YHR114W / BZZ1

SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR114W / BZZ1

Click on Significant Values for Screen Details ID:SGTC_293|Compound:4049-0273|FD-Score:2.97|P-value:5.76E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.71|P-value:2.51E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:2.84|P-value:9.20E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.83|P-value:1.84E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.15|P-value:3.56E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.71|P-value:2.55E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.05|P-value:4.16E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.75|P-value:1.50E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:4.67|P-value:1.68E-7 ID:SGTC_681|Compound:1642-0006|FD-Score:-4.49|P-value:6.34E-7 ID:SGTC_685|Compound:1278-0033|FD-Score:-4.45|P-value:7.88E-7 ID:SGTC_864|Compound:0469-0573|FD-Score:4.27|P-value:1.56E-6 ID:SGTC_1146|Compound:3579-1023|FD-Score:2.86|P-value:8.73E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.84|P-value:1.37E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:2.91|P-value:7.09E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.92|P-value:9.07E-6 ID:SGTC_1629|Compound:st005085|FD-Score:2.89|P-value:7.70E-4 ID:SGTC_1684|Compound:st024538|FD-Score:2.87|P-value:8.35E-4 ID:SGTC_1730|Compound:st033808|FD-Score:9.08|P-value:2.56E-23 ID:SGTC_1731|Compound:st035964|FD-Score:-3.25|P-value:2.40E-4 ID:SGTC_1734|Compound:st037168|FD-Score:6.69|P-value:1.61E-13 ID:SGTC_1735|Compound:st034310|FD-Score:3.36|P-value:1.21E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.19|P-value:7.34E-9 ID:SGTC_1884|Compound:5633444|FD-Score:2.85|P-value:8.93E-4 ID:SGTC_1940|Compound:st075990|FD-Score:6.14|P-value:1.11E-11 ID:SGTC_1945|Compound:st075991|FD-Score:2.93|P-value:6.67E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.28|P-value:1.64E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.57|P-value:6.05E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-3.39|P-value:1.30E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.15|P-value:2.84E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.15|P-value:2.79E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.27|P-value:1.74E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:2.84|P-value:9.42E-4 ID:SGTC_2812|Compound:7970281|FD-Score:5.50|P-value:9.97E-10 ID:SGTC_2834|Compound:9001755|FD-Score:-3.73|P-value:2.96E-5 ID:SGTC_2842|Compound:9000675|FD-Score:4.38|P-value:8.77E-7 ID:SGTC_2860|Compound:9025725|FD-Score:-3.24|P-value:2.46E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.00|P-value:5.17E-4 ID:SGTC_2877|Compound:9040724|FD-Score:2.91|P-value:7.08E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-2.90|P-value:9.28E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-2.91|P-value:8.85E-4 ID:SGTC_3083|Compound:9117465|FD-Score:2.83|P-value:9.70E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.71|P-value:1.37E-7 ID:SGTC_3137|Compound:9097352|FD-Score:-3.70|P-value:3.32E-5 ID:SGTC_3225|Compound:9130819|FD-Score:3.29|P-value:1.58E-4 ID:SGTC_3246|Compound:9135460|FD-Score:-3.12|P-value:3.90E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.05|P-value:4.27E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.48|P-value:9.04E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:2.97|P-value:5.76E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.71|P-value:2.51E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:2.84|P-value:9.20E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.83|P-value:1.84E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.15|P-value:3.56E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.71|P-value:2.55E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.05|P-value:4.16E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.75|P-value:1.50E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:4.67|P-value:1.68E-7 ID:SGTC_681|Compound:1642-0006|FD-Score:-4.49|P-value:6.34E-7 ID:SGTC_685|Compound:1278-0033|FD-Score:-4.45|P-value:7.88E-7 ID:SGTC_864|Compound:0469-0573|FD-Score:4.27|P-value:1.56E-6 ID:SGTC_1146|Compound:3579-1023|FD-Score:2.86|P-value:8.73E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.84|P-value:1.37E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:2.91|P-value:7.09E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.92|P-value:9.07E-6 ID:SGTC_1629|Compound:st005085|FD-Score:2.89|P-value:7.70E-4 ID:SGTC_1684|Compound:st024538|FD-Score:2.87|P-value:8.35E-4 ID:SGTC_1730|Compound:st033808|FD-Score:9.08|P-value:2.56E-23 ID:SGTC_1731|Compound:st035964|FD-Score:-3.25|P-value:2.40E-4 ID:SGTC_1734|Compound:st037168|FD-Score:6.69|P-value:1.61E-13 ID:SGTC_1735|Compound:st034310|FD-Score:3.36|P-value:1.21E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.19|P-value:7.34E-9 ID:SGTC_1884|Compound:5633444|FD-Score:2.85|P-value:8.93E-4 ID:SGTC_1940|Compound:st075990|FD-Score:6.14|P-value:1.11E-11 ID:SGTC_1945|Compound:st075991|FD-Score:2.93|P-value:6.67E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.28|P-value:1.64E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.57|P-value:6.05E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-3.39|P-value:1.30E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.15|P-value:2.84E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.15|P-value:2.79E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.27|P-value:1.74E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:2.84|P-value:9.42E-4 ID:SGTC_2812|Compound:7970281|FD-Score:5.50|P-value:9.97E-10 ID:SGTC_2834|Compound:9001755|FD-Score:-3.73|P-value:2.96E-5 ID:SGTC_2842|Compound:9000675|FD-Score:4.38|P-value:8.77E-7 ID:SGTC_2860|Compound:9025725|FD-Score:-3.24|P-value:2.46E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.00|P-value:5.17E-4 ID:SGTC_2877|Compound:9040724|FD-Score:2.91|P-value:7.08E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-2.90|P-value:9.28E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-2.91|P-value:8.85E-4 ID:SGTC_3083|Compound:9117465|FD-Score:2.83|P-value:9.70E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.71|P-value:1.37E-7 ID:SGTC_3137|Compound:9097352|FD-Score:-3.70|P-value:3.32E-5 ID:SGTC_3225|Compound:9130819|FD-Score:3.29|P-value:1.58E-4 ID:SGTC_3246|Compound:9135460|FD-Score:-3.12|P-value:3.90E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.05|P-value:4.27E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.48|P-value:9.04E-5

Top fitness defect scores for YHR114W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1730 st033808 9.08 45.1 µM 2.56E-23 2 5.57E-20
2 SGTC_1734 st037168 6.69 69.4 µM 1.61E-13 5 1.15E-11
3 SGTC_1940 st075990 6.14 51.1 µM 1.11E-11 60S ribosome export 3 4.18E-10
4 SGTC_2812 7970281 5.50 58.4 µM 9.97E-10 4 1.89E-8
5 SGTC_1787 fluconazole 5.19 80.0 µM 7.34E-9 iron homeostasis 8 1.03E-7
6 SGTC_3087 9117406 4.71 49.5 µM 1.37E-7 6 1.24E-6
7 SGTC_676 falcarinol 4.67 140.0 µM 1.68E-7 40 1.47E-6
8 SGTC_2842 9000675 4.38 19.5 µM 8.77E-7 14 6.00E-6
9 SGTC_864 0469-0573 4.27 172.0 µM 1.56E-6 11 9.80E-6
10 SGTC_1605 st000082 3.92 49.1 µM 9.07E-6 60S ribosome export 16 4.38E-5
11 SGTC_1363 1636-0063 3.84 10.4 µM 1.37E-5 Golgi 32 6.22E-5
12 SGTC_335 4077-0256 3.71 27.6 µM 2.51E-5 18 1.04E-4
13 SGTC_521 r062-0005 3.71 13.8 µM 2.55E-5 19 1.05E-4
14 SGTC_1735 st034310 3.36 56.8 µM 1.21E-4 Golgi 48 3.96E-4
15 SGTC_3225 9130819 3.29 49.5 µM 1.58E-4 amide catabolism 48 4.99E-4
16 SGTC_1955 wogonin 3.28 32.4 µM 1.64E-4 35 5.13E-4
17 SGTC_2450 5739737 3.27 12.9 µM 1.74E-4 50 5.40E-4
18 SGTC_2153 5569715 3.15 200.0 µM 2.79E-4 iron homeostasis 30 8.08E-4
19 SGTC_2112 5488546 3.15 200.0 µM 2.84E-4 TSC3-RPN4 48 8.21E-4
20 SGTC_600 1495-0418 3.05 41.6 µM 4.16E-4 RPP1 & pyrimidine depletion 45 0.00114

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 9.99E-13 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.11E-8 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.090 1.68E-7 YPR072W NOT5 hom Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
0.089 2.06E-7 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.083 1.58E-6 YCR081W SRB8 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
0.081 2.90E-6 YBR064W_d YBR064W_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C
0.080 3.85E-6 YGL197W MDS3 hom Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain
0.080 3.96E-6 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.079 4.85E-6 YLR435W TSR2 hom Protein with a potential role in pre-rRNA processing
0.079 5.19E-6 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.078 6.63E-6 YKL038W RGT1 hom Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication
0.075 1.23E-5 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.19E-5 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.073 2.43E-5 YER075C PTP3 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
0.072 2.75E-5 YPL135W ISU1 hom Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable