YHR073W / OSH3

Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR073W / OSH3

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-4.25|P-value:1.90E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:4.59|P-value:3.02E-6 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.36|P-value:5.71E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.07|P-value:3.02E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.84|P-value:7.72E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.56|P-value:4.76E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:3.66|P-value:1.56E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:6.09|P-value:1.09E-9 ID:SGTC_266|Compound:formosanin C|FD-Score:13.20|P-value:1.94E-38 ID:SGTC_346|Compound:4513-0042|FD-Score:4.16|P-value:2.09E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.52|P-value:2.57E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.34|P-value:4.85E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:6.79|P-value:1.24E-11 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_459|Compound:nigericin|FD-Score:6.02|P-value:1.63E-9 ID:SGTC_535|Compound:2293-4129|FD-Score:3.56|P-value:2.19E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.60|P-value:1.92E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.27|P-value:1.31E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:4.99|P-value:4.49E-7 ID:SGTC_658|Compound:3253-0951|FD-Score:5.12|P-value:2.33E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:4.82|P-value:1.05E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:3.19|P-value:8.23E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.74|P-value:1.13E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:4.87|P-value:8.25E-7 ID:SGTC_825|Compound:1988-2224|FD-Score:3.28|P-value:6.07E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.38|P-value:4.22E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.67|P-value:1.49E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-4.54|P-value:5.16E-6 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.13|P-value:9.92E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:12.60|P-value:3.15E-35 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.87|P-value:4.02E-9 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.27|P-value:1.30E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.95|P-value:5.56E-7 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.69|P-value:1.38E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.21|P-value:9.42E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.26|P-value:6.46E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.02|P-value:3.71E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.88|P-value:6.55E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.86|P-value:5.75E-15 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.27|P-value:1.31E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:31.10|P-value:4.36E-204 ID:SGTC_1621|Compound:st003705|FD-Score:3.21|P-value:7.61E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.18|P-value:8.45E-4 ID:SGTC_1643|Compound:st009866|FD-Score:3.74|P-value:1.13E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.98|P-value:4.30E-5 ID:SGTC_1649|Compound:st011737|FD-Score:3.15|P-value:9.24E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.64|P-value:1.62E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.26|P-value:1.35E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.67|P-value:1.45E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.66|P-value:1.51E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.46|P-value:4.00E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.42|P-value:4.82E-8 ID:SGTC_1884|Compound:5633444|FD-Score:3.68|P-value:1.43E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.37|P-value:5.62E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.60|P-value:1.90E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.20|P-value:7.84E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.37|P-value:5.62E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-4.77|P-value:1.79E-6 ID:SGTC_2275|Compound:7947463|FD-Score:3.54|P-value:2.42E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.89|P-value:6.16E-5 ID:SGTC_2317|Compound:5986382|FD-Score:-3.49|P-value:3.61E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.88|P-value:1.09E-6 ID:SGTC_2335|Compound:9018011|FD-Score:4.18|P-value:1.86E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-4.20|P-value:2.32E-5 ID:SGTC_2376|Compound:9072922|FD-Score:4.97|P-value:5.04E-7 ID:SGTC_2424|Compound:5537928|FD-Score:-3.23|P-value:8.97E-4 ID:SGTC_2435|Compound:5706476|FD-Score:5.17|P-value:1.79E-7 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.43|P-value:4.53E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.66|P-value:3.08E-11 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.44|P-value:3.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.75|P-value:1.41E-14 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.95|P-value:5.56E-7 ID:SGTC_2788|Compound:5282734|FD-Score:-4.53|P-value:5.56E-6 ID:SGTC_2838|Compound:9002687|FD-Score:-3.37|P-value:5.51E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.20|P-value:7.98E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.20|P-value:9.91E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.50|P-value:2.78E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.89|P-value:6.37E-5 ID:SGTC_3299|Compound:9121982|FD-Score:3.36|P-value:4.47E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.12|P-value:2.46E-5 ID:SGTC_3311|Compound:9131146|FD-Score:8.41|P-value:7.32E-17 ID:SGTC_37|Compound:0566-0070|FD-Score:-4.25|P-value:1.90E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:4.59|P-value:3.02E-6 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.36|P-value:5.71E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.07|P-value:3.02E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.84|P-value:7.72E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.56|P-value:4.76E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:3.66|P-value:1.56E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:6.09|P-value:1.09E-9 ID:SGTC_266|Compound:formosanin C|FD-Score:13.20|P-value:1.94E-38 ID:SGTC_346|Compound:4513-0042|FD-Score:4.16|P-value:2.09E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.52|P-value:2.57E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.34|P-value:4.85E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:6.79|P-value:1.24E-11 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_459|Compound:nigericin|FD-Score:6.02|P-value:1.63E-9 ID:SGTC_535|Compound:2293-4129|FD-Score:3.56|P-value:2.19E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.60|P-value:1.92E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.27|P-value:1.31E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:4.99|P-value:4.49E-7 ID:SGTC_658|Compound:3253-0951|FD-Score:5.12|P-value:2.33E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:4.82|P-value:1.05E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:3.19|P-value:8.23E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.74|P-value:1.13E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:4.87|P-value:8.25E-7 ID:SGTC_825|Compound:1988-2224|FD-Score:3.28|P-value:6.07E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.38|P-value:4.22E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.67|P-value:1.49E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-4.54|P-value:5.16E-6 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.13|P-value:9.92E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:12.60|P-value:3.15E-35 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.87|P-value:4.02E-9 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.27|P-value:1.30E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.95|P-value:5.56E-7 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.69|P-value:1.38E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.21|P-value:9.42E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.26|P-value:6.46E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.02|P-value:3.71E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.88|P-value:6.55E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.86|P-value:5.75E-15 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.27|P-value:1.31E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:31.10|P-value:4.36E-204 ID:SGTC_1621|Compound:st003705|FD-Score:3.21|P-value:7.61E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.18|P-value:8.45E-4 ID:SGTC_1643|Compound:st009866|FD-Score:3.74|P-value:1.13E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.98|P-value:4.30E-5 ID:SGTC_1649|Compound:st011737|FD-Score:3.15|P-value:9.24E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.64|P-value:1.62E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.26|P-value:1.35E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.67|P-value:1.45E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.66|P-value:1.51E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.46|P-value:4.00E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.42|P-value:4.82E-8 ID:SGTC_1884|Compound:5633444|FD-Score:3.68|P-value:1.43E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.37|P-value:5.62E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.60|P-value:1.90E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.20|P-value:7.84E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.37|P-value:5.62E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-4.77|P-value:1.79E-6 ID:SGTC_2275|Compound:7947463|FD-Score:3.54|P-value:2.42E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.89|P-value:6.16E-5 ID:SGTC_2317|Compound:5986382|FD-Score:-3.49|P-value:3.61E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.88|P-value:1.09E-6 ID:SGTC_2335|Compound:9018011|FD-Score:4.18|P-value:1.86E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-4.20|P-value:2.32E-5 ID:SGTC_2376|Compound:9072922|FD-Score:4.97|P-value:5.04E-7 ID:SGTC_2424|Compound:5537928|FD-Score:-3.23|P-value:8.97E-4 ID:SGTC_2435|Compound:5706476|FD-Score:5.17|P-value:1.79E-7 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.43|P-value:4.53E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.66|P-value:3.08E-11 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.44|P-value:3.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.75|P-value:1.41E-14 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.95|P-value:5.56E-7 ID:SGTC_2788|Compound:5282734|FD-Score:-4.53|P-value:5.56E-6 ID:SGTC_2838|Compound:9002687|FD-Score:-3.37|P-value:5.51E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.20|P-value:7.98E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.20|P-value:9.91E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.50|P-value:2.78E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.89|P-value:6.37E-5 ID:SGTC_3299|Compound:9121982|FD-Score:3.36|P-value:4.47E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.12|P-value:2.46E-5 ID:SGTC_3311|Compound:9131146|FD-Score:8.41|P-value:7.32E-17

Top fitness defect scores for YHR073W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1568 digitonin 31.10 820.0 nM 4.36E-204 sphingolipid biosynthesis & PDR1 3 5.70E-213
2 SGTC_266 formosanin C 13.20 406.0 nM 1.94E-38 sphingolipid biosynthesis & PDR1 9 6.23E-40
3 SGTC_1055 3448-0672 12.60 86.0 µM 3.15E-35 1 1.39E-36
4 SGTC_3311 9131146 8.41 2.9 µM 7.32E-17 cell wall 26 1.97E-17
5 SGTC_1317 1273-0028 7.86 910.0 nM 5.75E-15 azole & statin 16 1.85E-15
6 SGTC_2582 agaric acid 7.75 100.0 µM 1.41E-14 redox potentiating 109 4.70E-15
7 SGTC_439 amiodarone 6.79 34.4 µM 1.24E-11 NEO1-PIK1 31 5.44E-12
8 SGTC_2567 aureobasidin a 6.66 60.0 nM 3.08E-11 34 1.41E-11
9 SGTC_227 fluconazole 6.09 33.5 µM 1.09E-9 azole & statin 40 5.74E-10
10 SGTC_459 nigericin 6.02 15.3 µM 1.63E-9 31 8.74E-10
11 SGTC_1067 clotrimazole 5.87 1.4 µM 4.02E-9 azole & statin 14 2.23E-9
12 SGTC_1872 amphotericin b 5.42 148.0 nM 4.82E-8 RNA pol III & RNase P/MRP 14 2.94E-8
13 SGTC_2435 5706476 5.17 10.6 µM 1.79E-7 7 1.15E-7
14 SGTC_658 3253-0951 5.12 102.0 µM 2.33E-7 calcium & mitochondrial duress 29 1.51E-7
15 SGTC_651 3253-0966 4.99 34.4 µM 4.49E-7 calcium & mitochondrial duress 17 2.99E-7
16 SGTC_2376 9072922 4.97 81.3 µM 5.04E-7 9 3.37E-7
17 SGTC_1128 3448-9350 4.95 235.0 µM 5.56E-7 11 3.73E-7
18 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.95 70.0 µM 5.56E-7 redox potentiating 44 3.74E-7
19 SGTC_813 k007-0158 4.87 173.0 µM 8.25E-7 fatty acid desaturase (OLE1) 18 5.62E-7
20 SGTC_660 4031-1742 4.82 102.0 µM 1.05E-6 redox potentiating 25 7.22E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.538 2.03E-251 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.343 2.34E-93 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.307 5.53E-74 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.245 2.95E-47 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.205 3.18E-33 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.190 8.99E-29 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.184 7.50E-27 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.181 4.54E-26 YER119C-A_d YER119C-A_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2
0.181 5.52E-26 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.175 1.65E-24 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.170 3.30E-23 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.165 7.10E-22 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.159 1.79E-20 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.158 3.14E-20 YPR079W MRL1 hom Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress
0.158 3.69E-20 YBR036C CSG2 hom Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress