YHR113W / APE4

Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR113W / APE4

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.62|P-value:6.19E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.26|P-value:3.16E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.15|P-value:4.73E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.38|P-value:1.92E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.26|P-value:3.13E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.15|P-value:6.48E-6 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.13|P-value:5.05E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.32|P-value:2.43E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:2.98|P-value:8.82E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:5.84|P-value:4.36E-10 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.70|P-value:5.01E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.29|P-value:2.77E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.12|P-value:5.30E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.56|P-value:9.28E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.02|P-value:7.64E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.42|P-value:1.66E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.26|P-value:3.06E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.55|P-value:9.71E-5 ID:SGTC_1721|Compound:st082152|FD-Score:3.39|P-value:1.83E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.14|P-value:4.90E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.75|P-value:4.07E-5 ID:SGTC_1786|Compound:berberine|FD-Score:4.13|P-value:7.28E-6 ID:SGTC_1942|Compound:st076330|FD-Score:3.05|P-value:6.86E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.05|P-value:6.72E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.09|P-value:5.89E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.09|P-value:5.84E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.46|P-value:1.36E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.63|P-value:6.82E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.47|P-value:1.32E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.33|P-value:2.31E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:-3.45|P-value:1.44E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.65|P-value:6.20E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.17|P-value:4.40E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.91|P-value:2.03E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.21|P-value:4.80E-6 ID:SGTC_2844|Compound:9010103|FD-Score:-3.46|P-value:1.43E-4 ID:SGTC_2877|Compound:9040724|FD-Score:4.03|P-value:1.13E-5 ID:SGTC_2878|Compound:9043973|FD-Score:4.99|P-value:8.01E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.52|P-value:1.10E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.15|P-value:4.61E-4 ID:SGTC_3255|Compound:9139072|FD-Score:2.96|P-value:9.52E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-4.07|P-value:9.82E-6 ID:SGTC_3279|Compound:9140807|FD-Score:-2.95|P-value:9.92E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.62|P-value:6.19E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.26|P-value:3.16E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.15|P-value:4.73E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.38|P-value:1.92E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.26|P-value:3.13E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.15|P-value:6.48E-6 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.13|P-value:5.05E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.32|P-value:2.43E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:2.98|P-value:8.82E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:5.84|P-value:4.36E-10 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.70|P-value:5.01E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.29|P-value:2.77E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.12|P-value:5.30E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.56|P-value:9.28E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.02|P-value:7.64E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.42|P-value:1.66E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.26|P-value:3.06E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.55|P-value:9.71E-5 ID:SGTC_1721|Compound:st082152|FD-Score:3.39|P-value:1.83E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.14|P-value:4.90E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.75|P-value:4.07E-5 ID:SGTC_1786|Compound:berberine|FD-Score:4.13|P-value:7.28E-6 ID:SGTC_1942|Compound:st076330|FD-Score:3.05|P-value:6.86E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.05|P-value:6.72E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.09|P-value:5.89E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.09|P-value:5.84E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.46|P-value:1.36E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.63|P-value:6.82E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.47|P-value:1.32E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.33|P-value:2.31E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:-3.45|P-value:1.44E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.65|P-value:6.20E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.17|P-value:4.40E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.91|P-value:2.03E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.21|P-value:4.80E-6 ID:SGTC_2844|Compound:9010103|FD-Score:-3.46|P-value:1.43E-4 ID:SGTC_2877|Compound:9040724|FD-Score:4.03|P-value:1.13E-5 ID:SGTC_2878|Compound:9043973|FD-Score:4.99|P-value:8.01E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.52|P-value:1.10E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.15|P-value:4.61E-4 ID:SGTC_3255|Compound:9139072|FD-Score:2.96|P-value:9.52E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-4.07|P-value:9.82E-6 ID:SGTC_3279|Compound:9140807|FD-Score:-2.95|P-value:9.92E-4

Top fitness defect scores for YHR113W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_862 0452-0056 5.84 10.2 µM 4.36E-10 azole & statin 14 2.66E-9
2 SGTC_2878 9043973 4.99 26.0 µM 8.01E-8 5 3.04E-7
3 SGTC_35 0133-0054 4.62 64.1 µM 6.19E-7 14 1.95E-6
4 SGTC_2837 9008476 4.21 45.5 µM 4.80E-6 27 1.26E-5
5 SGTC_310 1273-0058 4.15 1.1 µM 6.48E-6 mitochondrial stress 230 1.65E-5
6 SGTC_1786 berberine 4.13 21.6 µM 7.28E-6 60S ribosome export 26 1.84E-5
7 SGTC_2877 9040724 4.03 71.4 µM 1.13E-5 7 2.74E-5
8 SGTC_2804 7954240 3.91 19.5 µM 2.03E-5 31 4.67E-5
9 SGTC_1764 st044502 3.75 93.5 µM 4.07E-5 34 8.81E-5
10 SGTC_1201 1889-3372 3.70 45.9 µM 5.01E-5 Golgi 15 1.06E-4
11 SGTC_2687 chenodiol 3.65 100.0 µM 6.20E-5 31 1.29E-4
12 SGTC_1317 1273-0028 3.56 910.0 nM 9.28E-5 azole & statin 66 1.87E-4
13 SGTC_1676 st018489 3.55 23.4 µM 9.71E-5 60S ribosome export 49 1.95E-4
14 SGTC_2936 9038235 3.52 15.6 µM 1.10E-4 37 2.18E-4
15 SGTC_2488 5268135 3.47 45.7 µM 1.32E-4 73 2.57E-4
16 SGTC_2399 5884133 3.46 200.0 µM 1.36E-4 cell wall signaling 95 2.65E-4
17 SGTC_1565 sinapyl alcohol 3.42 95.1 µM 1.66E-4 51 3.18E-4
18 SGTC_1721 st082152 3.39 9.3 µM 1.83E-4 60S ribosome export 37 3.47E-4
19 SGTC_279 1273-0055 3.38 2.9 µM 1.92E-4 azole & statin 56 3.62E-4
20 SGTC_2556 citropten 3.33 84.6 µM 2.31E-4 55 4.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 6.38E-24 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.168 1.03E-22 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.151 1.36E-18 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.138 1.01E-15 YPR198W SGE1 hom Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
0.130 3.30E-14 YPR197C_d YPR197C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.125 3.12E-13 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.110 1.65E-10 YOR011W AUS1 hom Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen
0.106 6.87E-10 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.103 1.95E-9 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.101 4.20E-9 YBR042C CST26 hom Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication
0.099 8.76E-9 YGR004W PEX31 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
0.095 3.60E-8 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.093 6.11E-8 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.092 9.30E-8 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.090 1.89E-7 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters