YHR104W / GRE3

Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR104W / GRE3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.82|P-value:1.48E-19 ID:SGTC_92|Compound:0063-0024|FD-Score:3.59|P-value:1.32E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.49|P-value:3.14E-18 ID:SGTC_138|Compound:0850-0259|FD-Score:3.35|P-value:3.31E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.27|P-value:7.25E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.04|P-value:1.96E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.76|P-value:6.62E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.53|P-value:2.07E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.77|P-value:6.36E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.16|P-value:6.75E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.49|P-value:2.59E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.33|P-value:3.65E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.19|P-value:6.00E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.94|P-value:3.07E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.53|P-value:1.70E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.06|P-value:8.94E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.06|P-value:9.45E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.09|P-value:8.41E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.19|P-value:1.03E-5 ID:SGTC_1659|Compound:st012954|FD-Score:3.15|P-value:6.87E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.43|P-value:2.45E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.55|P-value:1.48E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.37|P-value:3.08E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.79|P-value:5.65E-5 ID:SGTC_1917|Compound:st066507|FD-Score:4.79|P-value:5.73E-7 ID:SGTC_1975|Compound:st070967|FD-Score:4.91|P-value:3.01E-7 ID:SGTC_2036|Compound:5160441|FD-Score:3.79|P-value:5.78E-5 ID:SGTC_2037|Compound:5169046|FD-Score:4.94|P-value:2.63E-7 ID:SGTC_2040|Compound:5100729|FD-Score:3.16|P-value:6.54E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.32|P-value:3.69E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.19|P-value:6.02E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.23|P-value:5.25E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.29|P-value:4.19E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.61|P-value:1.24E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.76|P-value:6.61E-7 ID:SGTC_2486|Compound:5283202|FD-Score:3.62|P-value:1.18E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.11|P-value:7.92E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.46|P-value:2.17E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.83|P-value:4.94E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.05|P-value:9.75E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.57|P-value:1.40E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.81|P-value:5.43E-5 ID:SGTC_2838|Compound:9002687|FD-Score:3.20|P-value:5.87E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.34|P-value:3.33E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.15|P-value:6.84E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.59|P-value:1.28E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.59|P-value:1.30E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.66|P-value:9.50E-5 ID:SGTC_2988|Compound:9073640|FD-Score:4.66|P-value:1.07E-6 ID:SGTC_2991|Compound:9074669|FD-Score:-6.86|P-value:1.42E-12 ID:SGTC_2997|Compound:9067075|FD-Score:4.39|P-value:4.15E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-3.72|P-value:7.40E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.25|P-value:4.78E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.82|P-value:1.48E-19 ID:SGTC_92|Compound:0063-0024|FD-Score:3.59|P-value:1.32E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.49|P-value:3.14E-18 ID:SGTC_138|Compound:0850-0259|FD-Score:3.35|P-value:3.31E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.27|P-value:7.25E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.04|P-value:1.96E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.76|P-value:6.62E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.53|P-value:2.07E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.77|P-value:6.36E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.16|P-value:6.75E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.49|P-value:2.59E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.33|P-value:3.65E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.19|P-value:6.00E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.94|P-value:3.07E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.53|P-value:1.70E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.06|P-value:8.94E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.06|P-value:9.45E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.09|P-value:8.41E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.19|P-value:1.03E-5 ID:SGTC_1659|Compound:st012954|FD-Score:3.15|P-value:6.87E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.43|P-value:2.45E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.55|P-value:1.48E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.37|P-value:3.08E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.79|P-value:5.65E-5 ID:SGTC_1917|Compound:st066507|FD-Score:4.79|P-value:5.73E-7 ID:SGTC_1975|Compound:st070967|FD-Score:4.91|P-value:3.01E-7 ID:SGTC_2036|Compound:5160441|FD-Score:3.79|P-value:5.78E-5 ID:SGTC_2037|Compound:5169046|FD-Score:4.94|P-value:2.63E-7 ID:SGTC_2040|Compound:5100729|FD-Score:3.16|P-value:6.54E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.32|P-value:3.69E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.19|P-value:6.02E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.23|P-value:5.25E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.29|P-value:4.19E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.61|P-value:1.24E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.76|P-value:6.61E-7 ID:SGTC_2486|Compound:5283202|FD-Score:3.62|P-value:1.18E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.11|P-value:7.92E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.46|P-value:2.17E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.83|P-value:4.94E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.05|P-value:9.75E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.57|P-value:1.40E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.81|P-value:5.43E-5 ID:SGTC_2838|Compound:9002687|FD-Score:3.20|P-value:5.87E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.34|P-value:3.33E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.15|P-value:6.84E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.59|P-value:1.28E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.59|P-value:1.30E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.66|P-value:9.50E-5 ID:SGTC_2988|Compound:9073640|FD-Score:4.66|P-value:1.07E-6 ID:SGTC_2991|Compound:9074669|FD-Score:-6.86|P-value:1.42E-12 ID:SGTC_2997|Compound:9067075|FD-Score:4.39|P-value:4.15E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-3.72|P-value:7.40E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.25|P-value:4.78E-4

Top fitness defect scores for YHR104W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 8.82 9.0 µM 1.48E-19 cell wall 103 5.60E-19
2 SGTC_103 0844-0104 8.49 51.8 µM 3.14E-18 ERAD & cell cycle 43 1.07E-17
3 SGTC_2037 5169046 4.94 200.0 µM 2.63E-7 60S ribosome export 3 3.98E-7
4 SGTC_1975 st070967 4.91 30.8 µM 3.01E-7 16 4.54E-7
5 SGTC_1917 st066507 4.79 28.5 µM 5.73E-7 Golgi 22 8.45E-7
6 SGTC_2435 5706476 4.76 10.6 µM 6.61E-7 14 9.70E-7
7 SGTC_2988 9073640 4.66 71.4 µM 1.07E-6 13 1.54E-6
8 SGTC_839 0122-0028 4.53 230.0 µM 2.07E-6 RSC complex & mRNA processing 23 2.93E-6
9 SGTC_1245 0418-0076 4.49 17.2 µM 2.59E-6 ERG2 21 3.64E-6
10 SGTC_2997 9067075 4.39 71.4 µM 4.15E-6 unfolded protein response 44 5.75E-6
11 SGTC_157 1348-1695 4.27 65.8 µM 7.25E-6 iron homeostasis 54 9.87E-6
12 SGTC_1658 st012944 4.19 20.0 µM 1.03E-5 iron homeostasis 70 1.39E-5
13 SGTC_1331 1472-0049 3.94 76.2 µM 3.07E-5 20 3.99E-5
14 SGTC_2666 tannic acid 3.83 100.0 µM 4.94E-5 iron homeostasis 43 6.33E-5
15 SGTC_2836 9010338 3.81 19.5 µM 5.43E-5 RPP1 & pyrimidine depletion 29 6.95E-5
16 SGTC_2036 5160441 3.79 105.0 µM 5.78E-5 NEO1 86 7.38E-5
17 SGTC_1063 disulfiram 3.77 1.8 µM 6.36E-5 26 8.10E-5
18 SGTC_495 decylubiquinone 3.76 155.0 µM 6.62E-5 copper-dependent oxidative stress 27 8.42E-5
19 SGTC_2486 5283202 3.62 22.4 µM 1.18E-4 44 1.47E-4
20 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.61 200.0 µM 1.24E-4 20 1.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.220 5.88E-38 YPL179W PPQ1 hom Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors
0.219 1.28E-37 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.218 1.73E-37 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.218 2.04E-37 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.215 2.82E-36 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.214 3.40E-36 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.206 1.38E-33 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.206 1.94E-33 YKL121W_p DGR2_p hom Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds
0.204 8.76E-33 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.204 1.06E-32 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.191 7.17E-29 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress
0.190 1.54E-28 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.190 1.75E-28 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.187 9.17E-28 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.186 2.16E-27 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly