YHR049C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR049C-A / YHR049C-A

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.27|P-value:3.67E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.26|P-value:3.86E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.03|P-value:7.42E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.18|P-value:5.25E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.42|P-value:2.10E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.65|P-value:6.66E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.86|P-value:1.84E-7 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.40|P-value:2.24E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.87|P-value:3.20E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.58|P-value:1.10E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.45|P-value:1.49E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.26|P-value:4.17E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.30|P-value:2.74E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.14|P-value:6.02E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.37|P-value:2.55E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.04|P-value:1.17E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.05|P-value:6.88E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.08|P-value:6.25E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.44|P-value:1.56E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.99|P-value:8.57E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-3.47|P-value:1.66E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.03|P-value:8.90E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.51|P-value:1.19E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.17|P-value:5.42E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-5.52|P-value:5.60E-9 ID:SGTC_2399|Compound:5884133|FD-Score:3.20|P-value:3.99E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:2.98|P-value:8.96E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.15|P-value:4.78E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.38|P-value:2.39E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.01|P-value:8.09E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-4.47|P-value:1.92E-6 ID:SGTC_2788|Compound:5282734|FD-Score:-3.01|P-value:9.48E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.02|P-value:7.59E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.51|P-value:1.20E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.42|P-value:2.03E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.71|P-value:6.20E-5 ID:SGTC_2994|Compound:9053520|FD-Score:4.59|P-value:7.81E-7 ID:SGTC_3068|Compound:9116768|FD-Score:-4.12|P-value:1.02E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.96|P-value:2.13E-5 ID:SGTC_3103|Compound:9120822|FD-Score:-3.08|P-value:7.36E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.07|P-value:6.30E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.65|P-value:8.24E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.62|P-value:7.58E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.35|P-value:2.23E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.13|P-value:6.19E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.27|P-value:3.67E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.26|P-value:3.86E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.03|P-value:7.42E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.18|P-value:5.25E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.42|P-value:2.10E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.65|P-value:6.66E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.86|P-value:1.84E-7 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.40|P-value:2.24E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.87|P-value:3.20E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.58|P-value:1.10E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.45|P-value:1.49E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.26|P-value:4.17E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.30|P-value:2.74E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.14|P-value:6.02E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.37|P-value:2.55E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.04|P-value:1.17E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.05|P-value:6.88E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.08|P-value:6.25E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.44|P-value:1.56E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.99|P-value:8.57E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-3.47|P-value:1.66E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.03|P-value:8.90E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.51|P-value:1.19E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.17|P-value:5.42E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-5.52|P-value:5.60E-9 ID:SGTC_2399|Compound:5884133|FD-Score:3.20|P-value:3.99E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:2.98|P-value:8.96E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.15|P-value:4.78E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.38|P-value:2.39E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.01|P-value:8.09E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-4.47|P-value:1.92E-6 ID:SGTC_2788|Compound:5282734|FD-Score:-3.01|P-value:9.48E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.02|P-value:7.59E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.51|P-value:1.20E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.42|P-value:2.03E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.71|P-value:6.20E-5 ID:SGTC_2994|Compound:9053520|FD-Score:4.59|P-value:7.81E-7 ID:SGTC_3068|Compound:9116768|FD-Score:-4.12|P-value:1.02E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.96|P-value:2.13E-5 ID:SGTC_3103|Compound:9120822|FD-Score:-3.08|P-value:7.36E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.07|P-value:6.30E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.65|P-value:8.24E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.62|P-value:7.58E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.35|P-value:2.23E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.13|P-value:6.19E-4

Top fitness defect scores for YHR049C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_388 3',4'-dichloroisocoumarin 4.86 16.7 µM 1.84E-7 5 5.80E-7
2 SGTC_2994 9053520 4.59 71.4 µM 7.81E-7 RPP1 & pyrimidine depletion 16 2.20E-6
3 SGTC_1204 4049-0315 4.26 18.3 µM 4.17E-6 19 1.03E-5
4 SGTC_1544 7-methoxy-4-methylcoumarin 4.04 105.0 µM 1.17E-5 15 2.66E-5
5 SGTC_369 0957-0393 3.65 4.5 µM 6.66E-5 cell wall signaling 32 1.32E-4
6 SGTC_3203 9113543 3.62 49.5 µM 7.58E-5 42 1.49E-4
7 SGTC_2112 5488546 3.51 200.0 µM 1.19E-4 TSC3-RPN4 29 2.27E-4
8 SGTC_2924 9010168 3.51 62.8 µM 1.20E-4 cell wall signaling 55 2.28E-4
9 SGTC_1181 1222-0449 3.45 220.0 µM 1.49E-4 39 2.79E-4
10 SGTC_1929 genistein trimethyl ether 3.44 50.5 µM 1.56E-4 31 2.91E-4
11 SGTC_3235 9132602 3.35 49.5 µM 2.23E-4 47 4.04E-4
12 SGTC_1399 3562-5772 3.30 25.0 µM 2.74E-4 RPP1 & pyrimidine depletion 29 4.89E-4
13 SGTC_2399 5884133 3.20 200.0 µM 3.99E-4 cell wall signaling 114 6.90E-4
14 SGTC_2450 5739737 3.15 12.9 µM 4.78E-4 56 8.16E-4
15 SGTC_1708 st033234 3.08 31.8 µM 6.25E-4 43 0.00104
16 SGTC_3126 9127922 3.07 49.5 µM 6.30E-4 fatty acid desaturase (OLE1) 80 0.00105
17 SGTC_1611 st001856 3.05 99.4 µM 6.88E-4 58 0.00114
18 SGTC_248 streptozotocin 3.03 5.2 mM 7.42E-4 DNA damage response 51 0.00122
19 SGTC_2857 9024691 3.02 58.4 µM 7.59E-4 73 0.00125
20 SGTC_2782 7736369 3.01 71.4 µM 8.09E-4 88 0.00133

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.43E-18 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.126 2.49E-13 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.124 4.77E-13 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.110 2.02E-10 YOL085C_d YOL085C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
0.106 8.75E-10 YJL131C AIM23 hom Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
0.099 8.60E-9 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.099 1.02E-8 YCR089W FIG2 hom Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating
0.092 9.08E-8 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.092 9.61E-8 YPR041W TIF5 het Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
0.089 2.07E-7 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.087 4.70E-7 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.087 4.89E-7 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.086 5.84E-7 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.082 1.86E-6 YKR077W MSA2 hom Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
0.079 4.45E-6 YGL085W_p LCL3_p hom Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS