 296 1.73E-9
5 SGTC_2232 chlorophetanol 5.80 41.5 µM 2.98E-8 TRP & mitochondrial translation 45 3.39E-9
6 SGTC_2792 7535235 5.46 81.8 µM 1.65E-7 fatty acid desaturase (OLE1) 12 2.39E-8
7 SGTC_28 pentachloropyridine N-oxide 5.00 1.6 µM 1.47E-6 TSC3-RPN4 29 2.87E-7
8 SGTC_1107 amlodipine 4.87 47.0 µM 2.65E-6 17 5.61E-7
9 SGTC_883 0850-0245 4.83 24.6 µM 3.14E-6 cell wall 14 6.79E-7
10 SGTC_1440 4100-1550 4.82 40.0 µM 3.34E-6 1 7.30E-7
11 SGTC_892 0929-0076 4.81 29.0 µM 3.42E-6 TRP & mitochondrial translation 19 7.51E-7
12 SGTC_2797 7859098 4.74 81.8 µM 4.70E-6 13 1.08E-6
13 SGTC_1742 st038235 4.73 28.9 µM 4.86E-6 mitochondrial stress 87 1.12E-6
14 SGTC_1321 1326-2144 4.52 215.0 µM 1.18E-5 4 3.06E-6
15 SGTC_1442 4112-3290 4.47 3.0 µM 1.47E-5 3 3.93E-6
16 SGTC_1912 st060209 4.25 90.8 µM 3.48E-5 32 1.05E-5
17 SGTC_10 0279-0212 4.21 42.6 µM 4.22E-5 TRP & mitochondrial translation 109 1.30E-5
18 SGTC_1627 st003713 4.16 25.6 µM 4.94E-5 calcium & mitochondrial duress 65 1.56E-5
19 SGTC_63 0099-0242 4.07 26.7 µM 7.03E-5 mitochondrial stress 83 2.33E-5
20 SGTC_1623 st003709 4.06 20.3 µM 7.24E-5 calcium & mitochondrial duress 67 2.41E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.372 7.35E-111 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.363 4.02E-105 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.353 1.29E-98 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.347 1.70E-95 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.346 6.35E-95 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.344 9.69E-94 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.341 2.64E-92 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.336 3.15E-89 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.335 1.48E-88 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.332 5.63E-87 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.331 2.42E-86 YLR067C PET309 hom Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)
0.326 3.82E-84 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.326 1.08E-83 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.319 2.61E-80 YMR267W PPA2 hom Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
0.319 3.53E-80 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency