YHR098C / SFB3

Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR098C / SFB3

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.05|P-value:1.06E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.96|P-value:1.43E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.73|P-value:3.12E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.50|P-value:6.49E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:10.50|P-value:1.33E-21 ID:SGTC_51|Compound:1013-0126|FD-Score:12.40|P-value:1.31E-29 ID:SGTC_70|Compound:0141-0289|FD-Score:7.16|P-value:4.14E-11 ID:SGTC_74|Compound:000s-0487|FD-Score:7.71|P-value:1.39E-12 ID:SGTC_79|Compound:0052-0007|FD-Score:5.31|P-value:6.45E-7 ID:SGTC_89|Compound:0302-0250|FD-Score:8.12|P-value:9.33E-14 ID:SGTC_109|Compound:0132-0036|FD-Score:3.86|P-value:1.98E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.54|P-value:1.69E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:7.09|P-value:6.01E-11 ID:SGTC_153|Compound:4077-0274|FD-Score:4.59|P-value:1.39E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:4.61|P-value:1.27E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:3.41|P-value:8.58E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.59|P-value:1.37E-5 ID:SGTC_209|Compound:4077-0173|FD-Score:7.38|P-value:1.07E-11 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.65|P-value:4.08E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.85|P-value:4.87E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:12.60|P-value:1.93E-30 ID:SGTC_327|Compound:1273-0057|FD-Score:-4.24|P-value:9.73E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:4.36|P-value:3.39E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:7.46|P-value:6.39E-12 ID:SGTC_634|Compound:1611-4317|FD-Score:7.40|P-value:9.26E-12 ID:SGTC_787|Compound:4152-0075|FD-Score:9.21|P-value:3.83E-17 ID:SGTC_821|Compound:1114-0266|FD-Score:3.45|P-value:7.58E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:5.70|P-value:1.08E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:3.84|P-value:2.18E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.90|P-value:1.76E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.82|P-value:4.01E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:20.60|P-value:2.45E-77 ID:SGTC_989|Compound:1501-0895|FD-Score:4.09|P-value:8.97E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.38|P-value:5.77E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.03|P-value:1.12E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.98|P-value:1.34E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.88|P-value:1.88E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.69|P-value:9.38E-6 ID:SGTC_1618|Compound:st003135|FD-Score:4.04|P-value:1.07E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.89|P-value:3.25E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.99|P-value:1.29E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.69|P-value:3.60E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.42|P-value:8.48E-4 ID:SGTC_1921|Compound:5740136|FD-Score:7.61|P-value:2.51E-12 ID:SGTC_1955|Compound:wogonin|FD-Score:3.50|P-value:6.51E-4 ID:SGTC_1961|Compound:st076550|FD-Score:5.54|P-value:2.30E-7 ID:SGTC_2025|Compound:5147754|FD-Score:3.71|P-value:3.34E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.60|P-value:4.83E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.47|P-value:3.08E-7 ID:SGTC_2102|Compound:5377816|FD-Score:3.71|P-value:3.37E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-4.55|P-value:3.09E-5 ID:SGTC_2276|Compound:7947513|FD-Score:4.60|P-value:1.35E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-4.81|P-value:1.12E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.64|P-value:4.19E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.51|P-value:6.38E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.43|P-value:8.17E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.89|P-value:1.84E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.50|P-value:1.99E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:4.14|P-value:7.70E-5 ID:SGTC_2745|Compound:rifampicin|FD-Score:3.68|P-value:3.69E-4 ID:SGTC_2790|Compound:5423970|FD-Score:11.90|P-value:3.88E-27 ID:SGTC_2796|Compound:7949634|FD-Score:-4.58|P-value:2.77E-5 ID:SGTC_2819|Compound:7996655|FD-Score:4.29|P-value:4.29E-5 ID:SGTC_2826|Compound:7992541|FD-Score:-3.81|P-value:4.15E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.60|P-value:1.33E-5 ID:SGTC_3090|Compound:9117696|FD-Score:3.37|P-value:9.60E-4 ID:SGTC_3179|Compound:9107801|FD-Score:4.21|P-value:5.88E-5 ID:SGTC_3355|Compound:9151058|FD-Score:3.68|P-value:3.63E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.05|P-value:1.06E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.96|P-value:1.43E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.73|P-value:3.12E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.50|P-value:6.49E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:10.50|P-value:1.33E-21 ID:SGTC_51|Compound:1013-0126|FD-Score:12.40|P-value:1.31E-29 ID:SGTC_70|Compound:0141-0289|FD-Score:7.16|P-value:4.14E-11 ID:SGTC_74|Compound:000s-0487|FD-Score:7.71|P-value:1.39E-12 ID:SGTC_79|Compound:0052-0007|FD-Score:5.31|P-value:6.45E-7 ID:SGTC_89|Compound:0302-0250|FD-Score:8.12|P-value:9.33E-14 ID:SGTC_109|Compound:0132-0036|FD-Score:3.86|P-value:1.98E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.54|P-value:1.69E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:7.09|P-value:6.01E-11 ID:SGTC_153|Compound:4077-0274|FD-Score:4.59|P-value:1.39E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:4.61|P-value:1.27E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:3.41|P-value:8.58E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.59|P-value:1.37E-5 ID:SGTC_209|Compound:4077-0173|FD-Score:7.38|P-value:1.07E-11 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.65|P-value:4.08E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.85|P-value:4.87E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:12.60|P-value:1.93E-30 ID:SGTC_327|Compound:1273-0057|FD-Score:-4.24|P-value:9.73E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:4.36|P-value:3.39E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:7.46|P-value:6.39E-12 ID:SGTC_634|Compound:1611-4317|FD-Score:7.40|P-value:9.26E-12 ID:SGTC_787|Compound:4152-0075|FD-Score:9.21|P-value:3.83E-17 ID:SGTC_821|Compound:1114-0266|FD-Score:3.45|P-value:7.58E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:5.70|P-value:1.08E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:3.84|P-value:2.18E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.90|P-value:1.76E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.82|P-value:4.01E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:20.60|P-value:2.45E-77 ID:SGTC_989|Compound:1501-0895|FD-Score:4.09|P-value:8.97E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.38|P-value:5.77E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.03|P-value:1.12E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.98|P-value:1.34E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.88|P-value:1.88E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.69|P-value:9.38E-6 ID:SGTC_1618|Compound:st003135|FD-Score:4.04|P-value:1.07E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.89|P-value:3.25E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.99|P-value:1.29E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.69|P-value:3.60E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.42|P-value:8.48E-4 ID:SGTC_1921|Compound:5740136|FD-Score:7.61|P-value:2.51E-12 ID:SGTC_1955|Compound:wogonin|FD-Score:3.50|P-value:6.51E-4 ID:SGTC_1961|Compound:st076550|FD-Score:5.54|P-value:2.30E-7 ID:SGTC_2025|Compound:5147754|FD-Score:3.71|P-value:3.34E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.60|P-value:4.83E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.47|P-value:3.08E-7 ID:SGTC_2102|Compound:5377816|FD-Score:3.71|P-value:3.37E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-4.55|P-value:3.09E-5 ID:SGTC_2276|Compound:7947513|FD-Score:4.60|P-value:1.35E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-4.81|P-value:1.12E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.64|P-value:4.19E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.51|P-value:6.38E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.43|P-value:8.17E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.89|P-value:1.84E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.50|P-value:1.99E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:4.14|P-value:7.70E-5 ID:SGTC_2745|Compound:rifampicin|FD-Score:3.68|P-value:3.69E-4 ID:SGTC_2790|Compound:5423970|FD-Score:11.90|P-value:3.88E-27 ID:SGTC_2796|Compound:7949634|FD-Score:-4.58|P-value:2.77E-5 ID:SGTC_2819|Compound:7996655|FD-Score:4.29|P-value:4.29E-5 ID:SGTC_2826|Compound:7992541|FD-Score:-3.81|P-value:4.15E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.60|P-value:1.33E-5 ID:SGTC_3090|Compound:9117696|FD-Score:3.37|P-value:9.60E-4 ID:SGTC_3179|Compound:9107801|FD-Score:4.21|P-value:5.88E-5 ID:SGTC_3355|Compound:9151058|FD-Score:3.68|P-value:3.63E-4

Top fitness defect scores for YHR098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_983 1491-0821 20.60 12.2 µM 2.45E-77 1 7.75E-95
2 SGTC_307 1501-1223 12.60 22.3 µM 1.93E-30 1 6.89E-37
3 SGTC_51 1013-0126 12.40 23.4 µM 1.31E-29 5 7.33E-36
4 SGTC_2790 5423970 11.90 71.4 µM 3.88E-27 endomembrane recycling 5 8.16E-33
5 SGTC_50 0929-0078 10.50 56.4 µM 1.33E-21 6 5.33E-26
6 SGTC_787 4152-0075 9.21 138.0 µM 3.83E-17 1 1.63E-20
7 SGTC_89 0302-0250 8.12 142.1 µM 9.33E-14 2 2.34E-16
8 SGTC_74 000s-0487 7.71 160.3 µM 1.39E-12 2 6.46E-15
9 SGTC_1921 5740136 7.61 50.0 µM 2.51E-12 TRP & mitochondrial translation 5 1.32E-14
10 SGTC_592 k241-0073 7.46 46.5 µM 6.39E-12 4 4.17E-14
11 SGTC_634 1611-4317 7.40 11.2 µM 9.26E-12 ERG2 5 6.57E-14
12 SGTC_209 4077-0173 7.38 175.6 µM 1.07E-11 3 7.86E-14
13 SGTC_70 0141-0289 7.16 43.3 µM 4.14E-11 mitochondrial stress 52 4.11E-13
14 SGTC_124 0136-0217 7.09 7.1 µM 6.01E-11 mitochondrial stress 16 6.48E-13
15 SGTC_855 0428-0020 5.70 25.0 µM 1.08E-7 Golgi 4 6.15E-9
16 SGTC_1961 st076550 5.54 68.7 µM 2.30E-7 5 1.53E-8
17 SGTC_2056 5235370 5.47 200.0 µM 3.08E-7 18 2.19E-8
18 SGTC_79 0052-0007 5.31 94.1 µM 6.45E-7 16 5.38E-8
19 SGTC_275 trichlorophene 4.85 5.7 µM 4.87E-6 mitochondrial stress 177 6.27E-7
20 SGTC_1617 st002906 4.69 78.0 µM 9.38E-6 18 1.39E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 1.58E-32 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.141 2.63E-16 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.140 4.63E-16 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.133 8.38E-15 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.124 5.84E-13 YGL007W_d BRP1_d hom Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
0.121 2.04E-12 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.119 5.09E-12 YDL193W NUS1 het Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY
0.115 2.86E-11 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 7.29E-11 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.112 7.73E-11 YMR216C SKY1 hom SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
0.111 1.05E-10 YJR144W MGM101 hom Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
0.111 1.08E-10 YHL004W MRP4 hom Mitochondrial ribosomal protein of the small subunit
0.110 2.01E-10 YBR002C RER2 het Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
0.107 5.75E-10 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.103 1.88E-9 YOL066C RIB2 het Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs