YHR062C / RPP1

Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR062C / RPP1

Click on Significant Values for Screen Details ID:SGTC_112|Compound:phenothiazine|FD-Score:7.80|P-value:1.41E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:9.75|P-value:2.63E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:9.22|P-value:8.38E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:11.10|P-value:9.89E-8 ID:SGTC_202|Compound:3594-0513|FD-Score:7.88|P-value:1.24E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:7.21|P-value:4.07E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.70|P-value:9.45E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:10.00|P-value:1.37E-6 ID:SGTC_264|Compound:promethazine|FD-Score:9.25|P-value:7.91E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:18.60|P-value:9.66E-19 ID:SGTC_362|Compound:0310-0100|FD-Score:10.40|P-value:5.92E-7 ID:SGTC_389|Compound:tpck|FD-Score:13.10|P-value:3.60E-10 ID:SGTC_428|Compound:3448-4153|FD-Score:10.00|P-value:1.42E-6 ID:SGTC_456|Compound:gingerol|FD-Score:7.81|P-value:1.39E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:8.57|P-value:3.23E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:8.58|P-value:3.18E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:9.93|P-value:1.73E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:8.86|P-value:1.78E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:7.24|P-value:3.85E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:12.40|P-value:3.19E-9 ID:SGTC_667|Compound:1498-1044|FD-Score:9.77|P-value:2.48E-6 ID:SGTC_679|Compound:0422-0091|FD-Score:14.30|P-value:8.57E-12 ID:SGTC_680|Compound:0417-1641|FD-Score:7.58|P-value:2.13E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:6.80|P-value:8.10E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:8.41|P-value:4.44E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:8.87|P-value:1.75E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:7.37|P-value:3.06E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:7.10|P-value:4.93E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:7.44|P-value:2.72E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:11.90|P-value:1.38E-8 ID:SGTC_919|Compound:tnp00227|FD-Score:9.23|P-value:8.28E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:8.32|P-value:5.31E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:7.00|P-value:5.77E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:13.70|P-value:6.13E-11 ID:SGTC_1024|Compound:4507-0395|FD-Score:9.14|P-value:9.98E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-7.43|P-value:1.55E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:8.86|P-value:1.78E-5 ID:SGTC_1115|Compound:galangin|FD-Score:8.68|P-value:2.59E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:7.14|P-value:4.61E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:6.96|P-value:6.23E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:8.59|P-value:3.09E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:9.42|P-value:5.39E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:9.84|P-value:2.11E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:7.63|P-value:1.93E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:12.80|P-value:8.98E-10 ID:SGTC_1464|Compound:k208-0027|FD-Score:8.07|P-value:8.60E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:7.87|P-value:1.25E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:7.71|P-value:1.67E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:7.59|P-value:2.07E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:15.40|P-value:2.08E-13 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:7.58|P-value:2.12E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:6.89|P-value:6.93E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:8.87|P-value:1.77E-5 ID:SGTC_1603|Compound:st002045|FD-Score:8.45|P-value:4.11E-5 ID:SGTC_1604|Compound:st002052|FD-Score:17.30|P-value:2.08E-16 ID:SGTC_1619|Compound:st003326|FD-Score:-6.61|P-value:6.40E-4 ID:SGTC_1642|Compound:st009582|FD-Score:10.10|P-value:1.10E-6 ID:SGTC_1643|Compound:st009866|FD-Score:12.80|P-value:1.05E-9 ID:SGTC_1661|Compound:st013063|FD-Score:16.40|P-value:6.84E-15 ID:SGTC_1771|Compound:st048882|FD-Score:7.04|P-value:5.40E-4 ID:SGTC_1772|Compound:st048439|FD-Score:8.49|P-value:3.80E-5 ID:SGTC_1834|Compound:st055981|FD-Score:7.37|P-value:3.08E-4 ID:SGTC_1849|Compound:st056239|FD-Score:7.25|P-value:3.76E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-7.09|P-value:2.81E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:11.90|P-value:1.26E-8 ID:SGTC_1881|Compound:5652484|FD-Score:10.70|P-value:2.77E-7 ID:SGTC_1892|Compound:st058411|FD-Score:7.12|P-value:4.72E-4 ID:SGTC_1959|Compound:st077091|FD-Score:8.30|P-value:5.54E-5 ID:SGTC_1964|Compound:st076914|FD-Score:10.20|P-value:9.31E-7 ID:SGTC_2024|Compound:5144227|FD-Score:10.80|P-value:2.02E-7 ID:SGTC_2035|Compound:5154463|FD-Score:7.89|P-value:1.20E-4 ID:SGTC_2057|Compound:5236571|FD-Score:8.90|P-value:1.65E-5 ID:SGTC_2090|Compound:5301565|FD-Score:7.33|P-value:3.30E-4 ID:SGTC_2110|Compound:5483698|FD-Score:14.60|P-value:3.53E-12 ID:SGTC_2112|Compound:5488546|FD-Score:7.68|P-value:1.76E-4 ID:SGTC_2113|Compound:5491891|FD-Score:8.54|P-value:3.45E-5 ID:SGTC_2135|Compound:5326629|FD-Score:9.15|P-value:9.66E-6 ID:SGTC_2151|Compound:5563267|FD-Score:7.38|P-value:3.02E-4 ID:SGTC_2156|Compound:5649887|FD-Score:14.70|P-value:2.53E-12 ID:SGTC_2172|Compound:5754775|FD-Score:6.68|P-value:9.80E-4 ID:SGTC_2282|Compound:7944268|FD-Score:10.10|P-value:1.16E-6 ID:SGTC_2283|Compound:7944793|FD-Score:7.94|P-value:1.10E-4 ID:SGTC_2296|Compound:7971656|FD-Score:10.20|P-value:9.91E-7 ID:SGTC_2306|Compound:7482397|FD-Score:10.20|P-value:8.36E-7 ID:SGTC_2323|Compound:6148992|FD-Score:15.30|P-value:3.11E-13 ID:SGTC_2366|Compound:9070441|FD-Score:6.88|P-value:7.11E-4 ID:SGTC_2411|Compound:st077133|FD-Score:8.37|P-value:4.82E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:14.00|P-value:2.18E-11 ID:SGTC_2507|Compound:purpurin|FD-Score:15.80|P-value:5.86E-14 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:14.60|P-value:3.15E-12 ID:SGTC_2601|Compound:securinine|FD-Score:9.28|P-value:7.36E-6 ID:SGTC_2681|Compound:menadione|FD-Score:8.09|P-value:8.24E-5 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:10.90|P-value:1.87E-7 ID:SGTC_2686|Compound:alizarin|FD-Score:13.60|P-value:9.11E-11 ID:SGTC_2701|Compound:st077767|FD-Score:9.56|P-value:3.97E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:7.24|P-value:3.86E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:13.40|P-value:1.51E-10 ID:SGTC_2772|Compound:vinpocetine|FD-Score:7.84|P-value:1.33E-4 ID:SGTC_2791|Compound:5663188|FD-Score:8.93|P-value:1.55E-5 ID:SGTC_2800|Compound:7887935|FD-Score:8.47|P-value:3.94E-5 ID:SGTC_2838|Compound:9002687|FD-Score:-8.80|P-value:1.02E-5 ID:SGTC_2847|Compound:9005661|FD-Score:6.69|P-value:9.58E-4 ID:SGTC_2860|Compound:9025725|FD-Score:9.37|P-value:6.06E-6 ID:SGTC_2921|Compound:7974240|FD-Score:6.85|P-value:7.39E-4 ID:SGTC_2952|Compound:9073731|FD-Score:7.02|P-value:5.60E-4 ID:SGTC_2982|Compound:9019404|FD-Score:6.69|P-value:9.62E-4 ID:SGTC_3224|Compound:9130643|FD-Score:7.43|P-value:2.75E-4 ID:SGTC_3261|Compound:9137475|FD-Score:7.79|P-value:1.45E-4 ID:SGTC_3281|Compound:9140613|FD-Score:7.82|P-value:1.38E-4 ID:SGTC_3303|Compound:9125618|FD-Score:9.20|P-value:8.84E-6 ID:SGTC_3310|Compound:9130229|FD-Score:7.99|P-value:1.01E-4 ID:SGTC_3317|Compound:9138495|FD-Score:11.00|P-value:1.26E-7 ID:SGTC_112|Compound:phenothiazine|FD-Score:7.80|P-value:1.41E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:9.75|P-value:2.63E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:9.22|P-value:8.38E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:11.10|P-value:9.89E-8 ID:SGTC_202|Compound:3594-0513|FD-Score:7.88|P-value:1.24E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:7.21|P-value:4.07E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.70|P-value:9.45E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:10.00|P-value:1.37E-6 ID:SGTC_264|Compound:promethazine|FD-Score:9.25|P-value:7.91E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:18.60|P-value:9.66E-19 ID:SGTC_362|Compound:0310-0100|FD-Score:10.40|P-value:5.92E-7 ID:SGTC_389|Compound:tpck|FD-Score:13.10|P-value:3.60E-10 ID:SGTC_428|Compound:3448-4153|FD-Score:10.00|P-value:1.42E-6 ID:SGTC_456|Compound:gingerol|FD-Score:7.81|P-value:1.39E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:8.57|P-value:3.23E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:8.58|P-value:3.18E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:9.93|P-value:1.73E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:8.86|P-value:1.78E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:7.24|P-value:3.85E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:12.40|P-value:3.19E-9 ID:SGTC_667|Compound:1498-1044|FD-Score:9.77|P-value:2.48E-6 ID:SGTC_679|Compound:0422-0091|FD-Score:14.30|P-value:8.57E-12 ID:SGTC_680|Compound:0417-1641|FD-Score:7.58|P-value:2.13E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:6.80|P-value:8.10E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:8.41|P-value:4.44E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:8.87|P-value:1.75E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:7.37|P-value:3.06E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:7.10|P-value:4.93E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:7.44|P-value:2.72E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:11.90|P-value:1.38E-8 ID:SGTC_919|Compound:tnp00227|FD-Score:9.23|P-value:8.28E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:8.32|P-value:5.31E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:7.00|P-value:5.77E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:13.70|P-value:6.13E-11 ID:SGTC_1024|Compound:4507-0395|FD-Score:9.14|P-value:9.98E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-7.43|P-value:1.55E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:8.86|P-value:1.78E-5 ID:SGTC_1115|Compound:galangin|FD-Score:8.68|P-value:2.59E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:7.14|P-value:4.61E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:6.96|P-value:6.23E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:8.59|P-value:3.09E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:9.42|P-value:5.39E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:9.84|P-value:2.11E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:7.63|P-value:1.93E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:12.80|P-value:8.98E-10 ID:SGTC_1464|Compound:k208-0027|FD-Score:8.07|P-value:8.60E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:7.87|P-value:1.25E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:7.71|P-value:1.67E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:7.59|P-value:2.07E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:15.40|P-value:2.08E-13 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:7.58|P-value:2.12E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:6.89|P-value:6.93E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:8.87|P-value:1.77E-5 ID:SGTC_1603|Compound:st002045|FD-Score:8.45|P-value:4.11E-5 ID:SGTC_1604|Compound:st002052|FD-Score:17.30|P-value:2.08E-16 ID:SGTC_1619|Compound:st003326|FD-Score:-6.61|P-value:6.40E-4 ID:SGTC_1642|Compound:st009582|FD-Score:10.10|P-value:1.10E-6 ID:SGTC_1643|Compound:st009866|FD-Score:12.80|P-value:1.05E-9 ID:SGTC_1661|Compound:st013063|FD-Score:16.40|P-value:6.84E-15 ID:SGTC_1771|Compound:st048882|FD-Score:7.04|P-value:5.40E-4 ID:SGTC_1772|Compound:st048439|FD-Score:8.49|P-value:3.80E-5 ID:SGTC_1834|Compound:st055981|FD-Score:7.37|P-value:3.08E-4 ID:SGTC_1849|Compound:st056239|FD-Score:7.25|P-value:3.76E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-7.09|P-value:2.81E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:11.90|P-value:1.26E-8 ID:SGTC_1881|Compound:5652484|FD-Score:10.70|P-value:2.77E-7 ID:SGTC_1892|Compound:st058411|FD-Score:7.12|P-value:4.72E-4 ID:SGTC_1959|Compound:st077091|FD-Score:8.30|P-value:5.54E-5 ID:SGTC_1964|Compound:st076914|FD-Score:10.20|P-value:9.31E-7 ID:SGTC_2024|Compound:5144227|FD-Score:10.80|P-value:2.02E-7 ID:SGTC_2035|Compound:5154463|FD-Score:7.89|P-value:1.20E-4 ID:SGTC_2057|Compound:5236571|FD-Score:8.90|P-value:1.65E-5 ID:SGTC_2090|Compound:5301565|FD-Score:7.33|P-value:3.30E-4 ID:SGTC_2110|Compound:5483698|FD-Score:14.60|P-value:3.53E-12 ID:SGTC_2112|Compound:5488546|FD-Score:7.68|P-value:1.76E-4 ID:SGTC_2113|Compound:5491891|FD-Score:8.54|P-value:3.45E-5 ID:SGTC_2135|Compound:5326629|FD-Score:9.15|P-value:9.66E-6 ID:SGTC_2151|Compound:5563267|FD-Score:7.38|P-value:3.02E-4 ID:SGTC_2156|Compound:5649887|FD-Score:14.70|P-value:2.53E-12 ID:SGTC_2172|Compound:5754775|FD-Score:6.68|P-value:9.80E-4 ID:SGTC_2282|Compound:7944268|FD-Score:10.10|P-value:1.16E-6 ID:SGTC_2283|Compound:7944793|FD-Score:7.94|P-value:1.10E-4 ID:SGTC_2296|Compound:7971656|FD-Score:10.20|P-value:9.91E-7 ID:SGTC_2306|Compound:7482397|FD-Score:10.20|P-value:8.36E-7 ID:SGTC_2323|Compound:6148992|FD-Score:15.30|P-value:3.11E-13 ID:SGTC_2366|Compound:9070441|FD-Score:6.88|P-value:7.11E-4 ID:SGTC_2411|Compound:st077133|FD-Score:8.37|P-value:4.82E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:14.00|P-value:2.18E-11 ID:SGTC_2507|Compound:purpurin|FD-Score:15.80|P-value:5.86E-14 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:14.60|P-value:3.15E-12 ID:SGTC_2601|Compound:securinine|FD-Score:9.28|P-value:7.36E-6 ID:SGTC_2681|Compound:menadione|FD-Score:8.09|P-value:8.24E-5 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:10.90|P-value:1.87E-7 ID:SGTC_2686|Compound:alizarin|FD-Score:13.60|P-value:9.11E-11 ID:SGTC_2701|Compound:st077767|FD-Score:9.56|P-value:3.97E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:7.24|P-value:3.86E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:13.40|P-value:1.51E-10 ID:SGTC_2772|Compound:vinpocetine|FD-Score:7.84|P-value:1.33E-4 ID:SGTC_2791|Compound:5663188|FD-Score:8.93|P-value:1.55E-5 ID:SGTC_2800|Compound:7887935|FD-Score:8.47|P-value:3.94E-5 ID:SGTC_2838|Compound:9002687|FD-Score:-8.80|P-value:1.02E-5 ID:SGTC_2847|Compound:9005661|FD-Score:6.69|P-value:9.58E-4 ID:SGTC_2860|Compound:9025725|FD-Score:9.37|P-value:6.06E-6 ID:SGTC_2921|Compound:7974240|FD-Score:6.85|P-value:7.39E-4 ID:SGTC_2952|Compound:9073731|FD-Score:7.02|P-value:5.60E-4 ID:SGTC_2982|Compound:9019404|FD-Score:6.69|P-value:9.62E-4 ID:SGTC_3224|Compound:9130643|FD-Score:7.43|P-value:2.75E-4 ID:SGTC_3261|Compound:9137475|FD-Score:7.79|P-value:1.45E-4 ID:SGTC_3281|Compound:9140613|FD-Score:7.82|P-value:1.38E-4 ID:SGTC_3303|Compound:9125618|FD-Score:9.20|P-value:8.84E-6 ID:SGTC_3310|Compound:9130229|FD-Score:7.99|P-value:1.01E-4 ID:SGTC_3317|Compound:9138495|FD-Score:11.00|P-value:1.26E-7

Top fitness defect scores for YHR062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_265 mycophenolic acid 18.60 32.9 µM 9.66E-19 RPP1 & pyrimidine depletion 1 1.63E-77 13.40
2 SGTC_1604 st002052 17.30 72.4 µM 2.08E-16 TSC3-RPN4 1 3.40E-67 8.48
3 SGTC_1661 st013063 16.40 9.7 µM 6.84E-15 1 1.71E-60 3.94
4 SGTC_2507 purpurin 15.80 79.7 µM 5.86E-14 copper-dependent oxidative stress 2 2.25E-56 7.18
5 SGTC_1534 6-azauridine 15.40 81.6 µM 2.08E-13 RNA pol III & RNase P/MRP 1 6.02E-54 7.31
6 SGTC_2323 6148992 15.30 148.3 µM 3.11E-13 3 3.55E-53 8.35
7 SGTC_2156 5649887 14.70 115.0 µM 2.53E-12 RPP1 & pyrimidine depletion 3 3.72E-49 2.62
8 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 14.60 54.6 µM 3.15E-12 RPP1 & pyrimidine depletion 2 9.75E-49 6.41
9 SGTC_2110 5483698 14.60 200.0 µM 3.53E-12 TSC3-RPN4 1 1.61E-48 6.78
10 SGTC_679 0422-0091 14.30 41.4 µM 8.57E-12 Golgi 1 7.97E-47 7.21
11 SGTC_2498 4'-Methoxychalcone 14.00 54.6 µM 2.18E-11 RPP1 & pyrimidine depletion 1 4.90E-45 9.77
12 SGTC_1016 4226-1401 13.70 38.0 µM 6.13E-11 RNA pol III & RNase P/MRP 1 4.65E-43 3.43
13 SGTC_2686 alizarin 13.60 95.4 µM 9.11E-11 RPP1 & pyrimidine depletion 1 2.65E-42 7.51
14 SGTC_2752 diclazuril 13.40 33.1 µM 1.51E-10 1 2.46E-41 7.69
15 SGTC_389 tpck 13.10 16.7 µM 3.60E-10 2 1.12E-39 4.48
16 SGTC_1399 3562-5772 12.80 25.0 µM 8.98E-10 RPP1 & pyrimidine depletion 2 6.27E-38 4.09
17 SGTC_1643 st009866 12.80 20.2 µM 1.05E-9 4 1.22E-37 0.39
18 SGTC_639 0833-0042 12.40 114.0 µM 3.19E-9 2 1.63E-35 5.78
19 SGTC_1872 amphotericin b 11.90 148.0 nM 1.26E-8 RNA pol III & RNase P/MRP 5 6.95E-33 0.74
20 SGTC_820 1582-0060 11.90 59.9 µM 1.38E-8 1 1.01E-32 2.74

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Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 5.67E-49 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.223 1.09E-38 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.206 2.85E-33 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.195 6.39E-30 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.191 9.84E-29 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.186 2.31E-27 YDL150W RPC53 het RNA polymerase III subunit C53
0.186 2.59E-27 YKL052C ASK1 het Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
0.158 6.64E-20 YDL152W_d YDL152W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
0.155 2.51E-19 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
0.151 1.78E-18 YNL236W SIN4 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
0.139 8.62E-16 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.136 4.39E-15 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.131 3.88E-14 YML123C PHO84 hom High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity
0.130 4.94E-14 YML122C_d YML122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.121 2.97E-12 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene