YHR072W / ERG7

Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR072W / ERG7

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.61|P-value:2.06E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:-3.80|P-value:8.04E-5 ID:SGTC_32|Compound:0928-0142|FD-Score:4.56|P-value:3.98E-6 ID:SGTC_61|Compound:0978-8327|FD-Score:15.30|P-value:2.91E-51 ID:SGTC_145|Compound:3737-0113|FD-Score:6.74|P-value:1.85E-11 ID:SGTC_147|Compound:4466-0538|FD-Score:16.60|P-value:3.89E-60 ID:SGTC_167|Compound:3672-0051|FD-Score:6.31|P-value:2.91E-10 ID:SGTC_193|Compound:1273-0060|FD-Score:19.00|P-value:1.09E-78 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.84|P-value:6.91E-5 ID:SGTC_269|Compound:exalamide|FD-Score:10.80|P-value:9.80E-27 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.63|P-value:2.88E-6 ID:SGTC_279|Compound:1273-0055|FD-Score:3.22|P-value:8.25E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.54|P-value:2.71E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:5.36|P-value:7.19E-8 ID:SGTC_299|Compound:1273-0059|FD-Score:7.52|P-value:7.86E-14 ID:SGTC_327|Compound:1273-0057|FD-Score:9.30|P-value:3.09E-20 ID:SGTC_363|Compound:0455-0021|FD-Score:8.22|P-value:3.46E-16 ID:SGTC_393|Compound:acivicin|FD-Score:3.94|P-value:5.64E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-4.46|P-value:4.73E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.67|P-value:1.65E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.54|P-value:2.66E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:16.10|P-value:1.28E-56 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.29|P-value:5.28E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.96|P-value:4.28E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:5.96|P-value:2.50E-9 ID:SGTC_614|Compound:0462-0418|FD-Score:3.45|P-value:3.67E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.46|P-value:6.15E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:8.46|P-value:4.52E-17 ID:SGTC_788|Compound:1182-0090|FD-Score:6.01|P-value:1.85E-9 ID:SGTC_834|Compound:0312-0008|FD-Score:5.85|P-value:4.73E-9 ID:SGTC_862|Compound:0452-0056|FD-Score:11.40|P-value:3.12E-29 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.49|P-value:2.61E-4 ID:SGTC_917|Compound:harmaline|FD-Score:35.80|P-value:5.23E-272 ID:SGTC_969|Compound:1313-0238|FD-Score:4.66|P-value:2.49E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.85|P-value:8.28E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.28|P-value:5.59E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.16|P-value:2.34E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:22.30|P-value:2.46E-107 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.67|P-value:1.66E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.22|P-value:6.79E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:20.80|P-value:1.54E-93 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.31|P-value:1.20E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.36|P-value:5.03E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.59|P-value:2.26E-4 ID:SGTC_1547|Compound:harmine|FD-Score:24.30|P-value:2.68E-127 ID:SGTC_1581|Compound:himbacine|FD-Score:5.75|P-value:8.54E-9 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:10.50|P-value:4.39E-25 ID:SGTC_1638|Compound:st008370|FD-Score:6.85|P-value:8.79E-12 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.60|P-value:3.28E-6 ID:SGTC_1748|Compound:st037455|FD-Score:4.95|P-value:6.06E-7 ID:SGTC_1755|Compound:st041960|FD-Score:5.47|P-value:3.99E-8 ID:SGTC_1760|Compound:st045453|FD-Score:3.61|P-value:2.06E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.16|P-value:8.31E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.43|P-value:4.00E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.42|P-value:3.40E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.39|P-value:4.61E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.90|P-value:5.30E-5 ID:SGTC_2147|Compound:5545932|FD-Score:6.58|P-value:5.40E-11 ID:SGTC_2148|Compound:5546263|FD-Score:4.66|P-value:2.52E-6 ID:SGTC_2155|Compound:5570423|FD-Score:6.78|P-value:1.43E-11 ID:SGTC_2185|Compound:6113692|FD-Score:8.43|P-value:6.01E-17 ID:SGTC_2201|Compound:6605497|FD-Score:5.97|P-value:2.32E-9 ID:SGTC_2350|Compound:9023895|FD-Score:10.10|P-value:1.35E-23 ID:SGTC_2377|Compound:9073351|FD-Score:12.00|P-value:2.26E-32 ID:SGTC_2397|Compound:5161689|FD-Score:3.92|P-value:6.15E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.54|P-value:2.67E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.59|P-value:1.77E-4 ID:SGTC_2525|Compound:harmine|FD-Score:8.35|P-value:1.21E-16 ID:SGTC_2906|Compound:7926292|FD-Score:3.86|P-value:8.06E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.45|P-value:3.65E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.66|P-value:1.72E-4 ID:SGTC_2971|Compound:9092186|FD-Score:9.97|P-value:5.34E-23 ID:SGTC_2973|Compound:9094665|FD-Score:12.70|P-value:5.61E-36 ID:SGTC_2974|Compound:9094440|FD-Score:12.00|P-value:1.52E-32 ID:SGTC_2981|Compound:9013952|FD-Score:4.69|P-value:2.13E-6 ID:SGTC_3037|Compound:9091026|FD-Score:10.70|P-value:3.37E-26 ID:SGTC_3129|Compound:9127257|FD-Score:4.77|P-value:1.46E-6 ID:SGTC_3142|Compound:9086498|FD-Score:8.60|P-value:1.42E-17 ID:SGTC_3145|Compound:9085516|FD-Score:-3.63|P-value:1.57E-4 ID:SGTC_3152|Compound:9099253|FD-Score:12.90|P-value:4.54E-37 ID:SGTC_8|Compound:0354-0001|FD-Score:3.61|P-value:2.06E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:-3.80|P-value:8.04E-5 ID:SGTC_32|Compound:0928-0142|FD-Score:4.56|P-value:3.98E-6 ID:SGTC_61|Compound:0978-8327|FD-Score:15.30|P-value:2.91E-51 ID:SGTC_145|Compound:3737-0113|FD-Score:6.74|P-value:1.85E-11 ID:SGTC_147|Compound:4466-0538|FD-Score:16.60|P-value:3.89E-60 ID:SGTC_167|Compound:3672-0051|FD-Score:6.31|P-value:2.91E-10 ID:SGTC_193|Compound:1273-0060|FD-Score:19.00|P-value:1.09E-78 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.84|P-value:6.91E-5 ID:SGTC_269|Compound:exalamide|FD-Score:10.80|P-value:9.80E-27 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.63|P-value:2.88E-6 ID:SGTC_279|Compound:1273-0055|FD-Score:3.22|P-value:8.25E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.54|P-value:2.71E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:5.36|P-value:7.19E-8 ID:SGTC_299|Compound:1273-0059|FD-Score:7.52|P-value:7.86E-14 ID:SGTC_327|Compound:1273-0057|FD-Score:9.30|P-value:3.09E-20 ID:SGTC_363|Compound:0455-0021|FD-Score:8.22|P-value:3.46E-16 ID:SGTC_393|Compound:acivicin|FD-Score:3.94|P-value:5.64E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-4.46|P-value:4.73E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.67|P-value:1.65E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.54|P-value:2.66E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:16.10|P-value:1.28E-56 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.29|P-value:5.28E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.96|P-value:4.28E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:5.96|P-value:2.50E-9 ID:SGTC_614|Compound:0462-0418|FD-Score:3.45|P-value:3.67E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.46|P-value:6.15E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:8.46|P-value:4.52E-17 ID:SGTC_788|Compound:1182-0090|FD-Score:6.01|P-value:1.85E-9 ID:SGTC_834|Compound:0312-0008|FD-Score:5.85|P-value:4.73E-9 ID:SGTC_862|Compound:0452-0056|FD-Score:11.40|P-value:3.12E-29 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.49|P-value:2.61E-4 ID:SGTC_917|Compound:harmaline|FD-Score:35.80|P-value:5.23E-272 ID:SGTC_969|Compound:1313-0238|FD-Score:4.66|P-value:2.49E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.85|P-value:8.28E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.28|P-value:5.59E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.16|P-value:2.34E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:22.30|P-value:2.46E-107 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.67|P-value:1.66E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.22|P-value:6.79E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:20.80|P-value:1.54E-93 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.31|P-value:1.20E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.36|P-value:5.03E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.59|P-value:2.26E-4 ID:SGTC_1547|Compound:harmine|FD-Score:24.30|P-value:2.68E-127 ID:SGTC_1581|Compound:himbacine|FD-Score:5.75|P-value:8.54E-9 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:10.50|P-value:4.39E-25 ID:SGTC_1638|Compound:st008370|FD-Score:6.85|P-value:8.79E-12 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.60|P-value:3.28E-6 ID:SGTC_1748|Compound:st037455|FD-Score:4.95|P-value:6.06E-7 ID:SGTC_1755|Compound:st041960|FD-Score:5.47|P-value:3.99E-8 ID:SGTC_1760|Compound:st045453|FD-Score:3.61|P-value:2.06E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.16|P-value:8.31E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.43|P-value:4.00E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.42|P-value:3.40E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.39|P-value:4.61E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.90|P-value:5.30E-5 ID:SGTC_2147|Compound:5545932|FD-Score:6.58|P-value:5.40E-11 ID:SGTC_2148|Compound:5546263|FD-Score:4.66|P-value:2.52E-6 ID:SGTC_2155|Compound:5570423|FD-Score:6.78|P-value:1.43E-11 ID:SGTC_2185|Compound:6113692|FD-Score:8.43|P-value:6.01E-17 ID:SGTC_2201|Compound:6605497|FD-Score:5.97|P-value:2.32E-9 ID:SGTC_2350|Compound:9023895|FD-Score:10.10|P-value:1.35E-23 ID:SGTC_2377|Compound:9073351|FD-Score:12.00|P-value:2.26E-32 ID:SGTC_2397|Compound:5161689|FD-Score:3.92|P-value:6.15E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.54|P-value:2.67E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.59|P-value:1.77E-4 ID:SGTC_2525|Compound:harmine|FD-Score:8.35|P-value:1.21E-16 ID:SGTC_2906|Compound:7926292|FD-Score:3.86|P-value:8.06E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.45|P-value:3.65E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.66|P-value:1.72E-4 ID:SGTC_2971|Compound:9092186|FD-Score:9.97|P-value:5.34E-23 ID:SGTC_2973|Compound:9094665|FD-Score:12.70|P-value:5.61E-36 ID:SGTC_2974|Compound:9094440|FD-Score:12.00|P-value:1.52E-32 ID:SGTC_2981|Compound:9013952|FD-Score:4.69|P-value:2.13E-6 ID:SGTC_3037|Compound:9091026|FD-Score:10.70|P-value:3.37E-26 ID:SGTC_3129|Compound:9127257|FD-Score:4.77|P-value:1.46E-6 ID:SGTC_3142|Compound:9086498|FD-Score:8.60|P-value:1.42E-17 ID:SGTC_3145|Compound:9085516|FD-Score:-3.63|P-value:1.57E-4 ID:SGTC_3152|Compound:9099253|FD-Score:12.90|P-value:4.54E-37

Top fitness defect scores for YHR072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_917 harmaline 35.80 728.1 nM 5.23E-272 ergosterol biosynthesis 1 2.86E-280 28.90
2 SGTC_1547 harmine 24.30 94.2 µM 2.68E-127 ergosterol biosynthesis 1 3.17E-131 10.40
3 SGTC_1237 0330-0133 22.30 46.1 µM 2.46E-107 ergosterol biosynthesis 1 1.16E-110 11.80
4 SGTC_1317 1273-0028 20.80 910.0 nM 1.54E-93 azole & statin 1 1.92E-96 7.56
5 SGTC_193 1273-0060 19.00 1.6 µM 1.09E-78 ergosterol biosynthesis 1 3.83E-81 10.10
6 SGTC_147 4466-0538 16.60 29.2 µM 3.89E-60 ergosterol biosynthesis 1 5.05E-62 12.00
7 SGTC_555 4296-0685 16.10 37.0 µM 1.28E-56 ergosterol biosynthesis 1 2.13E-58 11.60
8 SGTC_61 0978-8327 15.30 98.6 µM 2.91E-51 ergosterol biosynthesis 1 7.07E-53 7.19
9 SGTC_3152 9099253 12.90 49.5 µM 4.54E-37 NEO1-PIK1 3 3.03E-38 1.03
10 SGTC_2973 9094665 12.70 18.0 µM 5.61E-36 NEO1 2 4.05E-37 3.42
11 SGTC_2974 9094440 12.00 9.7 µM 1.52E-32 ergosterol biosynthesis 2 1.40E-33 2.31
12 SGTC_2377 9073351 12.00 62.6 µM 2.26E-32 ergosterol biosynthesis 1 2.11E-33 6.26
13 SGTC_862 0452-0056 11.40 10.2 µM 3.12E-29 azole & statin 2 3.66E-30 7.26
14 SGTC_269 exalamide 10.80 29.0 µM 9.80E-27 ergosterol biosynthesis 1 1.37E-27 3.28
15 SGTC_3037 9091026 10.70 49.5 µM 3.37E-26 NEO1-PIK1 4 4.91E-27 0.45
16 SGTC_1597 7-benzyloxygramine 10.50 47.5 µM 4.39E-25 calcium & mitochondrial duress 16 6.95E-26 0.74
17 SGTC_2350 9023895 10.10 38.9 µM 1.35E-23 ergosterol biosynthesis 2 2.38E-24 4.38
18 SGTC_2971 9092186 9.97 9.9 µM 5.34E-23 ergosterol biosynthesis 1 9.84E-24 1.92
19 SGTC_327 1273-0057 9.30 4.0 µM 3.09E-20 azole & statin 2 6.96E-21 4.09
20 SGTC_3142 9086498 8.60 49.5 µM 1.42E-17 iron homeostasis 12 3.88E-18 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.220 4.98E-38 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.198 5.48E-31 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.194 7.58E-30 YLR255C_d YLR255C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.191 8.49E-29 YPL069C BTS1 hom Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
0.179 1.86E-25 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.157 7.13E-20 YLR228C ECM22 hom Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication
0.150 2.22E-18 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.150 2.90E-18 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.147 1.13E-17 YGR004W PEX31 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
0.141 1.85E-16 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.141 2.63E-16 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.140 3.26E-16 YOR319W HSH49 het U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
0.139 8.19E-16 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.128 1.21E-13 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.125 4.16E-13 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH