YHR076W / PTC7

Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR076W / PTC7

Click on Significant Values for Screen Details ID:SGTC_154|Compound:3389-1638|FD-Score:3.53|P-value:5.54E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.08|P-value:8.11E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.99|P-value:1.14E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:5.20|P-value:7.52E-7 ID:SGTC_315|Compound:k915-0449|FD-Score:3.35|P-value:9.70E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.92|P-value:1.46E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:6.73|P-value:2.47E-10 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.37|P-value:9.14E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.01|P-value:1.79E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.68|P-value:7.40E-8 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.83|P-value:1.95E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.94|P-value:1.34E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-4.54|P-value:1.37E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:4.40|P-value:2.36E-5 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.83|P-value:1.99E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.49|P-value:6.16E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:5.30|P-value:4.65E-7 ID:SGTC_913|Compound:3487-1245|FD-Score:3.97|P-value:1.22E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.35|P-value:2.89E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.51|P-value:5.84E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.62|P-value:9.86E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.44|P-value:1.97E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.38|P-value:9.01E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:6.05|P-value:1.12E-8 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.64|P-value:3.80E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.45|P-value:7.18E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.59|P-value:4.50E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.81|P-value:2.10E-4 ID:SGTC_1863|Compound:st057641|FD-Score:4.26|P-value:4.10E-5 ID:SGTC_2149|Compound:5554786|FD-Score:4.13|P-value:6.64E-5 ID:SGTC_2150|Compound:5556613|FD-Score:4.55|P-value:1.31E-5 ID:SGTC_2164|Compound:5685496|FD-Score:-4.25|P-value:4.17E-5 ID:SGTC_2167|Compound:5876490|FD-Score:-3.47|P-value:6.67E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.98|P-value:1.14E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.39|P-value:8.66E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.44|P-value:2.02E-5 ID:SGTC_2440|Compound:5628896|FD-Score:4.35|P-value:2.83E-5 ID:SGTC_2483|Compound:5729050|FD-Score:-4.58|P-value:1.15E-5 ID:SGTC_2487|Compound:5918373|FD-Score:-5.46|P-value:2.24E-7 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.76|P-value:2.56E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.02|P-value:9.86E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.23|P-value:4.62E-5 ID:SGTC_2883|Compound:9059145|FD-Score:3.74|P-value:2.67E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-5.08|P-value:1.33E-6 ID:SGTC_2890|Compound:9046729|FD-Score:-3.56|P-value:5.03E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-4.68|P-value:7.69E-6 ID:SGTC_2959|Compound:9079155|FD-Score:3.91|P-value:1.50E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.71|P-value:3.04E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.79|P-value:2.27E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.58|P-value:4.65E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.53|P-value:5.54E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.08|P-value:8.11E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.99|P-value:1.14E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:5.20|P-value:7.52E-7 ID:SGTC_315|Compound:k915-0449|FD-Score:3.35|P-value:9.70E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.92|P-value:1.46E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:6.73|P-value:2.47E-10 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.37|P-value:9.14E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.01|P-value:1.79E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.68|P-value:7.40E-8 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.83|P-value:1.95E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.94|P-value:1.34E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-4.54|P-value:1.37E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:4.40|P-value:2.36E-5 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.83|P-value:1.99E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.49|P-value:6.16E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:5.30|P-value:4.65E-7 ID:SGTC_913|Compound:3487-1245|FD-Score:3.97|P-value:1.22E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.35|P-value:2.89E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.51|P-value:5.84E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.62|P-value:9.86E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.44|P-value:1.97E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.38|P-value:9.01E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:6.05|P-value:1.12E-8 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.64|P-value:3.80E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.45|P-value:7.18E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.59|P-value:4.50E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.81|P-value:2.10E-4 ID:SGTC_1863|Compound:st057641|FD-Score:4.26|P-value:4.10E-5 ID:SGTC_2149|Compound:5554786|FD-Score:4.13|P-value:6.64E-5 ID:SGTC_2150|Compound:5556613|FD-Score:4.55|P-value:1.31E-5 ID:SGTC_2164|Compound:5685496|FD-Score:-4.25|P-value:4.17E-5 ID:SGTC_2167|Compound:5876490|FD-Score:-3.47|P-value:6.67E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.98|P-value:1.14E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.39|P-value:8.66E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.44|P-value:2.02E-5 ID:SGTC_2440|Compound:5628896|FD-Score:4.35|P-value:2.83E-5 ID:SGTC_2483|Compound:5729050|FD-Score:-4.58|P-value:1.15E-5 ID:SGTC_2487|Compound:5918373|FD-Score:-5.46|P-value:2.24E-7 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.76|P-value:2.56E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.02|P-value:9.86E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.23|P-value:4.62E-5 ID:SGTC_2883|Compound:9059145|FD-Score:3.74|P-value:2.67E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-5.08|P-value:1.33E-6 ID:SGTC_2890|Compound:9046729|FD-Score:-3.56|P-value:5.03E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-4.68|P-value:7.69E-6 ID:SGTC_2959|Compound:9079155|FD-Score:3.91|P-value:1.50E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.71|P-value:3.04E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.79|P-value:2.27E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.58|P-value:4.65E-4

Top fitness defect scores for YHR076W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_354 2783-3500 6.73 4.9 µM 2.47E-10 cell wall 13 8.76E-12
2 SGTC_1375 2910-0797 6.05 186.0 µM 1.12E-8 4 7.43E-10
3 SGTC_450 aminopyrene 5.68 156.0 nM 7.40E-8 9 6.70E-9
4 SGTC_901 1112-0062 5.30 60.1 µM 4.65E-7 3 5.69E-8
5 SGTC_306 1672-3436 5.20 11.6 µM 7.52E-7 Golgi 6 9.95E-8
6 SGTC_449 xestospongin c 5.01 11.2 µM 1.79E-6 NEO1-PIK1 30 2.73E-7
7 SGTC_2150 5556613 4.55 200.0 µM 1.31E-5 9 2.74E-6
8 SGTC_1276 0871-0068 4.44 94.2 µM 1.97E-5 13 4.42E-6
9 SGTC_794 k038-0031 4.40 316.0 µM 2.36E-5 ubiquinone biosynthesis & proteasome 92 5.44E-6
10 SGTC_2440 5628896 4.35 157.8 µM 2.83E-5 20 6.73E-6
11 SGTC_951 1171-0579 4.35 82.7 µM 2.89E-5 cell wall 61 6.90E-6
12 SGTC_1863 st057641 4.26 20.1 µM 4.10E-5 8 1.03E-5
13 SGTC_2682 pyrogallin 4.23 40.0 µM 4.62E-5 copper-dependent oxidative stress 20 1.19E-5
14 SGTC_2149 5554786 4.13 194.8 µM 6.64E-5 cell wall signaling 30 1.81E-5
15 SGTC_167 3672-0051 4.08 66.2 µM 8.11E-5 40 2.28E-5
16 SGTC_2659 sanguinarine 4.02 24.2 µM 9.86E-5 24 2.86E-5
17 SGTC_2338 7999974 3.98 200.0 µM 1.14E-4 20 3.39E-5
18 SGTC_913 3487-1245 3.97 167.0 µM 1.22E-4 29 3.65E-5
19 SGTC_345 1362-0200 3.92 395.0 µM 1.46E-4 17 4.50E-5
20 SGTC_2959 9079155 3.91 11.0 µM 1.50E-4 28 4.66E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.12E-8 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.091 1.37E-7 YNL059C ARP5 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.086 6.82E-7 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.080 3.55E-6 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.080 3.94E-6 YMR075C-A_d YMR075C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W
0.078 5.38E-6 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.078 5.42E-6 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.077 7.84E-6 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.075 1.27E-5 YPL025C_d YPL025C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.071 3.43E-5 YHR106W TRR2 hom Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
0.071 3.73E-5 YOR161C PNS1 hom Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
0.071 3.91E-5 YBR106W PHO88 hom Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
0.071 4.27E-5 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.070 5.25E-5 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.070 5.59E-5 YEL047C FRD1 hom Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication