YHR103W / SBE22

Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR103W / SBE22

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.21|P-value:1.64E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.96|P-value:4.66E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.64|P-value:1.61E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.53|P-value:2.45E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:4.83|P-value:9.26E-7 ID:SGTC_182|Compound:3448-4371|FD-Score:3.21|P-value:7.74E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.28|P-value:1.15E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.38|P-value:5.36E-8 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.38|P-value:4.17E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.46|P-value:5.30E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:5.39|P-value:5.05E-8 ID:SGTC_620|Compound:0109-0052|FD-Score:4.30|P-value:1.09E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:3.86|P-value:6.85E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.14|P-value:9.69E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:6.31|P-value:2.32E-10 ID:SGTC_721|Compound:1187-1332|FD-Score:6.70|P-value:1.89E-11 ID:SGTC_722|Compound:3534-0461|FD-Score:10.30|P-value:2.11E-24 ID:SGTC_725|Compound:1497-0963|FD-Score:10.60|P-value:5.07E-26 ID:SGTC_728|Compound:3030-5151|FD-Score:-5.74|P-value:7.00E-9 ID:SGTC_878|Compound:0828-0289|FD-Score:3.37|P-value:4.36E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.44|P-value:5.70E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.32|P-value:5.33E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.54|P-value:2.34E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.20|P-value:1.67E-5 ID:SGTC_1625|Compound:st003711|FD-Score:3.85|P-value:7.23E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.69|P-value:1.86E-6 ID:SGTC_1707|Compound:st032323|FD-Score:3.17|P-value:8.84E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.83|P-value:7.73E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-6.07|P-value:9.91E-10 ID:SGTC_1842|Compound:st055362|FD-Score:-3.95|P-value:4.79E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.96|P-value:4.56E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.22|P-value:7.34E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-6.22|P-value:3.91E-10 ID:SGTC_1913|Compound:st060213|FD-Score:11.00|P-value:8.21E-28 ID:SGTC_2092|Compound:5303694|FD-Score:3.48|P-value:3.00E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.55|P-value:3.51E-6 ID:SGTC_2166|Compound:5933061|FD-Score:-3.27|P-value:6.08E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.27|P-value:1.19E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.25|P-value:6.58E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.21|P-value:7.59E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.58|P-value:2.04E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.70|P-value:2.24E-31 ID:SGTC_2585|Compound:alliin|FD-Score:3.21|P-value:7.77E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.18|P-value:8.50E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.16|P-value:2.01E-5 ID:SGTC_2650|Compound:prasterone|FD-Score:4.39|P-value:7.38E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.16|P-value:1.73E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.40|P-value:3.94E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.29|P-value:5.72E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.71|P-value:1.23E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.22|P-value:7.36E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.34|P-value:4.83E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.81|P-value:8.33E-5 ID:SGTC_3225|Compound:9130819|FD-Score:3.39|P-value:4.07E-4 ID:SGTC_3234|Compound:9132280|FD-Score:6.40|P-value:1.32E-10 ID:SGTC_3299|Compound:9121982|FD-Score:4.37|P-value:8.03E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:4.21|P-value:1.64E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.96|P-value:4.66E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.64|P-value:1.61E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.53|P-value:2.45E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:4.83|P-value:9.26E-7 ID:SGTC_182|Compound:3448-4371|FD-Score:3.21|P-value:7.74E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.28|P-value:1.15E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.38|P-value:5.36E-8 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.38|P-value:4.17E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.46|P-value:5.30E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:5.39|P-value:5.05E-8 ID:SGTC_620|Compound:0109-0052|FD-Score:4.30|P-value:1.09E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:3.86|P-value:6.85E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.14|P-value:9.69E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:6.31|P-value:2.32E-10 ID:SGTC_721|Compound:1187-1332|FD-Score:6.70|P-value:1.89E-11 ID:SGTC_722|Compound:3534-0461|FD-Score:10.30|P-value:2.11E-24 ID:SGTC_725|Compound:1497-0963|FD-Score:10.60|P-value:5.07E-26 ID:SGTC_728|Compound:3030-5151|FD-Score:-5.74|P-value:7.00E-9 ID:SGTC_878|Compound:0828-0289|FD-Score:3.37|P-value:4.36E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.44|P-value:5.70E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.32|P-value:5.33E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.54|P-value:2.34E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.20|P-value:1.67E-5 ID:SGTC_1625|Compound:st003711|FD-Score:3.85|P-value:7.23E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.69|P-value:1.86E-6 ID:SGTC_1707|Compound:st032323|FD-Score:3.17|P-value:8.84E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.83|P-value:7.73E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-6.07|P-value:9.91E-10 ID:SGTC_1842|Compound:st055362|FD-Score:-3.95|P-value:4.79E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.96|P-value:4.56E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.22|P-value:7.34E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-6.22|P-value:3.91E-10 ID:SGTC_1913|Compound:st060213|FD-Score:11.00|P-value:8.21E-28 ID:SGTC_2092|Compound:5303694|FD-Score:3.48|P-value:3.00E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.55|P-value:3.51E-6 ID:SGTC_2166|Compound:5933061|FD-Score:-3.27|P-value:6.08E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.27|P-value:1.19E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.25|P-value:6.58E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.21|P-value:7.59E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.58|P-value:2.04E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.70|P-value:2.24E-31 ID:SGTC_2585|Compound:alliin|FD-Score:3.21|P-value:7.77E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.18|P-value:8.50E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.16|P-value:2.01E-5 ID:SGTC_2650|Compound:prasterone|FD-Score:4.39|P-value:7.38E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.16|P-value:1.73E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.40|P-value:3.94E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.29|P-value:5.72E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.71|P-value:1.23E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.22|P-value:7.36E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.34|P-value:4.83E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.81|P-value:8.33E-5 ID:SGTC_3225|Compound:9130819|FD-Score:3.39|P-value:4.07E-4 ID:SGTC_3234|Compound:9132280|FD-Score:6.40|P-value:1.32E-10 ID:SGTC_3299|Compound:9121982|FD-Score:4.37|P-value:8.03E-6

Top fitness defect scores for YHR103W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 11.70 100.0 µM 2.24E-31 redox potentiating 42 4.15E-32
2 SGTC_1913 st060213 11.00 96.1 µM 8.21E-28 1 1.86E-28
3 SGTC_725 1497-0963 10.60 19.0 µM 5.07E-26 copper-dependent oxidative stress 2 1.27E-26
4 SGTC_722 3534-0461 10.30 190.0 µM 2.11E-24 PDR1 1 5.78E-25
5 SGTC_721 1187-1332 6.70 279.0 µM 1.89E-11 cell wall signaling 3 1.07E-11
6 SGTC_3234 9132280 6.40 49.5 µM 1.32E-10 1 7.88E-11
7 SGTC_713 1488-1073 6.31 324.0 µM 2.32E-10 ERG2 4 1.40E-10
8 SGTC_558 k064-0027 5.39 21.3 µM 5.05E-8 DNA damage response 9 3.47E-8
9 SGTC_2651 1327-0036 5.16 5.0 µM 1.73E-7 103 1.23E-7
10 SGTC_169 k015-0017 4.83 16.0 µM 9.26E-7 12 6.84E-7
11 SGTC_1636 st007707 4.69 68.9 µM 1.86E-6 35 1.39E-6
12 SGTC_2111 5486399 4.55 200.0 µM 3.51E-6 29 2.68E-6
13 SGTC_427 1354-0053 4.46 47.3 µM 5.30E-6 9 4.08E-6
14 SGTC_1043 0916-0009 4.44 19.3 µM 5.70E-6 14 4.40E-6
15 SGTC_2650 prasterone 4.39 100.0 µM 7.38E-6 14 5.73E-6
16 SGTC_3299 9121982 4.37 43.1 µM 8.03E-6 16 6.25E-6
17 SGTC_620 0109-0052 4.30 432.0 µM 1.09E-5 11 8.50E-6
18 SGTC_58 0957-0393 4.21 9.0 µM 1.64E-5 cell wall 356 1.30E-5
19 SGTC_1606 st000094 4.20 49.2 µM 1.67E-5 60S ribosome export 12 1.32E-5
20 SGTC_2648 atorvastatin 4.16 78.7 µM 2.01E-5 azole & statin 22 1.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 1.90E-49 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.209 1.46E-34 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.199 2.40E-31 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.192 3.80E-29 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.186 1.47E-27 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.185 4.20E-27 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.182 2.38E-26 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.175 2.00E-24 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.171 2.21E-23 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.167 1.69E-22 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.165 7.56E-22 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.164 1.02E-21 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.159 2.43E-20 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.158 3.55E-20 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.158 3.63E-20 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication