YHR094C / HXT1

Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR094C / HXT1

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.36|P-value:3.79E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.73|P-value:9.17E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:-5.65|P-value:9.46E-9 ID:SGTC_343|Compound:4130-2827|FD-Score:3.56|P-value:1.81E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.80|P-value:6.93E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.41|P-value:3.18E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.34|P-value:4.13E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.35|P-value:3.92E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:4.00|P-value:3.07E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.28|P-value:5.12E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.23|P-value:1.16E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:3.30|P-value:4.65E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.91|P-value:5.08E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.25|P-value:5.70E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.29|P-value:8.88E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.54|P-value:1.94E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.19|P-value:7.66E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.31|P-value:4.57E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.91|P-value:5.14E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.76|P-value:9.46E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.82|P-value:7.52E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.34|P-value:4.58E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.39|P-value:3.86E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.88|P-value:5.16E-5 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.62|P-value:1.65E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.10|P-value:9.53E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.59|P-value:1.61E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.17|P-value:7.44E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.09|P-value:9.83E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-3.95|P-value:4.44E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.38|P-value:3.56E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.36|P-value:4.29E-4 ID:SGTC_2706|Compound:st078239|FD-Score:4.33|P-value:7.36E-6 ID:SGTC_2710|Compound:st078562|FD-Score:-3.56|P-value:2.06E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-4.24|P-value:1.24E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.17|P-value:7.44E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-3.60|P-value:1.76E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.68|P-value:1.15E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.93|P-value:3.96E-7 ID:SGTC_3299|Compound:9121982|FD-Score:5.36|P-value:4.01E-8 ID:SGTC_24|Compound:0417-1663|FD-Score:3.36|P-value:3.79E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.73|P-value:9.17E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:-5.65|P-value:9.46E-9 ID:SGTC_343|Compound:4130-2827|FD-Score:3.56|P-value:1.81E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.80|P-value:6.93E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.41|P-value:3.18E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.34|P-value:4.13E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.35|P-value:3.92E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:4.00|P-value:3.07E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.28|P-value:5.12E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.23|P-value:1.16E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:3.30|P-value:4.65E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.91|P-value:5.08E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.25|P-value:5.70E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.29|P-value:8.88E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.54|P-value:1.94E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.19|P-value:7.66E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.31|P-value:4.57E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.91|P-value:5.14E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.76|P-value:9.46E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.82|P-value:7.52E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.34|P-value:4.58E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.39|P-value:3.86E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.88|P-value:5.16E-5 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.62|P-value:1.65E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.10|P-value:9.53E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.59|P-value:1.61E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.17|P-value:7.44E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.09|P-value:9.83E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-3.95|P-value:4.44E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.38|P-value:3.56E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.36|P-value:4.29E-4 ID:SGTC_2706|Compound:st078239|FD-Score:4.33|P-value:7.36E-6 ID:SGTC_2710|Compound:st078562|FD-Score:-3.56|P-value:2.06E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-4.24|P-value:1.24E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.17|P-value:7.44E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-3.60|P-value:1.76E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.68|P-value:1.15E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.93|P-value:3.96E-7 ID:SGTC_3299|Compound:9121982|FD-Score:5.36|P-value:4.01E-8

Top fitness defect scores for YHR094C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3299 9121982 5.36 43.1 µM 4.01E-8 8 4.06E-8
2 SGTC_3211 9128781 4.93 49.5 µM 3.96E-7 38 4.04E-7
3 SGTC_920 mycophenolic acid 4.76 780.4 nM 9.46E-7 9 9.64E-7
4 SGTC_2706 st078239 4.33 82.5 µM 7.36E-6 3 7.53E-6
5 SGTC_769 0302-0231 4.29 76.0 µM 8.88E-6 28 9.08E-6
6 SGTC_627 1391-0720 4.23 175.0 µM 1.16E-5 9 1.19E-5
7 SGTC_595 3909-8003 4.00 73.7 µM 3.07E-5 11 3.15E-5
8 SGTC_1584 6-fluoro-dl-tryptophan 3.88 90.0 µM 5.16E-5 mitochondrial processes 15 5.29E-5
9 SGTC_346 4513-0042 3.80 7.2 µM 6.93E-5 azole & statin 47 7.11E-5
10 SGTC_166 k072-0058 3.73 166.4 µM 9.17E-5 DNA intercalators 45 9.41E-5
11 SGTC_3125 9127534 3.68 49.5 µM 1.15E-4 16 1.18E-4
12 SGTC_1944 st076371 3.59 56.9 µM 1.61E-4 32 1.66E-4
13 SGTC_343 4130-2827 3.56 29.8 µM 1.81E-4 41 1.86E-4
14 SGTC_801 0866-0028 3.54 10.1 µM 1.94E-4 46 2.00E-4
15 SGTC_527 4476-4215 3.41 268.0 µM 3.18E-4 PDR1 54 3.27E-4
16 SGTC_2289 7946404 3.38 165.1 µM 3.56E-4 118 3.66E-4
17 SGTC_24 0417-1663 3.36 219.0 µM 3.79E-4 35 3.90E-4
18 SGTC_542 3381-0244 3.35 89.3 µM 3.92E-4 65 4.03E-4
19 SGTC_541 4513-1321 3.34 94.0 µM 4.13E-4 39 4.24E-4
20 SGTC_885 0865-0106 3.31 16.8 µM 4.57E-4 TSC3-RPN4 49 4.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.25E-16 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.140 4.36E-16 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
0.120 3.10E-12 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.113 6.33E-11 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.110 2.15E-10 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.108 3.79E-10 YPL183C RTT10 hom WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6
0.096 2.78E-8 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.094 4.60E-8 YLR110C CCW12 hom Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication
0.085 7.33E-7 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.084 1.03E-6 YDR167W TAF10 het Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.084 1.08E-6 YBR061C TRM7 hom 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively
0.082 2.21E-6 YOR166C SWT1 hom RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
0.079 4.12E-6 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.076 9.73E-6 YNL243W SLA2 hom Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo
0.076 9.89E-6 YER039C-A_p YER039C-A_p hom Putative protein of unknown function; YER039C-A is not an essential gene