YHR068W / DYS1

Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR068W / DYS1

Click on Significant Values for Screen Details ID:SGTC_99|Compound:0109-0120|FD-Score:-3.22|P-value:6.88E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.29|P-value:5.63E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.36|P-value:4.43E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.19|P-value:7.84E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.16|P-value:8.33E-4 ID:SGTC_228|Compound:caffeine|FD-Score:-4.99|P-value:3.48E-7 ID:SGTC_349|Compound:k015-0014|FD-Score:3.42|P-value:3.59E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.22|P-value:1.44E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:5.12|P-value:1.98E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.21|P-value:7.43E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-5.26|P-value:8.45E-8 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.64|P-value:1.49E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.51|P-value:2.41E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.38|P-value:4.15E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.72|P-value:1.17E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:-4.40|P-value:6.18E-6 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.47|P-value:3.01E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-3.36|P-value:4.18E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.50|P-value:4.11E-6 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.14|P-value:9.01E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-4.09|P-value:2.38E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.42|P-value:3.50E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.49|P-value:2.61E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-4.18|P-value:1.62E-5 ID:SGTC_1626|Compound:st003712|FD-Score:-3.60|P-value:1.73E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.44|P-value:3.32E-4 ID:SGTC_1981|Compound:st071826|FD-Score:4.12|P-value:2.25E-5 ID:SGTC_1999|Compound:st074831|FD-Score:5.96|P-value:1.77E-9 ID:SGTC_2092|Compound:5303694|FD-Score:4.20|P-value:1.57E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.28|P-value:5.88E-4 ID:SGTC_2259|Compound:7964009|FD-Score:-3.13|P-value:9.10E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.31|P-value:5.03E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.25|P-value:6.14E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.27|P-value:6.08E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.38|P-value:4.08E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-3.20|P-value:7.22E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-4.84|P-value:7.44E-7 ID:SGTC_2813|Compound:7971799|FD-Score:-5.04|P-value:2.73E-7 ID:SGTC_2858|Compound:9025781|FD-Score:4.06|P-value:2.86E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.56|P-value:2.15E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.19|P-value:7.98E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-5.05|P-value:2.56E-7 ID:SGTC_2906|Compound:7926292|FD-Score:-3.22|P-value:6.80E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-4.24|P-value:1.26E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.52|P-value:2.49E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-11.10|P-value:1.99E-28 ID:SGTC_2966|Compound:9084041|FD-Score:-3.94|P-value:4.49E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.17|P-value:8.62E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.82|P-value:9.10E-7 ID:SGTC_2980|Compound:9014342|FD-Score:5.09|P-value:2.32E-7 ID:SGTC_2983|Compound:9022671|FD-Score:4.32|P-value:9.45E-6 ID:SGTC_2996|Compound:9066192|FD-Score:4.49|P-value:4.34E-6 ID:SGTC_3056|Compound:9094900|FD-Score:3.77|P-value:9.29E-5 ID:SGTC_3195|Compound:9113082|FD-Score:3.84|P-value:7.07E-5 ID:SGTC_3231|Compound:9132313|FD-Score:3.28|P-value:5.80E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.28|P-value:5.91E-4 ID:SGTC_3252|Compound:9135871|FD-Score:5.35|P-value:5.87E-8 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.22|P-value:6.88E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.29|P-value:5.63E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.36|P-value:4.43E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.19|P-value:7.84E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.16|P-value:8.33E-4 ID:SGTC_228|Compound:caffeine|FD-Score:-4.99|P-value:3.48E-7 ID:SGTC_349|Compound:k015-0014|FD-Score:3.42|P-value:3.59E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.22|P-value:1.44E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:5.12|P-value:1.98E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.21|P-value:7.43E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-5.26|P-value:8.45E-8 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.64|P-value:1.49E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.51|P-value:2.41E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.38|P-value:4.15E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.72|P-value:1.17E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:-4.40|P-value:6.18E-6 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.47|P-value:3.01E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-3.36|P-value:4.18E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.50|P-value:4.11E-6 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.14|P-value:9.01E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-4.09|P-value:2.38E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.42|P-value:3.50E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.49|P-value:2.61E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-4.18|P-value:1.62E-5 ID:SGTC_1626|Compound:st003712|FD-Score:-3.60|P-value:1.73E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.44|P-value:3.32E-4 ID:SGTC_1981|Compound:st071826|FD-Score:4.12|P-value:2.25E-5 ID:SGTC_1999|Compound:st074831|FD-Score:5.96|P-value:1.77E-9 ID:SGTC_2092|Compound:5303694|FD-Score:4.20|P-value:1.57E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.28|P-value:5.88E-4 ID:SGTC_2259|Compound:7964009|FD-Score:-3.13|P-value:9.10E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.31|P-value:5.03E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.25|P-value:6.14E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.27|P-value:6.08E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.38|P-value:4.08E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-3.20|P-value:7.22E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-4.84|P-value:7.44E-7 ID:SGTC_2813|Compound:7971799|FD-Score:-5.04|P-value:2.73E-7 ID:SGTC_2858|Compound:9025781|FD-Score:4.06|P-value:2.86E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.56|P-value:2.15E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.19|P-value:7.98E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-5.05|P-value:2.56E-7 ID:SGTC_2906|Compound:7926292|FD-Score:-3.22|P-value:6.80E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-4.24|P-value:1.26E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.52|P-value:2.49E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-11.10|P-value:1.99E-28 ID:SGTC_2966|Compound:9084041|FD-Score:-3.94|P-value:4.49E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.17|P-value:8.62E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.82|P-value:9.10E-7 ID:SGTC_2980|Compound:9014342|FD-Score:5.09|P-value:2.32E-7 ID:SGTC_2983|Compound:9022671|FD-Score:4.32|P-value:9.45E-6 ID:SGTC_2996|Compound:9066192|FD-Score:4.49|P-value:4.34E-6 ID:SGTC_3056|Compound:9094900|FD-Score:3.77|P-value:9.29E-5 ID:SGTC_3195|Compound:9113082|FD-Score:3.84|P-value:7.07E-5 ID:SGTC_3231|Compound:9132313|FD-Score:3.28|P-value:5.80E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.28|P-value:5.91E-4 ID:SGTC_3252|Compound:9135871|FD-Score:5.35|P-value:5.87E-8

Top fitness defect scores for YHR068W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1999 st074831 5.96 12.5 µM 1.77E-9 plasma membrane duress 4 1.27E-9 0.78
2 SGTC_3252 9135871 5.35 49.5 µM 5.87E-8 2 4.47E-8 0.63
3 SGTC_791 1348-1292 5.12 225.0 µM 1.98E-7 1 1.54E-7 1.02
4 SGTC_2980 9014342 5.09 25.3 µM 2.32E-7 10 1.81E-7 0.12
5 SGTC_2977 9011197 4.82 71.4 µM 9.10E-7 4 7.26E-7 0.21
6 SGTC_1202 1988-0068 4.50 29.6 µM 4.11E-6 RNA processing & uracil transport 7 3.36E-6 0.54
7 SGTC_2996 9066192 4.49 71.4 µM 4.34E-6 4 3.55E-6 0.30
8 SGTC_2983 9022671 4.32 13.0 µM 9.45E-6 60S ribosome export 8 7.84E-6 0.81
9 SGTC_636 0kpi-0074 4.22 126.0 µM 1.44E-5 3 1.20E-5 0.20
10 SGTC_2092 5303694 4.20 80.7 µM 1.57E-5 TSC3-RPN4 6 1.31E-5 0.26
11 SGTC_1981 st071826 4.12 47.0 µM 2.25E-5 3 1.90E-5 0.06
12 SGTC_2858 9025781 4.06 9.0 µM 2.86E-5 sphingolipid biosynthesis & PDR1 12 2.42E-5 0.08
13 SGTC_3195 9113082 3.84 49.5 µM 7.07E-5 2 6.06E-5 0.55
14 SGTC_3056 9094900 3.77 49.5 µM 9.29E-5 6 8.01E-5 0.01
15 SGTC_1147 3809-1045 3.72 12.3 µM 1.17E-4 5 1.01E-4 0.14
16 SGTC_2880 9042983 3.56 58.4 µM 2.15E-4 fatty acid desaturase (OLE1) 19 1.88E-4 0.13
17 SGTC_2916 7875993 3.52 68.8 µM 2.49E-4 9 2.18E-4 0.06
18 SGTC_1181 1222-0449 3.47 220.0 µM 3.01E-4 5 2.65E-4 0.06
19 SGTC_1678 st019265 3.44 80.2 µM 3.32E-4 60S ribosome export 9 2.93E-4 0.09
20 SGTC_1359 1582-0056 3.42 520.0 nM 3.50E-4 7 3.08E-4 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.32E-11 YIL063C YRB2 het Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
0.115 2.57E-11 YOR181W LAS17 het Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.110 1.82E-10 YMR128W ECM16 het Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
0.104 1.94E-9 YAR019C CDC15 het Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
0.101 5.54E-9 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.097 1.83E-8 YPL153C RAD53 het Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
0.097 1.99E-8 YGL032C AGA2 hom Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
0.093 7.98E-8 YDR190C RVB1 het ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
0.090 1.89E-7 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.089 2.46E-7 YBR195C MSI1 hom Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase
0.087 4.10E-7 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.086 6.40E-7 YCR073C SSK22 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
0.086 7.36E-7 YNL088W TOP2 het Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.085 8.16E-7 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.084 1.01E-6 YHR024C MAS2 het Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins