HIPHOP chemogenomics database
YHR049C-A_d 
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR049C-A deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.151 | 1.43E-18 | YGR136W | LSB1 | hom | Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress |
| 0.126 | 2.49E-13 | YOR152C_p | YOR152C_p | hom | Putative protein of unknown function; YOR152C is not an essential gene |
| 0.124 | 4.77E-13 | YJL171C | YJL171C | hom | GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress |
| 0.110 | 2.02E-10 | YOL085C_d | YOL085C_d | hom | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A |
| 0.106 | 8.75E-10 | YJL131C | AIM23 | hom | Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss |
| 0.099 | 8.60E-9 | YDR517W | GRH1 | hom | Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress |
| 0.099 | 1.02E-8 | YCR089W | FIG2 | hom | Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating |
| 0.092 | 9.08E-8 | YDR059C | UBC5 | hom | Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication |
| 0.092 | 9.61E-8 | YPR041W | TIF5 | het | Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2 |
| 0.089 | 2.07E-7 | YJR072C | NPA3 | het | Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress |
| 0.087 | 4.70E-7 | YGR045C_d | YGR045C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.087 | 4.89E-7 | YDR521W_d | YDR521W_d | hom | Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol |
| 0.086 | 5.84E-7 | YKL166C | TPK3 | hom | cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication |
| 0.082 | 1.86E-6 | YKR077W | MSA2 | hom | Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation |
| 0.079 | 4.45E-6 | YGL085W_p | LCL3_p | hom | Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS |