YHR069C / RRP4

Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR069C / RRP4

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:5.54|P-value:6.95E-6 ID:SGTC_228|Compound:caffeine|FD-Score:4.48|P-value:2.34E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.05|P-value:8.05E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:4.96|P-value:5.15E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:4.16|P-value:5.86E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.35|P-value:3.45E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:11.40|P-value:1.30E-19 ID:SGTC_644|Compound:1498-1197|FD-Score:3.98|P-value:9.77E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:4.76|P-value:9.83E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:7.32|P-value:4.14E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:8.10|P-value:8.44E-11 ID:SGTC_776|Compound:4476-4378|FD-Score:4.51|P-value:2.17E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.74|P-value:1.06E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.39|P-value:2.61E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:4.07|P-value:7.66E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:13.70|P-value:1.27E-27 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.45|P-value:9.52E-6 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.69|P-value:6.97E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.12|P-value:6.68E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.30|P-value:3.91E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.13|P-value:3.82E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:6.95|P-value:2.23E-8 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.60|P-value:1.62E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.72|P-value:1.14E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-8.11|P-value:3.03E-11 ID:SGTC_1700|Compound:st030840|FD-Score:4.07|P-value:7.50E-4 ID:SGTC_1768|Compound:st044301|FD-Score:4.24|P-value:4.73E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-5.14|P-value:1.54E-5 ID:SGTC_1834|Compound:st055981|FD-Score:4.43|P-value:2.73E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-4.14|P-value:3.76E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.21|P-value:5.15E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.93|P-value:5.69E-5 ID:SGTC_1992|Compound:st073643|FD-Score:4.05|P-value:7.99E-4 ID:SGTC_2002|Compound:4023503|FD-Score:8.17|P-value:5.87E-11 ID:SGTC_2005|Compound:4024620|FD-Score:4.43|P-value:2.74E-4 ID:SGTC_2015|Compound:5119600|FD-Score:5.67|P-value:4.39E-6 ID:SGTC_2156|Compound:5649887|FD-Score:4.97|P-value:5.07E-5 ID:SGTC_2194|Compound:5927483|FD-Score:4.40|P-value:2.98E-4 ID:SGTC_2290|Compound:7904846|FD-Score:4.15|P-value:6.08E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-3.82|P-value:9.13E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.75|P-value:1.02E-4 ID:SGTC_2463|Compound:5473429|FD-Score:5.70|P-value:3.93E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:5.02|P-value:4.30E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.35|P-value:1.98E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.68|P-value:6.99E-5 ID:SGTC_2780|Compound:5215298|FD-Score:8.44|P-value:1.39E-11 ID:SGTC_2782|Compound:7736369|FD-Score:5.14|P-value:2.89E-5 ID:SGTC_2785|Compound:7756463|FD-Score:4.54|P-value:1.93E-4 ID:SGTC_2791|Compound:5663188|FD-Score:4.42|P-value:2.77E-4 ID:SGTC_3028|Compound:9087778|FD-Score:4.33|P-value:3.64E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-4.60|P-value:9.10E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.54|P-value:6.95E-6 ID:SGTC_228|Compound:caffeine|FD-Score:4.48|P-value:2.34E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.05|P-value:8.05E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:4.96|P-value:5.15E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:4.16|P-value:5.86E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.35|P-value:3.45E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:11.40|P-value:1.30E-19 ID:SGTC_644|Compound:1498-1197|FD-Score:3.98|P-value:9.77E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:4.76|P-value:9.83E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:7.32|P-value:4.14E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:8.10|P-value:8.44E-11 ID:SGTC_776|Compound:4476-4378|FD-Score:4.51|P-value:2.17E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.74|P-value:1.06E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.39|P-value:2.61E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:4.07|P-value:7.66E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:13.70|P-value:1.27E-27 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.45|P-value:9.52E-6 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.69|P-value:6.97E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.12|P-value:6.68E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.30|P-value:3.91E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.13|P-value:3.82E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:6.95|P-value:2.23E-8 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.60|P-value:1.62E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.72|P-value:1.14E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-8.11|P-value:3.03E-11 ID:SGTC_1700|Compound:st030840|FD-Score:4.07|P-value:7.50E-4 ID:SGTC_1768|Compound:st044301|FD-Score:4.24|P-value:4.73E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-5.14|P-value:1.54E-5 ID:SGTC_1834|Compound:st055981|FD-Score:4.43|P-value:2.73E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-4.14|P-value:3.76E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.21|P-value:5.15E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.93|P-value:5.69E-5 ID:SGTC_1992|Compound:st073643|FD-Score:4.05|P-value:7.99E-4 ID:SGTC_2002|Compound:4023503|FD-Score:8.17|P-value:5.87E-11 ID:SGTC_2005|Compound:4024620|FD-Score:4.43|P-value:2.74E-4 ID:SGTC_2015|Compound:5119600|FD-Score:5.67|P-value:4.39E-6 ID:SGTC_2156|Compound:5649887|FD-Score:4.97|P-value:5.07E-5 ID:SGTC_2194|Compound:5927483|FD-Score:4.40|P-value:2.98E-4 ID:SGTC_2290|Compound:7904846|FD-Score:4.15|P-value:6.08E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-3.82|P-value:9.13E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.75|P-value:1.02E-4 ID:SGTC_2463|Compound:5473429|FD-Score:5.70|P-value:3.93E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:5.02|P-value:4.30E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.35|P-value:1.98E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.68|P-value:6.99E-5 ID:SGTC_2780|Compound:5215298|FD-Score:8.44|P-value:1.39E-11 ID:SGTC_2782|Compound:7736369|FD-Score:5.14|P-value:2.89E-5 ID:SGTC_2785|Compound:7756463|FD-Score:4.54|P-value:1.93E-4 ID:SGTC_2791|Compound:5663188|FD-Score:4.42|P-value:2.77E-4 ID:SGTC_3028|Compound:9087778|FD-Score:4.33|P-value:3.64E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-4.60|P-value:9.10E-5

Top fitness defect scores for YHR069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_879 0831-1030 13.70 162.0 µM 1.27E-27 1 7.36E-43 2.96
2 SGTC_617 3770-0098 11.40 35.0 µM 1.30E-19 exosome 5 3.31E-30 2.38
3 SGTC_2780 5215298 8.44 71.4 µM 1.39E-11 1 1.56E-17 2.15
4 SGTC_2002 4023503 8.17 131.0 µM 5.87E-11 mitochondrial processes 2 1.51E-16 2.23
5 SGTC_708 3448-5400 8.10 146.0 µM 8.44E-11 1 2.68E-16 2.08
6 SGTC_691 1548-0686 7.32 185.0 µM 4.14E-9 1 1.24E-13 1.18
7 SGTC_1354 1498-1681 6.95 81.0 µM 2.23E-8 1 1.77E-12 2.31
8 SGTC_800 3448-7362 6.39 155.0 µM 2.61E-7 translation 19 8.52E-11 0.13
9 SGTC_2463 5473429 5.70 200.0 µM 3.93E-6 ERG2 1 6.09E-9 1.49
10 SGTC_2015 5119600 5.67 184.0 µM 4.39E-6 2 7.25E-9 0.83
11 SGTC_118 0083-0097 5.54 135.3 µM 6.95E-6 translation 6 1.49E-8 0.09
12 SGTC_1001 4048-4355 5.45 44.4 µM 9.52E-6 copper-dependent oxidative stress 5 2.45E-8 0.83
13 SGTC_2782 7736369 5.14 71.4 µM 2.89E-5 3 1.41E-7 0.55
14 SGTC_2686 alizarin 5.02 95.4 µM 4.30E-5 RPP1 & pyrimidine depletion 4 2.62E-7 0.41
15 SGTC_2156 5649887 4.97 115.0 µM 5.07E-5 RPP1 & pyrimidine depletion 9 3.39E-7 0.23
16 SGTC_285 1486-1325 4.96 46.0 µM 5.15E-5 3 3.48E-7 0.63
17 SGTC_1964 st076914 4.93 61.0 µM 5.69E-5 RPP1 & pyrimidine depletion 3 4.07E-7 0.04
18 SGTC_667 1498-1044 4.76 59.0 µM 9.83E-5 RPP1 & pyrimidine depletion 5 9.59E-7 0.06
19 SGTC_2364 9055074 4.75 200.0 µM 1.02E-4 1 1.02E-6 1.15
20 SGTC_785 1270-0111 4.74 65.3 µM 1.06E-4 3 1.08E-6 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.247 7.69E-48 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.223 7.49E-39 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.218 1.68E-37 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.208 4.52E-34 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.203 1.75E-32 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.172 8.64E-24 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.167 3.13E-22 YLR275W SMD2 het Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
0.152 9.89E-19 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.150 3.03E-18 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.140 4.18E-16 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.139 5.81E-16 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.138 1.26E-15 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.136 2.28E-15 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.126 3.10E-13 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.124 5.16E-13 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15