YHR105W / YPT35

Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR105W / YPT35

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-5.58|P-value:9.80E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:3.72|P-value:6.62E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.11|P-value:6.79E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.90|P-value:3.16E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:-4.35|P-value:6.36E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:-5.72|P-value:4.37E-9 ID:SGTC_296|Compound:1222-0039|FD-Score:3.98|P-value:2.25E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.31|P-value:3.35E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.22|P-value:4.54E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.45|P-value:2.74E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.61|P-value:1.19E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:5.57|P-value:6.11E-9 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.01|P-value:2.83E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:3.17|P-value:5.52E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.47|P-value:2.30E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:4.39|P-value:3.36E-6 ID:SGTC_938|Compound:3126-1755|FD-Score:3.29|P-value:3.55E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.60|P-value:1.54E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.81|P-value:4.59E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.27|P-value:5.38E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.15|P-value:1.04E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.08|P-value:1.42E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.18|P-value:5.35E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.12|P-value:6.50E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.10|P-value:7.15E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.47|P-value:1.78E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.80|P-value:4.78E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.04|P-value:8.64E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.27|P-value:3.88E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.20|P-value:5.04E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.74|P-value:6.24E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.14|P-value:6.18E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.20|P-value:5.04E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.34|P-value:4.37E-6 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.17|P-value:5.62E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.05|P-value:2.40E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.48|P-value:1.05E-8 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.11|P-value:9.27E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.05|P-value:8.48E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.43|P-value:2.12E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.58|P-value:1.67E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.11|P-value:9.41E-4 ID:SGTC_2819|Compound:7996655|FD-Score:4.16|P-value:1.01E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-3.69|P-value:1.11E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.76|P-value:5.71E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-3.12|P-value:9.08E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.25|P-value:4.11E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.46|P-value:1.91E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-5.58|P-value:9.80E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:3.72|P-value:6.62E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.11|P-value:6.79E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.90|P-value:3.16E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:-4.35|P-value:6.36E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:-5.72|P-value:4.37E-9 ID:SGTC_296|Compound:1222-0039|FD-Score:3.98|P-value:2.25E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.31|P-value:3.35E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.22|P-value:4.54E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.45|P-value:2.74E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.61|P-value:1.19E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:5.57|P-value:6.11E-9 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.01|P-value:2.83E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:3.17|P-value:5.52E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.47|P-value:2.30E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:4.39|P-value:3.36E-6 ID:SGTC_938|Compound:3126-1755|FD-Score:3.29|P-value:3.55E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.60|P-value:1.54E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.81|P-value:4.59E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.27|P-value:5.38E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.15|P-value:1.04E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.08|P-value:1.42E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.18|P-value:5.35E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.12|P-value:6.50E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.10|P-value:7.15E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.47|P-value:1.78E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.80|P-value:4.78E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.04|P-value:8.64E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.27|P-value:3.88E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.20|P-value:5.04E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.74|P-value:6.24E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.14|P-value:6.18E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.20|P-value:5.04E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.34|P-value:4.37E-6 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.17|P-value:5.62E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.05|P-value:2.40E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.48|P-value:1.05E-8 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.11|P-value:9.27E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.05|P-value:8.48E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.43|P-value:2.12E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.58|P-value:1.67E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.11|P-value:9.41E-4 ID:SGTC_2819|Compound:7996655|FD-Score:4.16|P-value:1.01E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-3.69|P-value:1.11E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.76|P-value:5.71E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-3.12|P-value:9.08E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.25|P-value:4.11E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.46|P-value:1.91E-4

Top fitness defect scores for YHR105W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_680 0417-1641 5.57 114.0 µM 6.11E-9 RPP1 & pyrimidine depletion 2 1.28E-8
2 SGTC_2578 7,8-dihydroxyflavone 5.48 64.4 µM 1.05E-8 10 2.15E-8
3 SGTC_578 3460-0051 4.61 92.0 µM 1.19E-6 4 2.06E-6
4 SGTC_887 0885-0007 4.47 9.6 µM 2.30E-6 endomembrane recycling 27 3.89E-6
5 SGTC_889 0919-1524 4.39 82.7 µM 3.36E-6 8 5.61E-6
6 SGTC_2339 9000433 4.34 200.0 µM 4.37E-6 25 7.23E-6
7 SGTC_2819 7996655 4.16 46.4 µM 1.01E-5 18 1.62E-5
8 SGTC_1194 1488-0194 4.15 225.0 µM 1.04E-5 25 1.67E-5
9 SGTC_1281 0884-0031 4.08 11.8 µM 1.42E-5 fatty acid desaturase (OLE1) 21 2.24E-5
10 SGTC_296 1222-0039 3.98 74.9 µM 2.25E-5 11 3.51E-5
11 SGTC_135 0933-0004 3.90 26.4 µM 3.16E-5 60S ribosome export 27 4.85E-5
12 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 3.81 15.5 µM 4.59E-5 28 6.95E-5
13 SGTC_1495 4469-0029 3.80 237.0 µM 4.78E-5 117 7.23E-5
14 SGTC_2995 9067767 3.76 71.4 µM 5.71E-5 23 8.58E-5
15 SGTC_2050 5263056 3.74 171.0 µM 6.24E-5 fatty acid desaturase (OLE1) 52 9.35E-5
16 SGTC_76 0433-0009 3.72 400.3 µM 6.62E-5 17 9.90E-5
17 SGTC_1365 1672-3266 3.47 55.4 µM 1.78E-4 37 2.57E-4
18 SGTC_3322 9139058 3.46 2.1 µM 1.91E-4 cell wall 44 2.74E-4
19 SGTC_2638 epoxomicin 3.43 18.0 µM 2.12E-4 49 3.03E-4
20 SGTC_550 4123-0385 3.31 25.7 µM 3.35E-4 TSC3-RPN4 53 4.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 4.98E-8 YLR107W REX3 hom RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
0.094 5.08E-8 YGL226C-A OST5 hom Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.092 1.05E-7 YBR161W CSH1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication
0.089 2.65E-7 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.085 9.03E-7 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.083 1.46E-6 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.082 2.06E-6 YBL037W APL3 hom Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
0.077 7.35E-6 YDR338C_p YDR338C_p hom Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
0.077 8.37E-6 YAL029C MYO4 hom Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication
0.074 1.80E-5 YIL114C POR2 hom Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication
0.074 2.03E-5 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.074 2.02E-5 YPL033C SRL4 hom Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p
0.073 2.10E-5 YPR021C AGC1 hom Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis
0.073 2.58E-5 YCR092C MSH3 hom Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability
0.072 2.74E-5 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance