YHR097C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR097C / YHR097C

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.14|P-value:8.70E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.28|P-value:4.72E-4 ID:SGTC_433|Compound:pimozide|FD-Score:4.13|P-value:1.59E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.11|P-value:8.64E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.74|P-value:8.30E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:5.49|P-value:1.74E-8 ID:SGTC_857|Compound:0438-0306|FD-Score:3.27|P-value:4.89E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.71|P-value:9.30E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:8.83|P-value:3.72E-19 ID:SGTC_965|Compound:1291-5240|FD-Score:3.09|P-value:9.12E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.54|P-value:1.81E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.65|P-value:1.20E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.35|P-value:3.70E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.92|P-value:3.93E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.15|P-value:7.44E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.12|P-value:4.98E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.91|P-value:4.72E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.81|P-value:6.14E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.22|P-value:5.92E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.19|P-value:6.56E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.78|P-value:6.97E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.24|P-value:5.54E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.98|P-value:2.78E-7 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.19|P-value:7.29E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.38|P-value:3.25E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.90|P-value:4.30E-5 ID:SGTC_1636|Compound:st007707|FD-Score:3.77|P-value:7.51E-5 ID:SGTC_1650|Compound:st011916|FD-Score:4.27|P-value:8.63E-6 ID:SGTC_1660|Compound:st012960|FD-Score:4.29|P-value:7.86E-6 ID:SGTC_1671|Compound:st016596|FD-Score:3.30|P-value:4.42E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.47|P-value:2.35E-4 ID:SGTC_1930|Compound:st074634|FD-Score:5.63|P-value:7.68E-9 ID:SGTC_1936|Compound:st074407|FD-Score:3.28|P-value:4.79E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.39|P-value:3.59E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.17|P-value:6.98E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.37|P-value:3.42E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.24|P-value:5.57E-4 ID:SGTC_2153|Compound:5569715|FD-Score:-3.15|P-value:8.54E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.66|P-value:1.12E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.07|P-value:9.83E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.73|P-value:8.67E-5 ID:SGTC_2379|Compound:9035213|FD-Score:4.09|P-value:1.95E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.30|P-value:5.10E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.46|P-value:2.45E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.86|P-value:5.15E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.65|P-value:1.39E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.40|P-value:3.51E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.09|P-value:2.23E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-3.17|P-value:8.06E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.29|P-value:5.21E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.33|P-value:3.91E-4 ID:SGTC_3072|Compound:9116419|FD-Score:4.05|P-value:2.34E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-5.32|P-value:5.51E-8 ID:SGTC_3251|Compound:9135047|FD-Score:3.67|P-value:1.09E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.93|P-value:4.34E-5 ID:SGTC_1|Compound:0258-0098|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.14|P-value:8.70E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.28|P-value:4.72E-4 ID:SGTC_433|Compound:pimozide|FD-Score:4.13|P-value:1.59E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.11|P-value:8.64E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.74|P-value:8.30E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:5.49|P-value:1.74E-8 ID:SGTC_857|Compound:0438-0306|FD-Score:3.27|P-value:4.89E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.71|P-value:9.30E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:8.83|P-value:3.72E-19 ID:SGTC_965|Compound:1291-5240|FD-Score:3.09|P-value:9.12E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.54|P-value:1.81E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.65|P-value:1.20E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.35|P-value:3.70E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.92|P-value:3.93E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.15|P-value:7.44E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.12|P-value:4.98E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.91|P-value:4.72E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.81|P-value:6.14E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.22|P-value:5.92E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.19|P-value:6.56E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.78|P-value:6.97E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.24|P-value:5.54E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.98|P-value:2.78E-7 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.19|P-value:7.29E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.38|P-value:3.25E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.90|P-value:4.30E-5 ID:SGTC_1636|Compound:st007707|FD-Score:3.77|P-value:7.51E-5 ID:SGTC_1650|Compound:st011916|FD-Score:4.27|P-value:8.63E-6 ID:SGTC_1660|Compound:st012960|FD-Score:4.29|P-value:7.86E-6 ID:SGTC_1671|Compound:st016596|FD-Score:3.30|P-value:4.42E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.47|P-value:2.35E-4 ID:SGTC_1930|Compound:st074634|FD-Score:5.63|P-value:7.68E-9 ID:SGTC_1936|Compound:st074407|FD-Score:3.28|P-value:4.79E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.39|P-value:3.59E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.17|P-value:6.98E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.37|P-value:3.42E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.24|P-value:5.57E-4 ID:SGTC_2153|Compound:5569715|FD-Score:-3.15|P-value:8.54E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.66|P-value:1.12E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.07|P-value:9.83E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.73|P-value:8.67E-5 ID:SGTC_2379|Compound:9035213|FD-Score:4.09|P-value:1.95E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.30|P-value:5.10E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.46|P-value:2.45E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.86|P-value:5.15E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.65|P-value:1.39E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.40|P-value:3.51E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.09|P-value:2.23E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-3.17|P-value:8.06E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.29|P-value:5.21E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.33|P-value:3.91E-4 ID:SGTC_3072|Compound:9116419|FD-Score:4.05|P-value:2.34E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-5.32|P-value:5.51E-8 ID:SGTC_3251|Compound:9135047|FD-Score:3.67|P-value:1.09E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.93|P-value:4.34E-5

Top fitness defect scores for YHR097C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_963 1269-2853 8.83 151.0 µM 3.72E-19 1 5.13E-19
2 SGTC_1930 st074634 5.63 34.3 µM 7.68E-9 RNA pol III & RNase P/MRP 13 9.10E-9
3 SGTC_739 1486-1183 5.49 203.0 µM 1.74E-8 4 2.05E-8
4 SGTC_1362 1611-0397 4.98 101.0 µM 2.78E-7 5 3.21E-7
5 SGTC_1660 st012960 4.29 28.1 µM 7.86E-6 iron homeostasis 28 8.86E-6
6 SGTC_1650 st011916 4.27 45.8 µM 8.63E-6 8 9.72E-6
7 SGTC_433 pimozide 4.13 108.0 µM 1.59E-5 14 1.79E-5
8 SGTC_2379 9035213 4.09 200.0 µM 1.95E-5 17 2.18E-5
9 SGTC_3072 9116419 4.05 49.5 µM 2.34E-5 ERG2 13 2.61E-5
10 SGTC_1076 itraconazole 3.92 331.0 nM 3.93E-5 35 4.38E-5
11 SGTC_1541 2',3',6-trimethoxyflavone 3.90 64.0 µM 4.30E-5 13 4.79E-5
12 SGTC_2539 epi(13)torulosol 3.86 80.0 µM 5.15E-5 29 5.72E-5
13 SGTC_1201 1889-3372 3.81 45.9 µM 6.14E-5 Golgi 12 6.81E-5
14 SGTC_1301 naphtanilide LB 3.78 4.8 µM 6.97E-5 heme requiring 11 7.72E-5
15 SGTC_1636 st007707 3.77 68.9 µM 7.51E-5 54 8.32E-5
16 SGTC_645 0845-0943 3.74 5.4 µM 8.30E-5 60S ribosome export 13 9.18E-5
17 SGTC_2339 9000433 3.73 200.0 µM 8.67E-5 45 9.59E-5
18 SGTC_881 0833-0569 3.71 170.0 µM 9.30E-5 41 1.03E-4
19 SGTC_3251 9135047 3.67 49.5 µM 1.09E-4 60S ribosome export 8 1.20E-4
20 SGTC_2238 6671620 3.66 73.2 µM 1.12E-4 38 1.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.75E-12 YIR038C GTT1 hom ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
0.115 2.85E-11 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.110 1.88E-10 YNL305C BXI1 hom Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
0.107 4.99E-10 YNR056C BIO5 hom Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.096 2.29E-8 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.096 2.48E-8 YLL051C FRE6 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
0.095 3.43E-8 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.086 6.58E-7 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.085 8.50E-7 YMR160W YMR160W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress
0.080 3.18E-6 YCL069W VBA3 hom Permease of basic amino acids in the vacuolar membrane
0.080 3.46E-6 YOR177C MPC54 hom Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
0.079 4.17E-6 YJR025C BNA1 hom 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.079 4.76E-6 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.076 1.08E-5 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.074 1.57E-5 YKR066C CCP1 hom Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress