YHR057C / CPR2

Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR057C / CPR2

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:6.18|P-value:5.13E-10 ID:SGTC_53|Compound:0973-0023|FD-Score:4.38|P-value:6.92E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.31|P-value:6.96E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.28|P-value:5.47E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.19|P-value:7.50E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.33|P-value:4.57E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-4.30|P-value:1.54E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.37|P-value:4.01E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.13|P-value:2.07E-5 ID:SGTC_1115|Compound:galangin|FD-Score:3.21|P-value:7.08E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.27|P-value:5.73E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.80|P-value:8.06E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.77|P-value:9.19E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.44|P-value:3.07E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.65|P-value:2.00E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.37|P-value:3.95E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.91|P-value:7.75E-5 ID:SGTC_1522|Compound:st012842|FD-Score:6.34|P-value:1.89E-10 ID:SGTC_1608|Compound:st001473|FD-Score:3.72|P-value:1.09E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.16|P-value:8.19E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.28|P-value:5.49E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.14|P-value:2.03E-5 ID:SGTC_1737|Compound:st035557|FD-Score:3.19|P-value:7.58E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-4.44|P-value:8.32E-6 ID:SGTC_1938|Compound:st074717|FD-Score:3.80|P-value:8.12E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.12|P-value:9.40E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.45|P-value:2.96E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.00|P-value:5.42E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-4.34|P-value:1.31E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.95|P-value:4.37E-5 ID:SGTC_2804|Compound:7954240|FD-Score:4.91|P-value:5.92E-7 ID:SGTC_2810|Compound:7959871|FD-Score:-4.41|P-value:9.73E-6 ID:SGTC_2859|Compound:9028643|FD-Score:4.24|P-value:1.33E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.86|P-value:6.27E-5 ID:SGTC_24|Compound:0417-1663|FD-Score:6.18|P-value:5.13E-10 ID:SGTC_53|Compound:0973-0023|FD-Score:4.38|P-value:6.92E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.31|P-value:6.96E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.28|P-value:5.47E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.19|P-value:7.50E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.33|P-value:4.57E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-4.30|P-value:1.54E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.37|P-value:4.01E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.13|P-value:2.07E-5 ID:SGTC_1115|Compound:galangin|FD-Score:3.21|P-value:7.08E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.27|P-value:5.73E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.80|P-value:8.06E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.77|P-value:9.19E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.44|P-value:3.07E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.65|P-value:2.00E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.37|P-value:3.95E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.91|P-value:7.75E-5 ID:SGTC_1522|Compound:st012842|FD-Score:6.34|P-value:1.89E-10 ID:SGTC_1608|Compound:st001473|FD-Score:3.72|P-value:1.09E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.16|P-value:8.19E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.28|P-value:5.49E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.14|P-value:2.03E-5 ID:SGTC_1737|Compound:st035557|FD-Score:3.19|P-value:7.58E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-4.44|P-value:8.32E-6 ID:SGTC_1938|Compound:st074717|FD-Score:3.80|P-value:8.12E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.12|P-value:9.40E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.45|P-value:2.96E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.00|P-value:5.42E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-4.34|P-value:1.31E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.95|P-value:4.37E-5 ID:SGTC_2804|Compound:7954240|FD-Score:4.91|P-value:5.92E-7 ID:SGTC_2810|Compound:7959871|FD-Score:-4.41|P-value:9.73E-6 ID:SGTC_2859|Compound:9028643|FD-Score:4.24|P-value:1.33E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.86|P-value:6.27E-5

Top fitness defect scores for YHR057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1522 st012842 6.34 45.6 µM 1.89E-10 RNA pol III & RNase P/MRP 6 1.15E-10
2 SGTC_24 0417-1663 6.18 219.0 µM 5.13E-10 5 3.24E-10
3 SGTC_2804 7954240 4.91 19.5 µM 5.92E-7 12 4.64E-7
4 SGTC_1336 1486-0901 4.65 104.0 µM 2.00E-6 15 1.63E-6
5 SGTC_53 0973-0023 4.38 40.0 µM 6.92E-6 RNA processing & uracil transport 9 5.82E-6
6 SGTC_2859 9028643 4.24 45.5 µM 1.33E-5 11 1.14E-5
7 SGTC_1734 st037168 4.14 69.4 µM 2.03E-5 17 1.76E-5
8 SGTC_918 glabranin 4.13 770.7 nM 2.07E-5 27 1.80E-5
9 SGTC_2430 5571206 3.95 200.0 µM 4.37E-5 56 3.87E-5
10 SGTC_2936 9038235 3.86 15.6 µM 6.27E-5 20 5.60E-5
11 SGTC_1263 0774-1208 3.80 64.8 µM 8.06E-5 52 7.26E-5
12 SGTC_1938 st074717 3.80 56.4 µM 8.12E-5 13 7.30E-5
13 SGTC_1271 0832-2808 3.77 169.0 µM 9.19E-5 15 8.30E-5
14 SGTC_1608 st001473 3.72 40.5 µM 1.09E-4 42 9.91E-5
15 SGTC_2064 5220758 3.45 200.0 µM 2.96E-4 59 2.76E-4
16 SGTC_1281 0884-0031 3.44 11.8 µM 3.07E-4 fatty acid desaturase (OLE1) 39 2.86E-4
17 SGTC_217 ketoconazole 3.41 989.0 nM 3.45E-4 ergosterol depletion effects on membrane 45 3.22E-4
18 SGTC_1338 1486-1223 3.37 76.0 µM 3.95E-4 39 3.70E-4
19 SGTC_831 k061-1017 3.37 217.0 µM 4.01E-4 translation 100 3.76E-4
20 SGTC_561 1550-0330 3.33 72.9 µM 4.57E-4 28 4.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.59E-10 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.093 6.71E-8 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.090 1.93E-7 YJL048C UBX6 hom UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication
0.084 9.97E-7 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
0.082 1.89E-6 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.081 2.82E-6 YDR147W EKI1 hom Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication
0.079 4.97E-6 YNL155W YNL155W hom Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress
0.079 5.24E-6 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.076 1.11E-5 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.076 1.18E-5 YPL074W YTA6 hom Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress
0.075 1.31E-5 YNL286W CUS2 hom Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)
0.075 1.49E-5 YKL070W_p YKL070W_p hom Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.074 1.69E-5 YPL175W SPT14 het UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
0.073 2.14E-5 YOR046C DBP5 het Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p
0.073 2.53E-5 YMR155W_p YMR155W_p hom Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen