YHR051W / COX6

Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR051W / COX6

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.32|P-value:3.45E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.41|P-value:2.53E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.55|P-value:1.72E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:6.30|P-value:6.19E-11 ID:SGTC_84|Compound:0443-0269|FD-Score:3.30|P-value:3.71E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.47|P-value:2.49E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.20|P-value:5.49E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.71|P-value:7.59E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.99|P-value:2.27E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.30|P-value:6.35E-11 ID:SGTC_211|Compound:3455-0679|FD-Score:3.04|P-value:9.60E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.60|P-value:5.39E-23 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.95|P-value:2.73E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.64|P-value:4.20E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:-5.12|P-value:8.83E-8 ID:SGTC_365|Compound:0121-0052|FD-Score:4.59|P-value:1.37E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.43|P-value:2.36E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.10|P-value:1.45E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:3.04|P-value:9.65E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.34|P-value:4.76E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.95|P-value:2.76E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.66|P-value:3.71E-9 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.24|P-value:4.73E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:6.07|P-value:2.88E-10 ID:SGTC_648|Compound:0375-0473|FD-Score:5.05|P-value:1.27E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:3.84|P-value:4.35E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:4.03|P-value:1.92E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.30|P-value:3.79E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:4.56|P-value:1.62E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:5.02|P-value:1.46E-7 ID:SGTC_995|Compound:3931-2021|FD-Score:3.69|P-value:8.07E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.05|P-value:9.08E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.58|P-value:1.26E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.47|P-value:1.98E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.99|P-value:1.71E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.06|P-value:8.82E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.84|P-value:1.26E-9 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.68|P-value:8.50E-5 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.65|P-value:9.75E-5 ID:SGTC_1623|Compound:st003709|FD-Score:4.33|P-value:4.86E-6 ID:SGTC_1627|Compound:st003713|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.94|P-value:2.82E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.15|P-value:6.52E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.05|P-value:9.27E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-3.13|P-value:6.97E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.59|P-value:1.37E-6 ID:SGTC_2052|Compound:5265182|FD-Score:5.57|P-value:6.51E-9 ID:SGTC_2088|Compound:5278280|FD-Score:3.66|P-value:9.48E-5 ID:SGTC_2095|Compound:5432005|FD-Score:-3.36|P-value:3.02E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.31|P-value:3.62E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.25|P-value:4.55E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.45|P-value:2.73E-6 ID:SGTC_2370|Compound:9071495|FD-Score:3.11|P-value:7.55E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.51|P-value:1.72E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.14|P-value:6.86E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.65|P-value:4.18E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.25|P-value:4.47E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.52|P-value:1.64E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.12|P-value:1.27E-5 ID:SGTC_2843|Compound:9000894|FD-Score:3.10|P-value:7.76E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.27|P-value:3.77E-8 ID:SGTC_2921|Compound:7974240|FD-Score:4.73|P-value:6.88E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.53|P-value:1.60E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.57|P-value:1.37E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.43|P-value:2.29E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.32|P-value:3.45E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.41|P-value:2.53E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.55|P-value:1.72E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:6.30|P-value:6.19E-11 ID:SGTC_84|Compound:0443-0269|FD-Score:3.30|P-value:3.71E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.47|P-value:2.49E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.20|P-value:5.49E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.71|P-value:7.59E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.99|P-value:2.27E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.30|P-value:6.35E-11 ID:SGTC_211|Compound:3455-0679|FD-Score:3.04|P-value:9.60E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.60|P-value:5.39E-23 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.95|P-value:2.73E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.64|P-value:4.20E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:-5.12|P-value:8.83E-8 ID:SGTC_365|Compound:0121-0052|FD-Score:4.59|P-value:1.37E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.43|P-value:2.36E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.10|P-value:1.45E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:3.04|P-value:9.65E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.34|P-value:4.76E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.95|P-value:2.76E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.66|P-value:3.71E-9 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.24|P-value:4.73E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:6.07|P-value:2.88E-10 ID:SGTC_648|Compound:0375-0473|FD-Score:5.05|P-value:1.27E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:3.84|P-value:4.35E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:4.03|P-value:1.92E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.30|P-value:3.79E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:4.56|P-value:1.62E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:5.02|P-value:1.46E-7 ID:SGTC_995|Compound:3931-2021|FD-Score:3.69|P-value:8.07E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.05|P-value:9.08E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.58|P-value:1.26E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.47|P-value:1.98E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.99|P-value:1.71E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.06|P-value:8.82E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.84|P-value:1.26E-9 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.68|P-value:8.50E-5 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.65|P-value:9.75E-5 ID:SGTC_1623|Compound:st003709|FD-Score:4.33|P-value:4.86E-6 ID:SGTC_1627|Compound:st003713|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.94|P-value:2.82E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.15|P-value:6.52E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.05|P-value:9.27E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-3.13|P-value:6.97E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.59|P-value:1.37E-6 ID:SGTC_2052|Compound:5265182|FD-Score:5.57|P-value:6.51E-9 ID:SGTC_2088|Compound:5278280|FD-Score:3.66|P-value:9.48E-5 ID:SGTC_2095|Compound:5432005|FD-Score:-3.36|P-value:3.02E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.31|P-value:3.62E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.25|P-value:4.55E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.45|P-value:2.73E-6 ID:SGTC_2370|Compound:9071495|FD-Score:3.11|P-value:7.55E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.51|P-value:1.72E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.14|P-value:6.86E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.65|P-value:4.18E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.25|P-value:4.47E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.52|P-value:1.64E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.12|P-value:1.27E-5 ID:SGTC_2843|Compound:9000894|FD-Score:3.10|P-value:7.76E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.27|P-value:3.77E-8 ID:SGTC_2921|Compound:7974240|FD-Score:4.73|P-value:6.88E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.53|P-value:1.60E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.57|P-value:1.37E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.43|P-value:2.29E-4

Top fitness defect scores for YHR051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.60 5.3 µM 5.39E-23 204 3.87E-22
2 SGTC_70 0141-0289 6.30 43.3 µM 6.19E-11 mitochondrial stress 72 1.47E-10
3 SGTC_173 1273-0061 6.30 2.7 µM 6.35E-11 mitochondrial stress 103 1.50E-10
4 SGTC_630 4356-0227 6.07 183.0 µM 2.88E-10 1 6.42E-10
5 SGTC_1188 1403-0014 5.84 4.6 µM 1.26E-9 mitochondrial stress 18 2.64E-9
6 SGTC_625 k213-0058 5.66 121.0 µM 3.71E-9 translation 41 7.48E-9
7 SGTC_310 1273-0058 5.64 1.1 µM 4.20E-9 mitochondrial stress 154 8.43E-9
8 SGTC_2052 5265182 5.57 7.1 µM 6.51E-9 6 1.28E-8
9 SGTC_648 0375-0473 5.05 33.3 µM 1.27E-7 7 2.23E-7
10 SGTC_967 1306-0166 5.02 352.0 µM 1.46E-7 12 2.54E-7
11 SGTC_1136 pergolide 4.99 1.1 µM 1.71E-7 14 2.97E-7
12 SGTC_2921 7974240 4.73 10.7 µM 6.88E-7 29 1.13E-6
13 SGTC_365 0121-0052 4.59 13.6 µM 1.37E-6 mitochondrial response to ROS 39 2.19E-6
14 SGTC_1939 st074455 4.59 53.6 µM 1.37E-6 17 2.19E-6
15 SGTC_924 2046-0044 4.56 21.3 µM 1.62E-6 8 2.58E-6
16 SGTC_63 0099-0242 4.55 26.7 µM 1.72E-6 mitochondrial stress 69 2.72E-6
17 SGTC_87 0100-0052 4.47 35.5 µM 2.49E-6 78 3.89E-6
18 SGTC_2341 7987486 4.45 176.7 µM 2.73E-6 10 4.25E-6
19 SGTC_1623 st003709 4.33 20.3 µM 4.86E-6 calcium & mitochondrial duress 53 7.39E-6
20 SGTC_2834 9001755 4.12 58.4 µM 1.27E-5 28 1.87E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.442 2.90E-160 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.408 1.31E-134 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.397 8.65E-127 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.396 1.52E-126 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.393 1.21E-123 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.391 7.69E-123 YDR332W IRC3 hom Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.387 5.61E-120 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.382 7.59E-117 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.373 1.92E-111 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.369 6.55E-109 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.369 1.20E-108 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.368 2.68E-108 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.368 4.60E-108 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.360 2.23E-103 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.360 3.17E-103 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth