YHR048W_p / YHK8

Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR048W / YHK8

Click on Significant Values for Screen Details ID:SGTC_271|Compound:rotenone|FD-Score:-3.35|P-value:3.50E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.08|P-value:8.79E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:-3.09|P-value:8.64E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.89|P-value:7.80E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.29|P-value:4.20E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:4.66|P-value:2.72E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.29|P-value:4.25E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.50|P-value:3.43E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.43|P-value:2.54E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.05|P-value:4.11E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.20|P-value:5.92E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:-3.80|P-value:6.21E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.83|P-value:9.91E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-3.14|P-value:7.19E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.25|P-value:8.30E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.14|P-value:7.18E-4 ID:SGTC_2196|Compound:6573537|FD-Score:-3.56|P-value:1.57E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.92|P-value:7.87E-7 ID:SGTC_2332|Compound:7982454|FD-Score:4.20|P-value:2.13E-5 ID:SGTC_2381|Compound:9035592|FD-Score:3.40|P-value:4.93E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.92|P-value:7.65E-7 ID:SGTC_2537|Compound:larixol|FD-Score:3.41|P-value:4.67E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.67|P-value:2.66E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.46|P-value:2.32E-4 ID:SGTC_2911|Compound:7942208|FD-Score:4.46|P-value:6.87E-6 ID:SGTC_2916|Compound:7875993|FD-Score:-3.37|P-value:3.25E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.06|P-value:3.81E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.30|P-value:7.00E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-7.75|P-value:4.51E-15 ID:SGTC_3000|Compound:9075062|FD-Score:4.66|P-value:2.73E-6 ID:SGTC_3007|Compound:9078383|FD-Score:3.46|P-value:4.00E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.74|P-value:1.41E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.64|P-value:2.07E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.60|P-value:3.54E-6 ID:SGTC_271|Compound:rotenone|FD-Score:-3.35|P-value:3.50E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.08|P-value:8.79E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:-3.09|P-value:8.64E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.89|P-value:7.80E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.29|P-value:4.20E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:4.66|P-value:2.72E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.29|P-value:4.25E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.50|P-value:3.43E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.43|P-value:2.54E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.05|P-value:4.11E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.20|P-value:5.92E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:-3.80|P-value:6.21E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.83|P-value:9.91E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-3.14|P-value:7.19E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.25|P-value:8.30E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.14|P-value:7.18E-4 ID:SGTC_2196|Compound:6573537|FD-Score:-3.56|P-value:1.57E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.92|P-value:7.87E-7 ID:SGTC_2332|Compound:7982454|FD-Score:4.20|P-value:2.13E-5 ID:SGTC_2381|Compound:9035592|FD-Score:3.40|P-value:4.93E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.92|P-value:7.65E-7 ID:SGTC_2537|Compound:larixol|FD-Score:3.41|P-value:4.67E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.67|P-value:2.66E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.46|P-value:2.32E-4 ID:SGTC_2911|Compound:7942208|FD-Score:4.46|P-value:6.87E-6 ID:SGTC_2916|Compound:7875993|FD-Score:-3.37|P-value:3.25E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.06|P-value:3.81E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.30|P-value:7.00E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-7.75|P-value:4.51E-15 ID:SGTC_3000|Compound:9075062|FD-Score:4.66|P-value:2.73E-6 ID:SGTC_3007|Compound:9078383|FD-Score:3.46|P-value:4.00E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.74|P-value:1.41E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.64|P-value:2.07E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.60|P-value:3.54E-6

Top fitness defect scores for YHR048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2444 5485484 4.92 36.4 µM 7.65E-7 15 4.25E-7
2 SGTC_2265 7929201 4.92 200.0 µM 7.87E-7 9 4.38E-7
3 SGTC_2552 juarezic acid 4.67 87.0 µM 2.66E-6 TSC3-RPN4 18 1.54E-6
4 SGTC_630 4356-0227 4.66 183.0 µM 2.72E-6 5 1.57E-6
5 SGTC_3000 9075062 4.66 71.4 µM 2.73E-6 6 1.58E-6
6 SGTC_3278 9139605 4.60 49.5 µM 3.54E-6 3 2.07E-6
7 SGTC_2911 7942208 4.46 15.6 µM 6.87E-6 mitochondrial response to ROS 12 4.09E-6
8 SGTC_2332 7982454 4.20 138.9 µM 2.13E-5 39 1.32E-5
9 SGTC_2931 9014674 4.06 55.7 µM 3.81E-5 18 2.40E-5
10 SGTC_1392 3455-1037 4.05 33.9 µM 4.11E-5 12 2.60E-5
11 SGTC_624 k048-0052 3.89 28.0 µM 7.80E-5 Golgi 16 5.04E-5
12 SGTC_1736 st036774 3.83 51.0 µM 9.91E-5 38 6.46E-5
13 SGTC_3089 9117425 3.74 49.5 µM 1.41E-4 30 9.33E-5
14 SGTC_3267 9137951 3.64 49.5 µM 2.07E-4 11 1.39E-4
15 SGTC_1160 4092-0570 3.50 10.5 µM 3.43E-4 plasma membrane duress 54 2.33E-4
16 SGTC_3007 9078383 3.46 71.4 µM 4.00E-4 34 2.74E-4
17 SGTC_2537 larixol 3.41 68.9 µM 4.67E-4 42 3.22E-4
18 SGTC_2381 9035592 3.40 200.0 µM 4.93E-4 37 3.40E-4
19 SGTC_2939 9044578 3.30 71.4 µM 7.00E-4 62 4.89E-4
20 SGTC_2045 5106652 3.25 78.0 µM 8.30E-4 38 5.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.86E-9 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.097 1.86E-8 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.089 2.55E-7 YOR360C PDE2 hom High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
0.079 4.02E-6 YOL052C SPE2 hom S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
0.079 4.54E-6 YML096W_p YML096W_p hom Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
0.074 1.81E-5 YLR182W SWI6 hom Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators
0.072 3.15E-5 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.072 3.28E-5 YOR063W RPL3 het Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
0.071 4.10E-5 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.069 6.44E-5 YPL260W YPL260W hom Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress
0.067 9.73E-5 YGR030C POP6 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.066 1.38E-4 YLR452C SST2 hom GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
0.065 1.57E-4 YMR265C_p YMR265C_p hom Putative protein of unknown function
0.065 1.78E-4 YKR091W SRL3 hom Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
0.064 2.10E-4 YOR353C SOG2 het Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis