YHR081W / LRP1

Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR081W / LRP1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.26|P-value:8.70E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.36|P-value:6.39E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.47|P-value:4.44E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.96|P-value:6.34E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.86|P-value:1.18E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.58|P-value:7.24E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.58|P-value:7.27E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.63|P-value:8.26E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:4.00|P-value:7.00E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:3.99|P-value:7.25E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:4.42|P-value:1.38E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.47|P-value:4.50E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.97|P-value:7.83E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.43|P-value:5.14E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.05|P-value:5.83E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.35|P-value:6.55E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.86|P-value:3.87E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-4.76|P-value:1.45E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.76|P-value:5.38E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.41|P-value:1.46E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.42|P-value:5.33E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.59|P-value:6.93E-6 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.45|P-value:4.75E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.26|P-value:2.64E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.96|P-value:8.15E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.91|P-value:3.36E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.21|P-value:3.21E-5 ID:SGTC_1848|Compound:st056003|FD-Score:3.39|P-value:5.88E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.43|P-value:1.36E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.70|P-value:2.09E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.86|P-value:3.97E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.60|P-value:2.95E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.34|P-value:6.87E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.82|P-value:4.39E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-4.07|P-value:1.91E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-4.36|P-value:6.74E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.69|P-value:2.17E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-4.55|P-value:3.28E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-4.35|P-value:7.13E-5 ID:SGTC_3034|Compound:9090421|FD-Score:4.10|P-value:4.88E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.60|P-value:2.86E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.94|P-value:8.73E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.32|P-value:7.28E-4 ID:SGTC_3337|Compound:9144342|FD-Score:8.86|P-value:9.20E-17 ID:SGTC_18|Compound:0111-0177|FD-Score:3.26|P-value:8.70E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.36|P-value:6.39E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.47|P-value:4.44E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.96|P-value:6.34E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.86|P-value:1.18E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.58|P-value:7.24E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.58|P-value:7.27E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.63|P-value:8.26E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:4.00|P-value:7.00E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:3.99|P-value:7.25E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:4.42|P-value:1.38E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.47|P-value:4.50E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.97|P-value:7.83E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.43|P-value:5.14E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.05|P-value:5.83E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.35|P-value:6.55E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.86|P-value:3.87E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-4.76|P-value:1.45E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.76|P-value:5.38E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.41|P-value:1.46E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.42|P-value:5.33E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.59|P-value:6.93E-6 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.45|P-value:4.75E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.26|P-value:2.64E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.96|P-value:8.15E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.91|P-value:3.36E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.21|P-value:3.21E-5 ID:SGTC_1848|Compound:st056003|FD-Score:3.39|P-value:5.88E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.43|P-value:1.36E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.70|P-value:2.09E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.86|P-value:3.97E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.60|P-value:2.95E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.34|P-value:6.87E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.82|P-value:4.39E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-4.07|P-value:1.91E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-4.36|P-value:6.74E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.69|P-value:2.17E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-4.55|P-value:3.28E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-4.35|P-value:7.13E-5 ID:SGTC_3034|Compound:9090421|FD-Score:4.10|P-value:4.88E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.60|P-value:2.86E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.94|P-value:8.73E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.32|P-value:7.28E-4 ID:SGTC_3337|Compound:9144342|FD-Score:8.86|P-value:9.20E-17

Top fitness defect scores for YHR081W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3337 9144342 8.86 33.5 µM 9.20E-17 5 4.11E-19
2 SGTC_1483 3453-0561 4.59 55.9 µM 6.93E-6 11 2.18E-6
3 SGTC_364 0083-0097 4.58 67.7 µM 7.24E-6 16 2.29E-6
4 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 4.58 150.0 µM 7.27E-6 Golgi 31 2.30E-6
5 SGTC_2259 7964009 4.43 200.0 µM 1.36E-5 superoxide 23 4.75E-6
6 SGTC_988 1497-1057 4.42 103.0 µM 1.38E-5 6 4.83E-6
7 SGTC_1373 2887-0003 4.41 58.5 µM 1.46E-5 Golgi 14 5.13E-6
8 SGTC_1521 st012942 4.26 49.4 µM 2.64E-5 25 1.02E-5
9 SGTC_1845 st056753 4.21 3.0 µM 3.21E-5 TSC3-RPN4 28 1.27E-5
10 SGTC_3034 9090421 4.10 49.5 µM 4.88E-5 60S ribosome export 8 2.06E-5
11 SGTC_1167 k781-0610 4.05 148.0 µM 5.83E-5 RNA processing & uracil transport 22 2.53E-5
12 SGTC_797 k781-0471 4.00 270.0 µM 7.00E-5 RPP1 & pyrimidine depletion 20 3.12E-5
13 SGTC_955 1216-0110 3.99 33.0 µM 7.25E-5 sphingolipid biosynthesis & PDR1 63 3.25E-5
14 SGTC_1049 3226-0134 3.97 66.0 µM 7.83E-5 28 3.55E-5
15 SGTC_1698 5-fluorocytosine 3.96 1.1 µM 8.15E-5 exosome 8 3.72E-5
16 SGTC_3076 9116187 3.94 49.5 µM 8.73E-5 17 4.02E-5
17 SGTC_249 wiskostatin 3.86 11.2 µM 1.18E-4 14 5.67E-5
18 SGTC_2268 7933382 3.70 153.8 µM 2.09E-4 44 1.09E-4
19 SGTC_2795 7780010 3.69 54.5 µM 2.17E-4 38 1.14E-4
20 SGTC_3043 9092303 3.60 49.5 µM 2.86E-4 29 1.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.99E-16 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.126 2.79E-13 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.125 4.73E-13 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.112 9.27E-11 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.092 9.70E-8 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.090 1.59E-7 YDR433W_d YDR433W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 1.88E-7 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.087 5.28E-7 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.084 1.22E-6 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.081 2.68E-6 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.080 3.18E-6 YPL034W_p YPL034W_p hom Putative protein of unknown function; YPL034W is not essential gene
0.079 4.25E-6 YBR163W EXO5 hom Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2
0.079 5.36E-6 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.075 1.48E-5 YMR167W MLH1 hom Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
0.073 2.30E-5 YPR087W_d VPS69_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect