YHR043C / DOG2

2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR043C / DOG2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.75|P-value:2.83E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.71|P-value:5.20E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.66|P-value:3.25E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.41|P-value:5.30E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.48|P-value:4.25E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-5.23|P-value:4.94E-7 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.69|P-value:2.95E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.44|P-value:4.84E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-4.36|P-value:2.32E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.73|P-value:2.54E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.38|P-value:5.93E-4 ID:SGTC_1967|Compound:st070177|FD-Score:-3.42|P-value:7.21E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.66|P-value:2.24E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.66|P-value:2.26E-4 ID:SGTC_1994|Compound:st072947|FD-Score:6.23|P-value:1.47E-9 ID:SGTC_1996|Compound:st072960|FD-Score:4.53|P-value:7.27E-6 ID:SGTC_2000|Compound:st075254|FD-Score:-4.55|P-value:1.06E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.32|P-value:7.21E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.87|P-value:1.03E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-4.37|P-value:2.18E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.24|P-value:9.34E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.55|P-value:6.76E-6 ID:SGTC_2416|Compound:tofa|FD-Score:4.30|P-value:1.94E-5 ID:SGTC_2448|Compound:5185112|FD-Score:-3.34|P-value:9.42E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.23|P-value:9.49E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.54|P-value:4.85E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.18|P-value:3.21E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.38|P-value:8.14E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:9.47|P-value:1.07E-19 ID:SGTC_2610|Compound:ononetin|FD-Score:3.62|P-value:2.54E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-11.30|P-value:6.38E-27 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.46|P-value:9.91E-6 ID:SGTC_3026|Compound:9090633|FD-Score:4.10|P-value:4.31E-5 ID:SGTC_3039|Compound:9090270|FD-Score:-3.88|P-value:1.48E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.75|P-value:2.39E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.48|P-value:4.16E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-5.09|P-value:9.71E-7 ID:SGTC_3302|Compound:9125395|FD-Score:4.49|P-value:8.78E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:4.75|P-value:2.83E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.71|P-value:5.20E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.66|P-value:3.25E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.41|P-value:5.30E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.48|P-value:4.25E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-5.23|P-value:4.94E-7 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.69|P-value:2.95E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.44|P-value:4.84E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-4.36|P-value:2.32E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.73|P-value:2.54E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.38|P-value:5.93E-4 ID:SGTC_1967|Compound:st070177|FD-Score:-3.42|P-value:7.21E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.66|P-value:2.24E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.66|P-value:2.26E-4 ID:SGTC_1994|Compound:st072947|FD-Score:6.23|P-value:1.47E-9 ID:SGTC_1996|Compound:st072960|FD-Score:4.53|P-value:7.27E-6 ID:SGTC_2000|Compound:st075254|FD-Score:-4.55|P-value:1.06E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.32|P-value:7.21E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.87|P-value:1.03E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-4.37|P-value:2.18E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.24|P-value:9.34E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.55|P-value:6.76E-6 ID:SGTC_2416|Compound:tofa|FD-Score:4.30|P-value:1.94E-5 ID:SGTC_2448|Compound:5185112|FD-Score:-3.34|P-value:9.42E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.23|P-value:9.49E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.54|P-value:4.85E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.18|P-value:3.21E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.38|P-value:8.14E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:9.47|P-value:1.07E-19 ID:SGTC_2610|Compound:ononetin|FD-Score:3.62|P-value:2.54E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-11.30|P-value:6.38E-27 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.46|P-value:9.91E-6 ID:SGTC_3026|Compound:9090633|FD-Score:4.10|P-value:4.31E-5 ID:SGTC_3039|Compound:9090270|FD-Score:-3.88|P-value:1.48E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.75|P-value:2.39E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.48|P-value:4.16E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-5.09|P-value:9.71E-7 ID:SGTC_3302|Compound:9125395|FD-Score:4.49|P-value:8.78E-6

Top fitness defect scores for YHR043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2607 solasodine 9.47 47.4 µM 1.07E-19 13 1.36E-21
2 SGTC_1994 st072947 6.23 40.9 µM 1.47E-9 1 2.39E-10
3 SGTC_6 0844-0013 4.75 19.8 µM 2.83E-6 48 1.02E-6
4 SGTC_2409 alverine citrate 4.55 64.0 µM 6.76E-6 39 2.67E-6
5 SGTC_1996 st072960 4.53 66.8 µM 7.27E-6 5 2.89E-6
6 SGTC_3302 9125395 4.49 16.4 µM 8.78E-6 3 3.56E-6
7 SGTC_2660 2',4'-dihydroxychalcone 4.46 17.1 µM 9.91E-6 9 4.07E-6
8 SGTC_2416 tofa 4.30 880.0 nM 1.94E-5 sphingolipid biosynthesis & PDR1 41 8.54E-6
9 SGTC_2535 4',4'-dimethoxydalbergione 4.18 51.2 µM 3.21E-5 DNA damage response 14 1.48E-5
10 SGTC_3026 9090633 4.10 49.5 µM 4.31E-5 18 2.06E-5
11 SGTC_2357 9067248 3.87 200.0 µM 1.03E-4 18 5.35E-5
12 SGTC_1978 st071761 3.66 42.0 µM 2.24E-4 TSC3-RPN4 19 1.26E-4
13 SGTC_1984 st072354 3.66 53.1 µM 2.26E-4 21 1.27E-4
14 SGTC_2610 ononetin 3.62 44.2 µM 2.54E-4 57 1.45E-4
15 SGTC_3089 9117425 3.48 49.5 µM 4.16E-4 45 2.48E-4
16 SGTC_855 0428-0020 3.48 25.0 µM 4.25E-4 Golgi 35 2.54E-4
17 SGTC_1045 1348-1485 3.44 165.0 µM 4.84E-4 57 2.93E-4
18 SGTC_461 N-acetylfarnesylcysteine 3.41 136.0 µM 5.30E-4 6 3.23E-4
19 SGTC_1827 berberine 3.38 7.2 µM 5.93E-4 60S ribosome export 38 3.66E-4
20 SGTC_2297 7971671 3.32 152.3 µM 7.21E-4 RNA processing & uracil transport 51 4.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 9.21E-22 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.138 8.36E-16 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.136 3.61E-15 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.123 1.01E-12 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.122 1.12E-12 YBR220C_p YBR220C_p hom Putative protein of unknown function; YBR220C is not an essential gene
0.119 4.61E-12 YJL132W_p YJL132W_p hom Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
0.113 6.29E-11 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.112 9.17E-11 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.106 7.04E-10 YDR100W TVP15 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
0.106 8.34E-10 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.102 3.59E-9 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.100 6.42E-9 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.098 1.18E-8 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.097 1.82E-8 YLL052C AQY2 hom Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
0.096 2.21E-8 YPR082C DIB1 het 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein