YHR112C

Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR112C / YHR112C

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-3.45|P-value:1.23E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.37|P-value:1.94E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.48|P-value:1.21E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.29|P-value:3.00E-6 ID:SGTC_293|Compound:4049-0273|FD-Score:5.38|P-value:6.79E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:8.43|P-value:2.66E-19 ID:SGTC_363|Compound:0455-0021|FD-Score:4.13|P-value:6.70E-6 ID:SGTC_650|Compound:1328-0195|FD-Score:3.49|P-value:1.17E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.65|P-value:5.96E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:6.25|P-value:2.04E-11 ID:SGTC_683|Compound:panaxydol|FD-Score:3.88|P-value:2.16E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.87|P-value:2.27E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.90|P-value:2.00E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.04|P-value:6.82E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.10|P-value:4.86E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.94|P-value:1.66E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:2.99|P-value:8.31E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.16|P-value:5.82E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.47|P-value:1.28E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.95|P-value:1.52E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.11|P-value:4.78E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.75|P-value:3.90E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.63|P-value:6.48E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.71|P-value:4.58E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.14|P-value:4.27E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.49|P-value:1.07E-6 ID:SGTC_1835|Compound:st008666|FD-Score:2.96|P-value:9.05E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.27|P-value:1.36E-8 ID:SGTC_1982|Compound:st072467|FD-Score:3.08|P-value:5.93E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.59|P-value:7.66E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.05|P-value:9.92E-6 ID:SGTC_2136|Compound:5328288|FD-Score:-4.77|P-value:2.04E-7 ID:SGTC_2187|Compound:6125751|FD-Score:3.03|P-value:7.12E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.39|P-value:1.79E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.17|P-value:4.19E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.23|P-value:3.33E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.23|P-value:3.03E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.65|P-value:5.40E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.65|P-value:1.25E-9 ID:SGTC_2781|Compound:5567276|FD-Score:-3.15|P-value:4.08E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.35|P-value:2.12E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.93|P-value:1.95E-10 ID:SGTC_3024|Compound:9090631|FD-Score:3.71|P-value:4.61E-5 ID:SGTC_3044|Compound:9093193|FD-Score:5.93|P-value:1.98E-10 ID:SGTC_3049|Compound:9092223|FD-Score:3.25|P-value:3.03E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.01|P-value:7.66E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.91|P-value:1.91E-5 ID:SGTC_3312|Compound:9133330|FD-Score:3.21|P-value:3.62E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.45|P-value:1.23E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.37|P-value:1.94E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.48|P-value:1.21E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.29|P-value:3.00E-6 ID:SGTC_293|Compound:4049-0273|FD-Score:5.38|P-value:6.79E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:8.43|P-value:2.66E-19 ID:SGTC_363|Compound:0455-0021|FD-Score:4.13|P-value:6.70E-6 ID:SGTC_650|Compound:1328-0195|FD-Score:3.49|P-value:1.17E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.65|P-value:5.96E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:6.25|P-value:2.04E-11 ID:SGTC_683|Compound:panaxydol|FD-Score:3.88|P-value:2.16E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.87|P-value:2.27E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.90|P-value:2.00E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.04|P-value:6.82E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.10|P-value:4.86E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.94|P-value:1.66E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:2.99|P-value:8.31E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.16|P-value:5.82E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.47|P-value:1.28E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.95|P-value:1.52E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.11|P-value:4.78E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.75|P-value:3.90E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.63|P-value:6.48E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.71|P-value:4.58E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.14|P-value:4.27E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.49|P-value:1.07E-6 ID:SGTC_1835|Compound:st008666|FD-Score:2.96|P-value:9.05E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.27|P-value:1.36E-8 ID:SGTC_1982|Compound:st072467|FD-Score:3.08|P-value:5.93E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.59|P-value:7.66E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.05|P-value:9.92E-6 ID:SGTC_2136|Compound:5328288|FD-Score:-4.77|P-value:2.04E-7 ID:SGTC_2187|Compound:6125751|FD-Score:3.03|P-value:7.12E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.39|P-value:1.79E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.17|P-value:4.19E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.23|P-value:3.33E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.23|P-value:3.03E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.65|P-value:5.40E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.65|P-value:1.25E-9 ID:SGTC_2781|Compound:5567276|FD-Score:-3.15|P-value:4.08E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.35|P-value:2.12E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.93|P-value:1.95E-10 ID:SGTC_3024|Compound:9090631|FD-Score:3.71|P-value:4.61E-5 ID:SGTC_3044|Compound:9093193|FD-Score:5.93|P-value:1.98E-10 ID:SGTC_3049|Compound:9092223|FD-Score:3.25|P-value:3.03E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.01|P-value:7.66E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.91|P-value:1.91E-5 ID:SGTC_3312|Compound:9133330|FD-Score:3.21|P-value:3.62E-4

Top fitness defect scores for YHR112C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_352 k048-0007 8.43 5.1 µM 2.66E-19 ERAD & cell cycle 15 1.72E-17
2 SGTC_664 1222-0054 6.25 14.9 µM 2.04E-11 sphingolipid biosynthesis & PDR1 13 2.02E-10
3 SGTC_2858 9025781 5.93 9.0 µM 1.95E-10 sphingolipid biosynthesis & PDR1 47 1.53E-9
4 SGTC_3044 9093193 5.93 49.5 µM 1.98E-10 2 1.55E-9
5 SGTC_2752 diclazuril 5.65 33.1 µM 1.25E-9 62 8.11E-9
6 SGTC_293 4049-0273 5.38 38.5 µM 6.79E-9 6 3.71E-8
7 SGTC_1934 st074720 5.27 32.6 µM 1.36E-8 22 6.94E-8
8 SGTC_1730 st033808 4.49 45.1 µM 1.07E-6 20 3.51E-6
9 SGTC_167 3672-0051 4.29 66.2 µM 3.00E-6 34 8.87E-6
10 SGTC_1147 3809-1045 4.16 12.3 µM 5.82E-6 20 1.61E-5
11 SGTC_363 0455-0021 4.13 3.1 µM 6.70E-6 azole & statin 60 1.83E-5
12 SGTC_2129 girgensonine 4.05 121.0 µM 9.92E-6 heme biosynthesis & mitochondrial translocase 27 2.60E-5
13 SGTC_1287 0971-0001 3.95 34.6 µM 1.52E-5 sphingolipid biosynthesis & PDR1 43 3.83E-5
14 SGTC_955 1216-0110 3.94 33.0 µM 1.66E-5 sphingolipid biosynthesis & PDR1 67 4.13E-5
15 SGTC_3283 9109332 3.91 35.8 µM 1.91E-5 DNA intercalators 19 4.69E-5
16 SGTC_851 0394-0702 3.90 453.0 µM 2.00E-5 mitochondrial processes 17 4.90E-5
17 SGTC_683 panaxydol 3.88 45.0 µM 2.16E-5 sphingolipid biosynthesis & PDR1 43 5.24E-5
18 SGTC_839 0122-0028 3.87 230.0 µM 2.27E-5 RSC complex & mRNA processing 40 5.50E-5
19 SGTC_1355 1499-0035 3.75 1.7 µM 3.90E-5 23 8.94E-5
20 SGTC_1586 deoxycorticosterone acetate 3.71 53.7 µM 4.58E-5 17 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 3.37E-60 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.237 4.96E-44 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.226 3.63E-40 YGL253W HXK2 hom Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication
0.207 1.15E-33 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.169 9.11E-23 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.168 1.22E-22 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.156 9.95E-20 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.148 5.53E-18 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.148 6.40E-18 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.144 5.78E-17 YPL055C LGE1 hom Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
0.143 7.95E-17 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.137 1.93E-15 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.134 6.65E-15 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.132 1.33E-14 YNR001C CIT1 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.132 1.75E-14 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay