YHR077C / NMD2

Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR077C / NMD2

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.48|P-value:2.24E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.10|P-value:1.76E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:4.96|P-value:2.88E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:3.31|P-value:4.31E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.46|P-value:2.37E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.97|P-value:2.99E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.37|P-value:4.93E-6 ID:SGTC_183|Compound:3914-0051|FD-Score:4.43|P-value:3.90E-6 ID:SGTC_263|Compound:alizarin|FD-Score:3.68|P-value:1.05E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.57|P-value:1.58E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.18|P-value:1.18E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.65|P-value:1.41E-6 ID:SGTC_591|Compound:4299-0174|FD-Score:4.00|P-value:2.78E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.24|P-value:5.52E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.19|P-value:6.34E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.12|P-value:7.94E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.23|P-value:5.58E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.68|P-value:9.85E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:-4.62|P-value:1.51E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.11|P-value:1.69E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:5.82|P-value:2.16E-9 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.76|P-value:7.09E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.41|P-value:2.97E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:5.14|P-value:1.07E-7 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.45|P-value:2.50E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.21|P-value:6.03E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.26|P-value:5.16E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-3.94|P-value:3.48E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.80|P-value:6.30E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.95|P-value:9.84E-10 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-5.14|P-value:1.04E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:-5.21|P-value:6.89E-8 ID:SGTC_1634|Compound:st006576|FD-Score:3.15|P-value:7.38E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.71|P-value:8.94E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-4.45|P-value:3.50E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-4.43|P-value:3.73E-6 ID:SGTC_1745|Compound:st081495|FD-Score:-6.21|P-value:1.79E-10 ID:SGTC_1747|Compound:st037496|FD-Score:-4.44|P-value:3.62E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.49|P-value:3.04E-6 ID:SGTC_1855|Compound:st056195|FD-Score:4.54|P-value:2.34E-6 ID:SGTC_1970|Compound:st070122|FD-Score:3.74|P-value:8.00E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.73|P-value:8.46E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-3.92|P-value:3.70E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.15|P-value:7.53E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.47|P-value:2.37E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-3.34|P-value:3.70E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.16|P-value:6.90E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.29|P-value:4.62E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.29|P-value:4.65E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.16|P-value:6.99E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.71|P-value:8.80E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:6.97|P-value:1.04E-12 ID:SGTC_2608|Compound:thymoquinone|FD-Score:4.21|P-value:1.08E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.28|P-value:7.75E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.94|P-value:2.95E-7 ID:SGTC_2812|Compound:7970281|FD-Score:-3.88|P-value:4.40E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.10|P-value:8.90E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.24|P-value:5.31E-4 ID:SGTC_3053|Compound:9095903|FD-Score:-3.74|P-value:7.86E-5 ID:SGTC_3089|Compound:9117425|FD-Score:3.19|P-value:6.48E-4 ID:SGTC_3090|Compound:9117696|FD-Score:4.14|P-value:1.52E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.37|P-value:3.36E-4 ID:SGTC_3178|Compound:9107506|FD-Score:4.16|P-value:1.37E-5 ID:SGTC_3249|Compound:9135183|FD-Score:3.47|P-value:2.38E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.20|P-value:6.19E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.48|P-value:2.24E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.10|P-value:1.76E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:4.96|P-value:2.88E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:3.31|P-value:4.31E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.46|P-value:2.37E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.97|P-value:2.99E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.37|P-value:4.93E-6 ID:SGTC_183|Compound:3914-0051|FD-Score:4.43|P-value:3.90E-6 ID:SGTC_263|Compound:alizarin|FD-Score:3.68|P-value:1.05E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.57|P-value:1.58E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.18|P-value:1.18E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.65|P-value:1.41E-6 ID:SGTC_591|Compound:4299-0174|FD-Score:4.00|P-value:2.78E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.24|P-value:5.52E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.19|P-value:6.34E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.12|P-value:7.94E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.23|P-value:5.58E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.68|P-value:9.85E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:-4.62|P-value:1.51E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.11|P-value:1.69E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:5.82|P-value:2.16E-9 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.76|P-value:7.09E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.41|P-value:2.97E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:5.14|P-value:1.07E-7 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.45|P-value:2.50E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.21|P-value:6.03E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.26|P-value:5.16E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-3.94|P-value:3.48E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.80|P-value:6.30E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.95|P-value:9.84E-10 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-5.14|P-value:1.04E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:-5.21|P-value:6.89E-8 ID:SGTC_1634|Compound:st006576|FD-Score:3.15|P-value:7.38E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.71|P-value:8.94E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-4.45|P-value:3.50E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-4.43|P-value:3.73E-6 ID:SGTC_1745|Compound:st081495|FD-Score:-6.21|P-value:1.79E-10 ID:SGTC_1747|Compound:st037496|FD-Score:-4.44|P-value:3.62E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.49|P-value:3.04E-6 ID:SGTC_1855|Compound:st056195|FD-Score:4.54|P-value:2.34E-6 ID:SGTC_1970|Compound:st070122|FD-Score:3.74|P-value:8.00E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.73|P-value:8.46E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-3.92|P-value:3.70E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.15|P-value:7.53E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.47|P-value:2.37E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-3.34|P-value:3.70E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.16|P-value:6.90E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.29|P-value:4.62E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.29|P-value:4.65E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.16|P-value:6.99E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.71|P-value:8.80E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:6.97|P-value:1.04E-12 ID:SGTC_2608|Compound:thymoquinone|FD-Score:4.21|P-value:1.08E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.28|P-value:7.75E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.94|P-value:2.95E-7 ID:SGTC_2812|Compound:7970281|FD-Score:-3.88|P-value:4.40E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.10|P-value:8.90E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.24|P-value:5.31E-4 ID:SGTC_3053|Compound:9095903|FD-Score:-3.74|P-value:7.86E-5 ID:SGTC_3089|Compound:9117425|FD-Score:3.19|P-value:6.48E-4 ID:SGTC_3090|Compound:9117696|FD-Score:4.14|P-value:1.52E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.37|P-value:3.36E-4 ID:SGTC_3178|Compound:9107506|FD-Score:4.16|P-value:1.37E-5 ID:SGTC_3249|Compound:9135183|FD-Score:3.47|P-value:2.38E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.20|P-value:6.19E-4

Top fitness defect scores for YHR077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2606 farnesol 6.97 9.8 µM 1.04E-12 2 1.60E-12
2 SGTC_1528 arabinosylhypoxanthine 5.95 74.6 µM 9.84E-10 4 1.34E-9
3 SGTC_1081 sertraline 5.82 6.0 µM 2.16E-9 60S ribosome export 11 2.91E-9
4 SGTC_1361 1608-0041 5.14 5.6 µM 1.07E-7 RPP1 & pyrimidine depletion 6 1.35E-7
5 SGTC_133 0724-0033 4.96 378.9 µM 2.88E-7 10 3.57E-7
6 SGTC_568 1193-0097 4.65 7.5 µM 1.41E-6 ERAD & cell cycle 104 1.70E-6
7 SGTC_1855 st056195 4.54 39.6 µM 2.34E-6 60S ribosome export 8 2.80E-6
8 SGTC_1750 st081859 4.49 2.4 µM 3.04E-6 endomembrane recycling 153 3.61E-6
9 SGTC_183 3914-0051 4.43 30.6 µM 3.90E-6 60S ribosome export 12 4.62E-6
10 SGTC_2608 thymoquinone 4.21 42.7 µM 1.08E-5 13 1.26E-5
11 SGTC_3178 9107506 4.16 49.5 µM 1.37E-5 10 1.59E-5
12 SGTC_3090 9117696 4.14 49.5 µM 1.52E-5 14 1.77E-5
13 SGTC_1050 3232-1156 4.11 69.3 µM 1.69E-5 RSC complex & mRNA processing 17 1.96E-5
14 SGTC_66 0109-0187 4.10 42.4 µM 1.76E-5 35 2.03E-5
15 SGTC_591 4299-0174 4.00 154.0 µM 2.78E-5 8 3.19E-5
16 SGTC_1523 st012844 3.80 44.7 µM 6.30E-5 60S ribosome export 25 7.13E-5
17 SGTC_1970 st070122 3.74 35.8 µM 8.00E-5 TSC3-RPN4 31 9.02E-5
18 SGTC_2014 4013930 3.73 200.0 µM 8.46E-5 41 9.53E-5
19 SGTC_263 alizarin 3.68 107.9 µM 1.05E-4 iron homeostasis 70 1.18E-4
20 SGTC_453 enantio-paf c16 3.57 10.0 µM 1.58E-4 180 1.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.48E-22 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.163 1.87E-21 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.145 3.11E-17 YPR153W YPR153W hom Putative protein of unknown function
0.131 2.79E-14 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.123 7.58E-13 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.109 2.88E-10 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.108 3.16E-10 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.102 2.85E-9 YOL011W PLB3 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
0.102 3.79E-9 YMR135C GID8 hom Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START
0.099 8.49E-9 YHR151C MTC6 hom Protein of unknown function; mtc6 is synthetically sick with cdc13-1
0.099 8.96E-9 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.096 2.36E-8 YMR182C RGM1 hom Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
0.096 2.89E-8 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.092 9.37E-8 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.090 1.53E-7 YBR058C UBP14 hom Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T