YHR100C / GEP4

Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR100C / GEP4

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:5.84|P-value:3.35E-6 ID:SGTC_23|Compound:0213-0011|FD-Score:-4.19|P-value:5.00E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.41|P-value:3.81E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.41|P-value:3.47E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:8.25|P-value:8.77E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:5.46|P-value:1.27E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:4.26|P-value:5.20E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.74|P-value:1.30E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.69|P-value:1.51E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:6.14|P-value:1.06E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:5.14|P-value:3.70E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:7.59|P-value:2.21E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:7.68|P-value:1.44E-9 ID:SGTC_141|Compound:0443-0274|FD-Score:9.44|P-value:1.38E-13 ID:SGTC_142|Compound:0335-0849|FD-Score:4.95|P-value:6.95E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:5.26|P-value:2.48E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.26|P-value:4.18E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:5.69|P-value:5.64E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:-4.17|P-value:5.38E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.51|P-value:2.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:24.90|P-value:1.62E-83 ID:SGTC_245|Compound:methotrexate|FD-Score:-3.97|P-value:9.05E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:6.18|P-value:9.42E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:5.78|P-value:4.13E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:4.58|P-value:2.08E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.66|P-value:1.68E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.44|P-value:2.45E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:-4.47|P-value:2.26E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-4.14|P-value:5.75E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.35|P-value:3.21E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-5.54|P-value:7.12E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:6.91|P-value:4.77E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:-11.90|P-value:1.20E-20 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.11|P-value:6.33E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.10|P-value:8.18E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.78|P-value:8.86E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.74|P-value:1.00E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.37|P-value:3.07E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:4.05|P-value:9.23E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.30|P-value:4.66E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.98|P-value:6.23E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:4.59|P-value:2.06E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:7.36|P-value:6.58E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:5.50|P-value:1.13E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:4.32|P-value:4.42E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:-4.15|P-value:5.69E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.74|P-value:1.31E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.41|P-value:3.49E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:5.81|P-value:3.75E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:5.11|P-value:4.16E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:4.71|P-value:1.45E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.57|P-value:2.19E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:8.22|P-value:1.06E-10 ID:SGTC_985|Compound:1493-0307|FD-Score:4.47|P-value:2.88E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:5.58|P-value:8.35E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.80|P-value:1.11E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.88|P-value:8.55E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.37|P-value:1.73E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.18|P-value:6.48E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.49|P-value:2.72E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-4.58|P-value:1.65E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.84|P-value:9.50E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.86|P-value:3.12E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.52|P-value:2.37E-7 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.85|P-value:9.37E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.43|P-value:3.26E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:5.08|P-value:4.46E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:5.52|P-value:1.05E-5 ID:SGTC_1635|Compound:st007035|FD-Score:6.25|P-value:7.03E-7 ID:SGTC_1696|Compound:st025591|FD-Score:4.87|P-value:8.76E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-9.17|P-value:4.00E-13 ID:SGTC_1723|Compound:st034307|FD-Score:4.20|P-value:6.26E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.05|P-value:7.46E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.79|P-value:2.94E-6 ID:SGTC_1952|Compound:st077036|FD-Score:4.86|P-value:8.96E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.97|P-value:6.45E-5 ID:SGTC_1978|Compound:st071761|FD-Score:6.58|P-value:1.88E-7 ID:SGTC_1981|Compound:st071826|FD-Score:-4.03|P-value:7.88E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.85|P-value:9.30E-5 ID:SGTC_2013|Compound:4024628|FD-Score:4.43|P-value:3.25E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-6.18|P-value:6.75E-7 ID:SGTC_2084|Compound:5306078|FD-Score:4.13|P-value:7.50E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.15|P-value:7.13E-4 ID:SGTC_2166|Compound:5933061|FD-Score:6.84|P-value:6.31E-8 ID:SGTC_2177|Compound:5811945|FD-Score:5.19|P-value:3.21E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.46|P-value:2.98E-4 ID:SGTC_2356|Compound:9061756|FD-Score:5.36|P-value:1.80E-5 ID:SGTC_2366|Compound:9070441|FD-Score:5.16|P-value:3.47E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-4.02|P-value:7.99E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.25|P-value:5.31E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:10.40|P-value:4.19E-16 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.53|P-value:2.43E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.99|P-value:1.90E-6 ID:SGTC_2430|Compound:5571206|FD-Score:4.28|P-value:4.94E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:7.94|P-value:4.24E-10 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.40|P-value:3.52E-4 ID:SGTC_2526|Compound:patulin|FD-Score:8.81|P-value:4.66E-12 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:5.21|P-value:2.98E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.65|P-value:1.72E-4 ID:SGTC_2701|Compound:st077767|FD-Score:5.74|P-value:4.76E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:7.72|P-value:1.20E-9 ID:SGTC_2867|Compound:9039098|FD-Score:-5.39|P-value:1.21E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-8.80|P-value:3.18E-12 ID:SGTC_3062|Compound:9077494|FD-Score:4.17|P-value:6.74E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.76|P-value:9.40E-5 ID:SGTC_3225|Compound:9130819|FD-Score:4.65|P-value:1.73E-4 ID:SGTC_3236|Compound:9132701|FD-Score:4.02|P-value:9.85E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.66|P-value:1.66E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:5.84|P-value:3.35E-6 ID:SGTC_23|Compound:0213-0011|FD-Score:-4.19|P-value:5.00E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.41|P-value:3.81E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.41|P-value:3.47E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:8.25|P-value:8.77E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:5.46|P-value:1.27E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:4.26|P-value:5.20E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.74|P-value:1.30E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.69|P-value:1.51E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:6.14|P-value:1.06E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:5.14|P-value:3.70E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:7.59|P-value:2.21E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:7.68|P-value:1.44E-9 ID:SGTC_141|Compound:0443-0274|FD-Score:9.44|P-value:1.38E-13 ID:SGTC_142|Compound:0335-0849|FD-Score:4.95|P-value:6.95E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:5.26|P-value:2.48E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.26|P-value:4.18E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:5.69|P-value:5.64E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:-4.17|P-value:5.38E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.51|P-value:2.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:24.90|P-value:1.62E-83 ID:SGTC_245|Compound:methotrexate|FD-Score:-3.97|P-value:9.05E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:6.18|P-value:9.42E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:5.78|P-value:4.13E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:4.58|P-value:2.08E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.66|P-value:1.68E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.44|P-value:2.45E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:-4.47|P-value:2.26E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-4.14|P-value:5.75E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.35|P-value:3.21E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-5.54|P-value:7.12E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:6.91|P-value:4.77E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:-11.90|P-value:1.20E-20 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.11|P-value:6.33E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.10|P-value:8.18E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.78|P-value:8.86E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.74|P-value:1.00E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.37|P-value:3.07E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:4.05|P-value:9.23E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.30|P-value:4.66E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.98|P-value:6.23E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:4.59|P-value:2.06E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:7.36|P-value:6.58E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:5.50|P-value:1.13E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:4.32|P-value:4.42E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:-4.15|P-value:5.69E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.74|P-value:1.31E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.41|P-value:3.49E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:5.81|P-value:3.75E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:5.11|P-value:4.16E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:4.71|P-value:1.45E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.57|P-value:2.19E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:8.22|P-value:1.06E-10 ID:SGTC_985|Compound:1493-0307|FD-Score:4.47|P-value:2.88E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:5.58|P-value:8.35E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.80|P-value:1.11E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.88|P-value:8.55E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.37|P-value:1.73E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.18|P-value:6.48E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.49|P-value:2.72E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-4.58|P-value:1.65E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.84|P-value:9.50E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.86|P-value:3.12E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.52|P-value:2.37E-7 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.85|P-value:9.37E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.43|P-value:3.26E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:5.08|P-value:4.46E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:5.52|P-value:1.05E-5 ID:SGTC_1635|Compound:st007035|FD-Score:6.25|P-value:7.03E-7 ID:SGTC_1696|Compound:st025591|FD-Score:4.87|P-value:8.76E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-9.17|P-value:4.00E-13 ID:SGTC_1723|Compound:st034307|FD-Score:4.20|P-value:6.26E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-4.05|P-value:7.46E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.79|P-value:2.94E-6 ID:SGTC_1952|Compound:st077036|FD-Score:4.86|P-value:8.96E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.97|P-value:6.45E-5 ID:SGTC_1978|Compound:st071761|FD-Score:6.58|P-value:1.88E-7 ID:SGTC_1981|Compound:st071826|FD-Score:-4.03|P-value:7.88E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.85|P-value:9.30E-5 ID:SGTC_2013|Compound:4024628|FD-Score:4.43|P-value:3.25E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-6.18|P-value:6.75E-7 ID:SGTC_2084|Compound:5306078|FD-Score:4.13|P-value:7.50E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.15|P-value:7.13E-4 ID:SGTC_2166|Compound:5933061|FD-Score:6.84|P-value:6.31E-8 ID:SGTC_2177|Compound:5811945|FD-Score:5.19|P-value:3.21E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.46|P-value:2.98E-4 ID:SGTC_2356|Compound:9061756|FD-Score:5.36|P-value:1.80E-5 ID:SGTC_2366|Compound:9070441|FD-Score:5.16|P-value:3.47E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-4.02|P-value:7.99E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.25|P-value:5.31E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:10.40|P-value:4.19E-16 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.53|P-value:2.43E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.99|P-value:1.90E-6 ID:SGTC_2430|Compound:5571206|FD-Score:4.28|P-value:4.94E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:7.94|P-value:4.24E-10 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.40|P-value:3.52E-4 ID:SGTC_2526|Compound:patulin|FD-Score:8.81|P-value:4.66E-12 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:5.21|P-value:2.98E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.65|P-value:1.72E-4 ID:SGTC_2701|Compound:st077767|FD-Score:5.74|P-value:4.76E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:7.72|P-value:1.20E-9 ID:SGTC_2867|Compound:9039098|FD-Score:-5.39|P-value:1.21E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-8.80|P-value:3.18E-12 ID:SGTC_3062|Compound:9077494|FD-Score:4.17|P-value:6.74E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.76|P-value:9.40E-5 ID:SGTC_3225|Compound:9130819|FD-Score:4.65|P-value:1.73E-4 ID:SGTC_3236|Compound:9132701|FD-Score:4.02|P-value:9.85E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.66|P-value:1.66E-4

Top fitness defect scores for YHR100C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 24.90 5.3 µM 1.62E-83 32 2.58E-137
2 SGTC_2405 ticlatone 10.40 3.5 µM 4.19E-16 10 1.23E-25
3 SGTC_141 0443-0274 9.44 32.3 µM 1.38E-13 mitochondrial response to ROS 6 1.79E-21
4 SGTC_2526 patulin 8.81 37.6 µM 4.66E-12 11 5.99E-19
5 SGTC_63 0099-0242 8.25 26.7 µM 8.77E-11 mitochondrial stress 8 7.60E-17
6 SGTC_966 1300-0360 8.22 30.2 µM 1.06E-10 heme requiring 3 1.03E-16
7 SGTC_2513 baicalein 7.94 25.6 µM 4.24E-10 calcium & mitochondrial duress 4 1.02E-15
8 SGTC_2743 auranofin 7.72 4.3 µM 1.20E-9 RPP1 & pyrimidine depletion 4 5.69E-15
9 SGTC_120 rhodamine 6G 7.68 52.3 µM 1.44E-9 mitochondrial processes 5 7.72E-15
10 SGTC_116 0155-0182 7.59 31.8 µM 2.21E-9 mitochondrial response to ROS 13 1.56E-14
11 SGTC_778 3456-2434 7.36 196.0 µM 6.58E-9 mitochondrial response to ROS 12 9.39E-14
12 SGTC_428 3448-4153 6.91 16.5 µM 4.77E-8 TSC3-RPN4 5 2.45E-12
13 SGTC_2166 5933061 6.84 31.5 µM 6.31E-8 tubulin folding & SWR complex 9 3.88E-12
14 SGTC_1978 st071761 6.58 42.0 µM 1.88E-7 TSC3-RPN4 3 2.33E-11
15 SGTC_1353 1498-1206 6.52 8.1 µM 2.37E-7 mitochondrial response to ROS 12 3.42E-11
16 SGTC_28 pentachloropyridine N-oxide 6.41 1.6 µM 3.81E-7 TSC3-RPN4 11 7.48E-11
17 SGTC_1635 st007035 6.25 42.4 µM 7.03E-7 134 2.04E-10
18 SGTC_283 0987-0079 6.18 11.7 µM 9.42E-7 4 3.30E-10
19 SGTC_113 0099-0221 6.14 2.5 µM 1.06E-6 3 4.03E-10
20 SGTC_2418 pentamidine 5.99 31.7 µM 1.90E-6 mitochondrial processes 15 1.04E-9

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Cofit Genes
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Correlation pval ORF Gene Zygosity Description
0.341 1.05E-91 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.322 1.19E-81 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.319 3.77E-80 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.319 4.99E-80 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.319 5.96E-80 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.315 7.59E-78 YOR211C MGM1 hom Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy
0.314 2.16E-77 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.308 1.03E-74 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.307 4.11E-74 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.307 4.68E-74 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.305 4.03E-73 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.304 1.61E-72 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.302 8.32E-72 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.298 1.33E-69 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.297 2.82E-69 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene