YHR085W / IPI1

Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR085W / IPI1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.16|P-value:1.39E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:2.74|P-value:7.88E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.26|P-value:8.88E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:2.77|P-value:6.92E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.61|P-value:3.00E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.70|P-value:1.06E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.08|P-value:3.14E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-2.84|P-value:8.32E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.02|P-value:2.46E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-2.80|P-value:9.82E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-2.82|P-value:9.06E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.72|P-value:9.46E-6 ID:SGTC_1307|Compound:1187-1599|FD-Score:-2.99|P-value:4.67E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.10|P-value:1.76E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.97|P-value:3.08E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.41|P-value:2.17E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:2.84|P-value:5.22E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.15|P-value:1.41E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.43|P-value:3.91E-5 ID:SGTC_1616|Compound:st002734|FD-Score:3.53|P-value:2.49E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-3.01|P-value:4.20E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-2.83|P-value:8.50E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.06|P-value:3.38E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.15|P-value:2.39E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.80|P-value:9.60E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.69|P-value:9.47E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.15|P-value:1.40E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.66|P-value:1.01E-7 ID:SGTC_2624|Compound:nerol|FD-Score:6.29|P-value:3.52E-13 ID:SGTC_2643|Compound:anethole|FD-Score:2.73|P-value:8.18E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:2.74|P-value:7.81E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.28|P-value:7.98E-5 ID:SGTC_2692|Compound:st077426|FD-Score:2.73|P-value:8.10E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.43|P-value:2.79E-10 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.11|P-value:1.68E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.23|P-value:9.87E-5 ID:SGTC_2973|Compound:9094665|FD-Score:2.89|P-value:4.32E-4 ID:SGTC_3225|Compound:9130819|FD-Score:2.82|P-value:5.67E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-2.98|P-value:4.71E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.16|P-value:1.39E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:2.74|P-value:7.88E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.26|P-value:8.88E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:2.77|P-value:6.92E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.61|P-value:3.00E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.70|P-value:1.06E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.08|P-value:3.14E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-2.84|P-value:8.32E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.02|P-value:2.46E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-2.80|P-value:9.82E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-2.82|P-value:9.06E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.72|P-value:9.46E-6 ID:SGTC_1307|Compound:1187-1599|FD-Score:-2.99|P-value:4.67E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.10|P-value:1.76E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.97|P-value:3.08E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.41|P-value:2.17E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:2.84|P-value:5.22E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.15|P-value:1.41E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.43|P-value:3.91E-5 ID:SGTC_1616|Compound:st002734|FD-Score:3.53|P-value:2.49E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-3.01|P-value:4.20E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-2.83|P-value:8.50E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.06|P-value:3.38E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.15|P-value:2.39E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.80|P-value:9.60E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.69|P-value:9.47E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.15|P-value:1.40E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.66|P-value:1.01E-7 ID:SGTC_2624|Compound:nerol|FD-Score:6.29|P-value:3.52E-13 ID:SGTC_2643|Compound:anethole|FD-Score:2.73|P-value:8.18E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:2.74|P-value:7.81E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.28|P-value:7.98E-5 ID:SGTC_2692|Compound:st077426|FD-Score:2.73|P-value:8.10E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.43|P-value:2.79E-10 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.11|P-value:1.68E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.23|P-value:9.87E-5 ID:SGTC_2973|Compound:9094665|FD-Score:2.89|P-value:4.32E-4 ID:SGTC_3225|Compound:9130819|FD-Score:2.82|P-value:5.67E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-2.98|P-value:4.71E-4

Top fitness defect scores for YHR085W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2624 nerol 6.29 100.0 µM 3.52E-13 1 1.59E-10 2.49
2 SGTC_2754 granisetron 5.43 64.0 µM 2.79E-10 2 2.88E-8 0.24
3 SGTC_1403 3909-7815 4.41 62.9 µM 2.17E-7 3 5.15E-6 0.21
4 SGTC_1196 1588-0294 3.72 184.0 µM 9.46E-6 6 9.81E-5 0.38
5 SGTC_495 decylubiquinone 3.70 155.0 µM 1.06E-5 copper-dependent oxidative stress 2 1.07E-4 0.04
6 SGTC_1616 st002734 3.53 56.1 µM 2.49E-5 11 2.09E-4 0.19
7 SGTC_1602 st001878 3.43 87.6 µM 3.91E-5 13 2.97E-4 0.02
8 SGTC_2685 mycophenolic acid 3.28 18.9 µM 7.98E-5 RNA pol III & RNase P/MRP 6 5.18E-4 0.47
9 SGTC_362 0310-0100 3.26 9.0 µM 8.88E-5 RPP1 & pyrimidine depletion 14 5.64E-4 0.10
10 SGTC_2792 7535235 3.23 81.8 µM 9.87E-5 fatty acid desaturase (OLE1) 20 6.12E-4 0.04
11 SGTC_68 0986-0284 3.16 82.8 µM 1.39E-4 21 8.01E-4 0.02
12 SGTC_2608 thymoquinone 3.15 42.7 µM 1.40E-4 11 8.04E-4 0.08
13 SGTC_1538 2',3',6-trimethoxyflavanone 3.15 63.6 µM 1.41E-4 7 8.10E-4 0.02
14 SGTC_2757 clomiphene 3.11 4.2 µM 1.68E-4 fatty acid desaturase (OLE1) 29 9.26E-4 0.04
15 SGTC_1354 1498-1681 3.10 81.0 µM 1.76E-4 18 9.64E-4 0.01
16 SGTC_716 1683-5115 3.02 658.0 µM 2.46E-4 12 0.00125 0.11
17 SGTC_1383 3049-0032 2.97 20.7 µM 3.08E-4 60S ribosome export 21 0.00149 0.03
18 SGTC_2973 9094665 2.89 18.0 µM 4.32E-4 NEO1 36 0.00194 0.01
19 SGTC_1445 4239-0156 2.84 97.7 µM 5.22E-4 13 0.00225 0.05
20 SGTC_3225 9130819 2.82 49.5 µM 5.67E-4 amide catabolism 27 0.00240 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.19E-15 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.127 1.68E-13 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.124 6.39E-13 YOR120W GCY1 hom Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication
0.114 3.06E-11 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.097 2.06E-8 YJR100C AIM25 hom Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.095 3.95E-8 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.093 6.54E-8 YHR140W_p YHR140W_p hom Putative integral membrane protein of unknown function
0.091 1.44E-7 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.090 1.91E-7 YMR016C SOK2 hom Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication
0.089 2.46E-7 YAL048C GEM1 hom Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases
0.087 3.85E-7 YHL047C ARN2 hom Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
0.084 1.27E-6 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.083 1.69E-6 YBR072W HSP26 hom Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity
0.081 2.42E-6 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.081 2.43E-6 YIL007C NAS2 hom Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress