YHR046C / INM1

Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR046C / INM1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.58|P-value:3.41E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.94|P-value:9.21E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.84|P-value:1.33E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.08|P-value:5.48E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.91|P-value:1.05E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.67|P-value:2.52E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-4.11|P-value:4.62E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.41|P-value:5.74E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.42|P-value:5.91E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:5.67|P-value:3.57E-8 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.36|P-value:6.81E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.89|P-value:1.10E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.63|P-value:5.52E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.40|P-value:6.23E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.30|P-value:8.88E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.53|P-value:4.10E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.43|P-value:5.72E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.29|P-value:9.10E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.30|P-value:8.63E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.34|P-value:7.31E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:5.87|P-value:1.25E-8 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.33|P-value:7.85E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.60|P-value:2.99E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.84|P-value:1.36E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.59|P-value:3.31E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.37|P-value:6.95E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.61|P-value:3.11E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.56|P-value:3.66E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.47|P-value:5.03E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.99|P-value:7.79E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.38|P-value:6.35E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.48|P-value:4.53E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.25|P-value:9.69E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.53|P-value:4.01E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.48|P-value:4.83E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.01|P-value:7.11E-5 ID:SGTC_2986|Compound:9022445|FD-Score:3.56|P-value:3.68E-4 ID:SGTC_3029|Compound:9088683|FD-Score:5.68|P-value:3.53E-8 ID:SGTC_3034|Compound:9090421|FD-Score:4.70|P-value:4.03E-6 ID:SGTC_3076|Compound:9116187|FD-Score:3.68|P-value:2.43E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.29|P-value:9.12E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.85|P-value:1.21E-4 ID:SGTC_3161|Compound:9100388|FD-Score:-3.64|P-value:2.62E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.60|P-value:3.18E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.80|P-value:2.67E-6 ID:SGTC_3307|Compound:9126885|FD-Score:8.26|P-value:2.16E-15 ID:SGTC_25|Compound:0118-0223|FD-Score:3.58|P-value:3.41E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.94|P-value:9.21E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.84|P-value:1.33E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.08|P-value:5.48E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.91|P-value:1.05E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.67|P-value:2.52E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-4.11|P-value:4.62E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.41|P-value:5.74E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.42|P-value:5.91E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:5.67|P-value:3.57E-8 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.36|P-value:6.81E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.89|P-value:1.10E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.63|P-value:5.52E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.40|P-value:6.23E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.30|P-value:8.88E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.53|P-value:4.10E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.43|P-value:5.72E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.29|P-value:9.10E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.30|P-value:8.63E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.34|P-value:7.31E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:5.87|P-value:1.25E-8 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.33|P-value:7.85E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.60|P-value:2.99E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.84|P-value:1.36E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.59|P-value:3.31E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.37|P-value:6.95E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.61|P-value:3.11E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.56|P-value:3.66E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.47|P-value:5.03E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.99|P-value:7.79E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.38|P-value:6.35E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.48|P-value:4.53E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.25|P-value:9.69E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.53|P-value:4.01E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.48|P-value:4.83E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.01|P-value:7.11E-5 ID:SGTC_2986|Compound:9022445|FD-Score:3.56|P-value:3.68E-4 ID:SGTC_3029|Compound:9088683|FD-Score:5.68|P-value:3.53E-8 ID:SGTC_3034|Compound:9090421|FD-Score:4.70|P-value:4.03E-6 ID:SGTC_3076|Compound:9116187|FD-Score:3.68|P-value:2.43E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.29|P-value:9.12E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.85|P-value:1.21E-4 ID:SGTC_3161|Compound:9100388|FD-Score:-3.64|P-value:2.62E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.60|P-value:3.18E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.80|P-value:2.67E-6 ID:SGTC_3307|Compound:9126885|FD-Score:8.26|P-value:2.16E-15

Top fitness defect scores for YHR046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3307 9126885 8.26 69.3 µM 2.16E-15 2 7.27E-17
2 SGTC_1876 myriocin 5.87 605.0 nM 1.25E-8 15 2.18E-9
3 SGTC_3029 9088683 5.68 49.5 µM 3.53E-8 7 6.85E-9
4 SGTC_777 1315-0167 5.67 517.0 µM 3.57E-8 Golgi 8 6.94E-9
5 SGTC_3303 9125618 4.80 40.6 µM 2.67E-6 27 8.12E-7
6 SGTC_3034 9090421 4.70 49.5 µM 4.03E-6 60S ribosome export 5 1.28E-6
7 SGTC_925 2064-1272 4.63 59.6 µM 5.52E-6 11 1.82E-6
8 SGTC_194 1486-1323 4.08 56.9 µM 5.48E-5 18 2.28E-5
9 SGTC_2772 vinpocetine 4.01 57.1 µM 7.11E-5 20 3.04E-5
10 SGTC_2506 ethyl hematommate 3.99 54.2 µM 7.79E-5 RPP1 & pyrimidine depletion 17 3.37E-5
11 SGTC_44 0929-0055 3.94 61.2 µM 9.21E-5 33 4.05E-5
12 SGTC_266 formosanin C 3.91 406.0 nM 1.05E-4 sphingolipid biosynthesis & PDR1 69 4.67E-5
13 SGTC_790 1575-0012 3.89 79.1 µM 1.10E-4 TSC3-RPN4 30 4.92E-5
14 SGTC_140 0062-0056 3.84 502.5 µM 1.33E-4 25 6.07E-5
15 SGTC_1922 5578187 3.84 25.0 µM 1.36E-4 TRP & mitochondrial translation 37 6.20E-5
16 SGTC_3076 9116187 3.68 49.5 µM 2.43E-4 22 1.18E-4
17 SGTC_449 xestospongin c 3.67 11.2 µM 2.52E-4 NEO1-PIK1 83 1.23E-4
18 SGTC_2323 6148992 3.61 148.3 µM 3.11E-4 47 1.55E-4
19 SGTC_3186 9110464 3.60 49.5 µM 3.18E-4 RPP1 & pyrimidine depletion 19 1.59E-4
20 SGTC_2242 6630449 3.59 61.3 µM 3.31E-4 Golgi 54 1.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 2.37E-25 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.126 2.31E-13 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
0.122 1.19E-12 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.120 2.96E-12 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.104 1.81E-9 YDR071C PAA1 hom Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
0.099 8.73E-9 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.098 1.43E-8 YKL096W-A CWP2 hom Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
0.089 2.11E-7 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.081 2.39E-6 YLL031C GPI13 het ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
0.079 5.18E-6 YJL213W YJL213W hom Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
0.075 1.35E-5 YDR219C MFB1 hom Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
0.074 1.67E-5 YKR013W PRY2 hom Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication
0.074 1.70E-5 YDR333C RQC1 hom Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC
0.074 1.74E-5 YIL062C ARC15 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity
0.071 3.92E-5 YLR224W_p YLR224W_p hom F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene