YHR121W / LSM12

Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR121W / LSM12

Click on Significant Values for Screen Details ID:SGTC_130|Compound:0136-0219|FD-Score:5.12|P-value:7.93E-8 ID:SGTC_133|Compound:0724-0033|FD-Score:4.51|P-value:2.01E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:3.08|P-value:8.24E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.18|P-value:5.80E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.32|P-value:4.96E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:3.34|P-value:3.17E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.86|P-value:3.37E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.45|P-value:2.66E-6 ID:SGTC_512|Compound:prima-1|FD-Score:3.25|P-value:4.39E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.25|P-value:4.48E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.50|P-value:9.32E-9 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.90|P-value:3.22E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:3.20|P-value:5.42E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.61|P-value:1.13E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.08|P-value:7.92E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.15|P-value:1.07E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.04|P-value:9.32E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.88|P-value:3.61E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.32|P-value:3.47E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.44|P-value:2.21E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.30|P-value:3.73E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.20|P-value:5.36E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.39|P-value:3.56E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.06|P-value:8.56E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.37|P-value:2.82E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.69|P-value:7.94E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.69|P-value:7.71E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.61|P-value:1.06E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.18|P-value:5.64E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.03|P-value:9.63E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.46|P-value:1.98E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.12|P-value:7.14E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.14|P-value:6.73E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.39|P-value:2.62E-4 ID:SGTC_2125|Compound:5246583|FD-Score:8.15|P-value:3.59E-17 ID:SGTC_2127|Compound:5253358|FD-Score:-3.06|P-value:8.70E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.85|P-value:4.01E-5 ID:SGTC_2182|Compound:6325192|FD-Score:3.09|P-value:7.76E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.38|P-value:3.66E-6 ID:SGTC_2192|Compound:5915882|FD-Score:-3.11|P-value:7.12E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.08|P-value:8.09E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.21|P-value:5.06E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.03|P-value:9.86E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.70|P-value:7.68E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.02|P-value:9.92E-4 ID:SGTC_2437|Compound:5741531|FD-Score:6.80|P-value:1.78E-12 ID:SGTC_2443|Compound:5493264|FD-Score:3.30|P-value:3.72E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.19|P-value:5.43E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.49|P-value:2.14E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.10|P-value:7.69E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.26|P-value:4.26E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-4.74|P-value:6.02E-7 ID:SGTC_2807|Compound:7945238|FD-Score:3.17|P-value:5.93E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.27|P-value:6.34E-6 ID:SGTC_2897|Compound:9048598|FD-Score:3.17|P-value:6.04E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.03|P-value:1.88E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.31|P-value:3.42E-4 ID:SGTC_2950|Compound:9072895|FD-Score:7.12|P-value:1.64E-13 ID:SGTC_2951|Compound:9072950|FD-Score:-4.46|P-value:2.47E-6 ID:SGTC_2962|Compound:9082311|FD-Score:3.60|P-value:1.16E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.03|P-value:9.62E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.20|P-value:5.24E-4 ID:SGTC_3102|Compound:9121669|FD-Score:4.54|P-value:1.68E-6 ID:SGTC_3140|Compound:9094243|FD-Score:-3.58|P-value:1.23E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.12|P-value:6.99E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.05|P-value:8.94E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.29|P-value:5.69E-6 ID:SGTC_3262|Compound:9137218|FD-Score:3.10|P-value:7.57E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.09|P-value:7.97E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.58|P-value:1.24E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.05|P-value:9.12E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:5.12|P-value:7.93E-8 ID:SGTC_133|Compound:0724-0033|FD-Score:4.51|P-value:2.01E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:3.08|P-value:8.24E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.18|P-value:5.80E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.32|P-value:4.96E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:3.34|P-value:3.17E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.86|P-value:3.37E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.45|P-value:2.66E-6 ID:SGTC_512|Compound:prima-1|FD-Score:3.25|P-value:4.39E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.25|P-value:4.48E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.50|P-value:9.32E-9 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.90|P-value:3.22E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:3.20|P-value:5.42E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.61|P-value:1.13E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.08|P-value:7.92E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.15|P-value:1.07E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.04|P-value:9.32E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.88|P-value:3.61E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.32|P-value:3.47E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.44|P-value:2.21E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.30|P-value:3.73E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.20|P-value:5.36E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.39|P-value:3.56E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.06|P-value:8.56E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.37|P-value:2.82E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.69|P-value:7.94E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.69|P-value:7.71E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.61|P-value:1.06E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.18|P-value:5.64E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.03|P-value:9.63E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.46|P-value:1.98E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.12|P-value:7.14E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.14|P-value:6.73E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.39|P-value:2.62E-4 ID:SGTC_2125|Compound:5246583|FD-Score:8.15|P-value:3.59E-17 ID:SGTC_2127|Compound:5253358|FD-Score:-3.06|P-value:8.70E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.85|P-value:4.01E-5 ID:SGTC_2182|Compound:6325192|FD-Score:3.09|P-value:7.76E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.38|P-value:3.66E-6 ID:SGTC_2192|Compound:5915882|FD-Score:-3.11|P-value:7.12E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.08|P-value:8.09E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.21|P-value:5.06E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.03|P-value:9.86E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.70|P-value:7.68E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.02|P-value:9.92E-4 ID:SGTC_2437|Compound:5741531|FD-Score:6.80|P-value:1.78E-12 ID:SGTC_2443|Compound:5493264|FD-Score:3.30|P-value:3.72E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.19|P-value:5.43E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.49|P-value:2.14E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.10|P-value:7.69E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.26|P-value:4.26E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-4.74|P-value:6.02E-7 ID:SGTC_2807|Compound:7945238|FD-Score:3.17|P-value:5.93E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.27|P-value:6.34E-6 ID:SGTC_2897|Compound:9048598|FD-Score:3.17|P-value:6.04E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.03|P-value:1.88E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.31|P-value:3.42E-4 ID:SGTC_2950|Compound:9072895|FD-Score:7.12|P-value:1.64E-13 ID:SGTC_2951|Compound:9072950|FD-Score:-4.46|P-value:2.47E-6 ID:SGTC_2962|Compound:9082311|FD-Score:3.60|P-value:1.16E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.03|P-value:9.62E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.20|P-value:5.24E-4 ID:SGTC_3102|Compound:9121669|FD-Score:4.54|P-value:1.68E-6 ID:SGTC_3140|Compound:9094243|FD-Score:-3.58|P-value:1.23E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.12|P-value:6.99E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.05|P-value:8.94E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.29|P-value:5.69E-6 ID:SGTC_3262|Compound:9137218|FD-Score:3.10|P-value:7.57E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.09|P-value:7.97E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.58|P-value:1.24E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.05|P-value:9.12E-4

Top fitness defect scores for YHR121W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2125 5246583 8.15 200.0 µM 3.59E-17 tubulin folding & SWR complex 7 1.75E-16
2 SGTC_2950 9072895 7.12 21.5 µM 1.64E-13 4 5.51E-13
3 SGTC_2437 5741531 6.80 144.2 µM 1.78E-12 7 5.38E-12
4 SGTC_562 3772-2733 5.50 112.0 µM 9.32E-9 ERG2 40 1.93E-8
5 SGTC_130 0136-0219 5.12 337.7 µM 7.93E-8 9 1.49E-7
6 SGTC_358 0075-0058 4.86 9.4 µM 3.37E-7 31 5.96E-7
7 SGTC_3102 9121669 4.54 49.5 µM 1.68E-6 3 2.78E-6
8 SGTC_133 0724-0033 4.51 378.9 µM 2.01E-6 16 3.29E-6
9 SGTC_2461 5755302 4.49 26.1 µM 2.14E-6 19 3.49E-6
10 SGTC_402 epigallocatechin gallate 4.45 10.0 µM 2.66E-6 12 4.29E-6
11 SGTC_1445 4239-0156 4.39 97.7 µM 3.56E-6 20 5.68E-6
12 SGTC_2185 6113692 4.38 200.0 µM 3.66E-6 ergosterol biosynthesis 9 5.84E-6
13 SGTC_181 1447-1644 4.32 8.1 µM 4.96E-6 endomembrane recycling 25 7.80E-6
14 SGTC_3222 9128301 4.29 49.5 µM 5.69E-6 60S ribosome export 20 8.91E-6
15 SGTC_2825 7998094 4.27 58.4 µM 6.34E-6 fatty acid desaturase (OLE1) 23 9.86E-6
16 SGTC_2941 9056145 4.03 11.2 µM 1.88E-5 18 2.79E-5
17 SGTC_956 1185-0240 3.88 191.0 µM 3.61E-5 25 5.21E-5
18 SGTC_2364 9055074 3.70 200.0 µM 7.68E-5 26 1.07E-4
19 SGTC_1673 st016611 3.69 27.3 µM 7.94E-5 55 1.11E-4
20 SGTC_669 0108-0021 3.61 26.2 µM 1.13E-4 fatty acid desaturase (OLE1) 106 1.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 3.12E-21 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.128 1.21E-13 YKL103C APE1 hom Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress
0.127 1.94E-13 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.125 3.75E-13 YOL084W PHM7 hom Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress
0.116 1.48E-11 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.116 1.63E-11 YFL048C EMP47 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.104 1.30E-9 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.096 2.84E-8 YGL006W PMC1 hom Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
0.093 7.44E-8 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.092 8.76E-8 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.092 9.73E-8 YBL067C UBP13 hom Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication
0.092 1.06E-7 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.089 2.16E-7 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.087 4.94E-7 YKL207W EMC3 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.085 8.50E-7 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin