YHR118C / ORC6

Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR118C / ORC6

Click on Significant Values for Screen Details ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.59|P-value:6.05E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.07|P-value:6.65E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.11|P-value:4.26E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.76|P-value:2.91E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:3.67|P-value:4.25E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.27|P-value:1.50E-8 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.67|P-value:4.24E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:3.65|P-value:4.68E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:-5.39|P-value:6.90E-9 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.18|P-value:4.31E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:2.95|P-value:7.62E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.76|P-value:2.80E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.07|P-value:6.47E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.02|P-value:6.06E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.52|P-value:8.27E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.03|P-value:5.79E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.53|P-value:6.54E-7 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.83|P-value:2.13E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.02|P-value:5.97E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.48|P-value:9.74E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.14|P-value:3.83E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.01|P-value:6.10E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:2.92|P-value:8.72E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-6.89|P-value:1.93E-13 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.07|P-value:4.88E-4 ID:SGTC_1604|Compound:st002052|FD-Score:5.27|P-value:9.36E-9 ID:SGTC_1606|Compound:st000094|FD-Score:3.68|P-value:4.15E-5 ID:SGTC_1626|Compound:st003712|FD-Score:-4.06|P-value:1.03E-5 ID:SGTC_1657|Compound:st012939|FD-Score:3.14|P-value:3.82E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.83|P-value:2.11E-5 ID:SGTC_1700|Compound:st030840|FD-Score:3.58|P-value:6.44E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.41|P-value:1.32E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.20|P-value:3.49E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.99|P-value:9.77E-6 ID:SGTC_1948|Compound:st076329|FD-Score:3.68|P-value:4.03E-5 ID:SGTC_2069|Compound:5228469|FD-Score:2.93|P-value:8.39E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.20|P-value:4.00E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.20|P-value:3.49E-6 ID:SGTC_2193|Compound:5925765|FD-Score:2.90|P-value:9.32E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.81|P-value:2.32E-5 ID:SGTC_2327|Compound:6189656|FD-Score:5.47|P-value:2.66E-9 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.36|P-value:1.58E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.40|P-value:1.26E-6 ID:SGTC_2625|Compound:euphol|FD-Score:4.83|P-value:1.28E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.19|P-value:3.67E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.94|P-value:1.74E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-2.96|P-value:9.79E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.36|P-value:1.56E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.91|P-value:1.45E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.71|P-value:3.57E-5 ID:SGTC_3047|Compound:9092122|FD-Score:2.93|P-value:8.42E-4 ID:SGTC_3057|Compound:9095946|FD-Score:-3.27|P-value:3.09E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.77|P-value:3.76E-5 ID:SGTC_3202|Compound:9113761|FD-Score:5.28|P-value:8.99E-9 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.59|P-value:6.05E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.07|P-value:6.65E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.11|P-value:4.26E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.76|P-value:2.91E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:3.67|P-value:4.25E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.27|P-value:1.50E-8 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.67|P-value:4.24E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:3.65|P-value:4.68E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:-5.39|P-value:6.90E-9 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.18|P-value:4.31E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:2.95|P-value:7.62E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.76|P-value:2.80E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.07|P-value:6.47E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.02|P-value:6.06E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.52|P-value:8.27E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.03|P-value:5.79E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.53|P-value:6.54E-7 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.83|P-value:2.13E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.02|P-value:5.97E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.48|P-value:9.74E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.14|P-value:3.83E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.01|P-value:6.10E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:2.92|P-value:8.72E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-6.89|P-value:1.93E-13 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.07|P-value:4.88E-4 ID:SGTC_1604|Compound:st002052|FD-Score:5.27|P-value:9.36E-9 ID:SGTC_1606|Compound:st000094|FD-Score:3.68|P-value:4.15E-5 ID:SGTC_1626|Compound:st003712|FD-Score:-4.06|P-value:1.03E-5 ID:SGTC_1657|Compound:st012939|FD-Score:3.14|P-value:3.82E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.83|P-value:2.11E-5 ID:SGTC_1700|Compound:st030840|FD-Score:3.58|P-value:6.44E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.41|P-value:1.32E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.20|P-value:3.49E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.99|P-value:9.77E-6 ID:SGTC_1948|Compound:st076329|FD-Score:3.68|P-value:4.03E-5 ID:SGTC_2069|Compound:5228469|FD-Score:2.93|P-value:8.39E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.20|P-value:4.00E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.20|P-value:3.49E-6 ID:SGTC_2193|Compound:5925765|FD-Score:2.90|P-value:9.32E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.81|P-value:2.32E-5 ID:SGTC_2327|Compound:6189656|FD-Score:5.47|P-value:2.66E-9 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.36|P-value:1.58E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.40|P-value:1.26E-6 ID:SGTC_2625|Compound:euphol|FD-Score:4.83|P-value:1.28E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.19|P-value:3.67E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.94|P-value:1.74E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-2.96|P-value:9.79E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.36|P-value:1.56E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.91|P-value:1.45E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.71|P-value:3.57E-5 ID:SGTC_3047|Compound:9092122|FD-Score:2.93|P-value:8.42E-4 ID:SGTC_3057|Compound:9095946|FD-Score:-3.27|P-value:3.09E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.77|P-value:3.76E-5 ID:SGTC_3202|Compound:9113761|FD-Score:5.28|P-value:8.99E-9

Top fitness defect scores for YHR118C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2327 6189656 5.47 200.0 µM 2.66E-9 4 2.24E-8 1.05
2 SGTC_3202 9113761 5.28 49.5 µM 8.99E-9 3 6.59E-8 0.27
3 SGTC_1604 st002052 5.27 72.4 µM 9.36E-9 TSC3-RPN4 4 6.83E-8 0.40
4 SGTC_2625 euphol 4.83 100.0 µM 1.28E-7 4 6.99E-7 0.12
5 SGTC_1232 0279-0259 4.53 161.0 µM 6.54E-7 1 2.96E-6 0.29
6 SGTC_2620 irigenin 4.40 100.0 µM 1.26E-6 10 5.31E-6 0.11
7 SGTC_2191 5911152 4.20 200.0 µM 3.49E-6 1 1.31E-5 0.35
8 SGTC_1744 st037937 4.20 38.9 µM 3.49E-6 6 1.31E-5 0.40
9 SGTC_2627 acetyl isogambogic acid 4.19 100.0 µM 3.67E-6 TSC3-RPN4 2 1.37E-5 0.14
10 SGTC_1917 st066507 3.99 28.5 µM 9.77E-6 Golgi 8 3.27E-5 0.22
11 SGTC_2858 9025781 3.91 9.0 µM 1.45E-5 sphingolipid biosynthesis & PDR1 15 4.65E-5 0.07
12 SGTC_1698 5-fluorocytosine 3.83 1.1 µM 2.11E-5 exosome 15 6.49E-5 0.15
13 SGTC_1271 0832-2808 3.83 169.0 µM 2.13E-5 6 6.54E-5 0.07
14 SGTC_2318 6029776 3.81 164.0 µM 2.32E-5 5 7.04E-5 0.13
15 SGTC_1120 ficusin 3.76 1.8 µM 2.80E-5 4 8.33E-5 0.33
16 SGTC_130 0136-0219 3.76 337.7 µM 2.91E-5 11 8.61E-5 0.12
17 SGTC_2919 7978188 3.71 46.4 µM 3.57E-5 4 1.03E-4 0.15
18 SGTC_1948 st076329 3.68 66.6 µM 4.03E-5 4 1.15E-4 0.05
19 SGTC_1606 st000094 3.68 49.2 µM 4.15E-5 60S ribosome export 9 1.18E-4 0.12
20 SGTC_390 dec-rvkr-cmk 3.67 16.7 µM 4.24E-5 calcium & mitochondrial duress 11 1.20E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 6.57E-21 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
0.154 2.36E-19 YKL153W_d YKL153W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.149 3.87E-18 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress
0.137 1.47E-15 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.128 1.22E-13 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.127 1.35E-13 YER038C KRE29 het Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.124 4.92E-13 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.117 1.29E-11 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.113 4.45E-11 YDR328C SKP1 het Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress
0.109 2.51E-10 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.108 3.29E-10 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.106 6.13E-10 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.106 8.46E-10 YMR288W HSH155 het U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
0.100 6.08E-9 YMR199W CLN1 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.100 7.43E-9 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex