YHR080C

Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR080C / YHR080C

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:3.67|P-value:1.67E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.39|P-value:4.59E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.86|P-value:8.08E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.38|P-value:9.37E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.28|P-value:6.32E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.89|P-value:7.29E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.17|P-value:9.81E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.36|P-value:5.10E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:5.25|P-value:1.42E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.43|P-value:5.30E-8 ID:SGTC_1123|Compound:mangostin|FD-Score:4.52|P-value:4.95E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:4.77|P-value:1.57E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.77|P-value:1.55E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.18|P-value:8.85E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.42|P-value:4.16E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:5.03|P-value:4.43E-7 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.94|P-value:6.65E-7 ID:SGTC_1306|Compound:1185-0270|FD-Score:-3.18|P-value:8.76E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.99|P-value:4.86E-5 ID:SGTC_1558|Compound:st069300|FD-Score:3.63|P-value:1.92E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.44|P-value:3.87E-4 ID:SGTC_1611|Compound:st001856|FD-Score:-3.36|P-value:4.73E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.19|P-value:8.49E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.57|P-value:2.45E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.61|P-value:2.12E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.31|P-value:6.10E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.50|P-value:2.87E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-4.86|P-value:8.78E-7 ID:SGTC_2241|Compound:6772625|FD-Score:3.60|P-value:2.19E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.71|P-value:1.32E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.58|P-value:3.28E-6 ID:SGTC_2290|Compound:7904846|FD-Score:4.02|P-value:4.21E-5 ID:SGTC_2395|Compound:5646831|FD-Score:4.85|P-value:1.05E-6 ID:SGTC_2412|Compound:st077135|FD-Score:-3.26|P-value:6.76E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.26|P-value:7.29E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.65|P-value:1.83E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.05|P-value:3.96E-7 ID:SGTC_2620|Compound:irigenin|FD-Score:4.41|P-value:8.08E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.47|P-value:3.54E-4 ID:SGTC_2962|Compound:9082311|FD-Score:5.79|P-value:7.44E-9 ID:SGTC_2997|Compound:9067075|FD-Score:-3.18|P-value:8.83E-4 ID:SGTC_3222|Compound:9128301|FD-Score:5.38|P-value:6.92E-8 ID:SGTC_48|Compound:0382-0018|FD-Score:3.67|P-value:1.67E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.39|P-value:4.59E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.86|P-value:8.08E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.38|P-value:9.37E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.28|P-value:6.32E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.89|P-value:7.29E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.17|P-value:9.81E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.36|P-value:5.10E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:5.25|P-value:1.42E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.43|P-value:5.30E-8 ID:SGTC_1123|Compound:mangostin|FD-Score:4.52|P-value:4.95E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:4.77|P-value:1.57E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.77|P-value:1.55E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.18|P-value:8.85E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.42|P-value:4.16E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:5.03|P-value:4.43E-7 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.94|P-value:6.65E-7 ID:SGTC_1306|Compound:1185-0270|FD-Score:-3.18|P-value:8.76E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.99|P-value:4.86E-5 ID:SGTC_1558|Compound:st069300|FD-Score:3.63|P-value:1.92E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.44|P-value:3.87E-4 ID:SGTC_1611|Compound:st001856|FD-Score:-3.36|P-value:4.73E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.19|P-value:8.49E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.57|P-value:2.45E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.61|P-value:2.12E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.31|P-value:6.10E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.50|P-value:2.87E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-4.86|P-value:8.78E-7 ID:SGTC_2241|Compound:6772625|FD-Score:3.60|P-value:2.19E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.71|P-value:1.32E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.58|P-value:3.28E-6 ID:SGTC_2290|Compound:7904846|FD-Score:4.02|P-value:4.21E-5 ID:SGTC_2395|Compound:5646831|FD-Score:4.85|P-value:1.05E-6 ID:SGTC_2412|Compound:st077135|FD-Score:-3.26|P-value:6.76E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.26|P-value:7.29E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.65|P-value:1.83E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.05|P-value:3.96E-7 ID:SGTC_2620|Compound:irigenin|FD-Score:4.41|P-value:8.08E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.47|P-value:3.54E-4 ID:SGTC_2962|Compound:9082311|FD-Score:5.79|P-value:7.44E-9 ID:SGTC_2997|Compound:9067075|FD-Score:-3.18|P-value:8.83E-4 ID:SGTC_3222|Compound:9128301|FD-Score:5.38|P-value:6.92E-8

Top fitness defect scores for YHR080C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2962 9082311 5.79 13.2 µM 7.44E-9 4 3.57E-9
2 SGTC_1122 capsaicin 5.43 818.6 nM 5.30E-8 6 2.75E-8
3 SGTC_3222 9128301 5.38 49.5 µM 6.92E-8 60S ribosome export 8 3.64E-8
4 SGTC_1108 betulinic acid 5.25 729.1 nM 1.42E-7 5 7.69E-8
5 SGTC_2607 solasodine 5.05 47.4 µM 3.96E-7 35 2.23E-7
6 SGTC_1301 naphtanilide LB 5.03 4.8 µM 4.43E-7 heme requiring 2 2.51E-7
7 SGTC_1302 1159-0335 4.94 255.0 µM 6.65E-7 4 3.83E-7
8 SGTC_2395 5646831 4.85 180.2 µM 1.05E-6 13 6.17E-7
9 SGTC_1125 tnp00248 4.77 1.3 µM 1.55E-6 14 9.26E-7
10 SGTC_1124 fisetin 4.77 1.2 µM 1.57E-6 15 9.40E-7
11 SGTC_1123 mangostin 4.52 811.3 nM 4.95E-6 mitochondrial response to ROS 23 3.10E-6
12 SGTC_2620 irigenin 4.41 100.0 µM 8.08E-6 23 5.16E-6
13 SGTC_405 ebelactone b 4.38 50.0 µM 9.37E-6 7 6.02E-6
14 SGTC_2290 7904846 4.02 200.0 µM 4.21E-5 18 2.88E-5
15 SGTC_1381 2324-0066 3.99 62.1 µM 4.86E-5 27 3.34E-5
16 SGTC_852 0418-0143 3.89 439.0 µM 7.29E-5 calcium & mitochondrial duress 72 5.10E-5
17 SGTC_187 1488-2104 3.86 32.7 µM 8.08E-5 calcium & mitochondrial duress 44 5.67E-5
18 SGTC_48 0382-0018 3.67 55.0 µM 1.67E-4 15 1.21E-4
19 SGTC_2558 carylophyllene oxide 3.65 100.0 µM 1.83E-4 20 1.33E-4
20 SGTC_1558 st069300 3.63 45.6 µM 1.92E-4 13 1.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.40E-9 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.098 1.15E-8 YPR174C YPR174C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication
0.097 2.01E-8 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.093 5.94E-8 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.092 8.39E-8 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.092 9.45E-8 YGR048W UFD1 het Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.092 1.10E-7 YMR252C_p YMR252C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene
0.090 2.00E-7 YML012W ERV25 hom Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
0.087 4.49E-7 YOL112W MSB4 hom GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization
0.083 1.49E-6 YKR052C MRS4 hom Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication
0.081 2.90E-6 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.87E-6 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.077 7.42E-6 YER142C MAG1 hom 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress
0.076 9.20E-6 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.075 1.35E-5 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway