YHR091C / MSR1

Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR091C / MSR1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.37|P-value:6.36E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.58|P-value:3.19E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.39|P-value:5.98E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:7.17|P-value:6.03E-12 ID:SGTC_68|Compound:0986-0284|FD-Score:4.96|P-value:1.25E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.82|P-value:2.31E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.65|P-value:2.42E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.75|P-value:3.21E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:4.81|P-value:2.46E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:5.96|P-value:8.52E-9 ID:SGTC_211|Compound:3455-0679|FD-Score:3.79|P-value:1.50E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.01|P-value:9.85E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:8.65|P-value:1.71E-16 ID:SGTC_365|Compound:0121-0052|FD-Score:3.23|P-value:9.89E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.77|P-value:2.82E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.48|P-value:1.97E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.78|P-value:1.53E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.10|P-value:4.64E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:3.53|P-value:3.68E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.04|P-value:8.73E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.11|P-value:8.23E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.56|P-value:3.34E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.35|P-value:6.80E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.55|P-value:3.47E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:6.61|P-value:1.98E-10 ID:SGTC_1521|Compound:st012942|FD-Score:3.51|P-value:3.99E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-4.51|P-value:1.75E-5 ID:SGTC_1627|Compound:st003713|FD-Score:5.46|P-value:1.13E-7 ID:SGTC_1695|Compound:st026914|FD-Score:3.23|P-value:9.77E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.68|P-value:3.85E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-4.31|P-value:3.87E-5 ID:SGTC_1843|Compound:st055809|FD-Score:7.06|P-value:1.28E-11 ID:SGTC_1849|Compound:st056239|FD-Score:4.59|P-value:6.46E-6 ID:SGTC_1962|Compound:st076595|FD-Score:-3.59|P-value:5.25E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.50|P-value:6.96E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.38|P-value:6.14E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.21|P-value:3.05E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.64|P-value:2.58E-4 ID:SGTC_2097|Compound:5376186|FD-Score:6.14|P-value:3.01E-9 ID:SGTC_2237|Compound:6667747|FD-Score:-4.02|P-value:1.14E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.82|P-value:2.38E-6 ID:SGTC_2325|Compound:6158266|FD-Score:3.47|P-value:4.49E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.82|P-value:1.34E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.24|P-value:9.66E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-8.33|P-value:6.17E-15 ID:SGTC_2416|Compound:tofa|FD-Score:-4.76|P-value:6.12E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.86|P-value:1.98E-6 ID:SGTC_2486|Compound:5283202|FD-Score:3.32|P-value:7.53E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.50|P-value:6.99E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.63|P-value:2.59E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.43|P-value:1.27E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.75|P-value:2.96E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-4.16|P-value:6.92E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.47|P-value:4.60E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.57|P-value:3.29E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.57|P-value:5.52E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.40|P-value:3.38E-7 ID:SGTC_3050|Compound:9093513|FD-Score:5.24|P-value:3.30E-7 ID:SGTC_3203|Compound:9113543|FD-Score:3.46|P-value:4.78E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.36|P-value:1.67E-5 ID:SGTC_3238|Compound:9133470|FD-Score:3.98|P-value:7.37E-5 ID:SGTC_3249|Compound:9135183|FD-Score:-3.64|P-value:4.37E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.37|P-value:6.36E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.58|P-value:3.19E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.39|P-value:5.98E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:7.17|P-value:6.03E-12 ID:SGTC_68|Compound:0986-0284|FD-Score:4.96|P-value:1.25E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.82|P-value:2.31E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.65|P-value:2.42E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.75|P-value:3.21E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:4.81|P-value:2.46E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:5.96|P-value:8.52E-9 ID:SGTC_211|Compound:3455-0679|FD-Score:3.79|P-value:1.50E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.01|P-value:9.85E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:8.65|P-value:1.71E-16 ID:SGTC_365|Compound:0121-0052|FD-Score:3.23|P-value:9.89E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.77|P-value:2.82E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.48|P-value:1.97E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.78|P-value:1.53E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.10|P-value:4.64E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:3.53|P-value:3.68E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.04|P-value:8.73E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.11|P-value:8.23E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.56|P-value:3.34E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.35|P-value:6.80E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.55|P-value:3.47E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:6.61|P-value:1.98E-10 ID:SGTC_1521|Compound:st012942|FD-Score:3.51|P-value:3.99E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-4.51|P-value:1.75E-5 ID:SGTC_1627|Compound:st003713|FD-Score:5.46|P-value:1.13E-7 ID:SGTC_1695|Compound:st026914|FD-Score:3.23|P-value:9.77E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.68|P-value:3.85E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-4.31|P-value:3.87E-5 ID:SGTC_1843|Compound:st055809|FD-Score:7.06|P-value:1.28E-11 ID:SGTC_1849|Compound:st056239|FD-Score:4.59|P-value:6.46E-6 ID:SGTC_1962|Compound:st076595|FD-Score:-3.59|P-value:5.25E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.50|P-value:6.96E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.38|P-value:6.14E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.21|P-value:3.05E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.64|P-value:2.58E-4 ID:SGTC_2097|Compound:5376186|FD-Score:6.14|P-value:3.01E-9 ID:SGTC_2237|Compound:6667747|FD-Score:-4.02|P-value:1.14E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.82|P-value:2.38E-6 ID:SGTC_2325|Compound:6158266|FD-Score:3.47|P-value:4.49E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.82|P-value:1.34E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.24|P-value:9.66E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-8.33|P-value:6.17E-15 ID:SGTC_2416|Compound:tofa|FD-Score:-4.76|P-value:6.12E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.86|P-value:1.98E-6 ID:SGTC_2486|Compound:5283202|FD-Score:3.32|P-value:7.53E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.50|P-value:6.99E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.63|P-value:2.59E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.43|P-value:1.27E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.75|P-value:2.96E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-4.16|P-value:6.92E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.47|P-value:4.60E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.57|P-value:3.29E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.57|P-value:5.52E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.40|P-value:3.38E-7 ID:SGTC_3050|Compound:9093513|FD-Score:5.24|P-value:3.30E-7 ID:SGTC_3203|Compound:9113543|FD-Score:3.46|P-value:4.78E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.36|P-value:1.67E-5 ID:SGTC_3238|Compound:9133470|FD-Score:3.98|P-value:7.37E-5 ID:SGTC_3249|Compound:9135183|FD-Score:-3.64|P-value:4.37E-4

Top fitness defect scores for YHR091C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.01 5.3 µM 9.85E-18 220 1.02E-19
2 SGTC_310 1273-0058 8.65 1.1 µM 1.71E-16 mitochondrial stress 71 2.58E-18
3 SGTC_63 0099-0242 7.17 26.7 µM 6.03E-12 mitochondrial stress 15 3.62E-13
4 SGTC_1843 st055809 7.06 45.5 µM 1.28E-11 2 8.49E-13
5 SGTC_1371 2421-0008 6.61 32.7 µM 1.98E-10 mitochondrial processes 4 1.86E-11
6 SGTC_2097 5376186 6.14 200.0 µM 3.01E-9 3 4.02E-10
7 SGTC_173 1273-0061 5.96 2.7 µM 8.52E-9 mitochondrial stress 109 1.30E-9
8 SGTC_1627 st003713 5.46 25.6 µM 1.13E-7 calcium & mitochondrial duress 36 2.38E-8
9 SGTC_3050 9093513 5.24 49.5 µM 3.30E-7 6 7.94E-8
10 SGTC_1012 4112-3522 5.04 18.0 µM 8.73E-7 9 2.37E-7
11 SGTC_68 0986-0284 4.96 82.8 µM 1.25E-6 34 3.55E-7
12 SGTC_2418 pentamidine 4.86 31.7 µM 1.98E-6 mitochondrial processes 26 5.94E-7
13 SGTC_70 0141-0289 4.82 43.3 µM 2.31E-6 mitochondrial stress 118 7.08E-7
14 SGTC_2283 7944793 4.82 200.0 µM 2.38E-6 20 7.33E-7
15 SGTC_163 1327-0036 4.81 7.5 µM 2.46E-6 72 7.61E-7
16 SGTC_134 0269-0018 4.75 6.9 µM 3.21E-6 106 1.02E-6
17 SGTC_1849 st056239 4.59 19.2 µM 6.46E-6 RPP1 & pyrimidine depletion 11 2.24E-6
18 SGTC_2688 kanamycin b 4.43 96.7 µM 1.27E-5 calcium & mitochondrial duress 301 4.77E-6
19 SGTC_3208 9114115 4.36 49.5 µM 1.67E-5 26 6.49E-6
20 SGTC_2084 5306078 4.21 60.6 µM 3.05E-5 13 1.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.347 9.76E-96 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.346 3.41E-95 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.343 4.45E-93 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.332 3.28E-87 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.327 1.38E-84 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.323 1.70E-82 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.317 2.26E-79 YDR332W IRC3 hom Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.317 5.38E-79 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.313 3.73E-77 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.313 4.82E-77 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.311 2.00E-76 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.311 3.43E-76 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.308 9.51E-75 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.306 1.34E-73 YIL060W_p YIL060W_p hom Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene
0.303 4.41E-72 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci