HIPHOP chemogenomics database

YHR069C / RRP4

Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)

Zygosity: Heterozygous strain

fixedexpanded
Profile for YHR069C / RRP4

Click on Significant Values for Screen Details

Top fitness defect scores for YHR069C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_879	0831-1030	13.70	162.0 µM	1.27E-27		1	7.36E-43	2.96
2	SGTC_617	3770-0098	11.40	35.0 µM	1.30E-19	exosome	5	3.31E-30	2.38
3	SGTC_2780	5215298	8.44	71.4 µM	1.39E-11		1	1.56E-17	2.15
4	SGTC_2002	4023503	8.17	131.0 µM	5.87E-11	mitochondrial processes	2	1.51E-16	2.23
5	SGTC_708	3448-5400	8.10	146.0 µM	8.44E-11		1	2.68E-16	2.08
6	SGTC_691	1548-0686	7.32	185.0 µM	4.14E-9		1	1.24E-13	1.18
7	SGTC_1354	1498-1681	6.95	81.0 µM	2.23E-8		1	1.77E-12	2.31
8	SGTC_800	3448-7362	6.39	155.0 µM	2.61E-7	translation	19	8.52E-11	0.13
9	SGTC_2463	5473429	5.70	200.0 µM	3.93E-6	ERG2	1	6.09E-9	1.49
10	SGTC_2015	5119600	5.67	184.0 µM	4.39E-6		2	7.25E-9	0.83
11	SGTC_118	0083-0097	5.54	135.3 µM	6.95E-6	translation	6	1.49E-8	0.09
12	SGTC_1001	4048-4355	5.45	44.4 µM	9.52E-6	copper-dependent oxidative stress	5	2.45E-8	0.83
13	SGTC_2782	7736369	5.14	71.4 µM	2.89E-5		3	1.41E-7	0.55
14	SGTC_2686	alizarin	5.02	95.4 µM	4.30E-5	RPP1 & pyrimidine depletion	4	2.62E-7	0.41
15	SGTC_2156	5649887	4.97	115.0 µM	5.07E-5	RPP1 & pyrimidine depletion	9	3.39E-7	0.23
16	SGTC_285	1486-1325	4.96	46.0 µM	5.15E-5		3	3.48E-7	0.63
17	SGTC_1964	st076914	4.93	61.0 µM	5.69E-5	RPP1 & pyrimidine depletion	3	4.07E-7	0.04
18	SGTC_667	1498-1044	4.76	59.0 µM	9.83E-5	RPP1 & pyrimidine depletion	5	9.59E-7	0.06
19	SGTC_2364	9055074	4.75	200.0 µM	1.02E-4		1	1.02E-6	1.15
20	SGTC_785	1270-0111	4.74	65.3 µM	1.06E-4		3	1.08E-6	0.13

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.247	7.69E-48	YGR095C	RRP46	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.223	7.49E-39	YNL232W	CSL4	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.218	1.68E-37	YPR137W	RRP9	het	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.208	4.52E-34	YGR158C	MTR3	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.203	1.75E-32	YOL021C	DIS3	het	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.172	8.64E-24	YPR136C_d	YPR136C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.167	3.13E-22	YLR275W	SMD2	het	Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
0.152	9.89E-19	YDL111C	RRP42	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.150	3.03E-18	YNL061W	NOP2	het	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.140	4.18E-16	YHL015W	RPS20	het	Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.139	5.81E-16	YKR057W	RPS21A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.138	1.26E-15	YLR222C	UTP13	het	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.136	2.28E-15	YOL040C	RPS15	het	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.126	3.10E-13	YGR195W	SKI6	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.124	5.16E-13	YDR064W	RPS13	het	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15