YHR063C / PAN5

2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR063C / PAN5

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:3.26|P-value:8.51E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.73|P-value:1.64E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:7.92|P-value:8.86E-15 ID:SGTC_319|Compound:1348-1596|FD-Score:3.97|P-value:6.46E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.70|P-value:1.85E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.38|P-value:5.66E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.36|P-value:6.19E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.19|P-value:1.99E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:3.61|P-value:2.51E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.47|P-value:7.92E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:-5.40|P-value:6.42E-8 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.16|P-value:3.06E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.64|P-value:1.81E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.39|P-value:1.14E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.71|P-value:2.69E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.41|P-value:4.14E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.93|P-value:7.59E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.47|P-value:4.22E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.23|P-value:2.26E-5 ID:SGTC_1662|Compound:st014054|FD-Score:-3.17|P-value:9.31E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.15|P-value:3.09E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.75|P-value:1.51E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-3.22|P-value:7.75E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.32|P-value:7.12E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.08|P-value:4.26E-5 ID:SGTC_1968|Compound:st069590|FD-Score:4.32|P-value:1.53E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.87|P-value:9.48E-5 ID:SGTC_2191|Compound:5911152|FD-Score:-4.02|P-value:4.12E-5 ID:SGTC_2193|Compound:5925765|FD-Score:-3.20|P-value:8.41E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.22|P-value:9.83E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-3.50|P-value:3.02E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-4.06|P-value:3.49E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-3.75|P-value:1.17E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.49|P-value:3.12E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.84|P-value:1.07E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:5.18|P-value:2.83E-7 ID:SGTC_2649|Compound:anisomycin|FD-Score:5.02|P-value:6.38E-7 ID:SGTC_2908|Compound:7930301|FD-Score:-3.61|P-value:1.96E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.75|P-value:1.49E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.86|P-value:7.67E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-3.30|P-value:5.97E-4 ID:SGTC_3053|Compound:9095903|FD-Score:3.38|P-value:5.76E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.63|P-value:2.34E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.75|P-value:1.18E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.22|P-value:7.73E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.86|P-value:7.71E-5 ID:SGTC_3329|Compound:9141233|FD-Score:-3.33|P-value:5.46E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:3.26|P-value:8.51E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.73|P-value:1.64E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:7.92|P-value:8.86E-15 ID:SGTC_319|Compound:1348-1596|FD-Score:3.97|P-value:6.46E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.70|P-value:1.85E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.38|P-value:5.66E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.36|P-value:6.19E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.19|P-value:1.99E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:3.61|P-value:2.51E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.47|P-value:7.92E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:-5.40|P-value:6.42E-8 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.16|P-value:3.06E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.64|P-value:1.81E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.39|P-value:1.14E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.71|P-value:2.69E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.41|P-value:4.14E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.93|P-value:7.59E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.47|P-value:4.22E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.23|P-value:2.26E-5 ID:SGTC_1662|Compound:st014054|FD-Score:-3.17|P-value:9.31E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.15|P-value:3.09E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.75|P-value:1.51E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-3.22|P-value:7.75E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.32|P-value:7.12E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.08|P-value:4.26E-5 ID:SGTC_1968|Compound:st069590|FD-Score:4.32|P-value:1.53E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.87|P-value:9.48E-5 ID:SGTC_2191|Compound:5911152|FD-Score:-4.02|P-value:4.12E-5 ID:SGTC_2193|Compound:5925765|FD-Score:-3.20|P-value:8.41E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.22|P-value:9.83E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-3.50|P-value:3.02E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-4.06|P-value:3.49E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-3.75|P-value:1.17E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.49|P-value:3.12E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.84|P-value:1.07E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:5.18|P-value:2.83E-7 ID:SGTC_2649|Compound:anisomycin|FD-Score:5.02|P-value:6.38E-7 ID:SGTC_2908|Compound:7930301|FD-Score:-3.61|P-value:1.96E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.75|P-value:1.49E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.86|P-value:7.67E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-3.30|P-value:5.97E-4 ID:SGTC_3053|Compound:9095903|FD-Score:3.38|P-value:5.76E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.63|P-value:2.34E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.75|P-value:1.18E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.22|P-value:7.73E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.86|P-value:7.71E-5 ID:SGTC_3329|Compound:9141233|FD-Score:-3.33|P-value:5.46E-4

Top fitness defect scores for YHR063C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_212 3807-4682 7.92 38.8 µM 8.86E-15 tubulin folding & SWR complex 15 1.19E-15
2 SGTC_2586 curcumin 5.18 80.0 µM 2.83E-7 iron homeostasis 30 1.11E-7
3 SGTC_2649 anisomycin 5.02 9.6 µM 6.38E-7 2 2.63E-7
4 SGTC_1317 1273-0028 4.71 910.0 nM 2.69E-6 azole & statin 36 1.22E-6
5 SGTC_1131 3454-3128 4.47 32.3 µM 7.92E-6 22 3.83E-6
6 SGTC_1310 1188-0297 4.39 994.0 nM 1.14E-5 azole & statin 23 5.66E-6
7 SGTC_1968 st069590 4.32 43.6 µM 1.53E-5 10 7.71E-6
8 SGTC_1468 k284-1086 4.23 134.0 µM 2.26E-5 DNA intercalators 27 1.17E-5
9 SGTC_1170 0310-0127 4.16 64.8 µM 3.06E-5 20 1.61E-5
10 SGTC_1742 st038235 4.15 28.9 µM 3.09E-5 mitochondrial stress 111 1.63E-5
11 SGTC_1939 st074455 4.08 53.6 µM 4.26E-5 26 2.29E-5
12 SGTC_319 1348-1596 3.97 45.5 µM 6.46E-5 RSC & ERG11 17 3.57E-5
13 SGTC_1422 4031-0024 3.93 15.5 µM 7.59E-5 iron homeostasis 18 4.24E-5
14 SGTC_1993 st073995 3.87 70.8 µM 9.48E-5 22 5.37E-5
15 SGTC_2582 agaric acid 3.84 100.0 µM 1.07E-4 redox potentiating 330 6.13E-5
16 SGTC_2930 9013230 3.75 14.9 µM 1.49E-4 heme biosynthesis & mitochondrial translocase 46 8.71E-5
17 SGTC_1776 st049249 3.75 45.9 µM 1.51E-4 20 8.80E-5
18 SGTC_193 1273-0060 3.73 1.6 µM 1.64E-4 ergosterol biosynthesis 11 9.64E-5
19 SGTC_453 enantio-paf c16 3.70 10.0 µM 1.85E-4 164 1.09E-4
20 SGTC_3193 9111931 3.63 49.5 µM 2.34E-4 33 1.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.81E-24 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.127 1.44E-13 YOR366W_d YOR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.123 1.04E-12 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
0.120 3.29E-12 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.119 4.84E-12 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.114 3.39E-11 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.113 5.91E-11 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.112 6.47E-11 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.111 1.29E-10 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.110 1.94E-10 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.110 2.03E-10 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.105 1.22E-9 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.102 2.81E-9 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 1.04E-8 YGL065C ALG2 het Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
0.098 1.11E-8 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability