YHR086W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR086W-A / YHR086W-A

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:3.13|P-value:6.92E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.14|P-value:6.62E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.25|P-value:4.40E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.08|P-value:8.87E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.06|P-value:1.39E-7 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.23|P-value:5.20E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.60|P-value:1.32E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:5.39|P-value:1.88E-8 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.78|P-value:5.54E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.32|P-value:3.47E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.63|P-value:1.17E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:3.17|P-value:5.97E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:8.11|P-value:6.79E-17 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.79|P-value:5.90E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.60|P-value:1.17E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.26|P-value:6.86E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:-4.02|P-value:2.27E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:-4.32|P-value:5.85E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:3.28|P-value:4.00E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.48|P-value:1.91E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.34|P-value:3.23E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.55|P-value:1.41E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.06|P-value:1.70E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.13|P-value:1.21E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.17|P-value:6.60E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.51|P-value:1.65E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.24|P-value:5.12E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.43|P-value:2.26E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.07|P-value:8.62E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.13|P-value:6.98E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.66|P-value:9.24E-5 ID:SGTC_2033|Compound:5192550|FD-Score:3.19|P-value:5.49E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.16|P-value:6.17E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.99|P-value:2.33E-5 ID:SGTC_2505|Compound:galangin|FD-Score:-3.58|P-value:1.42E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.32|P-value:5.85E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.14|P-value:8.65E-8 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.27|P-value:4.11E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.71|P-value:7.63E-7 ID:SGTC_2601|Compound:securinine|FD-Score:-3.49|P-value:1.96E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.99|P-value:2.34E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.43|P-value:2.31E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.19|P-value:6.10E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-4.32|P-value:5.79E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-7.62|P-value:4.88E-15 ID:SGTC_2848|Compound:9016370|FD-Score:3.75|P-value:6.49E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.63|P-value:1.02E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.06|P-value:9.60E-4 ID:SGTC_3066|Compound:9117245|FD-Score:4.81|P-value:4.43E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:3.13|P-value:6.92E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.14|P-value:6.62E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.25|P-value:4.40E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.08|P-value:8.87E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.06|P-value:1.39E-7 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.23|P-value:5.20E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.60|P-value:1.32E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:5.39|P-value:1.88E-8 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.78|P-value:5.54E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.32|P-value:3.47E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.63|P-value:1.17E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:3.17|P-value:5.97E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:8.11|P-value:6.79E-17 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.79|P-value:5.90E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.60|P-value:1.17E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.26|P-value:6.86E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:-4.02|P-value:2.27E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:-4.32|P-value:5.85E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:3.28|P-value:4.00E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.48|P-value:1.91E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.34|P-value:3.23E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.55|P-value:1.41E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.06|P-value:1.70E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.13|P-value:1.21E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.17|P-value:6.60E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.51|P-value:1.65E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.24|P-value:5.12E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.43|P-value:2.26E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.07|P-value:8.62E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.13|P-value:6.98E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.66|P-value:9.24E-5 ID:SGTC_2033|Compound:5192550|FD-Score:3.19|P-value:5.49E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.16|P-value:6.17E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.99|P-value:2.33E-5 ID:SGTC_2505|Compound:galangin|FD-Score:-3.58|P-value:1.42E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.32|P-value:5.85E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.14|P-value:8.65E-8 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.27|P-value:4.11E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.71|P-value:7.63E-7 ID:SGTC_2601|Compound:securinine|FD-Score:-3.49|P-value:1.96E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.99|P-value:2.34E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.43|P-value:2.31E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.19|P-value:6.10E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-4.32|P-value:5.79E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-7.62|P-value:4.88E-15 ID:SGTC_2848|Compound:9016370|FD-Score:3.75|P-value:6.49E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.63|P-value:1.02E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.06|P-value:9.60E-4 ID:SGTC_3066|Compound:9117245|FD-Score:4.81|P-value:4.43E-7

Top fitness defect scores for YHR086W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_680 0417-1641 8.11 114.0 µM 6.79E-17 RPP1 & pyrimidine depletion 1 2.59E-16
2 SGTC_615 k087-0205 5.39 167.0 µM 1.88E-8 6 3.50E-8
3 SGTC_3066 9117245 4.81 49.5 µM 4.43E-7 5 7.37E-7
4 SGTC_2593 nobiletin 4.71 86.2 µM 7.63E-7 13 1.24E-6
5 SGTC_717 1532-0246 4.26 73.2 µM 6.86E-6 Golgi 25 1.03E-5
6 SGTC_1539 benzyladenosine 4.13 56.0 µM 1.21E-5 13 1.78E-5
7 SGTC_1438 4092-1045 4.06 4.0 µM 1.70E-5 6 2.47E-5
8 SGTC_2501 sodium tetradecyl sulfate 3.99 13.4 µM 2.33E-5 29 3.35E-5
9 SGTC_2664 lyso-paf C-16 3.99 73.5 µM 2.34E-5 12 3.37E-5
10 SGTC_636 0kpi-0074 3.78 126.0 µM 5.54E-5 22 7.73E-5
11 SGTC_2848 9016370 3.75 26.0 µM 6.49E-5 29 8.99E-5
12 SGTC_1960 st011366 3.66 51.8 µM 9.24E-5 14 1.26E-4
13 SGTC_2858 9025781 3.63 9.0 µM 1.02E-4 sphingolipid biosynthesis & PDR1 113 1.40E-4
14 SGTC_690 glyoxal 3.60 20.3 µM 1.17E-4 98 1.58E-4
15 SGTC_1376 2910-0861 3.55 41.3 µM 1.41E-4 33 1.90E-4
16 SGTC_1635 st007035 3.51 42.4 µM 1.65E-4 250 2.21E-4
17 SGTC_911 3456-4043 3.48 236.0 µM 1.91E-4 mitochondrial processes 43 2.55E-4
18 SGTC_1856 st057054 3.43 55.7 µM 2.26E-4 39 2.99E-4
19 SGTC_2805 7950783 3.43 58.4 µM 2.31E-4 48 3.05E-4
20 SGTC_1217 1183-1422 3.34 255.0 µM 3.23E-4 28 4.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 6.33E-18 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.142 1.22E-16 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.141 2.35E-16 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.139 7.16E-16 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.138 1.03E-15 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.137 1.61E-15 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.132 1.84E-14 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.131 2.39E-14 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.129 6.65E-14 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.129 7.81E-14 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.128 8.80E-14 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.124 4.62E-13 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.124 6.58E-13 YJL034W KAR2 het ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
0.121 1.62E-12 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.121 1.65E-12 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs