YHR067W / HTD2

Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR067W / HTD2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:5.61|P-value:5.43E-7 ID:SGTC_8|Compound:0354-0001|FD-Score:4.65|P-value:2.68E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:6.55|P-value:6.34E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:5.28|P-value:2.30E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:5.65|P-value:4.63E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:3.69|P-value:6.75E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.72|P-value:6.12E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:7.86|P-value:4.41E-12 ID:SGTC_118|Compound:0083-0097|FD-Score:3.72|P-value:6.20E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.98|P-value:2.77E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.09|P-value:1.92E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:4.29|P-value:9.79E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.88|P-value:1.11E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:7.11|P-value:3.39E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:11.20|P-value:1.56E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.20|P-value:3.88E-19 ID:SGTC_279|Compound:1273-0055|FD-Score:3.78|P-value:5.06E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.00|P-value:2.52E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.23|P-value:1.20E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-7.47|P-value:4.40E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.29|P-value:9.75E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.29|P-value:9.78E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:4.41|P-value:6.48E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:4.29|P-value:9.57E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:4.43|P-value:6.01E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.61|P-value:8.62E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.70|P-value:6.52E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.13|P-value:1.68E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.69|P-value:6.67E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.47|P-value:5.10E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.01|P-value:2.51E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.12|P-value:1.72E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.58|P-value:9.47E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.62|P-value:5.18E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.62|P-value:8.37E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.08|P-value:1.95E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:5.24|P-value:2.67E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.39|P-value:6.88E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.42|P-value:6.13E-5 ID:SGTC_1635|Compound:st007035|FD-Score:5.60|P-value:5.88E-7 ID:SGTC_1687|Compound:st020778|FD-Score:4.84|P-value:1.34E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-5.04|P-value:6.09E-6 ID:SGTC_1762|Compound:st045503|FD-Score:5.11|P-value:4.52E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.98|P-value:2.76E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.11|P-value:1.77E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.70|P-value:6.55E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-4.06|P-value:2.12E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.95|P-value:2.99E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.23|P-value:1.21E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.19|P-value:3.28E-6 ID:SGTC_2083|Compound:5306046|FD-Score:4.20|P-value:1.33E-4 ID:SGTC_2088|Compound:5278280|FD-Score:5.47|P-value:1.03E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.22|P-value:1.21E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-5.47|P-value:1.03E-6 ID:SGTC_2278|Compound:7948257|FD-Score:5.10|P-value:4.76E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.23|P-value:1.21E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.24|P-value:1.17E-4 ID:SGTC_2452|Compound:5863136|FD-Score:4.38|P-value:7.09E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.62|P-value:3.02E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.64|P-value:2.80E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.72|P-value:3.44E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.94|P-value:8.88E-6 ID:SGTC_2834|Compound:9001755|FD-Score:3.88|P-value:3.81E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.58|P-value:9.33E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.89|P-value:1.08E-9 ID:SGTC_2965|Compound:9082772|FD-Score:4.89|P-value:1.08E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-6.06|P-value:7.00E-8 ID:SGTC_2996|Compound:9066192|FD-Score:8.09|P-value:1.07E-12 ID:SGTC_3142|Compound:9086498|FD-Score:-3.61|P-value:8.67E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-4.01|P-value:2.47E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.68|P-value:6.91E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.89|P-value:3.68E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.63|P-value:8.15E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:5.61|P-value:5.43E-7 ID:SGTC_8|Compound:0354-0001|FD-Score:4.65|P-value:2.68E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:6.55|P-value:6.34E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:5.28|P-value:2.30E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:5.65|P-value:4.63E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:3.69|P-value:6.75E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.72|P-value:6.12E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:7.86|P-value:4.41E-12 ID:SGTC_118|Compound:0083-0097|FD-Score:3.72|P-value:6.20E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.98|P-value:2.77E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.09|P-value:1.92E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:4.29|P-value:9.79E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.88|P-value:1.11E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:7.11|P-value:3.39E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:11.20|P-value:1.56E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.20|P-value:3.88E-19 ID:SGTC_279|Compound:1273-0055|FD-Score:3.78|P-value:5.06E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.00|P-value:2.52E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.23|P-value:1.20E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-7.47|P-value:4.40E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.29|P-value:9.75E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.29|P-value:9.78E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:4.41|P-value:6.48E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:4.29|P-value:9.57E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:4.43|P-value:6.01E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.61|P-value:8.62E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.70|P-value:6.52E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.13|P-value:1.68E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.69|P-value:6.67E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.47|P-value:5.10E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.01|P-value:2.51E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.12|P-value:1.72E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.58|P-value:9.47E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.62|P-value:5.18E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.62|P-value:8.37E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.08|P-value:1.95E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:5.24|P-value:2.67E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.39|P-value:6.88E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.42|P-value:6.13E-5 ID:SGTC_1635|Compound:st007035|FD-Score:5.60|P-value:5.88E-7 ID:SGTC_1687|Compound:st020778|FD-Score:4.84|P-value:1.34E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-5.04|P-value:6.09E-6 ID:SGTC_1762|Compound:st045503|FD-Score:5.11|P-value:4.52E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.98|P-value:2.76E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.11|P-value:1.77E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.70|P-value:6.55E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-4.06|P-value:2.12E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.95|P-value:2.99E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.23|P-value:1.21E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.19|P-value:3.28E-6 ID:SGTC_2083|Compound:5306046|FD-Score:4.20|P-value:1.33E-4 ID:SGTC_2088|Compound:5278280|FD-Score:5.47|P-value:1.03E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.22|P-value:1.21E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-5.47|P-value:1.03E-6 ID:SGTC_2278|Compound:7948257|FD-Score:5.10|P-value:4.76E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.23|P-value:1.21E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.24|P-value:1.17E-4 ID:SGTC_2452|Compound:5863136|FD-Score:4.38|P-value:7.09E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.62|P-value:3.02E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.64|P-value:2.80E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.72|P-value:3.44E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.94|P-value:8.88E-6 ID:SGTC_2834|Compound:9001755|FD-Score:3.88|P-value:3.81E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.58|P-value:9.33E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.89|P-value:1.08E-9 ID:SGTC_2965|Compound:9082772|FD-Score:4.89|P-value:1.08E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-6.06|P-value:7.00E-8 ID:SGTC_2996|Compound:9066192|FD-Score:8.09|P-value:1.07E-12 ID:SGTC_3142|Compound:9086498|FD-Score:-3.61|P-value:8.67E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-4.01|P-value:2.47E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.68|P-value:6.91E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.89|P-value:3.68E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.63|P-value:8.15E-4

Top fitness defect scores for YHR067W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 11.20 5.3 µM 1.56E-22 169 3.02E-29
2 SGTC_275 trichlorophene 10.20 5.7 µM 3.88E-19 mitochondrial stress 43 9.31E-25
3 SGTC_2996 9066192 8.09 71.4 µM 1.07E-12 3 3.02E-16
4 SGTC_116 0155-0182 7.86 31.8 µM 4.41E-12 mitochondrial response to ROS 12 1.95E-15
5 SGTC_227 fluconazole 7.11 33.5 µM 3.39E-10 azole & statin 30 6.00E-13
6 SGTC_34 0469-0683 6.55 81.8 µM 6.34E-9 SWF1 & branched chain AA biosynthesis 9 2.84E-11
7 SGTC_2752 diclazuril 5.72 33.1 µM 3.44E-7 60 5.45E-9
8 SGTC_59 0330-0160 5.65 1.3 µM 4.63E-7 48 8.05E-9
9 SGTC_1317 1273-0028 5.62 910.0 nM 5.18E-7 azole & statin 29 9.34E-9
10 SGTC_7 0192-1582 5.61 4.2 µM 5.43E-7 29 9.93E-9
11 SGTC_1635 st007035 5.60 42.4 µM 5.88E-7 144 1.10E-8
12 SGTC_2088 5278280 5.47 127.4 µM 1.03E-6 7 2.30E-8
13 SGTC_36 0335-0881 5.28 14.2 µM 2.30E-6 ubiquinone biosynthesis & proteasome 80 6.61E-8
14 SGTC_1476 4112-3294 5.24 3.3 µM 2.67E-6 60S ribosome export 4 8.06E-8
15 SGTC_2077 5212015 5.19 200.0 µM 3.28E-6 33 1.05E-7
16 SGTC_1762 st045503 5.11 25.5 µM 4.52E-6 10 1.60E-7
17 SGTC_2278 7948257 5.10 134.3 µM 4.76E-6 8 1.72E-7
18 SGTC_2965 9082772 4.89 38.6 µM 1.08E-5 mitochondrial response to ROS 22 5.03E-7
19 SGTC_173 1273-0061 4.88 2.7 µM 1.11E-5 mitochondrial stress 152 5.20E-7
20 SGTC_1687 st020778 4.84 55.4 µM 1.34E-5 137 6.65E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.426 4.90E-148 YFL018C LPD1 hom Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
0.373 2.75E-111 YER061C CEM1 hom Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
0.340 1.75E-91 YJL046W AIM22 hom Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
0.332 2.80E-87 YGR257C MTM1 hom Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.329 1.75E-85 YOR196C LIP5 hom Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
0.326 5.90E-84 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.324 5.47E-83 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.316 7.43E-79 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.315 2.12E-78 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.310 6.12E-76 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.310 2.09E-75 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.308 8.29E-75 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.301 2.10E-71 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.300 6.83E-71 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.300 9.68E-71 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit