YHR107C / CDC12

Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR107C / CDC12

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:11.60|P-value:1.88E-28 ID:SGTC_54|Compound:0159-0055|FD-Score:5.84|P-value:1.47E-8 ID:SGTC_62|Compound:0180-0423|FD-Score:4.17|P-value:3.65E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:5.46|P-value:1.08E-7 ID:SGTC_106|Compound:0092-0003|FD-Score:4.99|P-value:1.06E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:3.93|P-value:9.01E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:18.90|P-value:9.31E-72 ID:SGTC_210|Compound:3551-0445|FD-Score:3.81|P-value:1.45E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.58|P-value:3.20E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.42|P-value:5.68E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:7.63|P-value:2.20E-13 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.64|P-value:2.62E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.42|P-value:6.57E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.66|P-value:3.75E-8 ID:SGTC_381|Compound:3461-2219|FD-Score:7.17|P-value:5.12E-12 ID:SGTC_523|Compound:1934-0222|FD-Score:4.75|P-value:3.12E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:5.85|P-value:1.34E-8 ID:SGTC_582|Compound:0987-0078|FD-Score:3.32|P-value:7.78E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.59|P-value:6.22E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:4.76|P-value:3.01E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:4.95|P-value:1.26E-6 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.38|P-value:7.38E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:7.01|P-value:1.37E-11 ID:SGTC_800|Compound:3448-7362|FD-Score:7.66|P-value:1.75E-13 ID:SGTC_839|Compound:0122-0028|FD-Score:4.46|P-value:1.12E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:3.26|P-value:9.45E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-4.33|P-value:2.31E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:4.62|P-value:5.65E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.70|P-value:2.55E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:5.78|P-value:1.97E-8 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.39|P-value:6.23E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.60|P-value:3.02E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.41|P-value:5.72E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.33|P-value:7.42E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.39|P-value:1.50E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.73|P-value:1.89E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.48|P-value:4.59E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:4.00|P-value:7.14E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.68|P-value:2.28E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.71|P-value:2.06E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.35|P-value:7.16E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.58|P-value:3.29E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:5.00|P-value:9.79E-7 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.69|P-value:2.18E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.51|P-value:4.84E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.66|P-value:2.47E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.37|P-value:6.69E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.38|P-value:6.38E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:9.03|P-value:5.43E-18 ID:SGTC_1522|Compound:st012842|FD-Score:4.20|P-value:3.17E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.44|P-value:5.24E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:8.97|P-value:8.35E-18 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.07|P-value:5.44E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:5.08|P-value:6.99E-7 ID:SGTC_1742|Compound:st038235|FD-Score:4.54|P-value:7.76E-6 ID:SGTC_1745|Compound:st081495|FD-Score:3.30|P-value:8.38E-4 ID:SGTC_1773|Compound:st048542|FD-Score:6.85|P-value:4.01E-11 ID:SGTC_1775|Compound:st081588|FD-Score:6.38|P-value:6.88E-10 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.09|P-value:8.25E-12 ID:SGTC_1963|Compound:st076565|FD-Score:4.15|P-value:3.88E-5 ID:SGTC_1968|Compound:st069590|FD-Score:9.83|P-value:5.71E-21 ID:SGTC_2022|Compound:5136654|FD-Score:3.45|P-value:5.01E-4 ID:SGTC_2070|Compound:5230947|FD-Score:4.76|P-value:2.99E-6 ID:SGTC_2112|Compound:5488546|FD-Score:3.35|P-value:6.94E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:5.41|P-value:1.34E-7 ID:SGTC_2172|Compound:5754775|FD-Score:-3.50|P-value:5.02E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.48|P-value:4.52E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:7.41|P-value:1.03E-12 ID:SGTC_2296|Compound:7971656|FD-Score:-4.44|P-value:1.45E-5 ID:SGTC_2299|Compound:7976368|FD-Score:3.66|P-value:2.43E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.45|P-value:5.05E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.40|P-value:5.91E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-6.87|P-value:4.76E-11 ID:SGTC_2470|Compound:5664817|FD-Score:3.28|P-value:8.77E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.13|P-value:4.19E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.89|P-value:1.05E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.45|P-value:7.72E-13 ID:SGTC_2782|Compound:7736369|FD-Score:-3.33|P-value:8.77E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.86|P-value:1.17E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.75|P-value:1.80E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.78|P-value:2.69E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-4.59|P-value:7.72E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.58|P-value:3.30E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.78|P-value:2.76E-6 ID:SGTC_2953|Compound:9074162|FD-Score:-4.35|P-value:2.16E-5 ID:SGTC_2976|Compound:9009005|FD-Score:4.74|P-value:3.30E-6 ID:SGTC_3127|Compound:9126946|FD-Score:-3.39|P-value:7.35E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.54|P-value:3.68E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.96|P-value:8.05E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.61|P-value:2.92E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.31|P-value:8.12E-4 ID:SGTC_3219|Compound:9131112|FD-Score:4.33|P-value:1.87E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.55|P-value:3.64E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.37|P-value:1.60E-5 ID:SGTC_3339|Compound:9145883|FD-Score:3.35|P-value:7.03E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.54|P-value:3.74E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:11.60|P-value:1.88E-28 ID:SGTC_54|Compound:0159-0055|FD-Score:5.84|P-value:1.47E-8 ID:SGTC_62|Compound:0180-0423|FD-Score:4.17|P-value:3.65E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:5.46|P-value:1.08E-7 ID:SGTC_106|Compound:0092-0003|FD-Score:4.99|P-value:1.06E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:3.93|P-value:9.01E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:18.90|P-value:9.31E-72 ID:SGTC_210|Compound:3551-0445|FD-Score:3.81|P-value:1.45E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.58|P-value:3.20E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.42|P-value:5.68E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:7.63|P-value:2.20E-13 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.64|P-value:2.62E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.42|P-value:6.57E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.66|P-value:3.75E-8 ID:SGTC_381|Compound:3461-2219|FD-Score:7.17|P-value:5.12E-12 ID:SGTC_523|Compound:1934-0222|FD-Score:4.75|P-value:3.12E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:5.85|P-value:1.34E-8 ID:SGTC_582|Compound:0987-0078|FD-Score:3.32|P-value:7.78E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.59|P-value:6.22E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:4.76|P-value:3.01E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:4.95|P-value:1.26E-6 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.38|P-value:7.38E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:7.01|P-value:1.37E-11 ID:SGTC_800|Compound:3448-7362|FD-Score:7.66|P-value:1.75E-13 ID:SGTC_839|Compound:0122-0028|FD-Score:4.46|P-value:1.12E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:3.26|P-value:9.45E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-4.33|P-value:2.31E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:4.62|P-value:5.65E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.70|P-value:2.55E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:5.78|P-value:1.97E-8 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.39|P-value:6.23E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.60|P-value:3.02E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.41|P-value:5.72E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.33|P-value:7.42E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.39|P-value:1.50E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.73|P-value:1.89E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.48|P-value:4.59E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:4.00|P-value:7.14E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.68|P-value:2.28E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.71|P-value:2.06E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.35|P-value:7.16E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.58|P-value:3.29E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:5.00|P-value:9.79E-7 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.69|P-value:2.18E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.51|P-value:4.84E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.66|P-value:2.47E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.37|P-value:6.69E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.38|P-value:6.38E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:9.03|P-value:5.43E-18 ID:SGTC_1522|Compound:st012842|FD-Score:4.20|P-value:3.17E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.44|P-value:5.24E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:8.97|P-value:8.35E-18 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.07|P-value:5.44E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:5.08|P-value:6.99E-7 ID:SGTC_1742|Compound:st038235|FD-Score:4.54|P-value:7.76E-6 ID:SGTC_1745|Compound:st081495|FD-Score:3.30|P-value:8.38E-4 ID:SGTC_1773|Compound:st048542|FD-Score:6.85|P-value:4.01E-11 ID:SGTC_1775|Compound:st081588|FD-Score:6.38|P-value:6.88E-10 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.09|P-value:8.25E-12 ID:SGTC_1963|Compound:st076565|FD-Score:4.15|P-value:3.88E-5 ID:SGTC_1968|Compound:st069590|FD-Score:9.83|P-value:5.71E-21 ID:SGTC_2022|Compound:5136654|FD-Score:3.45|P-value:5.01E-4 ID:SGTC_2070|Compound:5230947|FD-Score:4.76|P-value:2.99E-6 ID:SGTC_2112|Compound:5488546|FD-Score:3.35|P-value:6.94E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:5.41|P-value:1.34E-7 ID:SGTC_2172|Compound:5754775|FD-Score:-3.50|P-value:5.02E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.48|P-value:4.52E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:7.41|P-value:1.03E-12 ID:SGTC_2296|Compound:7971656|FD-Score:-4.44|P-value:1.45E-5 ID:SGTC_2299|Compound:7976368|FD-Score:3.66|P-value:2.43E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.45|P-value:5.05E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.40|P-value:5.91E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-6.87|P-value:4.76E-11 ID:SGTC_2470|Compound:5664817|FD-Score:3.28|P-value:8.77E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.13|P-value:4.19E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.89|P-value:1.05E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.45|P-value:7.72E-13 ID:SGTC_2782|Compound:7736369|FD-Score:-3.33|P-value:8.77E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.86|P-value:1.17E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.75|P-value:1.80E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.78|P-value:2.69E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-4.59|P-value:7.72E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.58|P-value:3.30E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.78|P-value:2.76E-6 ID:SGTC_2953|Compound:9074162|FD-Score:-4.35|P-value:2.16E-5 ID:SGTC_2976|Compound:9009005|FD-Score:4.74|P-value:3.30E-6 ID:SGTC_3127|Compound:9126946|FD-Score:-3.39|P-value:7.35E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.54|P-value:3.68E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.96|P-value:8.05E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.61|P-value:2.92E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.31|P-value:8.12E-4 ID:SGTC_3219|Compound:9131112|FD-Score:4.33|P-value:1.87E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.55|P-value:3.64E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.37|P-value:1.60E-5 ID:SGTC_3339|Compound:9145883|FD-Score:3.35|P-value:7.03E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.54|P-value:3.74E-4

Top fitness defect scores for YHR107C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_151 3013-0144 18.90 2.3 µM 9.31E-72 iron homeostasis 1 1.08E-79 12.90
2 SGTC_29 0299-0004 11.60 13.0 µM 1.88E-28 1 2.00E-31 5.74
3 SGTC_1968 st069590 9.83 43.6 µM 5.71E-21 5 4.28E-23 1.31
4 SGTC_1480 1070-0044 9.03 41.2 µM 5.43E-18 1 8.82E-20 2.74
5 SGTC_1545 lovastatin 8.97 49.4 µM 8.35E-18 1 1.42E-19 2.98
6 SGTC_800 3448-7362 7.66 155.0 µM 1.75E-13 translation 14 9.10E-15 0.15
7 SGTC_237 nikkomycin 7.63 200.0 µM 2.20E-13 RSC complex & mRNA processing 4 1.17E-14 2.46
8 SGTC_2679 rapamycin 7.45 1.0 nM 7.72E-13 19 4.73E-14 0.63
9 SGTC_2247 cerulenin 7.41 830.0 nM 1.03E-12 1 6.54E-14 2.90
10 SGTC_381 3461-2219 7.17 42.7 µM 5.12E-12 copper-dependent oxidative stress 1 3.87E-13 2.73
11 SGTC_1844 rapamycin 7.09 4.0 nM 8.25E-12 19 6.58E-13 0.53
12 SGTC_764 1951-2361 7.01 146.0 µM 1.37E-11 4 1.16E-12 0.87
13 SGTC_1773 st048542 6.85 73.6 µM 4.01E-11 7 3.81E-12 0.08
14 SGTC_1775 st081588 6.38 35.2 µM 6.88E-10 60S ribosome export 4 8.94E-11 0.25
15 SGTC_572 0960-0087 5.85 17.7 µM 1.34E-8 3 2.42E-9 0.83
16 SGTC_54 0159-0055 5.84 9.0 µM 1.47E-8 ERG2 1 2.68E-9 0.71
17 SGTC_1112 tnp00069 5.78 1.2 µM 1.97E-8 1 3.69E-9 0.97
18 SGTC_341 1486-1430 5.66 230.0 µM 3.75E-8 8 7.54E-9 0.20
19 SGTC_97 0535-0701 5.46 19.1 µM 1.08E-7 60S ribosome export 6 2.45E-8 0.27
20 SGTC_2170 morpholine 5.41 200.0 µM 1.34E-7 1 3.10E-8 0.85

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 5.64E-16 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.136 2.92E-15 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.133 9.85E-15 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.131 2.88E-14 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.128 1.01E-13 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.124 6.60E-13 YBR101C FES1 hom Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.121 2.11E-12 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.119 5.07E-12 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.115 3.12E-11 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.112 7.63E-11 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.108 3.44E-10 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.108 4.22E-10 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.106 6.58E-10 YLL024C SSA2 hom ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
0.106 7.44E-10 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.106 9.22E-10 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication