YHR106W / TRR2

Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR106W / TRR2

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.00|P-value:7.04E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.25|P-value:2.83E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.75|P-value:9.44E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:5.06|P-value:5.65E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.41|P-value:3.61E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.30|P-value:2.91E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:3.43|P-value:1.38E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.82|P-value:2.67E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.08|P-value:5.23E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.99|P-value:7.37E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.01|P-value:6.86E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.20|P-value:4.82E-6 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.05|P-value:9.51E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.52|P-value:9.68E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:2.95|P-value:8.44E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.99|P-value:8.04E-8 ID:SGTC_1705|Compound:st027868|FD-Score:4.31|P-value:2.83E-6 ID:SGTC_1772|Compound:st048439|FD-Score:2.97|P-value:7.79E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.50|P-value:1.07E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.48|P-value:1.20E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.39|P-value:1.60E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.33|P-value:2.04E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-3.63|P-value:1.54E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.82|P-value:7.20E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-7.18|P-value:2.09E-13 ID:SGTC_2063|Compound:5246145|FD-Score:3.09|P-value:5.09E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.85|P-value:2.38E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.14|P-value:4.28E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.13|P-value:4.35E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.48|P-value:1.15E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.39|P-value:1.62E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.19|P-value:4.94E-6 ID:SGTC_2671|Compound:danthron|FD-Score:3.02|P-value:6.53E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.04|P-value:6.16E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.13|P-value:9.78E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.58|P-value:2.57E-9 ID:SGTC_2755|Compound:lomerizine|FD-Score:-5.27|P-value:5.95E-8 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.20|P-value:7.65E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.69|P-value:4.86E-5 ID:SGTC_2819|Compound:7996655|FD-Score:4.42|P-value:1.63E-6 ID:SGTC_2820|Compound:7989630|FD-Score:2.99|P-value:7.31E-4 ID:SGTC_3217|Compound:9129673|FD-Score:5.07|P-value:5.28E-8 ID:SGTC_3324|Compound:9138759|FD-Score:3.04|P-value:5.99E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.00|P-value:7.04E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.25|P-value:2.83E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.75|P-value:9.44E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:5.06|P-value:5.65E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.41|P-value:3.61E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.30|P-value:2.91E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:3.43|P-value:1.38E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.82|P-value:2.67E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.08|P-value:5.23E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.99|P-value:7.37E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.01|P-value:6.86E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.20|P-value:4.82E-6 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.05|P-value:9.51E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.52|P-value:9.68E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:2.95|P-value:8.44E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.99|P-value:8.04E-8 ID:SGTC_1705|Compound:st027868|FD-Score:4.31|P-value:2.83E-6 ID:SGTC_1772|Compound:st048439|FD-Score:2.97|P-value:7.79E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.50|P-value:1.07E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.48|P-value:1.20E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.39|P-value:1.60E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.33|P-value:2.04E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-3.63|P-value:1.54E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.82|P-value:7.20E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-7.18|P-value:2.09E-13 ID:SGTC_2063|Compound:5246145|FD-Score:3.09|P-value:5.09E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.85|P-value:2.38E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.14|P-value:4.28E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.13|P-value:4.35E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.48|P-value:1.15E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.39|P-value:1.62E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.19|P-value:4.94E-6 ID:SGTC_2671|Compound:danthron|FD-Score:3.02|P-value:6.53E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.04|P-value:6.16E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.13|P-value:9.78E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.58|P-value:2.57E-9 ID:SGTC_2755|Compound:lomerizine|FD-Score:-5.27|P-value:5.95E-8 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.20|P-value:7.65E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.69|P-value:4.86E-5 ID:SGTC_2819|Compound:7996655|FD-Score:4.42|P-value:1.63E-6 ID:SGTC_2820|Compound:7989630|FD-Score:2.99|P-value:7.31E-4 ID:SGTC_3217|Compound:9129673|FD-Score:5.07|P-value:5.28E-8 ID:SGTC_3324|Compound:9138759|FD-Score:3.04|P-value:5.99E-4

Top fitness defect scores for YHR106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2754 granisetron 5.58 64.0 µM 2.57E-9 10 1.20E-8
2 SGTC_3217 9129673 5.07 49.5 µM 5.28E-8 9 2.01E-7
3 SGTC_354 2783-3500 5.06 4.9 µM 5.65E-8 cell wall 30 2.14E-7
4 SGTC_1576 erythromycin ethylsuccinate 4.99 23.2 µM 8.04E-8 8 2.97E-7
5 SGTC_1912 st060209 4.48 90.8 µM 1.20E-6 27 3.67E-6
6 SGTC_2819 7996655 4.42 46.4 µM 1.63E-6 12 4.88E-6
7 SGTC_1705 st027868 4.31 56.3 µM 2.83E-6 4 8.15E-6
8 SGTC_403 arphamenine a 4.30 50.0 µM 2.91E-6 60S ribosome export 12 8.38E-6
9 SGTC_1363 1636-0063 4.20 10.4 µM 4.82E-6 Golgi 21 1.34E-5
10 SGTC_2664 lyso-paf C-16 4.19 73.5 µM 4.94E-6 7 1.37E-5
11 SGTC_1430 4049-0248 4.05 69.1 µM 9.51E-6 17 2.51E-5
12 SGTC_2083 5306046 3.85 65.9 µM 2.38E-5 31 5.89E-5
13 SGTC_655 k060-0012 3.82 42.0 µM 2.67E-5 12 6.56E-5
14 SGTC_2767 sibutramine 3.69 71.5 µM 4.86E-5 28 1.14E-4
15 SGTC_1565 sinapyl alcohol 3.52 95.1 µM 9.68E-5 43 2.16E-4
16 SGTC_1861 st057647 3.50 17.4 µM 1.07E-4 37 2.37E-4
17 SGTC_2328 6201408 3.48 200.0 µM 1.15E-4 35 2.54E-4
18 SGTC_639 0833-0042 3.43 114.0 µM 1.38E-4 66 3.00E-4
19 SGTC_1939 st074455 3.39 53.6 µM 1.60E-4 48 3.45E-4
20 SGTC_2415 st077333 3.39 57.7 µM 1.62E-4 78 3.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.65E-16 YDL149W ATG9 hom Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS
0.123 8.09E-13 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
0.122 1.07E-12 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.101 4.22E-9 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.096 2.83E-8 YHL040C ARN1 hom ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress
0.095 3.62E-8 YMR247C RKR1 hom RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice
0.094 4.64E-8 YMR182C RGM1 hom Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
0.093 7.62E-8 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.090 1.83E-7 YNR056C BIO5 hom Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.090 2.02E-7 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.089 2.39E-7 YIL119C RPI1 hom Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF
0.088 3.07E-7 YJR147W HMS2 hom Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.086 7.01E-7 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.084 1.20E-6 YIL114C POR2 hom Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication
0.083 1.30E-6 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair