YHR039C / MSC7

Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR039C / MSC7

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:5.89|P-value:3.03E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:3.45|P-value:7.50E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:5.41|P-value:3.22E-7 ID:SGTC_162|Compound:k030-0015|FD-Score:4.40|P-value:2.59E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.94|P-value:1.46E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.38|P-value:9.35E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.44|P-value:2.22E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:4.31|P-value:3.75E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:5.08|P-value:1.49E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:4.05|P-value:9.88E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.98|P-value:1.26E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.32|P-value:3.60E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.99|P-value:1.21E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.70|P-value:3.08E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.49|P-value:6.72E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.03|P-value:1.06E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.17|P-value:6.24E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.46|P-value:7.41E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:5.59|P-value:1.35E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.04|P-value:1.03E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.88|P-value:1.67E-4 ID:SGTC_1733|Compound:st037357|FD-Score:5.48|P-value:2.31E-7 ID:SGTC_1736|Compound:st036774|FD-Score:-3.44|P-value:7.44E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.58|P-value:5.02E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-4.76|P-value:5.51E-6 ID:SGTC_1927|Compound:st060202|FD-Score:-3.35|P-value:9.77E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.32|P-value:3.48E-5 ID:SGTC_2034|Compound:5197015|FD-Score:-3.59|P-value:4.46E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.58|P-value:4.67E-4 ID:SGTC_2063|Compound:5246145|FD-Score:6.15|P-value:7.73E-9 ID:SGTC_2073|Compound:5212005|FD-Score:-5.12|P-value:1.14E-6 ID:SGTC_2266|Compound:7929956|FD-Score:3.42|P-value:8.42E-4 ID:SGTC_2365|Compound:9042475|FD-Score:12.60|P-value:2.07E-31 ID:SGTC_2398|Compound:5228213|FD-Score:6.78|P-value:2.17E-10 ID:SGTC_2461|Compound:5755302|FD-Score:3.59|P-value:4.91E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:4.98|P-value:2.33E-6 ID:SGTC_2767|Compound:sibutramine|FD-Score:-4.61|P-value:1.03E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-3.50|P-value:6.01E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.74|P-value:2.96E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.34|P-value:3.34E-5 ID:SGTC_2972|Compound:9093619|FD-Score:4.22|P-value:5.24E-5 ID:SGTC_2980|Compound:9014342|FD-Score:4.05|P-value:9.73E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-8.51|P-value:2.06E-15 ID:SGTC_3152|Compound:9099253|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-4.51|P-value:1.52E-5 ID:SGTC_3154|Compound:9100113|FD-Score:4.07|P-value:8.96E-5 ID:SGTC_3157|Compound:9099274|FD-Score:-5.45|P-value:2.43E-7 ID:SGTC_3171|Compound:9103192|FD-Score:4.20|P-value:5.72E-5 ID:SGTC_3184|Compound:9108758|FD-Score:4.75|P-value:6.25E-6 ID:SGTC_3188|Compound:9110789|FD-Score:-4.10|P-value:7.66E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:5.89|P-value:3.03E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:3.45|P-value:7.50E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:5.41|P-value:3.22E-7 ID:SGTC_162|Compound:k030-0015|FD-Score:4.40|P-value:2.59E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.94|P-value:1.46E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.38|P-value:9.35E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.44|P-value:2.22E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:4.31|P-value:3.75E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:5.08|P-value:1.49E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:4.05|P-value:9.88E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.98|P-value:1.26E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.32|P-value:3.60E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.99|P-value:1.21E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.70|P-value:3.08E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.49|P-value:6.72E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.03|P-value:1.06E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.17|P-value:6.24E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.46|P-value:7.41E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:5.59|P-value:1.35E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.04|P-value:1.03E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.88|P-value:1.67E-4 ID:SGTC_1733|Compound:st037357|FD-Score:5.48|P-value:2.31E-7 ID:SGTC_1736|Compound:st036774|FD-Score:-3.44|P-value:7.44E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.58|P-value:5.02E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-4.76|P-value:5.51E-6 ID:SGTC_1927|Compound:st060202|FD-Score:-3.35|P-value:9.77E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.32|P-value:3.48E-5 ID:SGTC_2034|Compound:5197015|FD-Score:-3.59|P-value:4.46E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.58|P-value:4.67E-4 ID:SGTC_2063|Compound:5246145|FD-Score:6.15|P-value:7.73E-9 ID:SGTC_2073|Compound:5212005|FD-Score:-5.12|P-value:1.14E-6 ID:SGTC_2266|Compound:7929956|FD-Score:3.42|P-value:8.42E-4 ID:SGTC_2365|Compound:9042475|FD-Score:12.60|P-value:2.07E-31 ID:SGTC_2398|Compound:5228213|FD-Score:6.78|P-value:2.17E-10 ID:SGTC_2461|Compound:5755302|FD-Score:3.59|P-value:4.91E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:4.98|P-value:2.33E-6 ID:SGTC_2767|Compound:sibutramine|FD-Score:-4.61|P-value:1.03E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-3.50|P-value:6.01E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.74|P-value:2.96E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.34|P-value:3.34E-5 ID:SGTC_2972|Compound:9093619|FD-Score:4.22|P-value:5.24E-5 ID:SGTC_2980|Compound:9014342|FD-Score:4.05|P-value:9.73E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-8.51|P-value:2.06E-15 ID:SGTC_3152|Compound:9099253|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-4.51|P-value:1.52E-5 ID:SGTC_3154|Compound:9100113|FD-Score:4.07|P-value:8.96E-5 ID:SGTC_3157|Compound:9099274|FD-Score:-5.45|P-value:2.43E-7 ID:SGTC_3171|Compound:9103192|FD-Score:4.20|P-value:5.72E-5 ID:SGTC_3184|Compound:9108758|FD-Score:4.75|P-value:6.25E-6 ID:SGTC_3188|Compound:9110789|FD-Score:-4.10|P-value:7.66E-5

Top fitness defect scores for YHR039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2365 9042475 12.60 200.0 µM 2.07E-31 1 1.16E-36
2 SGTC_2398 5228213 6.78 48.8 µM 2.17E-10 iron homeostasis 6 5.98E-12
3 SGTC_2063 5246145 6.15 200.0 µM 7.73E-9 6 3.97E-10
4 SGTC_36 0335-0881 5.89 14.2 µM 3.03E-8 ubiquinone biosynthesis & proteasome 66 1.97E-9
5 SGTC_1424 4048-1941 5.59 275.0 µM 1.35E-7 6 1.14E-8
6 SGTC_1733 st037357 5.48 54.9 µM 2.31E-7 60S ribosome export 6 2.14E-8
7 SGTC_158 k038-0087 5.41 26.4 µM 3.22E-7 ubiquinone biosynthesis & proteasome 82 3.16E-8
8 SGTC_794 k038-0031 5.08 316.0 µM 1.49E-6 ubiquinone biosynthesis & proteasome 79 1.91E-7
9 SGTC_2748 diazoxide 4.98 86.7 µM 2.33E-6 1 3.22E-7
10 SGTC_3184 9108758 4.75 49.5 µM 6.25E-6 2 1.02E-6
11 SGTC_669 0108-0021 4.44 26.2 µM 2.22E-5 fatty acid desaturase (OLE1) 60 4.50E-6
12 SGTC_162 k030-0015 4.40 37.8 µM 2.59E-5 iron homeostasis 15 5.40E-6
13 SGTC_2938 9059746 4.34 27.3 µM 3.34E-5 fatty acid desaturase (OLE1) 33 7.26E-6
14 SGTC_1945 st075991 4.32 56.6 µM 3.48E-5 60S ribosome export 12 7.63E-6
15 SGTC_831 k061-1017 4.32 217.0 µM 3.60E-5 translation 41 7.94E-6
16 SGTC_768 0384-0033 4.31 77.3 µM 3.75E-5 fatty acid desaturase (OLE1) 73 8.31E-6
17 SGTC_2972 9093619 4.22 59.9 µM 5.24E-5 15 1.23E-5
18 SGTC_3171 9103192 4.20 49.5 µM 5.72E-5 4 1.36E-5
19 SGTC_1297 1068-0111 4.17 14.1 µM 6.24E-5 6 1.51E-5
20 SGTC_3154 9100113 4.07 49.5 µM 8.96E-5 26 2.30E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.25E-22 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.162 3.10E-21 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.160 1.61E-20 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.157 5.91E-20 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.157 8.32E-20 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152 8.41E-19 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.152 9.78E-19 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.151 1.54E-18 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.144 4.46E-17 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.143 8.91E-17 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.141 2.96E-16 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.141 3.32E-16 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.140 4.56E-16 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.140 5.23E-16 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.135 3.57E-15 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data