YHR045W_p

Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR045W / YHR045W

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.41|P-value:2.49E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:5.92|P-value:7.97E-10 ID:SGTC_57|Compound:miconazole|FD-Score:4.79|P-value:5.14E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:3.06|P-value:9.04E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.04|P-value:1.88E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:4.69|P-value:8.71E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:4.61|P-value:1.28E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:3.27|P-value:4.23E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.45|P-value:2.20E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.09|P-value:1.51E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.32|P-value:3.54E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:6.17|P-value:1.56E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:12.70|P-value:7.46E-39 ID:SGTC_252|Compound:miconazole|FD-Score:7.47|P-value:1.24E-14 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.52|P-value:1.99E-6 ID:SGTC_263|Compound:alizarin|FD-Score:3.60|P-value:1.21E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:8.37|P-value:7.06E-18 ID:SGTC_346|Compound:4513-0042|FD-Score:7.46|P-value:1.40E-14 ID:SGTC_383|Compound:2324-0395|FD-Score:20.10|P-value:4.70E-94 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.28|P-value:4.17E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.70|P-value:7.86E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:7.06|P-value:3.08E-13 ID:SGTC_526|Compound:4469-0568|FD-Score:13.00|P-value:1.50E-40 ID:SGTC_547|Compound:1120-0019|FD-Score:5.07|P-value:1.15E-7 ID:SGTC_553|Compound:k007-0256|FD-Score:3.25|P-value:4.50E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.17|P-value:6.15E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.86|P-value:3.50E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:4.74|P-value:6.72E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:4.91|P-value:2.69E-7 ID:SGTC_689|Compound:0833-0039|FD-Score:5.55|P-value:7.67E-9 ID:SGTC_778|Compound:3456-2434|FD-Score:5.16|P-value:7.05E-8 ID:SGTC_852|Compound:0418-0143|FD-Score:3.25|P-value:4.51E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.63|P-value:1.08E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:12.20|P-value:1.18E-35 ID:SGTC_922|Compound:1866-0035|FD-Score:4.41|P-value:3.36E-6 ID:SGTC_942|Compound:3253-1115|FD-Score:3.20|P-value:5.44E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.42|P-value:2.42E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.52|P-value:1.65E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.15|P-value:1.17E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.70|P-value:8.23E-7 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.87|P-value:1.03E-9 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.21|P-value:5.29E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:7.95|P-value:2.49E-16 ID:SGTC_1311|Compound:1190-0148|FD-Score:10.20|P-value:7.38E-26 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.18|P-value:1.47E-10 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.57|P-value:1.36E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.14|P-value:1.21E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.12|P-value:1.33E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.23|P-value:4.90E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:11.10|P-value:4.60E-30 ID:SGTC_1818|Compound:st052136|FD-Score:-3.29|P-value:4.02E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.10|P-value:7.73E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.06|P-value:9.06E-4 ID:SGTC_2389|Compound:9091542|FD-Score:7.46|P-value:1.37E-14 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.08|P-value:8.44E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.16|P-value:6.38E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.47|P-value:1.99E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.31|P-value:3.70E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.09|P-value:1.52E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.43|P-value:2.32E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.42|P-value:2.46E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.09|P-value:8.22E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.07|P-value:8.57E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.65|P-value:1.04E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:7.84|P-value:6.25E-16 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.98|P-value:2.49E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.26|P-value:4.47E-4 ID:SGTC_2816|Compound:7982706|FD-Score:6.04|P-value:3.67E-10 ID:SGTC_2824|Compound:7998404|FD-Score:-3.16|P-value:6.31E-4 ID:SGTC_2925|Compound:9010536|FD-Score:10.60|P-value:2.01E-27 ID:SGTC_2928|Compound:9011484|FD-Score:4.91|P-value:2.70E-7 ID:SGTC_2930|Compound:9013230|FD-Score:4.37|P-value:4.14E-6 ID:SGTC_2965|Compound:9082772|FD-Score:3.63|P-value:1.08E-4 ID:SGTC_2991|Compound:9074669|FD-Score:10.50|P-value:6.06E-27 ID:SGTC_3016|Compound:9080866|FD-Score:3.99|P-value:2.30E-5 ID:SGTC_3018|Compound:9082602|FD-Score:14.10|P-value:2.51E-47 ID:SGTC_3062|Compound:9077494|FD-Score:4.08|P-value:1.57E-5 ID:SGTC_1|Compound:0258-0098|FD-Score:3.41|P-value:2.49E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:5.92|P-value:7.97E-10 ID:SGTC_57|Compound:miconazole|FD-Score:4.79|P-value:5.14E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:3.06|P-value:9.04E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.04|P-value:1.88E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:4.69|P-value:8.71E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:4.61|P-value:1.28E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:3.27|P-value:4.23E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.45|P-value:2.20E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.09|P-value:1.51E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.32|P-value:3.54E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:6.17|P-value:1.56E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:12.70|P-value:7.46E-39 ID:SGTC_252|Compound:miconazole|FD-Score:7.47|P-value:1.24E-14 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.52|P-value:1.99E-6 ID:SGTC_263|Compound:alizarin|FD-Score:3.60|P-value:1.21E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:8.37|P-value:7.06E-18 ID:SGTC_346|Compound:4513-0042|FD-Score:7.46|P-value:1.40E-14 ID:SGTC_383|Compound:2324-0395|FD-Score:20.10|P-value:4.70E-94 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.28|P-value:4.17E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.70|P-value:7.86E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:7.06|P-value:3.08E-13 ID:SGTC_526|Compound:4469-0568|FD-Score:13.00|P-value:1.50E-40 ID:SGTC_547|Compound:1120-0019|FD-Score:5.07|P-value:1.15E-7 ID:SGTC_553|Compound:k007-0256|FD-Score:3.25|P-value:4.50E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.17|P-value:6.15E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.86|P-value:3.50E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:4.74|P-value:6.72E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:4.91|P-value:2.69E-7 ID:SGTC_689|Compound:0833-0039|FD-Score:5.55|P-value:7.67E-9 ID:SGTC_778|Compound:3456-2434|FD-Score:5.16|P-value:7.05E-8 ID:SGTC_852|Compound:0418-0143|FD-Score:3.25|P-value:4.51E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.63|P-value:1.08E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:12.20|P-value:1.18E-35 ID:SGTC_922|Compound:1866-0035|FD-Score:4.41|P-value:3.36E-6 ID:SGTC_942|Compound:3253-1115|FD-Score:3.20|P-value:5.44E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.42|P-value:2.42E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.52|P-value:1.65E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.15|P-value:1.17E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.70|P-value:8.23E-7 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.87|P-value:1.03E-9 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.21|P-value:5.29E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:7.95|P-value:2.49E-16 ID:SGTC_1311|Compound:1190-0148|FD-Score:10.20|P-value:7.38E-26 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.18|P-value:1.47E-10 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.57|P-value:1.36E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.14|P-value:1.21E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.12|P-value:1.33E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.23|P-value:4.90E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:11.10|P-value:4.60E-30 ID:SGTC_1818|Compound:st052136|FD-Score:-3.29|P-value:4.02E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.10|P-value:7.73E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.06|P-value:9.06E-4 ID:SGTC_2389|Compound:9091542|FD-Score:7.46|P-value:1.37E-14 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.08|P-value:8.44E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.16|P-value:6.38E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.47|P-value:1.99E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.31|P-value:3.70E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.09|P-value:1.52E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.43|P-value:2.32E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.42|P-value:2.46E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.09|P-value:8.22E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.07|P-value:8.57E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.65|P-value:1.04E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:7.84|P-value:6.25E-16 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.98|P-value:2.49E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.26|P-value:4.47E-4 ID:SGTC_2816|Compound:7982706|FD-Score:6.04|P-value:3.67E-10 ID:SGTC_2824|Compound:7998404|FD-Score:-3.16|P-value:6.31E-4 ID:SGTC_2925|Compound:9010536|FD-Score:10.60|P-value:2.01E-27 ID:SGTC_2928|Compound:9011484|FD-Score:4.91|P-value:2.70E-7 ID:SGTC_2930|Compound:9013230|FD-Score:4.37|P-value:4.14E-6 ID:SGTC_2965|Compound:9082772|FD-Score:3.63|P-value:1.08E-4 ID:SGTC_2991|Compound:9074669|FD-Score:10.50|P-value:6.06E-27 ID:SGTC_3016|Compound:9080866|FD-Score:3.99|P-value:2.30E-5 ID:SGTC_3018|Compound:9082602|FD-Score:14.10|P-value:2.51E-47 ID:SGTC_3062|Compound:9077494|FD-Score:4.08|P-value:1.57E-5

Top fitness defect scores for YHR045W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_383 2324-0395 20.10 7.4 µM 4.70E-94 azole & statin 1 1.77E-90
2 SGTC_3018 9082602 14.10 49.5 µM 2.51E-47 5 1.45E-45
3 SGTC_526 4469-0568 13.00 170.0 µM 1.50E-40 azole & statin 2 4.73E-39
4 SGTC_227 fluconazole 12.70 33.5 µM 7.46E-39 azole & statin 8 2.03E-37
5 SGTC_902 1120-0002 12.20 2.1 µM 1.18E-35 azole & statin 1 2.41E-34
6 SGTC_1788 fluconazole 11.10 20.0 µM 4.60E-30 azole & statin 9 5.72E-29
7 SGTC_2925 9010536 10.60 32.5 µM 2.01E-27 azole & statin 3 1.98E-26
8 SGTC_2991 9074669 10.50 71.4 µM 6.06E-27 azole & statin 6 5.71E-26
9 SGTC_1311 1190-0148 10.20 100.0 µM 7.38E-26 azole & statin 1 6.32E-25
10 SGTC_273 hydroxyurea 8.37 18.1 mM 7.06E-18 heme biosynthesis & mitochondrial translocase 4 2.98E-17
11 SGTC_1310 1188-0297 7.95 994.0 nM 2.49E-16 azole & statin 3 9.15E-16
12 SGTC_2765 myclobutanil 7.84 7.7 µM 6.25E-16 azole & statin 4 2.22E-15
13 SGTC_252 miconazole 7.47 1.3 nM 1.24E-14 ergosterol depletion effects on membrane 8 3.93E-14
14 SGTC_2389 9091542 7.46 195.5 µM 1.37E-14 iron homeostasis 8 4.32E-14
15 SGTC_346 4513-0042 7.46 7.2 µM 1.40E-14 azole & statin 3 4.40E-14
16 SGTC_431 k089-0097 7.06 107.0 µM 3.08E-13 iron homeostasis 6 8.62E-13
17 SGTC_1353 1498-1206 6.18 8.1 µM 1.47E-10 mitochondrial response to ROS 15 3.24E-10
18 SGTC_217 ketoconazole 6.17 989.0 nM 1.56E-10 ergosterol depletion effects on membrane 5 3.44E-10
19 SGTC_2816 7982706 6.04 58.4 µM 3.67E-10 azole & statin 15 7.84E-10
20 SGTC_40 0327-0103 5.92 19.8 µM 7.97E-10 6 1.65E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.644 0 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.373 3.31E-111 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.315 2.84E-78 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.293 2.81E-67 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.291 1.07E-66 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.291 2.33E-66 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.285 1.27E-63 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.270 3.45E-57 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.252 6.63E-50 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.235 2.37E-43 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.235 3.58E-43 YKR052C MRS4 hom Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication
0.230 1.27E-41 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.222 1.03E-38 YBL103C RTG3 hom Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
0.216 1.01E-36 YGR270W YTA7 hom Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p
0.209 2.64E-34 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress