YHR082C / KSP1

Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR082C / KSP1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.70|P-value:1.64E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.37|P-value:3.96E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.21|P-value:1.55E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.51|P-value:2.58E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.27|P-value:6.14E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.42|P-value:3.59E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.15|P-value:2.02E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.78|P-value:9.36E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:3.14|P-value:9.43E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.81|P-value:8.07E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.60|P-value:1.86E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.21|P-value:7.45E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.29|P-value:5.41E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-4.98|P-value:3.73E-7 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.96|P-value:4.45E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.84|P-value:7.25E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.23|P-value:7.13E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.42|P-value:3.54E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.24|P-value:6.33E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.74|P-value:9.87E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.22|P-value:7.29E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.29|P-value:5.41E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.50|P-value:2.51E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.87|P-value:6.46E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-8.45|P-value:2.45E-17 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.33|P-value:4.72E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:9.61|P-value:8.38E-22 ID:SGTC_2816|Compound:7982706|FD-Score:-5.56|P-value:1.69E-8 ID:SGTC_2818|Compound:7996756|FD-Score:-3.70|P-value:1.18E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.51|P-value:2.59E-4 ID:SGTC_2828|Compound:7998861|FD-Score:-3.33|P-value:4.60E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.70|P-value:1.17E-4 ID:SGTC_2834|Compound:9001755|FD-Score:5.03|P-value:3.21E-7 ID:SGTC_2894|Compound:9048625|FD-Score:-3.96|P-value:4.21E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-5.99|P-value:1.31E-9 ID:SGTC_3002|Compound:9075603|FD-Score:4.09|P-value:2.57E-5 ID:SGTC_3013|Compound:9080133|FD-Score:-3.12|P-value:9.64E-4 ID:SGTC_3066|Compound:9117245|FD-Score:6.91|P-value:3.94E-12 ID:SGTC_3073|Compound:9114972|FD-Score:4.75|P-value:1.33E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-3.74|P-value:1.01E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.46|P-value:2.96E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.52|P-value:2.51E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.99|P-value:3.67E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.87|P-value:6.41E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.17|P-value:8.75E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.70|P-value:1.64E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.37|P-value:3.96E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.21|P-value:1.55E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.51|P-value:2.58E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.27|P-value:6.14E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.42|P-value:3.59E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.15|P-value:2.02E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.78|P-value:9.36E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:3.14|P-value:9.43E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.81|P-value:8.07E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.60|P-value:1.86E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.21|P-value:7.45E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.29|P-value:5.41E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-4.98|P-value:3.73E-7 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.96|P-value:4.45E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.84|P-value:7.25E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.23|P-value:7.13E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.42|P-value:3.54E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.24|P-value:6.33E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.74|P-value:9.87E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.22|P-value:7.29E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.29|P-value:5.41E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.50|P-value:2.51E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.87|P-value:6.46E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-8.45|P-value:2.45E-17 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.33|P-value:4.72E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:9.61|P-value:8.38E-22 ID:SGTC_2816|Compound:7982706|FD-Score:-5.56|P-value:1.69E-8 ID:SGTC_2818|Compound:7996756|FD-Score:-3.70|P-value:1.18E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.51|P-value:2.59E-4 ID:SGTC_2828|Compound:7998861|FD-Score:-3.33|P-value:4.60E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.70|P-value:1.17E-4 ID:SGTC_2834|Compound:9001755|FD-Score:5.03|P-value:3.21E-7 ID:SGTC_2894|Compound:9048625|FD-Score:-3.96|P-value:4.21E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-5.99|P-value:1.31E-9 ID:SGTC_3002|Compound:9075603|FD-Score:4.09|P-value:2.57E-5 ID:SGTC_3013|Compound:9080133|FD-Score:-3.12|P-value:9.64E-4 ID:SGTC_3066|Compound:9117245|FD-Score:6.91|P-value:3.94E-12 ID:SGTC_3073|Compound:9114972|FD-Score:4.75|P-value:1.33E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-3.74|P-value:1.01E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.46|P-value:2.96E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.52|P-value:2.51E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.99|P-value:3.67E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.87|P-value:6.41E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.17|P-value:8.75E-4

Top fitness defect scores for YHR082C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2651 1327-0036 9.61 5.0 µM 8.38E-22 28 3.50E-22
2 SGTC_3066 9117245 6.91 49.5 µM 3.94E-12 2 2.45E-12
3 SGTC_2834 9001755 5.03 58.4 µM 3.21E-7 16 2.45E-7
4 SGTC_3073 9114972 4.75 49.5 µM 1.33E-6 60S ribosome export 3 1.04E-6
5 SGTC_58 0957-0393 4.70 9.0 µM 1.64E-6 cell wall 316 1.29E-6
6 SGTC_180 1486-1293 4.21 102.8 µM 1.55E-5 38 1.27E-5
7 SGTC_513 4245-1575 4.15 41.7 µM 2.02E-5 unfolded protein response 102 1.67E-5
8 SGTC_3002 9075603 4.09 71.4 µM 2.57E-5 21 2.13E-5
9 SGTC_1040 k898-0338 3.96 155.0 µM 4.45E-5 21 3.72E-5
10 SGTC_3282 9108498 3.87 15.5 µM 6.41E-5 31 5.40E-5
11 SGTC_1215 3852-0577 3.84 11.2 µM 7.25E-5 19 6.13E-5
12 SGTC_995 3931-2021 3.81 34.6 µM 8.07E-5 RPP1 & pyrimidine depletion 26 6.83E-5
13 SGTC_626 0214-0009 3.78 33.0 µM 9.36E-5 copper-dependent oxidative stress 25 7.94E-5
14 SGTC_1009 4106-0057 3.60 9.9 µM 1.86E-4 22 1.59E-4
15 SGTC_3185 9108267 3.52 49.5 µM 2.51E-4 60S ribosome export 32 2.17E-4
16 SGTC_304 1310-0298 3.51 97.0 µM 2.58E-4 cell wall 81 2.23E-4
17 SGTC_2822 7994718 3.51 71.4 µM 2.59E-4 29 2.24E-4
18 SGTC_1231 0242-0792 3.42 125.0 µM 3.54E-4 32 3.08E-4
19 SGTC_363 0455-0021 3.42 3.1 µM 3.59E-4 azole & statin 91 3.12E-4
20 SGTC_332 4112-0506 3.27 40.9 µM 6.14E-4 47 5.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 2.16E-36 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.176 1.00E-24 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.174 3.91E-24 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.165 8.06E-22 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.160 1.33E-20 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion
0.158 4.48E-20 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.146 1.49E-17 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.145 3.16E-17 YOR322C LDB19 hom Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye
0.145 3.80E-17 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.142 1.24E-16 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.139 6.04E-16 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.139 6.91E-16 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.138 9.31E-16 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.134 7.13E-15 YOR170W_d YOR170W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4
0.133 9.44E-15 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188